DK515188A - Fremgangsmaade til industriel syntese af perindopril og dens vigtigste syntesemellemprodukter - Google Patents

Fremgangsmaade til industriel syntese af perindopril og dens vigtigste syntesemellemprodukter

Info

Publication number
DK515188A
DK515188A DK515188A DK515188A DK515188A DK 515188 A DK515188 A DK 515188A DK 515188 A DK515188 A DK 515188A DK 515188 A DK515188 A DK 515188A DK 515188 A DK515188 A DK 515188A
Authority
DK
Denmark
Prior art keywords
synthesis
perindopril
procedure
industrial
intermediate products
Prior art date
Application number
DK515188A
Other languages
English (en)
Other versions
DK171470B1 (da
DK515188D0 (da
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9354991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK515188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adir filed Critical Adir
Publication of DK515188D0 publication Critical patent/DK515188D0/da
Publication of DK515188A publication Critical patent/DK515188A/da
Application granted granted Critical
Publication of DK171470B1 publication Critical patent/DK171470B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Casting Devices For Molds (AREA)
DK515188A 1987-09-17 1988-09-15 Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre DK171470B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8712896A FR2620709B1 (fr) 1987-09-17 1987-09-17 Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR8712896 1987-09-17

Publications (3)

Publication Number Publication Date
DK515188D0 DK515188D0 (da) 1988-09-15
DK515188A true DK515188A (da) 1989-03-18
DK171470B1 DK171470B1 (da) 1996-11-11

Family

ID=9354991

Family Applications (1)

Application Number Title Priority Date Filing Date
DK515188A DK171470B1 (da) 1987-09-17 1988-09-15 Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre

Country Status (15)

Country Link
US (1) US4914214A (da)
EP (1) EP0308341B1 (da)
JP (1) JPH01110696A (da)
AT (1) ATE59047T1 (da)
CA (1) CA1336348C (da)
DE (1) DE3861275D1 (da)
DK (1) DK171470B1 (da)
ES (1) ES2019703B3 (da)
FR (1) FR2620709B1 (da)
GR (1) GR3001539T3 (da)
IE (1) IE61453B1 (da)
NZ (1) NZ226224A (da)
OA (1) OA08915A (da)
PT (1) PT88527B (da)
ZA (1) ZA886932B (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
SI1333026T1 (sl) * 2002-01-30 2007-10-31 Servier Lab Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi
CA2477391A1 (en) * 2002-03-01 2003-09-12 Denis Schrier Method of treating osteoarthritis
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
WO2004065368A1 (ja) * 2003-01-21 2004-08-05 Ohara Chemical Industries, Ltd. トランドラプリル合成中間体の製造方法
DE60301930T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
WO2004075889A1 (en) * 2003-02-28 2004-09-10 Lupin Limited Process for preparation of perindopril and salts thereof
DK1338591T3 (da) * 2003-02-28 2006-01-23 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
GB0305066D0 (en) * 2003-03-06 2003-04-09 Ibm System and method for publish/subscribe messaging
DK1348684T3 (da) * 2003-04-09 2006-07-03 Servier Lab Fremgangsmåde til syntese af (2S)-indolin-2-carboxylsyre og anvendelse heraf til syntese af perindopril
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
WO2004113293A1 (de) 2003-06-24 2004-12-29 Les Laboratoires Servier Neue kristalline formen von perindopril erbumine
SI1362864T1 (sl) * 2003-06-30 2007-08-31 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
BR0318561A (pt) * 2003-10-21 2006-10-10 Lupin Ltd processo seletivo para a preparação de erbumino perindopril cristalino
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril
DK1422236T3 (da) * 2003-11-19 2007-06-11 Servier Lab Syntesefremgangsmåde for perindopril og farmaceutisk acceptable salte heraf
DK1420028T3 (da) * 2003-11-19 2007-06-18 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
LT1729739T (lt) * 2004-03-29 2016-11-10 Les Laboratoires Servier Kietos farmacinės kompozicijos gamybos būdas
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US20060178422A1 (en) * 2004-05-31 2006-08-10 Ashok Kumar Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
DE602005009918D1 (de) 2005-01-06 2008-11-06 Ipca Lab Ltd Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
MY138209A (en) * 2005-03-11 2009-05-29 Servier Lab New (y) crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it.
WO2006097941A1 (en) * 2005-03-14 2006-09-21 Lupin Limited An improved process for the purification of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
US7973173B2 (en) * 2005-07-05 2011-07-05 Cipla Limited Process for the synthesis of an ACE inhibitor
UA92752C2 (ru) * 2005-07-25 2010-12-10 Лек Фармасьютикалз Д.Д. Способ получения кристаллического периндоприла
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
EA007988B1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ξ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
CN101514180B (zh) * 2008-02-20 2012-08-01 上海医药工业研究院 培哚普利叔丁铵盐的ⅰ晶型及其制备方法
HUE025982T2 (en) 2008-06-24 2016-05-30 Mylan Laboratories Ltd New polymorphic forms of perindopril (L) -arginine and a process for their preparation
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN106631977A (zh) * 2016-11-11 2017-05-10 上海雅本化学有限公司 一种s‑吲哚啉‑2‑羧酸合成的优化方法
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung

Also Published As

Publication number Publication date
IE882806L (en) 1989-03-17
PT88527A (pt) 1988-10-01
GR3001539T3 (en) 1992-11-23
DE3861275D1 (de) 1991-01-24
JPH01110696A (ja) 1989-04-27
PT88527B (pt) 1993-03-31
ES2019703B3 (es) 1991-07-01
FR2620709B1 (fr) 1990-09-07
ATE59047T1 (de) 1990-12-15
DK171470B1 (da) 1996-11-11
FR2620709A1 (fr) 1989-03-24
NZ226224A (en) 1990-09-26
OA08915A (fr) 1989-10-31
EP0308341A1 (fr) 1989-03-22
CA1336348C (fr) 1995-07-18
ZA886932B (en) 1989-05-30
JPH0543717B2 (da) 1993-07-02
DK515188D0 (da) 1988-09-15
US4914214A (en) 1990-04-03
AU608363B2 (en) 1991-03-28
AU2236288A (en) 1989-03-23
EP0308341B1 (fr) 1990-12-12
IE61453B1 (en) 1994-11-02

Similar Documents

Publication Publication Date Title
DK515188A (da) Fremgangsmaade til industriel syntese af perindopril og dens vigtigste syntesemellemprodukter
Kovacs et al. Polypeptides with Known Repeating Sequence of Amino Acids. Synthesis of Poly-L-glutamyl-L-alanyl-L-glutamic Acid and Polyglycylglycyl-L-phenylalanine through Pentachlorophenyl Active Ester1
DK81583D0 (da) Derivater af 3-hydroxysmoersyre og fremgangsmade til fremstilling deraf
DE3788397D1 (de) Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung.
DK472184D0 (da) 2-amino-5-hydroxy-4-methylpyrimidin-derivater og farmeceutiske praeparater indeholdende disse
NO20001950L (no) Syntese av SAPO-44
PT73161B (fr) Procede pour la preparation de derives de n-(vynblastinoyl-23) aux amino-acides et peptides et son application terapeutique
GB1359123A (en) Preparation of aspartyl amino-acid alkyl esters
PT78064A (en) Process for preparing benzazocinone and benzazoninone derivatives
Brew et al. The isolation and characterization of the tryptic, chymotryptic, peptic, and cyanogen bromide peptides from bovine α-lactalbumin
Srinivasan et al. Synthesis of dehydroalanine peptides from. beta.-chloroalanine peptide derivatives
Barton et al. Reductive radical decarboxylation of amino-acids and peptides
Saltman et al. Co‐oligopeptides of aromatic amino acids and glycine with variable distance between the aromatic residues. VII. Enzymatic synthesis of N‐protected peptide amides
Narita Isolation of acetylpeptide from the protein of cucumber virus 4
DK514988A (da) Fremgangsmaade til industriel syntese af (2s,3as,7as)-2-carboxyperhydroindol
DK52987D0 (da) Dna-fragmenter af humant papillomavirus og fremgangsmaade til in vitro diagnosticering af papillomavirusinfektioner
DK147944B (da) Fremgangsmaade til fremstilling af biologisk aktive polypeptider som indeholder asparaginylgrupper
Diederich et al. Properties of pure acyl phosphatase from bovine brain
Abe et al. Synthesis of cyclo-diglycyl-L-lysyl-diglycyl-L-lysyl and hydrolysis by trypsin
AU2004270428A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof
Fridkin et al. Thiolysis of O-2, 4-dinitrophenyltyrosines: Spectrophotometric monitoring of the reaction and its use in peptide synthesis
DK105391D0 (da) Et rent faktor i produkt og fremgangsmaade til fremstilling heraf
GB1411184A (en) Polypeptides process for preparing them and their use as polyvalent isoinhibitors
Sawada Studies on the Acid-protease of Paecilomyces varioti BAINIER TPR-220: Part IV. Physical and Chemical Properties of the Crystalline Acid-protease
SE8004659L (sv) Forfarande for syntes av 2-isopropylaminopyrimidin

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)