PT92043A - Processo para a preparacao de novas isohirudinas - Google Patents

Processo para a preparacao de novas isohirudinas

Info

Publication number: PT92043A
Authority: PT; Portugal
Prior art keywords: isohirudines; preparation; new; hirudins; mutation
Prior art date: 1988-10-21

Application number

PT92043A

Other languages

English (en)

Other versions

PT92043B (pt

Inventor

Paul Habermann

Dominique Tripier

Peter Crausse

Martin Kramer

Joachim Engels

Matthias Scharf

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-21

Filing date

1989-10-19

Publication date

1990-04-30

1989-10-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1990-04-30 Publication of PT92043A publication Critical patent/PT92043A/pt

1995-06-30 Publication of PT92043B publication Critical patent/PT92043B/pt

Links

102000007625 Hirudins Human genes 0.000 abstract 3
108010007267 Hirudins Proteins 0.000 abstract 3
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 3
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT92043A 1988-10-21 1989-10-19 Processo para a preparacao de novas isohirudinas PT92043B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3835815A DE3835815A1 (de)	1988-10-21	1988-10-21	Neue isohirudine

Publications (2)

Publication Number	Publication Date
PT92043A true PT92043A (pt)	1990-04-30
PT92043B PT92043B (pt)	1995-06-30

Family

ID=6365580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT92043A PT92043B (pt)	1988-10-21	1989-10-19	Processo para a preparacao de novas isohirudinas

Country Status (10)

Country	Link
US (1)	US5322926A (pt)
EP (1)	EP0364942B1 (pt)
JP (1)	JP2833798B2 (pt)
AT (1)	ATE118789T1 (pt)
DE (2)	DE3835815A1 (pt)
DK (1)	DK175408B1 (pt)
ES (1)	ES2068870T3 (pt)
GR (1)	GR3015491T3 (pt)
IE (1)	IE67041B1 (pt)
PT (1)	PT92043B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0687731T3 (da) *	1990-11-08	1999-09-20	Japan Energy Corp	Sekretionsvektor, transformerede mikroorganismer indeholdende vektoren og fremstilling af produkter fra denne mikroorganism
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
HU214698B (hu) *	1992-04-09	1998-06-29	Gyógyszerkutató Intézet Kft.	Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
US6344486B1 (en) *	1998-04-03	2002-02-05	3-Dimensional Pharmaceuticals, Inc.	Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
DE10012732A1 (de) *	2000-03-18	2001-09-20	Aventis Behring Gmbh	Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
WO1985004418A1 (fr) *	1984-03-27	1985-10-10	Transgene S.A.	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
ATE64956T1 (de) *	1984-06-14	1991-07-15	Ciba Geigy Ag	Verfahren zur herstellung von thrombininhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3738541A1 (de) *	1987-11-13	1989-05-24	Hoechst Ag	Verfahren zur isolierung und reinigung von hirudin
ES2055149T3 (es) *	1985-04-11	1994-08-16	Hoechst Ag	Derivado de hirudina.
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
AU604925B2 (en) *	1988-02-23	1991-01-03	Schering Aktiengesellschaft	A hirudin derivative
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
DE4009268A1 (de) *	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten

1988
- 1988-10-21 DE DE3835815A patent/DE3835815A1/de not_active Withdrawn
1989
- 1989-10-17 EP EP89119233A patent/EP0364942B1/de not_active Expired - Lifetime
- 1989-10-17 ES ES89119233T patent/ES2068870T3/es not_active Expired - Lifetime
- 1989-10-17 AT AT89119233T patent/ATE118789T1/de not_active IP Right Cessation
- 1989-10-17 DE DE58909027T patent/DE58909027D1/de not_active Expired - Lifetime
- 1989-10-19 PT PT92043A patent/PT92043B/pt not_active IP Right Cessation
- 1989-10-20 IE IE339989A patent/IE67041B1/en not_active IP Right Cessation
- 1989-10-20 DK DK198905226A patent/DK175408B1/da not_active IP Right Cessation
- 1989-10-20 JP JP1271932A patent/JP2833798B2/ja not_active Expired - Lifetime
1993
- 1993-03-22 US US08/035,498 patent/US5322926A/en not_active Expired - Lifetime
1995
- 1995-03-20 GR GR950400622T patent/GR3015491T3/el unknown

Also Published As

Publication number	Publication date
JP2833798B2 (ja)	1998-12-09
DE3835815A1 (de)	1990-04-26
ATE118789T1 (de)	1995-03-15
EP0364942A2 (de)	1990-04-25
JPH02218695A (ja)	1990-08-31
EP0364942B1 (de)	1995-02-22
US5322926A (en)	1994-06-21
ES2068870T3 (es)	1995-05-01
DE58909027D1 (de)	1995-03-30
DK522689D0 (da)	1989-10-20
IE67041B1 (en)	1996-02-21
IE893399L (en)	1990-04-21
GR3015491T3 (en)	1995-06-30
EP0364942A3 (en)	1990-09-05
PT92043B (pt)	1995-06-30
DK522689A (da)	1990-04-22
DK175408B1 (da)	2004-09-27

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Legal Events

Date

Code

Title

Description

2003-01-31

PC3A

Transfer or assignment

Free format text: SCHERING AKTIENGESELLSCHAFT DE

Effective date: 20021128

2009-12-22

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20091213