DK475186A - Fremgangsmaade til fremstilling af amikacin - Google Patents

Fremgangsmaade til fremstilling af amikacin Download PDF

Info

Publication number: DK475186A
Authority: DK; Denmark
Prior art keywords: amikacin; metal cation; solvent; reaction; manufacturing
Prior art date: 1985-10-10

Application number

DK475186A

Other languages

English (en)

Other versions

DK475186D0 (da

DK166829B1 (da

Inventor

Alberto Mangia

Vincenzo Giobbio

Giorgio Ornato

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-10

Filing date

1986-10-03

Publication date

1987-04-11

1986-10-03 Application filed by Pierrel Spa filed Critical Pierrel Spa

1986-10-03 Publication of DK475186D0 publication Critical patent/DK475186D0/da

1987-04-11 Publication of DK475186A publication Critical patent/DK475186A/da

1993-07-19 Application granted granted Critical

1993-07-19 Publication of DK166829B1 publication Critical patent/DK166829B1/da

Links

229960004821 amikacin Drugs 0.000 title abstract 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
150000001768 cations Chemical class 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052793 cadmium Inorganic materials 0.000 abstract 1
BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 abstract 1
229910017052 cobalt Inorganic materials 0.000 abstract 1
239000010941 cobalt Substances 0.000 abstract 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
229910052802 copper Inorganic materials 0.000 abstract 1
239000010949 copper Substances 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
229960000318 kanamycin Drugs 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
229930182823 kanamycin A Natural products 0.000 abstract 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052759 nickel Inorganic materials 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Materials For Medical Uses (AREA)
Floor Finish (AREA)
Quinoline Compounds (AREA)
Peptides Or Proteins (AREA)
Removal Of Specific Substances (AREA)

DK475186A 1985-10-10 1986-10-03 Fremgangsmaade til fremstilling af amikacin DK166829B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT22425/85A IT1200774B (it)	1985-10-10	1985-10-10	Procedimento di sentisi dell'amikacina
IT2242585		1985-10-10

Publications (3)

Publication Number	Publication Date
DK475186D0 DK475186D0 (da)	1986-10-03
DK475186A true DK475186A (da)	1987-04-11
DK166829B1 DK166829B1 (da)	1993-07-19

Family

ID=11196139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK475186A DK166829B1 (da)	1985-10-10	1986-10-03	Fremgangsmaade til fremstilling af amikacin

Country Status (21)

Country	Link
US (1)	US4902790A (da)
EP (1)	EP0218292B1 (da)
JP (1)	JPS6293297A (da)
KR (1)	KR910005897B1 (da)
AT (1)	ATE55391T1 (da)
AU (1)	AU603998B2 (da)
BG (1)	BG50164A3 (da)
CA (1)	CA1296331C (da)
CS (1)	CS257292B2 (da)
DD (1)	DD258991A1 (da)
DE (1)	DE3673305D1 (da)
DK (1)	DK166829B1 (da)
HU (1)	HU196421B (da)
IT (1)	IT1200774B (da)
NO (1)	NO165297C (da)
NZ (1)	NZ217862A (da)
PH (1)	PH22748A (da)
PL (1)	PL147396B1 (da)
RU (1)	RU1771477C (da)
YU (1)	YU44579B (da)
ZA (1)	ZA867440B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1225484B (it) *	1987-11-27	1990-11-14	Pierrel Spa	Procedimento di sintesi dell'amikacina
IT1237490B (it) *	1989-09-22	1993-06-07	Chementecno S R L Monza Milano	Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
YU45590A (sh) *	1990-03-07	1992-07-20	PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o.	Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
DE69104092T2 (de) *	1990-03-08	1995-01-26	Opos Biochimica Srl	Verfahren zur Herstellung von Amikacin-Vorläufern.
US6653456B2 (en) *	2001-07-31	2003-11-25	Roche Diagnostics Corporation	Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
IL163668A0 (en) *	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Use of peptide-drug conjugation to reduce inter-subject variability ofdrug serum levels
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) *	2005-10-28	2009-03-19	Sabbadini Roger A	Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) *	2005-10-28	2008-09-04	Sabbadini Roger A	Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) *	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
CN102256989B (zh)	2008-10-03	2016-01-06	聚糖生物科学有限责任公司	糖基化细菌代谢物的阴离子轭合物
CN103113429B (zh) *	2013-03-05	2015-02-18	齐鲁天和惠世制药有限公司	一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) *	2014-08-27	2018-03-09	北大医药重庆大新药业股份有限公司	一种阿米卡星的合成方法
CN111138505B (zh) *	2020-02-17	2021-10-08	山东安信制药有限公司	一种阿米卡星的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4230847A (en) *	1976-06-17	1980-10-28	Schering Corporation	Aminoglycoside antibiotic compounds
IE48972B1 (en) *	1978-11-11	1985-06-26	Microbial Chem Res Found	The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4468513A (en) *	1980-09-22	1984-08-28	Eli Lilly And Company	2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
JPS5782399A (en) *	1980-09-22	1982-05-22	Lilly Co Eli	2-deoxystreptamine aminoglycoside derivative and manufacture
US4424344A (en) *	1980-09-22	1984-01-03	Eli Lilly And Company	2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process

1985
- 1985-10-10 IT IT22425/85A patent/IT1200774B/it active
1986
- 1986-06-23 YU YU1086/86A patent/YU44579B/xx unknown
- 1986-06-30 HU HU862726A patent/HU196421B/hu not_active IP Right Cessation
- 1986-07-10 BG BG075682A patent/BG50164A3/xx unknown
- 1986-07-11 DD DD86292400A patent/DD258991A1/de not_active IP Right Cessation
- 1986-07-14 PL PL1986260615A patent/PL147396B1/pl unknown
- 1986-08-07 CS CS865913A patent/CS257292B2/cs unknown
- 1986-09-25 EP EP86201663A patent/EP0218292B1/en not_active Expired - Lifetime
- 1986-09-25 AT AT86201663T patent/ATE55391T1/de active
- 1986-09-25 DE DE8686201663T patent/DE3673305D1/de not_active Expired - Fee Related
- 1986-09-30 ZA ZA867440A patent/ZA867440B/xx unknown
- 1986-10-02 US US06/914,451 patent/US4902790A/en not_active Expired - Fee Related
- 1986-10-03 DK DK475186A patent/DK166829B1/da not_active IP Right Cessation
- 1986-10-07 CA CA000520035A patent/CA1296331C/en not_active Expired - Fee Related
- 1986-10-08 KR KR1019860008418A patent/KR910005897B1/ko not_active Expired
- 1986-10-08 NO NO864011A patent/NO165297C/no unknown
- 1986-10-08 PH PH34334A patent/PH22748A/en unknown
- 1986-10-09 JP JP61239398A patent/JPS6293297A/ja active Granted
- 1986-10-09 AU AU63633/86A patent/AU603998B2/en not_active Ceased
- 1986-10-09 RU SU864028258A patent/RU1771477C/ru active
- 1986-10-09 NZ NZ217862A patent/NZ217862A/xx unknown

Also Published As

Publication number	Publication date
CA1296331C (en)	1992-02-25
KR870004050A (ko)	1987-05-07
RU1771477C (ru)	1992-10-23
KR910005897B1 (ko)	1991-08-06
PL260615A1 (en)	1987-06-15
BG50164A3 (en)	1992-05-15
YU44579B (en)	1990-10-31
US4902790A (en)	1990-02-20
JPS6293297A (ja)	1987-04-28
AU6363386A (en)	1987-04-16
NO165297B (no)	1990-10-15
ZA867440B (en)	1987-06-24
EP0218292B1 (en)	1990-08-08
EP0218292A1 (en)	1987-04-15
NZ217862A (en)	1990-06-26
DD258991A1 (de)	1988-08-10
YU108686A (en)	1987-12-31
JPH0212958B2 (da)	1990-03-30
ATE55391T1 (de)	1990-08-15
NO165297C (no)	1991-01-23
AU603998B2 (en)	1990-12-06
DK475186D0 (da)	1986-10-03
DE3673305D1 (de)	1990-09-13
HU196421B (en)	1988-11-28
NO864011D0 (no)	1986-10-08
PL147396B1 (en)	1989-05-31
CS257292B2 (en)	1988-04-15
NO864011L (no)	1987-04-13
DK166829B1 (da)	1993-07-19
HUT43084A (en)	1987-09-28
IT8522425A0 (it)	1985-10-10
IT1200774B (it)	1989-01-27
PH22748A (en)	1988-11-28

Legal Events

Date	Code	Title	Description
1993-07-19	B1	Patent granted (law 1993)
1996-06-17	PBP	Patent lapsed

Publication	Publication Date	Title
DK475186D0 (da)	1986-10-03	Fremgangsmaade til fremstilling af amikacin
FR2447975B1 (fr)	1985-06-28	Procede de production d'alliages ternaires adsorbants non vaporisables
PT72275A (fr)	1981-01-01	Procede pour ameliorer la permeabilite des roches adapte ala production d'energie calorifique par geothermie haute energie
DE3162601D1 (en)	1984-04-19	Solutions which can be shaped, shaped articles obtained from these solutions as well as process of production of same
DK661588D0 (da)	1988-11-25	Fremgangsmaade til fremstilling af amikacin
JPS5488242A (en)	1979-07-13	Novel derivative of fortimicin b and its preparation
JPS5369127A (en)	1978-06-20	Culture soil by utilizing soil provided from water purifying process as raw material
FR2318931A1 (fr)	1977-02-18	Procede d'epaississement d'une boue de scories en granules pour la production de scories en granules
JPS53135896A (en)	1978-11-27	Adsorbent with superior selective adsorbing property, production thereof, and adsorbing method
JPS52138015A (en)	1977-11-17	Method of recovering zinc from residual solution obtained by electrodeposition process of zinc
JPS5782400A (en)	1982-05-22	Erythromycin derivative
CA1223887A (en)	1987-07-07	Process for producing d,l-homocystine (ii)
GB1429405A (en)	1976-03-24	Process for the manufacture of polyhalogenated nicotinic acids
JPS5219622A (en)	1977-02-15	Process for preparation of tartaric acid salts
JPS5579333A (en)	1980-06-14	Preparation of beta-chlorostyrene
JPS572285A (en)	1982-01-07	Production of benzoheteroring derivative
JPS5535024A (en)	1980-03-11	Novel method of production of 3',4'-dideoxy-6'-n-methylkanamycin b
JPS5225726A (en)	1977-02-25	Process for preparation of omega-aminoalkanoic acid arylamides
DE3162924D1 (en)	1984-05-10	Process for producing d-2-amino-2-(1,4-cyclohexadienyl) acetic acid
JPS55104227A (en)	1980-08-09	Preparation of 3-pentenoic acid
ES455673A1 (es)	1978-01-01	Un procedimiento nuevo de transformacion de cefalotina sodi-ca en hidrotiocianato 7-(2-tienilacetamida)-3-(1-piridilme- til) 3-cefen-4-4carboxilico betaina acida.
JPS523048A (en)	1977-01-11	Method ofpurifying anthraquinone
JPS5484539A (en)	1979-07-05	Production of m-phenoxytoluene
JPS5632525A (en)	1981-04-02	Production of chemically modified concanavalin a monomer
JPS56142240A (en)	1981-11-06	Production of diphenylmethane derivative