DK528989A - Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf - Google Patents

Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf

Info

Publication number
DK528989A
DK528989A DK528989A DK528989A DK528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A DK 528989 A DK528989 A DK 528989A
Authority
DK
Denmark
Prior art keywords
muteines
procedures
producing
tissue plasma
minogen activator
Prior art date
Application number
DK528989A
Other languages
English (en)
Other versions
DK528989D0 (da
Inventor
Anne Stern
Ulrich Weidle
Ralf Mattes
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK528989D0 publication Critical patent/DK528989D0/da
Publication of DK528989A publication Critical patent/DK528989A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK528989A 1988-10-24 1989-10-24 Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf DK528989A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836200A DE3836200A1 (de) 1988-10-24 1988-10-24 Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)

Publications (2)

Publication Number Publication Date
DK528989D0 DK528989D0 (da) 1989-10-24
DK528989A true DK528989A (da) 1990-04-25

Family

ID=6365810

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528989A DK528989A (da) 1988-10-24 1989-10-24 Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf

Country Status (6)

Country Link
EP (1) EP0366091A3 (da)
JP (1) JPH02215384A (da)
AU (1) AU609337B2 (da)
DE (1) DE3836200A1 (da)
DK (1) DK528989A (da)
IL (1) IL92015A0 (da)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289508A1 (en) * 1985-12-20 1988-11-09 The Upjohn Company Tissue plasminogen activator (tpa) analogs
JPS63501841A (ja) * 1985-12-20 1988-07-28 ジ・アップジョン・カンパニ− 組織プラスミノ−ゲンアクチベ−タ−（ｔｐａ）同族体
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
EP0293934B1 (en) * 1987-06-04 1994-08-31 Zymogenetics, Inc. Mutant t-PA with kringle replacement

Also Published As

Publication number Publication date
AU4365789A (en) 1990-04-26
DK528989D0 (da) 1989-10-24
JPH02215384A (ja) 1990-08-28
AU609337B2 (en) 1991-04-26
DE3836200A1 (de) 1990-04-26
EP0366091A2 (de) 1990-05-02
EP0366091A3 (de) 1990-09-05
IL92015A0 (en) 1990-07-12

Similar Documents

Publication Publication Date Title
DK194589D0 (da) Partikelformede vaskemidler og fremgangsmaade til fremstilling deraf
DK414789D0 (da) Polymerer og fremgangsmaade til fremstilling heraf
DK268189D0 (da) Aromatiske forbindelser og fremgangsmaader til fremstilling deraf
DK413588A (da) Vaevsfaktor-inhibitor (tfi) og fremgangmsaade til fresmtilling heraf
DK159288D0 (da) Saccharidblanding og fremgangsmaade til fremstilling deraf
DK290287D0 (da) Antibiotika og fremgangsmaade til fremstilling deraf
DK202989A (da) Antitumormidler og fremgangsmaade til fremstilling deraf
DK381288D0 (da) Fremgangsmaade og anordning til maaling af vaevsplasminogenaktivator (t-pa) aktivitet
DK397788A (da) Polyarylalkan-oligomer-praeparater og fremgangsmaade til fremstilling deraf
HU912739D0 (en) Stabilization of glycozylized tissue plasminogene activator (t-pa)
FI892358L (fi) Menetelmä ihmisen kudosplasminogeeniaktivaattorin valmistamiseksi
NO891713D0 (no) Monoklonale antistoffer til vevplasminogenaktivator (t-pa)
DK34491A (da) Ekstruderet, biaksialt strakt skumplastroer og fremgangsmaade til fremstilling deraf
DK528989A (da) Vaevsplasminogenaktivator-(t-pa)-muteiner og fremgangsmaade til fremstilling deraf
DK585988D0 (da) Isopolypeptider og fremgangsmaade til fremstilling deraf
DK265288A (da) Oximino-ether-forbindelser og fremgangsmaade til fremstilling deraf
DK131189D0 (da) Fremgangsmaade og middel til ophthalmisk anaestesi
DK129689D0 (da) Ifosfamid-mesna-lyofilisat og fremgangsmaade til fremstilling deraf
FI894657L (fi) Menetelmä ihmiskudostyyppisen plasminogeeniaktivaattorin tuottamiseksi
DK357189D0 (da) Palladiumbaserede kompleksforbindelser og fremgangsmaade til fremstilling heraf
GB8815245D0 (en) New tissue plasminogen activator
GB8826692D0 (en) Tissue plasminogen activator
IE882534L (en) Peg complex of tissue plasminogen activator
AU608232C (en) Modified tissue plasminogen activator
GB8815246D0 (en) New tissue plasminogen activator

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment