DK504389A - Adjuveret antigenoploesning, dens fremstilling samt zink- eller jernhydroxidgel til anvendelse derved - Google Patents

Adjuveret antigenoploesning, dens fremstilling samt zink- eller jernhydroxidgel til anvendelse derved

Info

Publication number: DK504389A
Authority: DK; Denmark
Prior art keywords: zinc; iron; hydroxidgel; preparation; antigen solution
Prior art date: 1988-10-12

Application number

DK504389A

Other languages

English (en)

Other versions

DK504389D0 (da

DK170224B1 (da

Inventor

Dieter Bernhardt

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-12

Filing date

1989-10-11

Publication date

1990-04-13

1989-10-11 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1989-10-11 Publication of DK504389D0 publication Critical patent/DK504389D0/da

1990-04-13 Publication of DK504389A publication Critical patent/DK504389A/da

1995-07-03 Application granted granted Critical

1995-07-03 Publication of DK170224B1 publication Critical patent/DK170224B1/da

Links

239000000427 antigen Substances 0.000 title abstract 2
102000036639 antigens Human genes 0.000 title abstract 2
108091007433 antigens Proteins 0.000 title abstract 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
229910052742 iron Inorganic materials 0.000 title 1
239000011701 zinc Substances 0.000 title 1
229910052725 zinc Inorganic materials 0.000 title 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
235000014413 iron hydroxide Nutrition 0.000 abstract 1
NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 abstract 1
229940007718 zinc hydroxide Drugs 0.000 abstract 1
229910021511 zinc hydroxide Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Mycology (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

DK504389A 1988-10-12 1989-10-11 Adjuveret antigenopløsning, dens fremstilling samt zink- eller jernhydroxidgel til anvendelse derved DK170224B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3834729A DE3834729A1 (de)	1988-10-12	1988-10-12	Verwendung von zink-oder eisenhydroxid zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
DE3834729		1988-10-12

Publications (3)

Publication Number	Publication Date
DK504389D0 DK504389D0 (da)	1989-10-11
DK504389A true DK504389A (da)	1990-04-13
DK170224B1 DK170224B1 (da)	1995-07-03

Family

ID=6364944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK504389A DK170224B1 (da)	1988-10-12	1989-10-11	Adjuveret antigenopløsning, dens fremstilling samt zink- eller jernhydroxidgel til anvendelse derved

Country Status (13)

Country	Link
US (1)	US5252327A (da)
EP (1)	EP0363835B1 (da)
JP (1)	JP2756321B2 (da)
KR (1)	KR0162074B1 (da)
AT (1)	ATE90568T1 (da)
AU (1)	AU626920B2 (da)
CA (1)	CA1333257C (da)
DE (2)	DE3834729A1 (da)
DK (1)	DK170224B1 (da)
ES (1)	ES2058432T3 (da)
FI (1)	FI100946B (da)
IE (1)	IE63271B1 (da)
PT (1)	PT91953B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4007315A1 (de) *	1990-03-08	1991-09-12	Behringwerke Ag	Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
EP0640348A1 (en) *	1993-07-26	1995-03-01	Akzo Nobel N.V.	Oil-based and water-based adjuvant mixture
DE4333376C2 (de) *	1993-09-30	1995-09-07	Gerbu Biotechnik Gmbh	Mittel zur Steigerung der Ausbeute von Antikörpern in der Immunologie
DE19511276C2 (de) *	1995-03-27	1999-02-18	Immuno Ag	Adjuvans auf der Basis kolloidaler Eisenverbindungen
ES2284287T3 (es) *	1998-10-16	2007-11-01	Glaxosmithkline Biologicals S.A.	Sistemas adyuvantes y vacunas.
AT408721B (de)	1999-10-01	2002-02-25	Cistem Biotechnologies Gmbh	Pharmazeutische zusammensetzung enthaltend ein antigen
WO2002069985A2 (en) *	2001-03-05	2002-09-12	Forinnova As	Immune response potentiation
DE20103715U1 (de) *	2001-03-05	2002-07-25	Nawa-Heilmittel GmbH, 92361 Berngau	Medizinisches Präparat zur Förderung des Anwachsens eines Transplantats, insbesondere von transplantierter Haut an einem Transplantationsort
FR2854803B1 (fr) *	2003-05-16	2005-06-24	Aventis Pasteur	Composition vaccinale comprenant du phosphate de fer a titre d'adjuvent vaccinal.
CA2530062A1 (en) *	2003-07-11	2005-01-20	Intercell Ag	Hcv vaccines
WO2007025332A1 (en) *	2005-08-29	2007-03-08	Dia-B Tech Limited	A peptide and zinc ion composition for treating diabetes and enhancing immune function
JP5798356B2 (ja) *	2011-04-06	2015-10-21	一般財団法人化学及血清療法研究所	新規インフルエンザワクチン安定化剤
GB2571925A (en) *	2018-03-08	2019-09-18	Univ Antwerpen	Iron-based vaccine adjuvants
KR20260012291A (ko) *	2018-07-12	2026-01-26	더 리젠츠 오브 더 유니버시티 오브 미시간	면역 반응을 조절할 수 있는 금속 함유 제형의 조성물 및 방법
AU2020256646A1 (en)	2019-04-11	2021-12-09	Xiamen Innovax Biotech Co., Ltd.	Preparation of zinc zoledronate micro-nanoparticle adjuvant and use thereof as vaccine adjuvant
CN115463211A (zh) *	2022-08-25	2022-12-13	浙江大学	一种Zn基免疫调节佐剂的制备方法及产品和应用
JPWO2025028658A1 (da) *	2023-08-03	2025-02-06

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1189340A (en) *	1967-09-13	1970-04-22	American Cyanamid Co	Antigen-Adjuvant Composition
US4684625A (en) *	1982-07-08	1987-08-04	Syntex (U.S.A.) Inc.	Method for enhancing the anti-infective activity of muramyldipeptide derivatives
DE3241113A1 (de) *	1982-11-06	1984-05-10	Bayer Ag, 5090 Leverkusen	Vakzinen mit zuschlagstoffen
US4981684A (en) *	1989-10-24	1991-01-01	Coopers Animal Health Limited	Formation of adjuvant complexes

1988
- 1988-10-12 DE DE3834729A patent/DE3834729A1/de not_active Withdrawn
1989
- 1989-09-29 CA CA000614543A patent/CA1333257C/en not_active Expired - Fee Related
- 1989-10-06 EP EP89118565A patent/EP0363835B1/de not_active Expired - Lifetime
- 1989-10-06 DE DE8989118565T patent/DE58904713D1/de not_active Expired - Fee Related
- 1989-10-06 ES ES89118565T patent/ES2058432T3/es not_active Expired - Lifetime
- 1989-10-06 AT AT89118565T patent/ATE90568T1/de not_active IP Right Cessation
- 1989-10-10 US US07/419,105 patent/US5252327A/en not_active Expired - Fee Related
- 1989-10-10 KR KR1019890014464A patent/KR0162074B1/ko not_active Expired - Fee Related
- 1989-10-10 FI FI894804A patent/FI100946B/fi not_active IP Right Cessation
- 1989-10-11 IE IE328389A patent/IE63271B1/en not_active IP Right Cessation
- 1989-10-11 PT PT91953A patent/PT91953B/pt not_active IP Right Cessation
- 1989-10-11 JP JP1263172A patent/JP2756321B2/ja not_active Expired - Fee Related
- 1989-10-11 DK DK504389A patent/DK170224B1/da not_active IP Right Cessation
- 1989-10-12 AU AU42766/89A patent/AU626920B2/en not_active Ceased

Also Published As

Publication number	Publication date
FI100946B (fi)	1998-03-31
KR900005986A (ko)	1990-05-07
AU626920B2 (en)	1992-08-13
US5252327A (en)	1993-10-12
IE893283L (en)	1990-04-12
DK504389D0 (da)	1989-10-11
CA1333257C (en)	1994-11-29
DE3834729A1 (de)	1990-04-19
AU4276689A (en)	1990-04-26
EP0363835A1 (de)	1990-04-18
FI894804A0 (fi)	1989-10-10
DK170224B1 (da)	1995-07-03
PT91953A (pt)	1990-04-30
PT91953B (pt)	1995-05-31
ATE90568T1 (de)	1993-07-15
JP2756321B2 (ja)	1998-05-25
DE58904713D1 (de)	1993-07-22
JPH02149530A (ja)	1990-06-08
IE63271B1 (en)	1995-04-05
FI894804L (fi)	1990-04-13
ES2058432T3 (es)	1994-11-01
EP0363835B1 (de)	1993-06-16
KR0162074B1 (ko)	1998-12-01

Legal Events

Date	Code	Title	Description
1995-07-03	B1	Patent granted (law 1993)
2004-06-07	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK504389D0 (da)	1989-10-11	Adjuveret antigenoploesning, dens fremstilling samt zink- eller jernhydroxidgel til anvendelse derved
FI886051A7 (fi)	1990-07-01	Reglerventil.
DE3668230D1 (de)	1990-02-15	Siliziumventil.
DK198388A (da)	1989-01-16	Hydrofob silica samt fremgangsmaade til fremstilling og anvendelse af denne
GR3006630T3 (da)	1993-06-30
DE59001941D1 (de)	1993-08-19	Magnetventilbatterie.
BR8602204A (pt)	1987-01-13	Valvula cardiaca
DE3774857D1 (de)	1992-01-09	Auf-/zu-absperrventil.
NO862775D0 (no)	1986-07-09	Anordning med ventilfunksjon.
NO881215L (no)	1989-08-10	Fremgangsmaate for fremstilling av alger med forbedrete biologiske virkninger.
DE69001463D1 (de)	1993-06-03	Mikroleckregulierventil.
FI872914A7 (fi)	1988-01-04	Venttiililaite.
EP0329961A3 (en)	1990-10-31	Use of 2-oxo-pyrrolidine-1-acetamide for the determination of glomerular filtration rate in humans
NO864941D0 (no)	1986-12-09	Injeksjonsventil.
EP0350738A3 (de)	1991-04-03	(S)-Emopamil zur Anwendung bei der Behandlung von Migräne
CA2037709A1 (en)	1991-09-09	Use of zinc calcium hydroxide, lecithin and pao as an adjuvant for antigen solutions, and antigen solutions treated with an adjuvant of this type
DE3462688D1 (en)	1987-04-23	1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
DE3773696D1 (de)	1991-11-21	Magnetventilanordnungen.
IT8821300A0 (it)	1988-07-08	Procedimento di preparazione di morniflumato e analoghi.
FI890568L (fi)	1989-08-24	Ulkokäyttöisellä venttiilillä varustettu veriviljelylaite
AU585129B2 (en)	1989-06-08	N-tridecyl-2,6-dimethyl-morpholine fluoboric acid salt
ZA891242B (en)	1989-10-25	24r-scymnol,and preparation and use thereof
DE3771468D1 (de)	1991-08-22	Einsatzventil.
SE8404090L (sv)	1985-02-27	Raffinerat detoxifierat endotoxin
DE68920643D1 (de)	1995-03-02	Ventileinrichtung.