DK522689A - Isohirudiner deres fremstilling og anvendelse - Google Patents

Isohirudiner deres fremstilling og anvendelse

Info

Publication number: DK522689A
Authority: DK; Denmark
Prior art keywords: hirudins; isohirudines; preparation; mutation; distinguished
Prior art date: 1988-10-21

Application number

DK522689A

Other languages

English (en)

Other versions

DK522689D0 (da

DK175408B1 (da

Inventor

Dominique Tripier

Peter Crause

Paul Habermann

Martin Kramer

Joachim Engels

Matthias Scharf

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-21

Filing date

1989-10-20

Publication date

1990-04-22

1989-10-20 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-10-20 Publication of DK522689D0 publication Critical patent/DK522689D0/da

1990-04-22 Publication of DK522689A publication Critical patent/DK522689A/da

2004-09-27 Application granted granted Critical

2004-09-27 Publication of DK175408B1 publication Critical patent/DK175408B1/da

Links

102000007625 Hirudins Human genes 0.000 abstract 3
108010007267 Hirudins Proteins 0.000 abstract 3
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 3
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK198905226A 1988-10-21 1989-10-20 Isohirudiner, fremgangsmåde til deres fremstilling, pharmaceutisk middel samt fremgangsmåde til dets fremstilling DK175408B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3835815		1988-10-21
DE3835815A DE3835815A1 (de)	1988-10-21	1988-10-21	Neue isohirudine

Publications (3)

Publication Number	Publication Date
DK522689D0 DK522689D0 (da)	1989-10-20
DK522689A true DK522689A (da)	1990-04-22
DK175408B1 DK175408B1 (da)	2004-09-27

Family

ID=6365580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198905226A DK175408B1 (da)	1988-10-21	1989-10-20	Isohirudiner, fremgangsmåde til deres fremstilling, pharmaceutisk middel samt fremgangsmåde til dets fremstilling

Country Status (10)

Country	Link
US (1)	US5322926A (da)
EP (1)	EP0364942B1 (da)
JP (1)	JP2833798B2 (da)
AT (1)	ATE118789T1 (da)
DE (2)	DE3835815A1 (da)
DK (1)	DK175408B1 (da)
ES (1)	ES2068870T3 (da)
GR (1)	GR3015491T3 (da)
IE (1)	IE67041B1 (da)
PT (1)	PT92043B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE176500T1 (de) *	1990-11-08	1999-02-15	Japan Energy Corp	Sekretionsvektor, diesen enthaltene transformierte mikroorganismen und herstellung von produkten durch obigen mikroorganismus
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
HU214698B (hu) *	1992-04-09	1998-06-29	Gyógyszerkutató Intézet Kft.	Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
US6344486B1 (en) *	1998-04-03	2002-02-05	3-Dimensional Pharmaceuticals, Inc.	Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
DE10012732A1 (de) *	2000-03-18	2001-09-20	Aventis Behring Gmbh	Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3586333T2 (de) *	1984-03-27	1992-12-10	Transgene Sa	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
ES2055149T3 (es) *	1985-04-11	1994-08-16	Hoechst Ag	Derivado de hirudina.
DE3738541A1 (de) *	1987-11-13	1989-05-24	Hoechst Ag	Verfahren zur isolierung und reinigung von hirudin
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
AU604925B2 (en) *	1988-02-23	1991-01-03	Schering Aktiengesellschaft	A hirudin derivative
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
DE4009268A1 (de) *	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten

1988
- 1988-10-21 DE DE3835815A patent/DE3835815A1/de not_active Withdrawn
1989
- 1989-10-17 AT AT89119233T patent/ATE118789T1/de not_active IP Right Cessation
- 1989-10-17 EP EP89119233A patent/EP0364942B1/de not_active Expired - Lifetime
- 1989-10-17 ES ES89119233T patent/ES2068870T3/es not_active Expired - Lifetime
- 1989-10-17 DE DE58909027T patent/DE58909027D1/de not_active Expired - Lifetime
- 1989-10-19 PT PT92043A patent/PT92043B/pt not_active IP Right Cessation
- 1989-10-20 JP JP1271932A patent/JP2833798B2/ja not_active Expired - Lifetime
- 1989-10-20 DK DK198905226A patent/DK175408B1/da not_active IP Right Cessation
- 1989-10-20 IE IE339989A patent/IE67041B1/en not_active IP Right Cessation
1993
- 1993-03-22 US US08/035,498 patent/US5322926A/en not_active Expired - Lifetime
1995
- 1995-03-20 GR GR950400622T patent/GR3015491T3/el unknown

Also Published As

Publication number	Publication date
ATE118789T1 (de)	1995-03-15
DK522689D0 (da)	1989-10-20
IE67041B1 (en)	1996-02-21
JP2833798B2 (ja)	1998-12-09
ES2068870T3 (es)	1995-05-01
JPH02218695A (ja)	1990-08-31
IE893399L (en)	1990-04-21
EP0364942A2 (de)	1990-04-25
EP0364942B1 (de)	1995-02-22
PT92043A (pt)	1990-04-30
EP0364942A3 (en)	1990-09-05
PT92043B (pt)	1995-06-30
DE3835815A1 (de)	1990-04-26
US5322926A (en)	1994-06-21
DK175408B1 (da)	2004-09-27
GR3015491T3 (en)	1995-06-30
DE58909027D1 (de)	1995-03-30

Legal Events

Date	Code	Title	Description
2009-11-09	PUP	Patent expired

Publication	Publication Date	Title
DK77490A (da)	1990-03-26	Substituerede arylurinstofderivater, deres fremstilling og anvendelse som soedemidler
DK0388321T3 (da)	1997-01-06	Hidtil ukendt piperidinylforbindelser og deres anvendelse som fotostabilisatorer for polymerer
DE3862217D1 (de)	1991-05-08	Stuhl, insbesondere arbeitsstuhl.
ES2052062T3 (es)	1994-07-01	Nuevos polipeptidos con actividad anticoagulante.
FI891713L (fi)	1989-10-14	Slangskal, speciellt konstgjort korvskal med limband i laengsaxelriktningen.
DK270789A (da)	1989-12-05	Hirudin-derivater, deres fremstilling og anvendelse
NO882858L (no)	1988-12-30	Silikapartikler, fremstilling og anvendelse derav.
FI884156A7 (fi)	1989-03-12	Polymeerit, joka perustuvat booriin ja typpeen ja joita voidaan käyttää erikoisesti keraamisten aineiden ja artikkeleiden valmistamiseen, jotka perustuvat boorinitridiin, samoin kuin niiden valmistusmenetelmä.
LU90127I2 (fr)	1997-10-06	Lepirudin et ses sels et dérivés pharmaceutiquement acceptables (REFLUDAN)
DE68912940D1 (de)	1994-03-17	Gestell zum zusammenbau von möbeln.
DK522689D0 (da)	1989-10-20	Isohirudiner deres fremstilling og anvendelse
FI893605A0 (fi)	1989-07-28	Imidatso (4,5-b) pyridinderivat.
DE59001552D1 (de)	1993-07-01	Haecksler zum zerkleinern von halmfoermigem erntegut.
NO904728L (no)	1991-05-02	Flerlags massivtreprodukter saasom bjelker, bord og limtre.
FI883266A0 (fi)	1988-07-08	4-aminosubstituerade 1,2-dihydronaftalenderivat.
DK361288A (da)	1989-01-02	Hydroxyethylazolylderivater, deres fremstilling og anvendelse samt mellemprodukter til fremstilling og disses fremstilling
DE69004589D1 (de)	1993-12-23	Förderer, gespeist von mehreren Bahnen.
DK641989A (da)	1990-06-20	Bis-arylphosphatestere, deres fremstilling og anvendelse
DE3886390D1 (de)	1994-01-27	Pneumatische bohrmaschine.
DE58905525D1 (de)	1993-10-14	Holzzerspanungsmaschine.
AT379344B (de)	1985-12-27	Holzspalter mit zweiteiligem hubbalken
NO885020D0 (no)	1988-11-10	Isokinolinderivater, deres fremstilling og anvendelse.
DE68902518D1 (de)	1992-09-24	Absperrwerkzeug.
IT1204543B (it)	1989-03-03	Inchiodatrice multipla perfezionata,in particolare per palette
NO884260D0 (no)	1988-09-27	Ryggreguleringsanordning for hvilestol, sofa o.l.