DK476387A - Naphthylderivater, og laegemidler med indhold af saadanne forbindelser - Google Patents

Naphthylderivater, og laegemidler med indhold af saadanne forbindelser

Info

Publication number: DK476387A
Authority: DK; Denmark
Prior art keywords: alkyl; group; optionally substituted; straight chained; alkylene group
Prior art date: 1986-09-12

Application number

DK476387A

Other languages

English (en)

Other versions

DK476387D0 (da

Inventor

Joachim Heider

Manfred Psiorz

Andreas Bomhard

Norbert Hauel

Berthold Narr

Klaus Noll

Christian Lillie

Walter Kobinger

Juergen Daemmgen

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-12

Filing date

1987-09-11

Publication date

1988-03-13

1987-09-11 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1987-09-11 Publication of DK476387D0 publication Critical patent/DK476387D0/da

1988-03-13 Publication of DK476387A publication Critical patent/DK476387A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000002947 alkylene group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Cosmetics (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK476387A 1986-09-12 1987-09-11 Naphthylderivater, og laegemidler med indhold af saadanne forbindelser DK476387A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863631013 DE3631013A1 (de)	1986-09-12	1986-09-12	Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number	Publication Date
DK476387D0 DK476387D0 (da)	1987-09-11
DK476387A true DK476387A (da)	1988-03-13

Family

ID=6309407

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK476387A DK476387A (da)	1986-09-12	1987-09-11	Naphthylderivater, og laegemidler med indhold af saadanne forbindelser

Country Status (17)

Country	Link
US (1)	US4871735A (da)
EP (1)	EP0259793B1 (da)
JP (1)	JPS6379876A (da)
KR (1)	KR880003913A (da)
AT (1)	ATE77818T1 (da)
AU (1)	AU605789B2 (da)
DD (1)	DD271517A5 (da)
DE (2)	DE3631013A1 (da)
DK (1)	DK476387A (da)
FI (1)	FI873934A7 (da)
HU (1)	HU201020B (da)
IL (1)	IL83871A (da)
NO (1)	NO873815L (da)
NZ (1)	NZ221771A (da)
PH (1)	PH25314A (da)
PT (1)	PT85688B (da)
ZA (1)	ZA876805B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175157A (en) *	1985-11-27	1992-12-29	Boehringer Ingelheim Gmbh	Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
JP2807577B2 (ja) *	1990-06-15	1998-10-08	エーザイ株式会社	環状アミド誘導体
US5162340A (en) *	1991-05-10	1992-11-10	Merck & Co., Inc.	Substituted 1-(2h)-isoquinolinones bearing acidic functional groups as angiotensin ii antagonists
US6262068B1 (en)	1997-02-21	2001-07-17	Bristol-Myers Squibb Company	Lactam derivatives as antiarrhythmic agents
US6664250B2 (en)	1998-01-20	2003-12-16	Bristol-Myers Squibb Co.	Lactam derivatives as antiarrhythmic agents
PL204753B1 (pl)	2000-05-25	2010-02-26	Hoffmann La Roche	Podstawiony 1-aminoalkilolaktam , zawierający go środek farmaceutyczny, sposób wytwarzania podstawionego 1-aminoalkilolaktamu i jego zastosowanie
CU23844B1 (es) *	2009-04-17	2012-10-15	Ct De Neurociencias De Cuba	Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
UA118548C2 (uk)	2012-12-21	2019-02-11	Епізайм, Інк.	Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування
MX2020003242A (es)	2017-09-22	2020-09-18	Jubilant Epipad LLC	Compuestos heterociclicos como inhibidores de pad.
AU2018352142B2 (en)	2017-10-18	2022-08-25	Jubilant Epipad LLC	Imidazo-pyridine compounds as PAD inhibitors
KR20200085836A (ko)	2017-11-06	2020-07-15	주빌런트 프로델 엘엘씨	Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt)	2017-11-24	2020-11-17	Jubilant Episcribe Llc	composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en)	2018-03-13	2020-10-29	Jubilant Prodel LLC	Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT352135B (de) *	1975-07-30	1979-09-10	Thomae Gmbh Dr K	Verfahren zur herstellung neuer homophthalimide und ihrer salze
DE2639718C2 (de) *	1976-09-03	1987-03-05	Dr. Karl Thomae Gmbh, 7950 Biberach	1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
US4490369A (en) *	1981-05-19	1984-12-25	Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung	Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DD224318A1 (de) *	1984-04-12	1985-07-03	Isis Chemie Zwickau Veb	Verfahren zur herstellung neuer 2-(2-guanidinoethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisochinoline
DE3418271A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

1986
- 1986-09-12 DE DE19863631013 patent/DE3631013A1/de not_active Withdrawn
1987
- 1987-09-04 DE DE8787112920T patent/DE3780106D1/de not_active Expired - Lifetime
- 1987-09-04 EP EP87112920A patent/EP0259793B1/de not_active Expired - Lifetime
- 1987-09-04 AT AT87112920T patent/ATE77818T1/de not_active IP Right Cessation
- 1987-09-10 DD DD86306853A patent/DD271517A5/de not_active IP Right Cessation
- 1987-09-10 PH PH35791A patent/PH25314A/en unknown
- 1987-09-10 NZ NZ221771A patent/NZ221771A/en unknown
- 1987-09-11 HU HU874057A patent/HU201020B/hu unknown
- 1987-09-11 FI FI873934A patent/FI873934A7/fi not_active IP Right Cessation
- 1987-09-11 NO NO873815A patent/NO873815L/no unknown
- 1987-09-11 US US07/096,097 patent/US4871735A/en not_active Expired - Fee Related
- 1987-09-11 ZA ZA876805A patent/ZA876805B/xx unknown
- 1987-09-11 IL IL83871A patent/IL83871A/xx not_active IP Right Cessation
- 1987-09-11 DK DK476387A patent/DK476387A/da not_active Application Discontinuation
- 1987-09-11 AU AU78295/87A patent/AU605789B2/en not_active Ceased
- 1987-09-11 JP JP62228238A patent/JPS6379876A/ja active Pending
- 1987-09-11 PT PT85688A patent/PT85688B/pt not_active IP Right Cessation
- 1987-09-11 KR KR1019870010109A patent/KR880003913A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
PT85688A (de)	1987-10-01
NZ221771A (en)	1990-12-21
IL83871A0 (en)	1988-02-29
KR880003913A (ko)	1988-05-31
ATE77818T1 (de)	1992-07-15
FI873934A0 (fi)	1987-09-11
NO873815D0 (no)	1987-09-11
DE3631013A1 (de)	1988-03-24
EP0259793B1 (de)	1992-07-01
DE3780106D1 (de)	1992-08-06
HUT45019A (en)	1988-05-30
DK476387D0 (da)	1987-09-11
EP0259793A1 (de)	1988-03-16
US4871735A (en)	1989-10-03
NO873815L (no)	1988-03-14
AU7829587A (en)	1988-03-17
PH25314A (en)	1991-04-30
FI873934A7 (fi)	1988-03-13
JPS6379876A (ja)	1988-04-09
PT85688B (pt)	1990-05-31
HU201020B (en)	1990-09-28
IL83871A (en)	1991-05-12
DD271517A5 (de)	1989-09-06
AU605789B2 (en)	1991-01-24
ZA876805B (en)	1989-05-30

Legal Events

Date	Code	Title	Description
1993-05-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK476387D0 (da)	1987-09-11	Naphthylderivater, og laegemidler med indhold af saadanne forbindelser
ES8400422A1 (es)	1983-11-01	"procedimiento de preparacion de eteres triciclicos, asi como de sus sales de adicion con un acido mineral u organico terapeuticamente compatible".
DE3370478D1 (en)	1987-04-30	Isoquinolinesulfonamide derivatives and process for the preparation thereof
KR880001583A (ko)	1988-04-25	광학적 활성 벤젠설폰아미드 유도체의 제조방법
MY102117A (en)	1992-03-31	Naphthquinone derivatives
ATE26263T1 (de)	1987-04-15	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.
ES8506633A1 (es)	1985-08-01	Un procedimiento para la preparacion de dihidropiridinas.
ES534505A0 (es)	1986-11-16	Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
SE7710873L (sv)	1978-03-30	Nya 1h-pyrazolo(3,4-b)pyridiner
ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
RU92016234A (ru)	1995-03-27	Производные 3(2н)-пиридазинона, способ их получения, применение, фармацевтическая композиция, способ лечения
ES484571A1 (es)	1980-05-16	Procedimiento para la obtencion de compuestos de n-oxaciclil-alquil-piperidil-diaza
ES2077777T3 (es)	1995-12-01	Derivado del acido naftoico.
PT80502A (en)	1985-06-01	Process for preparing 1-fluoro-1-azolyl-2,2-diarylethane derivatives having microbicidal action
ES8306143A1 (es)	1983-05-01	"procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona".
ES8801298A3 (es)	1987-12-16	Un procedimiento para la preparacion de un complejo de platino
ES8400743A1 (es)	1983-11-01	"procedimiento para la preparacion de compuestos de 1-fenilindazol-3-ona".
ATE115567T1 (de)	1994-12-15	Verfahren zur herstellung von halogensulfonyl- substituierten pyridinen.
DE69324854D1 (de)	1999-06-17	Pyridazinone-Derivate und Verfahren zur deren Herstellung
ATE31297T1 (de)	1987-12-15	2-substituierte oder nicht-substituierte aminocarbonyloxyalkyl-1,4-dihydropyridine.
AU587086B2 (en)	1989-08-03	New pyridine compounds with basic substituents, a process for their preparation, medicaments containing them, and their use
HUT43598A (en)	1987-11-30	Process for production of derivatives of new 4-hidroxiquinoline carbonic acid and medical compound containing thereof
ES8607939A1 (es)	1986-06-16	Procedimiento de preparacion de nuevos derivados de la 8-al-coxicarbonilaminoisoquinolina y de sus sales de adicion aci-da
ES8704459A1 (es)	1987-04-01	Procedimiento para la obtencion de acemetacina.
HUT37126A (en)	1985-11-28	Pocess for the production of new amino-ethyl-imidazola-derivatives, as well as of pharmaceutical preparations containing thes compounds