DK49289A - Laegemiddel indeholdende lactamer, de paagaeldende substituerede lactamer samt fremgangsmaade til fremstilling heraf - Google Patents

Laegemiddel indeholdende lactamer, de paagaeldende substituerede lactamer samt fremgangsmaade til fremstilling heraf

Info

Publication number
DK49289A
DK49289A DK049289A DK49289A DK49289A DK 49289 A DK49289 A DK 49289A DK 049289 A DK049289 A DK 049289A DK 49289 A DK49289 A DK 49289A DK 49289 A DK49289 A DK 49289A
Authority
DK
Denmark
Prior art keywords
lactames
concerned
procedures
substituted
preparing
Prior art date
Application number
DK049289A
Other languages
Danish (da)
English (en)
Other versions
DK49289D0 (da
Inventor
Harald Zilch
Alfred Mertens
Wolfgang Von Der Saal
Erwin Boehm
Klaus Strein
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK49289D0 publication Critical patent/DK49289D0/da
Publication of DK49289A publication Critical patent/DK49289A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK049289A 1988-02-09 1989-02-02 Laegemiddel indeholdende lactamer, de paagaeldende substituerede lactamer samt fremgangsmaade til fremstilling heraf DK49289A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803775A DE3803775A1 (de) 1988-02-09 1988-02-09 Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
DK49289D0 DK49289D0 (da) 1989-02-02
DK49289A true DK49289A (da) 1989-08-10

Family

ID=6346898

Family Applications (1)

Application Number Title Priority Date Filing Date
DK049289A DK49289A (da) 1988-02-09 1989-02-02 Laegemiddel indeholdende lactamer, de paagaeldende substituerede lactamer samt fremgangsmaade til fremstilling heraf

Country Status (14)

Country Link
US (2) US4985448A (fr)
EP (1) EP0327986A3 (fr)
JP (1) JPH01250352A (fr)
KR (1) KR890012966A (fr)
AU (1) AU617760B2 (fr)
DD (1) DD283376A5 (fr)
DE (1) DE3803775A1 (fr)
DK (1) DK49289A (fr)
FI (1) FI890605A7 (fr)
HU (1) HUT50118A (fr)
IL (1) IL89192A0 (fr)
NZ (1) NZ227868A (fr)
PT (1) PT89655B (fr)
ZA (1) ZA89958B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US5076835A (en) * 1990-05-31 1991-12-31 America Cyanamid Company Aryloxyspiroalkylindolinone herbicides
DE4021063A1 (de) * 1990-07-03 1992-01-09 Boehringer Mannheim Gmbh Neue ss-galactosidase-substrate fuer den cedia
BR9200951A (pt) * 1991-03-21 1992-11-17 Hoffmann La Roche Compostos, processo para sua producao,preparacoes farmaceuticas e uso
DE69429584T2 (de) * 1993-11-26 2002-08-08 Tanabe Seiyaku Co., Ltd. 2-oxoindolin-derivate als cholecystokinin rezeptor antagonisten
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU9309898A (en) * 1997-09-09 1999-03-29 Du Pont Pharmaceuticals Company Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor xa
WO2000000475A1 (fr) * 1998-06-30 2000-01-06 Du Pont Pharmaceuticals Company Quinoline-2(1h)-ones substituees utiles comme inhibiteurs de la transcriptase inverse du vih
CA2338804A1 (fr) * 1998-07-28 2000-02-10 Smithkline Beecham Corporation Propenamides tenant lieu de modulateurs de ccr5
JP2002523455A (ja) 1998-08-31 2002-07-30 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US6586460B1 (en) * 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
JP2005518371A (ja) * 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
CA2553968A1 (fr) * 2004-01-23 2005-08-11 Amgen Inc. Ligands du recepteur vanilloide et leur application au traitement des douleurs inflammatoires et neuropathiques
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
KR20070113286A (ko) * 2005-04-14 2007-11-28 에프. 호프만-라 로슈 아게 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도
DE602006002887D1 (de) * 2005-04-14 2008-11-06 Hoffmann La Roche Tricyclische azolderivate, ihre herstellung und ihre verwendung als pharmazeutische mittel
JP2009530337A (ja) * 2006-03-23 2009-08-27 エフ．ホフマン−ラ ロシュ アーゲー 置換インダゾール誘導体、その製造方法、及びその薬剤としての利用法
KR101706877B1 (ko) 2012-09-13 2017-02-15 에프. 호프만-라 로슈 아게 Cns 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌
JP6759514B2 (ja) 2014-08-01 2020-09-23 ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ ブロモドメインに対して活性な化合物
CN105085492A (zh) * 2015-09-29 2015-11-25 青岛友诚高新技术有限公司 一种可用于制备治疗冠状动脉粥样硬化药物的化合物及其制备方法、用途
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2159360A1 (de) * 1971-11-30 1973-06-14 Bayer Ag Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
GR851085B (fr) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
JPS6232459A (ja) * 1985-08-05 1987-02-12 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU6966187A (en) * 1987-03-04 1988-09-08 Higuchi, Y. Carbostyril derivatives
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0327986A3 (fr) 1992-01-08
HUT50118A (en) 1989-12-28
EP0327986A2 (fr) 1989-08-16
DE3803775A1 (de) 1989-08-17
US5373019A (en) 1994-12-13
US4985448A (en) 1991-01-15
PT89655A (pt) 1989-10-04
DK49289D0 (da) 1989-02-02
IL89192A0 (en) 1989-09-10
DD283376A5 (de) 1990-10-10
FI890605A0 (fi) 1989-02-08
NZ227868A (en) 1991-03-26
KR890012966A (ko) 1989-09-20
ZA89958B (en) 1989-10-25
AU2974189A (en) 1989-08-10
AU617760B2 (en) 1991-12-05
FI890605A7 (fi) 1989-08-10
JPH01250352A (ja) 1989-10-05
PT89655B (pt) 1994-02-28

Similar Documents

Publication Publication Date Title
DK49289D0 (da) Laegemiddel indeholdende lactamer, de paagaeldende substituerede lactamer samt fremgangsmaade til fremstilling heraf
DK273587D0 (da) 1,5-diaryl-3-substituerede pyrazoler samt fremgangsmaade til fremstilling deraf
DK510384D0 (da) Laegemiddeltilberedning til intravenoes injektion samt fremgangsmaadetil fremstilling heraf
DK328586A (da) Phenylethanolaminotetraliner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem
DK355485A (da) Dinatrium-3-amino-l-hydroxy-propan-1,1-diphosphonat samt fremgangsmaade til fremstilling deraf
BR8901346A (pt) Frasco de remedio
DK165249C (da) Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf
BR8702620A (pt) Dispositivo de medicao
DK161327C (da) Substituerede 2-piperazinopteridiner, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende forbindelserne
DK219387D0 (da) Aminothiazol- og aminooxazolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK605989D0 (da) Propenonoximethere og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem
DK276189D0 (da) Polypeptidforbindelser, fremgangsmaader til fremstilling heraf farmaceutiske midler indeholdende disse
DK64183D0 (da) Farmaceutisk praeparat samt fremgangsmade til fremstilling deraf
DE3581704D1 (de) Medikamentenabgabesystem.
DK162221C (da) Cinnolinforbindelser, fremgangsmaade til fremstilling deraf og farmaceutiske midler indeholdende forbindelserne
DK642588D0 (da) Indanderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK592189A (da) Nitroimidazoler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK163057C (da) Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK346889A (da) Heteropolysaccharid bm07, fremgangsmaade til fremstilling deraf samt anvendelse deraf
DK13089D0 (da) Substituerede 5,6,7,8-tetrahydro-4h-thieno-(2,3-d)azepin-forbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK469189D0 (da) Substituerede thienopyraner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK645988A (da) Biphenylderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende samme
DK404587A (da) 5-deoxy-5-flourkanamycin b-derivater samt fremgangsmaader til fremstilling deraf
DK164670C (da) Pyrrolooe3,2,1-hiaaindol-derivater, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende saadanne forbindelser
DK160827C (da) Pteridinderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk praeparat

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment