DK513982A - Fremgangsmaade til fremstilling af cis-bicyclo(3.3.0)octanderivater - Google Patents

Fremgangsmaade til fremstilling af cis-bicyclo(3.3.0)octanderivater Download PDF

Info

Publication number
DK513982A
DK513982A DK513982A DK513982A DK513982A DK 513982 A DK513982 A DK 513982A DK 513982 A DK513982 A DK 513982A DK 513982 A DK513982 A DK 513982A DK 513982 A DK513982 A DK 513982A
Authority
DK
Denmark
Prior art keywords
compounds
bicyclo
group
octander
derivatives
Prior art date
Application number
DK513982A
Other languages
English (en)
Other versions
DK155934B (da
DK155934C (da
Inventor
Horst Boehlke
Gerriet Loschen
Gudrun Michel
Bernd Mueller
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of DK513982A publication Critical patent/DK513982A/da
Publication of DK155934B publication Critical patent/DK155934B/da
Application granted granted Critical
Publication of DK155934C publication Critical patent/DK155934C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK513982A 1981-11-21 1982-11-18 Analogifremgangsmaade til fremstilling af cis-bicyclo-oe3.3.0aaoctanderivater DK155934C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3146278A DE3146278C2 (de) 1981-11-21 1981-11-21 cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen
DE3146278 1981-11-21

Publications (3)

Publication Number Publication Date
DK513982A true DK513982A (da) 1983-05-22
DK155934B DK155934B (da) 1989-06-05
DK155934C DK155934C (da) 1989-10-09

Family

ID=6146953

Family Applications (1)

Application Number Title Priority Date Filing Date
DK513982A DK155934C (da) 1981-11-21 1982-11-18 Analogifremgangsmaade til fremstilling af cis-bicyclo-oe3.3.0aaoctanderivater

Country Status (21)

Country Link
US (1) US4510323A (da)
EP (1) EP0080061B1 (da)
JP (1) JPS5892637A (da)
AT (1) ATE11668T1 (da)
AU (1) AU556560B2 (da)
CA (1) CA1202968A (da)
DD (1) DD207196A5 (da)
DE (2) DE3146278C2 (da)
DK (1) DK155934C (da)
ES (1) ES8308299A1 (da)
GR (1) GR77643B (da)
HK (1) HK40488A (da)
HU (1) HU187814B (da)
IE (1) IE53785B1 (da)
MY (1) MY8700890A (da)
PL (1) PL137185B1 (da)
PT (1) PT75694B (da)
SG (1) SG5788G (da)
SU (1) SU1225482A3 (da)
YU (1) YU42604B (da)
ZA (1) ZA826928B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3914735A1 (de) * 1989-05-05 1990-11-08 Gruenenthal Gmbh Pharmakologisch wirksame ester, diese enthaltende arzneimittel und die herstellung dieser ester und arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201699A (en) * 1922-06-02 1923-08-09 Joseph Gardner Improvements in mechanical lubricators
DE2912409A1 (de) * 1978-03-31 1979-10-11 Ono Pharmaceutical Co 6,9-methano-pgi tief 2 -analoge
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
JPS56145239A (en) * 1980-04-11 1981-11-11 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation

Also Published As

Publication number Publication date
US4510323A (en) 1985-04-09
AU556560B2 (en) 1986-11-06
ATE11668T1 (de) 1985-02-15
HK40488A (en) 1988-06-10
DE3146278C2 (de) 1984-10-31
PT75694B (de) 1985-01-10
JPH0336821B2 (da) 1991-06-03
YU42604B (en) 1988-10-31
SG5788G (en) 1989-06-02
DK155934B (da) 1989-06-05
ES517545A0 (es) 1983-08-16
HU187814B (en) 1986-02-28
ES8308299A1 (es) 1983-08-16
ZA826928B (en) 1983-11-30
DK155934C (da) 1989-10-09
GR77643B (da) 1984-09-25
EP0080061B1 (de) 1985-02-06
IE53785B1 (en) 1989-02-15
AU8881382A (en) 1983-05-26
MY8700890A (en) 1987-12-31
DD207196A5 (de) 1984-02-22
PT75694A (de) 1982-11-01
DE3262233D1 (en) 1985-03-21
IE822252L (en) 1983-04-21
PL137185B1 (en) 1986-05-31
JPS5892637A (ja) 1983-06-02
CA1202968A (en) 1986-04-08
PL239099A1 (en) 1983-05-23
DE3146278A1 (de) 1983-06-01
YU257882A (en) 1985-03-20
SU1225482A3 (ru) 1986-04-15
EP0080061A1 (de) 1983-06-01

Similar Documents

Publication Publication Date Title
ES8604558A1 (es) Un metodo para preparar derivados de piperazina
IL77717A (en) Pharmaceutical compositions containing derivatives of imidazole,their preparation and some novel compounds of this type
ATE109770T1 (de) Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten.
AU556560B2 (en) Cis-bicyclo(3,3,0)octane derivatives
AU542775B2 (en) 6,9-epoxy prostaglandins
ATE18993T1 (de) Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
ES556048A0 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
KR840008012A (ko) 아미노에틸-피리딘 및 -피라진유도체의 제조방법
DK10085D0 (da) Aminoethylimidazoler, farmaceutisk komposition indeholdende disse forbindelser og fremgangsmaade til forbindelsernes fremstilling
ATE61352T1 (de) 4-hydroxy-4-(substituierte alkenyl)cyclohexancarbons|ure.

Legal Events

Date Code Title Description
PBP Patent lapsed