DK486685A - Analoge til kortikotropinfrigivende faktorer - Google Patents

Analoge til kortikotropinfrigivende faktorer Download PDF

Info

Publication number: DK486685A
Authority: DK; Denmark
Prior art keywords: leu; glu; ala; gln; agonists
Prior art date: 1984-02-23

Application number

DK486685A

Other languages

English (en)

Other versions

DK172518B1 (da

DK486685D0 (da

Inventor

Catherine Laure Rivier

Jean Edouard Frederic Rivier

Walker Vale Wylie Jr

Marvin Ross Brown

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-23

Filing date

1985-10-23

Publication date

1985-10-23

1984-02-23 Priority claimed from US06/583,092 external-priority patent/US4605642A/en

1984-05-14 Priority claimed from US06/610,110 external-priority patent/US4594329A/en

1985-10-23 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1985-10-23 Publication of DK486685A publication Critical patent/DK486685A/da

1985-10-23 Publication of DK486685D0 publication Critical patent/DK486685D0/da

1998-11-09 Application granted granted Critical

1998-11-09 Publication of DK172518B1 publication Critical patent/DK172518B1/da

Links

IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title abstract 2
229960000258 corticotropin Drugs 0.000 title abstract 2
102400000739 Corticotropin Human genes 0.000 title 1
101800000414 Corticotropin Proteins 0.000 title 1
239000000556 agonist Substances 0.000 abstract 4
102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 3
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
101800005049 Beta-endorphin Proteins 0.000 abstract 1
OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
108010069820 Pro-Opiomelanocortin Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
108010042362 beta-Lipotropin Proteins 0.000 abstract 1
WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
230000036651 mood Effects 0.000 abstract 1
AOCUKGFDRUSDQH-PIKKTMSISA-N ocrf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)CC)[C@@H](C)O)C(C)C)C(C)O)C1=CNC=N1 AOCUKGFDRUSDQH-PIKKTMSISA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Polyesters Or Polycarbonates (AREA)
Developing Agents For Electrophotography (AREA)
Train Traffic Observation, Control, And Security (AREA)
Details Of Television Scanning (AREA)
Amplifiers (AREA)
Steroid Compounds (AREA)
Control Of Eletrric Generators (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Vehicle Body Suspensions (AREA)

DK198504866A 1984-02-23 1985-10-23 Derivater af ovin CRF, farmacutiske eller veterinære sammensætninger, der indeholder disse, samt midler til mindskelse af s DK172518B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US06/583,092 US4605642A (en)	1984-02-23	1984-02-23	CRF antagonists
US58309284		1984-02-23
US06/610,110 US4594329A (en)	1984-05-14	1984-05-14	CRF analogs
US61011084		1984-05-14
PCT/US1985/000297 WO1985003705A1 (en)	1984-02-23	1985-02-21	Crf analogs
US8500297		1985-02-21

Publications (3)

Publication Number	Publication Date
DK486685A true DK486685A (da)	1985-10-23
DK486685D0 DK486685D0 (da)	1985-10-23
DK172518B1 DK172518B1 (da)	1998-11-09

Family

ID=27078728

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198504866A DK172518B1 (da)	1984-02-23	1985-10-23	Derivater af ovin CRF, farmacutiske eller veterinære sammensætninger, der indeholder disse, samt midler til mindskelse af s

Country Status (13)

Country	Link
EP (2)	EP0153845B1 (da)
JP (1)	JPH0742318B2 (da)
KR (1)	KR870000812B1 (da)
AT (1)	ATE88481T1 (da)
AU (1)	AU585500B2 (da)
DE (1)	DE3587276T2 (da)
DK (1)	DK172518B1 (da)
ES (1)	ES8606403A1 (da)
FI (1)	FI91413C (da)
GR (1)	GR850454B (da)
IE (2)	IE64241B1 (da)
NO (1)	NO171729C (da)
WO (1)	WO1985003705A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3703340A1 (de) *	1987-02-04	1988-08-18	Dirck Dr Med Oppermann	Pharmazeutische zubereitung zur behandlung der herzinsuffizienz
IE64788B1 (en) *	1988-06-21	1995-09-06	Salk Inst For Biological Studi	CRF analogs
CA1341051C (en) *	1988-09-23	2000-07-11	Jean Edouard Frederic Rivier	Crf antagonists
CA1340964C (en) *	1988-09-30	2000-04-18	Jean E. F. Rivier	Crf analogs
CA2002004A1 (en) *	1988-11-14	1990-05-14	Karl P. Lederis	Fish crf
US5235036A (en) *	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
JP3243250B2 (ja) *	1990-03-23	2002-01-07	ザ・ソーク・インスティチュート・フォー・バイオロジカル・スタディーズ	Ｃｒｆ同族体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4244946A (en) *	1979-06-11	1981-01-13	The Salk Institute For Biological Studies	Water-soluble peptides affecting gonadal function
US4415558A (en) *	1981-06-08	1983-11-15	The Salk Institute For Biological Studies	CRF And analogs
GR75679B (da) *	1981-06-08	1984-08-02	Salk Inst For Biological Studi
US4385050A (en) *	1981-06-26	1983-05-24	Armour Pharmaceutical Company	Antihypertensive polypeptides
US4533654A (en) *	1982-09-29	1985-08-06	The Salk Institute For Biological Studies	Urotensin peptides
US4489163A (en) *	1983-04-14	1984-12-18	The Salk Institute For Biological Studies	rCRF and analogs

1985
- 1985-02-19 EP EP85301093A patent/EP0153845B1/en not_active Expired - Lifetime
- 1985-02-19 EP EP92115541A patent/EP0518391A1/en not_active Ceased
- 1985-02-19 DE DE8585301093T patent/DE3587276T2/de not_active Expired - Lifetime
- 1985-02-19 AT AT85301093T patent/ATE88481T1/de not_active IP Right Cessation
- 1985-02-21 KR KR1019850700252A patent/KR870000812B1/ko not_active Expired
- 1985-02-21 AU AU40693/85A patent/AU585500B2/en not_active Expired
- 1985-02-21 WO PCT/US1985/000297 patent/WO1985003705A1/en not_active Ceased
- 1985-02-21 GR GR850454A patent/GR850454B/el unknown
- 1985-02-21 JP JP60501132A patent/JPH0742318B2/ja not_active Expired - Lifetime
- 1985-02-22 ES ES540632A patent/ES8606403A1/es not_active Expired
- 1985-02-22 IE IE940016A patent/IE64241B1/en not_active IP Right Cessation
- 1985-02-22 IE IE45285A patent/IE63601B1/en not_active IP Right Cessation
- 1985-10-22 NO NO85854208A patent/NO171729C/no not_active IP Right Cessation
- 1985-10-22 FI FI854122A patent/FI91413C/fi not_active IP Right Cessation
- 1985-10-23 DK DK198504866A patent/DK172518B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI854122A0 (fi)	1985-10-22
FI91413B (fi)	1994-03-15
DK172518B1 (da)	1998-11-09
JPS61502396A (ja)	1986-10-23
EP0518391A1 (en)	1992-12-16
IE850452L (en)	1985-08-23
GR850454B (da)	1985-06-19
IE63601B1 (en)	1995-05-17
ES8606403A1 (es)	1986-04-16
WO1985003705A1 (en)	1985-08-29
ATE88481T1 (de)	1993-05-15
AU585500B2 (en)	1989-06-22
DK486685D0 (da)	1985-10-23
ES540632A0 (es)	1986-04-16
IE64241B1 (en)	1995-07-26
DE3587276D1 (de)	1993-05-27
KR850700246A (ko)	1985-12-26
NO171729B (no)	1993-01-18
JPH0742318B2 (ja)	1995-05-10
AU4069385A (en)	1985-09-10
EP0153845B1 (en)	1993-04-21
KR870000812B1 (ko)	1987-04-20
NO171729C (no)	1993-04-28
FI854122L (fi)	1985-10-22
EP0153845A3 (en)	1988-09-07
EP0153845A2 (en)	1985-09-04
DE3587276T2 (de)	1993-07-29
NO854208L (no)	1985-12-20
IE940016L (en)	1985-08-23
FI91413C (fi)	1994-06-27

Legal Events

Date	Code	Title	Description
1998-11-09	B1	Patent granted (law 1993)
2005-03-07	PUP	Patent expired

Publication	Publication Date	Title
ES531585A0 (es)	1986-04-01	Un procedimiento para preparar peptidos analogos al factor de liberacion de corticotropina
DK486685A (da)	1985-10-23	Analoge til kortikotropinfrigivende faktorer
EP0361954A3 (en)	1991-12-04	Crf analogs
DK0521963T3 (da)	1999-05-10	CRF-analoger
DE68918271D1 (de)	1994-10-20	Crf-analoge.