DK515789A - Fremgangsmaade til adskillelse af folinsyre - Google Patents

Fremgangsmaade til adskillelse af folinsyre

Info

Publication number: DK515789A
Authority: DK; Denmark
Prior art keywords: separation; procedure; folic acid; folic; acid
Prior art date: 1988-11-11

Application number

DK515789A

Other languages

English (en)

Other versions

DK173425B1 (da

DK515789D0 (da

Inventor

Hans Rudolf Mueller

Martin Ulmann

Josef Conti

Guenter Muerdel

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-11

Filing date

1989-10-17

Publication date

1990-05-12

1989-10-17 Application filed by Eprova Ag filed Critical Eprova Ag

1989-10-17 Publication of DK515789D0 publication Critical patent/DK515789D0/da

1990-05-12 Publication of DK515789A publication Critical patent/DK515789A/da

2000-10-09 Application granted granted Critical

2000-10-09 Publication of DK173425B1 publication Critical patent/DK173425B1/da

Links

OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title 2
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title 1
229960000304 folic acid Drugs 0.000 title 1
235000019152 folic acid Nutrition 0.000 title 1
239000011724 folic acid Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000000926 separation method Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
Saccharide Compounds (AREA)

DK198905157A 1988-11-11 1989-10-17 Fremgangsmåde til adskillelse af (6R,S)-folinater DK173425B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH418288		1988-11-11
CH4182/88A CH676981A5 (da)	1988-11-11	1988-11-11

Publications (3)

Publication Number	Publication Date
DK515789D0 DK515789D0 (da)	1989-10-17
DK515789A true DK515789A (da)	1990-05-12
DK173425B1 DK173425B1 (da)	2000-10-09

Family

ID=4271318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198905157A DK173425B1 (da)	1988-11-11	1989-10-17	Fremgangsmåde til adskillelse af (6R,S)-folinater

Country Status (21)

Country	Link
US (1)	US5010194A (da)
EP (1)	EP0367902B1 (da)
JP (1)	JPH0645621B2 (da)
KR (1)	KR920005744B1 (da)
CN (1)	CN1029956C (da)
AR (1)	AR245130A1 (da)
AT (1)	ATE102201T1 (da)
AU (1)	AU607641B2 (da)
CA (1)	CA2002430C (da)
CH (1)	CH676981A5 (da)
DD (1)	DD284879A5 (da)
DE (1)	DE58907088D1 (da)
DK (1)	DK173425B1 (da)
ES (1)	ES2061804T3 (da)
FI (1)	FI91157C (da)
HU (1)	HU201777B (da)
IE (1)	IE63929B1 (da)
NO (1)	NO170334C (da)
NZ (1)	NZ231193A (da)
PT (1)	PT92232B (da)
ZA (1)	ZA897284B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5124452A (en) *	1978-07-10	1992-06-23	Bioresearch S.P.A.	Process for producing d,1-5-methyltetrahydrofolic acid and its salts
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (da) *	1987-05-15	1990-03-15	Eprova Ag
FR2643081B1 (fr) *	1989-02-14	1991-06-07	Panmedica Sa	Folates de magnesium, procede de preparation et compositions pharmaceutiques
CH680731A5 (da) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (da) *	1991-01-16	1993-02-26	Eprova Ag
ES2077808T5 (es) †	1991-03-29	2002-10-16	Lilly Co Eli	Procedimiento terapeutico mejorado.
US5217974A (en) *	1991-03-29	1993-06-08	Eli Lilly And Company	Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH684270A5 (de) *	1991-10-04	1994-08-15	Sapec Fine Chemicals	Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) *	1992-01-22	1994-02-15	Applied Pharma Res	Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
US5599931A (en) *	1992-02-20	1997-02-04	Bracco S.P.A.	Process for separating stereoisomers of folinic acid
IT1254635B (it) *	1992-02-20	1995-09-28	Bracco Spa	Processo per la separazione degli stereoisomeri dell'acido folinico
US5198547A (en) *	1992-03-16	1993-03-30	South Alabama Medical Science Foundation, Usa	Process for N5-formylating tetrahydropteridines
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5698693A (en) *	1992-11-16	1997-12-16	The United States Of America As Represented By The Department Of Health And Human Services	Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
US5710271A (en) *	1994-06-08	1998-01-20	Dibra S.P.A.	Process for the preparation and separation of diastereomeric salts of folinic acid
US7721732B2 (en) *	2002-04-04	2010-05-25	Qxtec, Inc.	Respiratory heat exchanger
CN101792444B (zh) *	2009-02-02	2011-10-12	天津康鸿医药科技发展有限公司	左亚叶酸钠及其制备方法及药物组合物
CN117486884A (zh) *	2023-09-26	2024-02-02	湖州展望药业有限公司	一种亚叶酸钙的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2688018A (en) *	1952-06-28	1954-08-31	American Cyanamid Co	Method of preparing alkaline earth metal salts of 1-leucovorin
US4500711A (en) *	1977-03-21	1985-02-19	Burroughs Wellcome Co.	Synthesis of leucovorin
US4148999A (en) *	1977-08-22	1979-04-10	The Government Of The United States Of America	Preparation and purification of citrovorum factor
CH649550A5 (en) *	1984-02-09	1985-05-31	Eprova Ag	Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (da) *	1987-05-15	1990-03-15	Eprova Ag

1988
- 1988-11-11 CH CH4182/88A patent/CH676981A5/de not_active IP Right Cessation
1989
- 1989-06-29 AT AT89111820T patent/ATE102201T1/de not_active IP Right Cessation
- 1989-06-29 ES ES89111820T patent/ES2061804T3/es not_active Expired - Lifetime
- 1989-06-29 DE DE89111820T patent/DE58907088D1/de not_active Expired - Lifetime
- 1989-06-29 EP EP89111820A patent/EP0367902B1/de not_active Expired - Lifetime
- 1989-09-25 ZA ZA897284A patent/ZA897284B/xx unknown
- 1989-10-17 DK DK198905157A patent/DK173425B1/da not_active IP Right Cessation
- 1989-10-30 NZ NZ231193A patent/NZ231193A/en unknown
- 1989-10-31 AU AU43924/89A patent/AU607641B2/en not_active Expired
- 1989-11-01 DD DD89334113A patent/DD284879A5/de unknown
- 1989-11-07 US US07/432,819 patent/US5010194A/en not_active Expired - Lifetime
- 1989-11-07 CA CA002002430A patent/CA2002430C/en not_active Expired - Lifetime
- 1989-11-08 AR AR89315393A patent/AR245130A1/es active
- 1989-11-08 PT PT92232A patent/PT92232B/pt not_active IP Right Cessation
- 1989-11-09 JP JP1290140A patent/JPH0645621B2/ja not_active Expired - Lifetime
- 1989-11-10 KR KR1019890016278A patent/KR920005744B1/ko not_active Expired
- 1989-11-10 HU HU895859A patent/HU201777B/hu unknown
- 1989-11-10 NO NO894499A patent/NO170334C/no not_active IP Right Cessation
- 1989-11-10 CN CN89109727A patent/CN1029956C/zh not_active Expired - Lifetime
- 1989-11-10 IE IE362389A patent/IE63929B1/en not_active IP Right Cessation
- 1989-11-10 FI FI895380A patent/FI91157C/fi active IP Right Grant

Also Published As

Publication number	Publication date
JPH0645621B2 (ja)	1994-06-15
HU201777B (en)	1990-12-28
US5010194A (en)	1991-04-23
DD284879A5 (de)	1990-11-28
HUT51648A (en)	1990-05-28
FI895380A0 (fi)	1989-11-10
EP0367902B1 (de)	1994-03-02
AU607641B2 (en)	1991-03-07
FI91157B (fi)	1994-02-15
FI91157C (fi)	1994-05-25
NO170334B (no)	1992-06-29
IE63929B1 (en)	1995-06-28
ATE102201T1 (de)	1994-03-15
AU4392489A (en)	1990-05-17
HU895859D0 (en)	1990-02-28
CA2002430A1 (en)	1990-05-11
JPH02178284A (ja)	1990-07-11
IE893623L (en)	1990-05-11
AR245130A1 (es)	1993-12-30
DE58907088D1 (de)	1994-04-07
PT92232A (pt)	1991-04-18
NZ231193A (en)	1991-03-26
NO894499D0 (no)	1989-11-10
DK173425B1 (da)	2000-10-09
CH676981A5 (da)	1991-03-28
CA2002430C (en)	1997-03-04
PT92232B (pt)	1995-07-06
KR900007420A (ko)	1990-06-01
ES2061804T3 (es)	1994-12-16
NO170334C (no)	1992-10-07
KR920005744B1 (ko)	1992-07-18
NO894499L (no)	1990-05-14
CN1042541A (zh)	1990-05-30
DK515789D0 (da)	1989-10-17
ZA897284B (en)	1991-04-24
CN1029956C (zh)	1995-10-11
EP0367902A2 (de)	1990-05-16
EP0367902A3 (de)	1991-04-03

Legal Events

Date	Code	Title	Description
2000-10-09	B1	Patent granted (law 1993)
2009-11-02	PUP	Patent expired

Publication	Publication Date	Title
DK515789D0 (da)	1989-10-17	Fremgangsmaade til adskillelse af folinsyre
DK254688A (da)	1988-11-16	Fremgangsmaade til fremstilling af folininsyre
DK86193D0 (da)	1993-07-21	Fremgangsmaade til fremstilling af trifluorbenzoesyrederivater
DK165984C (da)	1993-07-19	Fremgangsmaade til fremstilling af sphingosinderivater
DK271588A (da)	1988-11-20	Genteknologisk fremgangsmaade til fremstilling af angiogeniner
DK516286D0 (da)	1986-10-28	Fremgangsmaade til fremstilling af oxazolderivater
DK39789D0 (da)	1989-01-27	Fremgangsmaade til fremstilling af n-phosphonmethyliminodieddikesyre
DK209288A (da)	1988-10-18	Fraskillelse af aktiveret humant protein c
DK514785A (da)	1986-08-28	Fremgangsmaade til fremstilling af derivater af alkoholer
DK574688D0 (da)	1988-10-14	Fremgangsmaade til fremstilling af propensyrederivater
DK28788A (da)	1988-07-24	Fremgangsmaade til fremstilling af alkansulfonamider
DK314988A (da)	1988-12-12	Fremgangsmaade til fremstilling af 6-deoxyguaninderivater
DK498388A (da)	1989-03-10	Fremgangsmaade til fremstilling af propensyrederivater
DK382886D0 (da)	1986-08-11	Fremgangsmaade til fremstilling af hormonfaktorderivater
DK351588D0 (da)	1988-06-24	Fremgangsmaade til modificering af cellemembran
DK547488D0 (da)	1988-09-30	Fremgangsmaade til fremstilling af pyrodruesyre
DK258886A (da)	1986-12-04	Fremgangsmaade til fremstilling af alkyloxiraner
DK210586D0 (da)	1986-05-07	Fremgangsmaade til sammensvejsning af roerformede plastgenstande
DK99388A (da)	1988-08-26	Fremgangsmaade til fremstilling af piperazinderivater
DK509986A (da)	1987-04-27	Fremgangsmaade til fremstilling af aryl-cyanamider
DK450087D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
DK163830C (da)	1992-09-07	Fremgangsmaade til fremstilling af riboflavin
DK130992D0 (da)	1992-10-27	Fremgangsmaade til fremstilling af angiotenxinomdannende enzyminhibitorer
DK433887D0 (da)	1987-08-20	System til fjernelse af neglelak
DK68688D0 (da)	1988-02-10	Fremgangmsaade til adskillelse af stoebeemne