DK50491A - 11beta-phenyl-14betah-steroider - Google Patents

11beta-phenyl-14betah-steroider Download PDF

Info

Publication number: DK50491A
Authority: DK; Denmark
Prior art keywords: pct; residue; hydrogen atom; atom; steroids
Prior art date: 1988-09-20

Application number

DK050491A

Other languages

English (en)

Other versions

DK50491D0 (da

Inventor

Stefan Scholz

Guenter Neef

Eckhard Ottow

Walter Elger

Sybille Beier

Krzysztof Chwalisz

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-20

Filing date

1991-03-20

Publication date

1991-03-20

1991-03-20 Application filed by Schering Ag filed Critical Schering Ag

1991-03-20 Publication of DK50491D0 publication Critical patent/DK50491D0/da

1991-03-20 Publication of DK50491A publication Critical patent/DK50491A/da

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000000380 anti-gestagenic effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004404 heteroalkyl group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK050491A 1988-09-20 1991-03-20 11beta-phenyl-14betah-steroider DK50491A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3832303A DE3832303A1 (de)	1988-09-20	1988-09-20	11ss-phenyl-14ssh-steroide
PCT/EP1989/001090 WO1990003385A1 (de)	1988-09-20	1989-09-20	11β-PHENYL-14βH-STEROIDE

Publications (2)

Publication Number	Publication Date
DK50491D0 DK50491D0 (da)	1991-03-20
DK50491A true DK50491A (da)	1991-03-20

Family

ID=6363531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK050491A DK50491A (da)	1988-09-20	1991-03-20	11beta-phenyl-14betah-steroider

Country Status (17)

Country	Link
US (1)	US5244886A (da)
EP (1)	EP0360369B1 (da)
JP (1)	JP2760870B2 (da)
AT (1)	ATE122052T1 (da)
AU (1)	AU640616B2 (da)
CA (1)	CA1339924C (da)
DD (1)	DD284682A5 (da)
DE (2)	DE3832303A1 (da)
DK (1)	DK50491A (da)
ES (1)	ES2074073T3 (da)
HU (1)	HU208151B (da)
IE (1)	IE67514B1 (da)
IL (1)	IL91672A (da)
NO (1)	NO301119B1 (da)
PT (1)	PT91746B (da)
WO (1)	WO1990003385A1 (da)
ZA (1)	ZA897191B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3822770A1 (de) *	1988-07-01	1990-01-04	Schering Ag	13-alkyl-11ss-phenylgonane
DE4018168A1 (de) *	1990-06-01	1991-12-05	Schering Ag	Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
DE4042004A1 (de) *	1990-12-22	1992-06-25	Schering Ag	14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
DE4038128A1 (de) *	1990-11-27	1992-06-04	Schering Ag	8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE4232681C2 (de) *	1992-09-29	1994-11-24	Sigma Tau Ind Farmaceuti	17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
USD348244S (en)	1992-10-01	1994-06-28	Hydro-Bikes, Inc.	Dual personalized watercraft
DE4235220A1 (de) *	1992-10-13	1994-06-16	Schering Ag	Gestagen wirksame 19,11ß-überbrückte 4-Estrene
DE69500542T2 (de) *	1994-05-19	1998-01-02	Akzo Nobel Nv	11,21-Bisphenyl-19-nor-pregnan Derivate
DE4434488A1 (de) *	1994-09-14	1996-03-21	Schering Ag	Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
AU710139B2 (en) *	1996-05-01	1999-09-16	Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The	21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) *	1996-05-01	2005-05-31	The United States Of America As Represented By The Department Of Health And Human Services	Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
AU4093799A (en)	1998-05-22	1999-12-13	Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP1945240B1 (en)	2005-09-16	2016-12-28	Raptor Pharmaceutical Inc	Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
AU2007327707B2 (en)	2006-10-24	2012-07-12	Allergan pharmaceuticals International Ltd.	Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN107260745A (zh)	2010-03-22	2017-10-20	利普生物药剂公司	用于抗孕酮的非毒性递送的组合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
EP0116974B1 (de) *	1983-02-18	1986-10-29	Schering Aktiengesellschaft	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
ES533260A0 (es) *	1983-06-15	1985-02-01	Schering Ag	Procedimiento para la preparacion de 13a-alquilgonanos
IE60780B1 (en) *	1987-01-23	1994-08-10	Akzo Nv	New 11-aryl steroid derivatives
DE3708942A1 (de) *	1987-03-18	1988-09-29	Schering Ag	19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US4954490A (en) *	1988-06-23	1990-09-04	Research Triangle Institute	11 β-substituted progesterone analogs
DE3917274A1 (de) *	1989-05-24	1990-11-29	Schering Ag	9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate

1988
- 1988-09-20 DE DE3832303A patent/DE3832303A1/de not_active Withdrawn
1989
- 1989-09-18 IL IL9167289A patent/IL91672A/en not_active IP Right Cessation
- 1989-09-19 PT PT91746A patent/PT91746B/pt not_active IP Right Cessation
- 1989-09-20 JP JP1509963A patent/JP2760870B2/ja not_active Expired - Fee Related
- 1989-09-20 WO PCT/EP1989/001090 patent/WO1990003385A1/de not_active Ceased
- 1989-09-20 CA CA000612115A patent/CA1339924C/en not_active Expired - Fee Related
- 1989-09-20 DE DE58909213T patent/DE58909213D1/de not_active Expired - Lifetime
- 1989-09-20 ES ES89250040T patent/ES2074073T3/es not_active Expired - Lifetime
- 1989-09-20 IE IE300289A patent/IE67514B1/en not_active IP Right Cessation
- 1989-09-20 US US07/663,819 patent/US5244886A/en not_active Expired - Fee Related
- 1989-09-20 HU HU895541A patent/HU208151B/hu not_active IP Right Cessation
- 1989-09-20 AU AU43049/89A patent/AU640616B2/en not_active Ceased
- 1989-09-20 ZA ZA897191A patent/ZA897191B/xx unknown
- 1989-09-20 EP EP89250040A patent/EP0360369B1/de not_active Expired - Lifetime
- 1989-09-20 AT AT89250040T patent/ATE122052T1/de not_active IP Right Cessation
- 1989-09-20 DD DD89332836A patent/DD284682A5/de not_active IP Right Cessation
1991
- 1991-03-19 NO NO911102A patent/NO301119B1/no unknown
- 1991-03-20 DK DK050491A patent/DK50491A/da unknown

Also Published As

Publication number	Publication date
CA1339924C (en)	1998-06-23
NO911102D0 (no)	1991-03-19
AU640616B2 (en)	1993-09-02
ES2074073T3 (es)	1995-09-01
IL91672A0 (en)	1990-04-29
IE67514B1 (en)	1996-04-03
EP0360369A1 (de)	1990-03-28
PT91746B (pt)	1995-05-31
JP2760870B2 (ja)	1998-06-04
DK50491D0 (da)	1991-03-20
IL91672A (en)	1994-12-29
AU4304989A (en)	1990-04-18
US5244886A (en)	1993-09-14
HU208151B (en)	1993-08-30
DD284682A5 (de)	1990-11-21
DE58909213D1 (de)	1995-06-14
HUT56851A (en)	1991-10-28
JPH04501712A (ja)	1992-03-26
HU895541D0 (en)	1991-08-28
DE3832303A1 (de)	1990-04-12
IE893002L (en)	1990-03-20
NO911102L (no)	1991-03-19
PT91746A (pt)	1990-03-30
EP0360369B1 (de)	1995-05-03
NO301119B1 (no)	1997-09-15
ZA897191B (en)	1990-10-31
WO1990003385A1 (de)	1990-04-05
ATE122052T1 (de)	1995-05-15

Publication	Publication Date	Title
ES2074073T3 (es)	1995-09-01	11beta-fenil-14betah-esteroides.
NZ508918A (en)	2003-03-28	2-(Purin-9-YL)-tetrahydrofuran-3,4-diol derivatives useful for the treatment of inflammation
IE861917L (en)	1987-01-19	Tertiary hydroxyalkylxanthines
AU551834B2 (en)	1986-05-15	Photopolymerisation process
ATE38831T1 (de)	1988-12-15	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU5999896A (en)	1996-12-11	Aqueous dispersions of organopolysiloxanes
SE9102068L (sv)	1993-01-04	Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
GR3004855T3 (da)	1993-04-28
SE8304007D0 (sv)	1983-07-15	Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling
GB9320299D0 (en)	1993-11-17	Isoxazole derivatives
JPS6461466A (en)	1989-03-08	Derivatives of ureylene, 2,4-triminopyrimidine- 3-oxide, preparation and use for cosmetic and pharmacological composition
HUP0004736A2 (hu)	2001-04-28	Üzemanyag-kompozíció és keverék
ATE51002T1 (de)	1990-03-15	Neue anthracycline und diese enthaltende arzneimittel.
GB2231584B (en)	1991-03-06	Improved fuel additives
ATE119542T1 (de)	1995-03-15	Verfahren zur herstellung von 3-desoxy-4-en- steroiden.
ATE133649T1 (de)	1996-02-15	Verbesserter prozess zur darstellung von keton- verbindungen
ATE42957T1 (de)	1989-05-15	Waessrige kristallsuspension von steroidglykoestern.
KR910006313A (ko)	1991-04-29	테트라사카라이드 및 이의 제조방법
DE69102994D1 (de)	1994-08-25	Bogen für streichinstrumente.
ES450708A2 (es)	1977-12-01	Procedimiento para la obtencion de colorantes azoicos.
KR850008685A (ko)	1985-12-21	반응성 흑색 염료 조성물
ATE173737T1 (de)	1998-12-15	3-(aminoacyl-amino)-saccharide und verfahren zu ihrer herstellung
KR870006836A (ko)	1987-08-13	브라시노 라이드 유사체의 제조방법
DK0431151T3 (da)	1995-07-24	Fremgangsmåde til fremstilling af 21-brom-4-pregnen-3,20-dion-derivater
TH24218A (th)	1997-03-19	การใช้สารประกอบคาร์โบไฮเดรทที่เป็นสารเสริมสำหรับการย้อมสีและการพิมพ์วัสดุเส้นใย