DK472082A - Fremgangsmaade til fremstilling af alkan- og alkenderivater eller ugiftige, farmaceutisk acceptable salte og estere deraf - Google Patents

Fremgangsmaade til fremstilling af alkan- og alkenderivater eller ugiftige, farmaceutisk acceptable salte og estere deraf Download PDF

Info

Publication number: DK472082A
Authority: DK; Denmark
Prior art keywords: sub; compounds; hydrogen; carbon atoms; preparation
Prior art date: 1981-10-26

Application number

DK472082A

Other languages

English (en)

Inventor

Marja-Liisa Soedervall

Kauko Oiva Antero Kurkela

Arto Johannes Karjalainen

Reijo Juhani Toivola

Lauri Veikko Matti Kangas

Guillermo Luis Blanco

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-26

Filing date

1982-10-25

Publication date

1983-04-27

1982-10-25 Application filed by Farmos Oy filed Critical Farmos Oy

1983-04-27 Publication of DK472082A publication Critical patent/DK472082A/da

Links

150000003839 salts Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
150000001335 aliphatic alkanes Chemical class 0.000 title 1
150000001344 alkene derivatives Chemical class 0.000 title 1
231100000614 poison Toxicity 0.000 title 1
230000007096 poisonous effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
-1 2,3-epoxypropoxy, 2,3-dihydroxypropoxy Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005336 allyloxy group Chemical group 0.000 abstract 1
230000001833 anti-estrogenic effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000328 estrogen antagonist Substances 0.000 abstract 1
230000001076 estrogenic effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms using aldehydes or ketones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/11—Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Separation Of Gases By Adsorption (AREA)
Inorganic Insulating Materials (AREA)
Treating Waste Gases (AREA)
Epoxy Compounds (AREA)
Steroid Compounds (AREA)

DK472082A 1981-10-26 1982-10-25 Fremgangsmaade til fremstilling af alkan- og alkenderivater eller ugiftige, farmaceutisk acceptable salte og estere deraf DK472082A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB08132240A GB2108486B (en)	1981-10-26	1981-10-26	Alkane and alkene derivatives and their preparation and use

Publications (1)

Publication Number	Publication Date
DK472082A true DK472082A (da)	1983-04-27

Family

ID=10525401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK472082A DK472082A (da)	1981-10-26	1982-10-25	Fremgangsmaade til fremstilling af alkan- og alkenderivater eller ugiftige, farmaceutisk acceptable salte og estere deraf

Country Status (18)

Country	Link
US (1)	US4556677A (da)
EP (1)	EP0078158B1 (da)
JP (1)	JPS5879934A (da)
AT (1)	ATE22065T1 (da)
AU (1)	AU555477B2 (da)
CA (1)	CA1310974C (da)
DD (1)	DD211548A1 (da)
DE (1)	DE3273219D1 (da)
DK (1)	DK472082A (da)
FI (1)	FI77842C (da)
GB (1)	GB2108486B (da)
HU (1)	HU193268B (da)
IE (1)	IE54586B1 (da)
IL (1)	IL67049A (da)
NO (1)	NO159079C (da)
NZ (1)	NZ202269A (da)
SU (1)	SU1329615A3 (da)
ZA (1)	ZA827742B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2108486B (en) *	1981-10-26	1986-01-29	Farmos Group Ltd	Alkane and alkene derivatives and their preparation and use
US4760053A (en) *	1984-08-02	1988-07-26	Fernand Labrie	Combination therapy for selected sex steroid dependent cancers
US4666885A (en) *	1985-02-08	1987-05-19	Fernand Labrie	Combination therapy for treatment of female breast cancer
US4775660A (en) *	1984-08-02	1988-10-04	Fernand Labrie	Treatment of breast cancer by combination therapy
US4895715A (en) *	1988-04-14	1990-01-23	Schering Corporation	Method of treating gynecomastia
EP0462189B1 (en) *	1989-03-10	1995-09-27	Endorecherche Inc.	Combination therapy for treatment of estrogen sensitive diseases
NL1018247C2 (nl)	2001-06-08	2002-12-10	Sara Lee De Nv	Inrichting voor het bereiden van een voor consumptie geschikte drank zoals koffie.
JP2004010479A (ja) *	2002-06-03	2004-01-15	Japan Science & Technology Corp	ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法
AU2009324422A1 (en) *	2008-12-12	2011-07-07	Celexion, Llc	Biological synthesis of difunctional alkanes from alpha ketoacids
FR3071837B1 (fr)	2017-09-29	2019-11-01	Institut National De La Recherche Agronomique	Derive de lignine chimiquement stable et procede pour sa preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1306604A (fr) *	1959-03-03	1962-10-19	Ferrosan Ab	Procédé pour préparer des bisphényléthylènes substitués
GB1289966A (da) *	1968-12-24	1972-09-20
US3661976A (en) *	1969-05-16	1972-05-09	Parke Davis & Co	4,4'-(2-cycloalkyl-alkylidene) diphenols and ethers and esters thereof
BE793686A (fr) *	1972-01-07	1973-07-04	Beecham Group Ltd	Composes di-aryliques biologiquement actifs
GB2108486B (en) *	1981-10-26	1986-01-29	Farmos Group Ltd	Alkane and alkene derivatives and their preparation and use

1981
- 1981-10-26 GB GB08132240A patent/GB2108486B/en not_active Expired
1982
- 1982-10-12 FI FI823465A patent/FI77842C/fi not_active IP Right Cessation
- 1982-10-18 SU SU823503159A patent/SU1329615A3/ru active
- 1982-10-21 DE DE8282305612T patent/DE3273219D1/de not_active Expired
- 1982-10-21 EP EP82305612A patent/EP0078158B1/en not_active Expired
- 1982-10-21 AT AT82305612T patent/ATE22065T1/de not_active IP Right Cessation
- 1982-10-22 IL IL67049A patent/IL67049A/xx not_active IP Right Cessation
- 1982-10-22 IE IE2551/82A patent/IE54586B1/en not_active IP Right Cessation
- 1982-10-22 NZ NZ202269A patent/NZ202269A/en unknown
- 1982-10-22 ZA ZA827742A patent/ZA827742B/xx unknown
- 1982-10-22 AU AU89702/82A patent/AU555477B2/en not_active Ceased
- 1982-10-23 JP JP57186650A patent/JPS5879934A/ja active Granted
- 1982-10-25 CA CA000414128A patent/CA1310974C/en not_active Expired - Fee Related
- 1982-10-25 NO NO823537A patent/NO159079C/no unknown
- 1982-10-25 DD DD82244246A patent/DD211548A1/de not_active IP Right Cessation
- 1982-10-25 HU HU823395A patent/HU193268B/hu not_active IP Right Cessation
- 1982-10-25 DK DK472082A patent/DK472082A/da not_active Application Discontinuation
- 1982-10-26 US US06/436,805 patent/US4556677A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI77842C (fi)	1989-05-10
IL67049A (en)	1987-07-31
NO159079C (no)	1988-11-30
GB2108486A (en)	1983-05-18
DE3273219D1 (en)	1986-10-16
EP0078158B1 (en)	1986-09-10
EP0078158A2 (en)	1983-05-04
FI823465A0 (fi)	1982-10-12
FI823465L (fi)	1983-04-27
CA1310974C (en)	1992-12-01
IE54586B1 (en)	1989-12-06
ZA827742B (en)	1983-08-31
AU8970282A (en)	1983-05-12
SU1329615A3 (ru)	1987-08-07
NO823537L (no)	1983-04-27
DD211548A1 (de)	1984-07-18
NO159079B (no)	1988-08-22
US4556677A (en)	1985-12-03
JPH0239492B2 (da)	1990-09-05
HU193268B (en)	1987-09-28
JPS5879934A (ja)	1983-05-13
EP0078158A3 (en)	1984-01-18
GB2108486B (en)	1986-01-29
NZ202269A (en)	1985-05-31
FI77842B (fi)	1989-01-31
IE822551L (en)	1983-04-26
ATE22065T1 (de)	1986-09-15
AU555477B2 (en)	1986-09-25

Legal Events

Date	Code	Title	Description
1997-05-26	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
ES483767A1 (es)	1980-04-16	Procedimiento para producir n-arilsulfonil-l-argininamidas
SE7807404L (sv)	1979-12-31	Nya foreningar
DK57181A (da)	1981-08-14	Fremgangsmaade til fremstilling af 4-substituerede imidazolderivater eller ugiftige farmaceutisk acceptable syreadditionssalte deraf
PT81855B (pt)	1987-11-30	Processo de preparacao de arilciclobutilalquilaminas e de composicoes farmaceuticas que as contem
NO823537L (no)	1983-04-27	Fremgangsmaate for fremstilling av farmakologisk aktive alkan- og alkenderivater
IL57691A0 (en)	1979-10-31	New 3,20-dioxo-4,9-diene-21-hydroxyl steroid derivatives,process for preparing them and their use as medicaments and the pharmaceutical compositions containing them
MX7157E (es)	1987-11-27	Procedimiento para preparar derivados de fenilpiperazina
FI840746A0 (fi)	1984-02-23	Foerfarande foer framstaellning av cellulosaetrar med ett dimetoxietan innehaollande dispergeringshjaelpmedel
ES552003A0 (es)	1987-02-16	Procedimiento para preparar derivados monobasicos de disobutamida.
ES543802A0 (es)	1986-01-16	Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo n-carbamiloxi sustituido
ES447751A1 (es)	1977-10-01	Procedimiento para preparar derivados de imidazolilquinazo- lina.
KR840005107A (ko)	1984-11-03	피리미디온 및 그의 산부가염의 제조방법
ATE29251T1 (de)	1987-09-15	Aminopyridincarbonsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FI834792A0 (fi)	1983-12-27	Foerfarande foer framstaellning av aminoetoxibensylalkohol-derivat
DK508384A (da)	1985-04-26	Isoquinolinderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende dem
ATE36154T1 (de)	1988-08-15	4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES402471A1 (es)	1976-01-01	Un procedimiento para la preparacion de derivados de 1-ari-loxi-3-amino-propanol.
JPS5227757A (en)	1977-03-02	Preparation of 6-aminomethylnaphthalene derivatives
KR860004046A (ko)	1986-06-16	헤테로폴리사이클릭 화합물의 제법 및 그 약학제제
JPS5271447A (en)	1977-06-14	Synthesis of 2,3-epoxycyclopentanone derivatives
JPS51115483A (en)	1976-10-12	Method for preparing glycerol derivatives
JPS5271484A (en)	1977-06-14	Synthesis of novel quinazoline derivatives