DK528989A - Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf - Google Patents

Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf

Info

Publication number
DK528989A
DK528989A DK528989A DK528989A DK528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A
Authority
DK
Denmark
Prior art keywords
muteines
procedures
producing
tissue plasma
minogen activator
Prior art date
Application number
DK528989A
Other languages
English (en)
Other versions
DK528989D0 (da
Inventor
Anne Stern
Ulrich Weidle
Ralf Mattes
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK528989D0 publication Critical patent/DK528989D0/da
Publication of DK528989A publication Critical patent/DK528989A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK528989A 1988-10-24 1989-10-24 Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf DK528989A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836200A DE3836200A1 (de) 1988-10-24 1988-10-24 Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)

Publications (2)

Publication Number Publication Date
DK528989D0 DK528989D0 (da) 1989-10-24
DK528989A true DK528989A (da) 1990-04-25

Family

ID=6365810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528989A DK528989A (da) 1988-10-24 1989-10-24 Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf

Country Status (6)

Country Link
EP (1) EP0366091A3 (da)
JP (1) JPH02215384A (da)
AU (1) AU609337B2 (da)
DE (1) DE3836200A1 (da)
DK (1) DK528989A (da)
IL (1) IL92015A0 (da)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501841A (ja) * 1985-12-20 1988-07-28 ジ・アップジョン・カンパニ− 組織プラスミノ−ゲンアクチベ−タ−（ｔｐａ）同族体
EP0231624B1 (en) * 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs
DE3682891D1 (de) * 1986-02-17 1992-01-23 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
ZA883958B (en) * 1987-06-04 1989-07-26 Zymogenetics Inc Mutant t-pa with ringle replacement

Also Published As

Publication number Publication date
AU4365789A (en) 1990-04-26
DK528989D0 (da) 1989-10-24
IL92015A0 (en) 1990-07-12
EP0366091A2 (de) 1990-05-02
AU609337B2 (en) 1991-04-26
DE3836200A1 (de) 1990-04-26
JPH02215384A (ja) 1990-08-28
EP0366091A3 (de) 1990-09-05

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment