DK540485D0 - Substituerede imidazolderivater samt fremgangsmaade til fremstilling deraf og forbindelsernes anvendelse - Google Patents

Substituerede imidazolderivater samt fremgangsmaade til fremstilling deraf og forbindelsernes anvendelse

Info

Publication number: DK540485D0
Authority: DK; Denmark
Prior art keywords: och3; ch2ch3; hal; relationships; procedures
Prior art date: 1984-11-23

Application number

DK540485A

Other languages

English (en)

Other versions

DK540485A (da

DK164903B (da

DK164903C (da

Inventor

A J Karjalainen

R E Virtanen

A L Karjalainen

K O A Kurkela

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-23

Filing date

1985-11-22

Publication date

1985-11-22

1985-11-22 Application filed by Farmos Oy filed Critical Farmos Oy

1985-11-22 Publication of DK540485D0 publication Critical patent/DK540485D0/da

1986-05-24 Publication of DK540485A publication Critical patent/DK540485A/da

1992-09-07 Publication of DK164903B publication Critical patent/DK164903B/da

1993-01-25 Application granted granted Critical

1993-01-25 Publication of DK164903C publication Critical patent/DK164903C/da

Links

238000000034 method Methods 0.000 title abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
-1 R4 is H Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Lubricants (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Dental Preparations (AREA)
Golf Clubs (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Epoxy Resins (AREA)

DK540485A 1984-11-23 1985-11-22 Substituerede imidazolderivater og fremgangsmaader til fremstilling deraf DK164903C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB08429578A GB2167408B (en)	1984-11-23	1984-11-23	Substituted imidazole derivatives and their preparation and use
GB8429578		1984-11-23

Publications (4)

Publication Number	Publication Date
DK540485D0 true DK540485D0 (da)	1985-11-22
DK540485A DK540485A (da)	1986-05-24
DK164903B DK164903B (da)	1992-09-07
DK164903C DK164903C (da)	1993-01-25

Family

ID=10570140

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK540485A DK164903C (da)	1984-11-23	1985-11-22	Substituerede imidazolderivater og fremgangsmaader til fremstilling deraf
DK92582A DK58292D0 (da)	1984-11-23	1992-05-04	Som mellemprodukter anvendelige 4(5)-imidazolderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK92582A DK58292D0 (da)	1984-11-23	1992-05-04	Som mellemprodukter anvendelige 4(5)-imidazolderivater

Country Status (26)

Country	Link
US (1)	US4689339A (da)
EP (2)	EP0183492B1 (da)
JP (1)	JPH064597B2 (da)
KR (1)	KR930004673B1 (da)
AT (2)	ATE85050T1 (da)
AU (2)	AU586839B2 (da)
BG (1)	BG60762B2 (da)
CA (1)	CA1268770C (da)
DD (1)	DD258230A1 (da)
DE (2)	DE3587045T2 (da)
DK (2)	DK164903C (da)
ES (2)	ES8704462A1 (da)
FI (1)	FI80264C (da)
GB (1)	GB2167408B (da)
GR (1)	GR852817B (da)
HK (1)	HK3592A (da)
HU (1)	HU195189B (da)
IE (1)	IE58165B1 (da)
IL (1)	IL77111A (da)
NO (1)	NO166585C (da)
NZ (1)	NZ214258A (da)
PH (1)	PH22016A (da)
PT (1)	PT81542B (da)
SG (1)	SG106891G (da)
SU (1)	SU1424736A3 (da)
ZA (1)	ZA858942B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987004431A1 (fr) *	1986-01-28	1987-07-30	Mitsui Petrochemical Industries, Ltd.	Procede de preparation de 2-imidazoles non substitues
FI862039A0 (fi) *	1986-05-15	1986-05-15	Farmos Oy	Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) *	1986-05-15	1990-09-10	Farmos Oy	Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) *	1987-03-20	1997-01-29	アイシン精機株式会社	原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) *	1987-10-06	1990-01-05	Commissariat Energie Atomique	Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) *	1988-12-09	1990-06-13	Farmos Group Limited	Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) *	1989-02-15	1989-04-05	Erba Carlo Spa	Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) *	1989-02-21	1993-08-31	Eugene C. Crichlow	Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) *	1989-07-12	1989-07-12	Novo Nordisk As	Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) *	1990-05-31	1991-12-04	Farmos Oy	Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en)	1991-05-31	1995-01-18	Orion Yhtymae Oy	Transdermal administration of 4-substituted imidazoles
US5541211A (en) *	1991-06-18	1996-07-30	Orion-Yhtyma Oy	Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
HUT67665A (en) *	1991-11-05	1995-04-28	Smithkline Beckman Corp	Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
GB9127050D0 (en) *	1991-12-20	1992-02-19	Orion Yhtymae Oy	Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) *	1991-12-27	1992-02-19	Scras	Benzofuranylimidazole derivatives
GB9312669D0 (en) *	1993-06-18	1993-08-04	Orion Yhtymae Oy	New opticla isomers
GB9425211D0 (en) *	1994-12-14	1995-02-15	Ucb Sa	Substituted 1H-imidazoles
FR2733983B1 (fr) *	1995-05-10	1997-08-01	Pf Medicament	Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en)	1995-10-03	1995-12-06	Orion Yhtymae Oy	New imidazole derivatives
FR2754709B1 (fr)	1996-10-23	1999-03-05	Sanofi Sa	Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2002510300A (ja)	1997-06-05	2002-04-02	ヴィーナンティアス・リミテッド	インダン化合物及びそれらの医薬学的使用
WO1999051593A1 (en) *	1998-04-02	1999-10-14	Ortho-Mcneil Pharmaceutical, Inc.	4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) *	1998-09-10	2002-09-27	Fabre Pierre Sante	Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000042023A1 (en) *	1999-01-18	2000-07-20	Novo Nordisk A/S	Substituted imidazoles, their preparation and use
US6388090B2 (en)	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
US6593324B2 (en)	2000-03-01	2003-07-15	Orion Corporation	Dervatives of quinoline as alpha-2 antagonists
DE60112917T2 (de)	2000-05-08	2006-06-08	Orion Corp.	Neue polyzyklische indanylimidazole mit alpha2 adrenergik aktivität
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en)	2001-06-26	2003-04-08	Pfizer Inc.	Insecticidal pet collar
HRP20041026A2 (en)	2002-04-03	2005-06-30	Orion Corporation	Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en)	2002-05-16	2012-05-29	Pierre Fabre Medicament	Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) *	2003-01-08	2005-10-31	Juvantia Pharma Ltd Oy	Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
DE602004017347D1 (de) *	2003-11-04	2008-12-04	Intervet Int Bv	Azol-pestiziden
FI20050657A0 (fi) *	2005-06-17	2005-06-17	Orion Corp	Atipametsolin kiteytysmenetelmä
GEP20125432B (en)	2005-10-12	2012-03-26	Unimed Pharmaceuticals Llc	Improved testosterone gel and use thereof
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20100179205A1 (en) *	2006-08-08	2010-07-15	Intervet International B.V.	Composition for Enhanced Antiparasitic Activity
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) *	2007-12-05	2009-11-27	Grindeks Jsc	Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP3065741B1 (en)	2013-11-05	2021-09-22	3M Innovative Properties Company	Sesame oil based injection formulations
AR104882A1 (es)	2015-06-05	2017-08-23	Orion Corp	DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
US12414937B2 (en)	2015-11-05	2025-09-16	University Of Louisville Research Foundation, Inc.	Local and regional anesthesia and analgesia
US20190152992A1 (en)	2016-06-29	2019-05-23	Orion Corporation	Benzodioxane derivatives and their pharmaceutical use
MX2021007131A (es)	2018-12-21	2021-07-02	Nestle Sa	Composicion nutricional para inducir una sensacion de saciedad, un mejor sueño y/o limitar el despertar nocturno en infantes o niños pequeños.
CN111978254A (zh) *	2019-05-22	2020-11-24	南京康德祥医药科技有限公司	一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) *	2020-09-07	2020-11-13	上海阿达玛斯试剂有限公司	一种阿替美唑的制备方法
EP4658639A1 (en)	2023-02-01	2025-12-10	Univerza V Ljubljani	N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
LU103072B1 (en)	2023-02-15	2024-08-19	Univ Ljubljani	N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
CN117186010B (zh) *	2023-08-15	2026-04-14	厦门欧瑞捷生物科技有限公司	一种盐酸阿替美唑的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2933962A1 (de) *	1979-08-22	1981-03-26	Hoechst Ag, 65929 Frankfurt	Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) *	1980-03-04	1982-08-03	Farmitalia Carlo Erba S.P.A.	3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) *	1980-09-10	1981-11-24	Syntex (U.S.A.) Inc.	2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) *	1981-07-28	1984-10-19	Reckitt & Colmann Prod Ltd	Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES8503669A1 (es) *	1982-07-05	1985-03-01	Erba Farmitalia	Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) *	1983-01-14	1985-09-13	Adir	Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) *	1983-03-18	1984-09-21	Synthelabo	Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

1984
- 1984-11-23 GB GB08429578A patent/GB2167408B/en not_active Expired
1985
- 1985-11-05 FI FI854335A patent/FI80264C/fi not_active IP Right Cessation
- 1985-11-18 CA CA 495608 patent/CA1268770C/xx not_active Expired - Lifetime
- 1985-11-20 AU AU50083/85A patent/AU586839B2/en not_active Expired
- 1985-11-20 NZ NZ214258A patent/NZ214258A/xx unknown
- 1985-11-20 IL IL77111A patent/IL77111A/xx not_active IP Right Cessation
- 1985-11-20 DD DD85283044A patent/DD258230A1/de not_active IP Right Cessation
- 1985-11-21 PH PH33077A patent/PH22016A/en unknown
- 1985-11-21 US US06/800,192 patent/US4689339A/en not_active Expired - Lifetime
- 1985-11-21 KR KR1019850008704A patent/KR930004673B1/ko not_active Expired - Fee Related
- 1985-11-21 EP EP85308491A patent/EP0183492B1/en not_active Expired
- 1985-11-21 ZA ZA858942A patent/ZA858942B/xx unknown
- 1985-11-21 DE DE8888106210T patent/DE3587045T2/de not_active Expired - Fee Related
- 1985-11-21 EP EP88106210A patent/EP0310745B1/en not_active Expired - Lifetime
- 1985-11-21 IE IE292985A patent/IE58165B1/en not_active IP Right Cessation
- 1985-11-21 AT AT88106210T patent/ATE85050T1/de not_active IP Right Cessation
- 1985-11-21 AT AT85308491T patent/ATE47997T1/de not_active IP Right Cessation
- 1985-11-21 DE DE8585308491T patent/DE3574252D1/de not_active Expired
- 1985-11-21 GR GR852817A patent/GR852817B/el unknown
- 1985-11-22 ES ES549178A patent/ES8704462A1/es not_active Expired
- 1985-11-22 HU HU854471A patent/HU195189B/hu unknown
- 1985-11-22 NO NO854671A patent/NO166585C/no unknown
- 1985-11-22 DK DK540485A patent/DK164903C/da not_active IP Right Cessation
- 1985-11-22 JP JP60263586A patent/JPH064597B2/ja not_active Expired - Lifetime
- 1985-11-22 SU SU853979907A patent/SU1424736A3/ru active
- 1985-11-22 PT PT81542A patent/PT81542B/pt unknown
1986
- 1986-12-29 ES ES557268A patent/ES8801248A1/es not_active Expired
1989
- 1989-04-21 AU AU33329/89A patent/AU3332989A/en not_active Abandoned
1991
- 1991-12-17 SG SG1068/91A patent/SG106891G/en unknown
1992
- 1992-01-09 HK HK35/92A patent/HK3592A/en not_active IP Right Cessation
- 1992-05-04 DK DK92582A patent/DK58292D0/da not_active Application Discontinuation
1994
- 1994-01-18 BG BG098378A patent/BG60762B2/bg unknown

Also Published As

Publication number	Publication date
ATE47997T1 (de)	1989-12-15
ES8704462A1 (es)	1987-04-01
FI80264C (fi)	1990-05-10
DE3574252D1 (en)	1989-12-21
DE3587045D1 (de)	1993-03-11
HU195189B (en)	1988-04-28
IL77111A0 (en)	1986-04-29
IE58165B1 (en)	1993-07-28
NO854671L (no)	1986-05-26
PH22016A (en)	1988-05-13
US4689339A (en)	1987-08-25
NO166585C (no)	1991-08-21
EP0183492A1 (en)	1986-06-04
DD258230A1 (de)	1988-07-13
SG106891G (en)	1992-02-14
HUT38913A (en)	1986-07-28
IE852929L (en)	1986-05-23
FI854335A0 (fi)	1985-11-05
ES557268A0 (es)	1987-12-16
JPH064597B2 (ja)	1994-01-19
EP0310745A2 (en)	1989-04-12
ES549178A0 (es)	1987-04-01
NZ214258A (en)	1989-02-24
ZA858942B (en)	1986-08-27
AU5008385A (en)	1986-05-29
KR860004028A (ko)	1986-06-16
SU1424736A3 (ru)	1988-09-15
DK540485A (da)	1986-05-24
EP0310745B1 (en)	1993-01-27
BG60762B2 (bg)	1996-02-29
DE3587045T2 (de)	1993-06-03
GB2167408A (en)	1986-05-29
HK3592A (en)	1992-01-17
FI80264B (fi)	1990-01-31
EP0183492B1 (en)	1989-11-15
AU3332989A (en)	1989-08-10
ES8801248A1 (es)	1987-12-16
FI854335A7 (fi)	1986-05-24
IL77111A (en)	1989-09-28
GB2167408B (en)	1988-05-25
AU586839B2 (en)	1989-07-27
DK164903B (da)	1992-09-07
DK58292A (da)	1992-05-04
EP0310745A3 (en)	1989-10-11
GB8429578D0 (en)	1985-01-03
GR852817B (da)	1986-03-21
NO166585B (no)	1991-05-06
DK58292D0 (da)	1992-05-04
DK164903C (da)	1993-01-25
CA1266669A1 (en)	1990-03-13
CA1268770C (en)	1990-05-08
JPS61143366A (ja)	1986-07-01
PT81542B (pt)	1988-03-03
KR930004673B1 (ko)	1993-06-03
ATE85050T1 (de)	1993-02-15
PT81542A (en)	1985-12-01

Legal Events

Date	Code	Title	Description
2005-12-12	PUP	Patent expired

Publication	Publication Date	Title
DK540485D0 (da)	1985-11-22	Substituerede imidazolderivater samt fremgangsmaade til fremstilling deraf og forbindelsernes anvendelse
DK623586A (da)	1987-06-28	Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FI850140L (fi)	1985-07-14	Kemiska foereningar.
PL237655A1 (en)	1983-03-28	Process for preparing derivatives of imidazoline
FI860369A0 (fi)	1986-01-27	Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
FI871655A7 (fi)	1987-11-16	Foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
PT87277A (pt)	1988-05-01	Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
JPS56103168A (en)	1981-08-18	Thiazole derivative, its preparation, and antihistaminic agent containing the same
NZ213222A (en)	1989-03-29	2-(3,5-dialkyl-4-hydroxyphenyl)-indole derivatives and pharmaceutical compositions
DE3569376D1 (en)	1989-05-18	1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
DE3160719D1 (en)	1983-09-08	Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them