DK55192D0 - 1-piperazino-1,2-dihydroindenderivater - Google Patents

1-piperazino-1,2-dihydroindenderivater

Info

Publication number: DK55192D0
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; cycloalkylalkyl; cycloalkyl; alkenyl
Prior art date: 1992-04-28

Application number

DK92551A

Other languages

Danish (da)

English (en)

Inventor

Klaus Bogeso

Peter Bregnedal

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-28

Filing date

1992-04-28

Publication date

1992-04-28

1992-04-28 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1992-04-28 Priority to DK92551A priority Critical patent/DK55192D0/da

1992-04-28 Publication of DK55192D0 publication Critical patent/DK55192D0/da

1993-04-20 Priority to IL105464A priority patent/IL105464A/en

1993-04-22 Priority to ZA932840A priority patent/ZA932840B/xx

1993-04-23 Priority to PCT/DK1993/000136 priority patent/WO1993022293A1/en

1993-04-23 Priority to PT93909807T priority patent/PT638073E/pt

1993-04-23 Priority to AT93909807T priority patent/ATE194003T1/de

1993-04-23 Priority to JP51884593A priority patent/JP3255416B2/ja

1993-04-23 Priority to AU40599/93A priority patent/AU669709B2/en

1993-04-23 Priority to KR1019940703815A priority patent/KR100267635B1/ko

1993-04-23 Priority to EP93909807A priority patent/EP0638073B1/en

1993-04-23 Priority to SK1293-94A priority patent/SK281613B6/sk

1993-04-23 Priority to HU9403098A priority patent/HUT71419A/hu

1993-04-23 Priority to RU94045948A priority patent/RU2114106C1/ru

1993-04-23 Priority to CA002134566A priority patent/CA2134566C/en

1993-04-23 Priority to NZ252098A priority patent/NZ252098A/en

1993-04-23 Priority to ES93909807T priority patent/ES2148227T3/es

1993-04-23 Priority to CZ942619A priority patent/CZ281676B6/cs

1993-04-23 Priority to DK93909807T priority patent/DK0638073T3/da

1993-04-23 Priority to DE69328901T priority patent/DE69328901T2/de

1993-04-23 Priority to HK98115090.0A priority patent/HK1013816B/en

1994-10-26 Priority to FI945042A priority patent/FI113862B/fi

1994-10-27 Priority to NO944090A priority patent/NO306946B1/no

1994-10-28 Priority to US08/331,213 priority patent/US5807855A/en

1995-06-29 Priority to HU95P/P00587P priority patent/HU211909A9/hu

2000-09-13 Priority to GR20000402086T priority patent/GR3034396T3/el

2003-10-10 Priority to CL200302050A priority patent/CL2003002050A1/es

Links

PWOUAMWQYHOLIB-UHFFFAOYSA-N 1-(2,3-dihydro-1h-inden-1-yl)piperazine Chemical class C1CC2=CC=CC=C2C1N1CCNCC1 PWOUAMWQYHOLIB-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
102000004076 Dopamine D1 Receptors Human genes 0.000 abstract 1
108090000511 Dopamine D1 Receptors Proteins 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
208000022925 sleep disturbance Diseases 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

DK92551A 1992-04-28 1992-04-28 1-piperazino-1,2-dihydroindenderivater DK55192D0 (da)

Priority Applications (26)

Application Number	Priority Date	Filing Date	Title
DK92551A DK55192D0 (da)	1992-04-28	1992-04-28	1-piperazino-1,2-dihydroindenderivater
IL105464A IL105464A (en)	1992-04-28	1993-04-20	Trans-(1-piperazin- 1-yl)-3-aryl-1, 2-dihydroindene compounds substituted in 3-position of the piperazine ring and pharmaceutical compositions containing them
ZA932840A ZA932840B (en)	1992-04-28	1993-04-22	1-piperazino-1,3-dihydroindene derivatives
HK98115090.0A HK1013816B (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives
RU94045948A RU2114106C1 (ru)	1992-04-28	1993-04-23	Производные транс-изомеров 1-пиперазин-1,2-дигидроиндена
NZ252098A NZ252098A (en)	1992-04-28	1993-04-23	1-aryl-3-piperazino indane derivatives and medicaments
AT93909807T ATE194003T1 (de)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindenderivate
JP51884593A JP3255416B2 (ja)	1992-04-28	1993-04-23	１‐ピペラジノ‐１，２‐ジヒドロインデン誘導体
AU40599/93A AU669709B2 (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives
KR1019940703815A KR100267635B1 (ko)	1992-04-28	1993-04-23	1-피페라지노-1, 2-디히드로인덴 유도체
EP93909807A EP0638073B1 (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives
SK1293-94A SK281613B6 (sk)	1992-04-28	1993-04-23	Trans-izoméry derivátov 1-piperazín-1,2-dihydroindénu, farmaceutický prípravok s ich obsahom a ich použitie
HU9403098A HUT71419A (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives and pharmaceutical compositions containing them
PCT/DK1993/000136 WO1993022293A1 (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives
CA002134566A CA2134566C (en)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindene derivatives
PT93909807T PT638073E (pt)	1992-04-28	1993-04-23	Derivados de 1-piperazino-1, 2-dihidroindeno
ES93909807T ES2148227T3 (es)	1992-04-28	1993-04-23	Derivados de 1-piperazino-1,2-dihidroindeno.
CZ942619A CZ281676B6 (cs)	1992-04-28	1993-04-23	1-piperazin-1,2-dihydroindenové deriváty, farmaceutické prostředky s jejich obsahem a použití uvedených látek pro výrobu farmaceutických prostředků
DK93909807T DK0638073T3 (da)	1992-04-28	1993-04-23	1-Piperazino-1,2-dihydroindenderivater
DE69328901T DE69328901T2 (de)	1992-04-28	1993-04-23	1-piperazino-1,2-dihydroindenderivate
FI945042A FI113862B (fi)	1992-04-28	1994-10-26	Menetelmä uusien terapeuttisesti käyttökelpoisten 1-piperatsino-1,2-dihydroindeenijohdannaisten valmistamiseksi
NO944090A NO306946B1 (no)	1992-04-28	1994-10-27	Trans-isomerer av 1-piperazino-1,2-dihydroindenforbindelser
US08/331,213 US5807855A (en)	1992-04-28	1994-10-28	1-piperazino-1,2-dihydroindene derivatives
HU95P/P00587P HU211909A9 (en)	1992-04-28	1995-06-29	1-piperazino-1,2-dihydroindene derivatives
GR20000402086T GR3034396T3 (en)	1992-04-28	2000-09-13	1-piperazino-1,2-dihydroindene derivatives.
CL200302050A CL2003002050A1 (es)	1992-04-28	2003-10-10	Compuestos derivados de 1-piperazin-1,2-dihidroindeno, su composicion farmaceutica y el uso de esta para tratar enfermedades del sistema nervioso central.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK92551A DK55192D0 (da)	1992-04-28	1992-04-28	1-piperazino-1,2-dihydroindenderivater

Publications (1)

Publication Number	Publication Date
DK55192D0 true DK55192D0 (da)	1992-04-28

Family

ID=8094828

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK92551A DK55192D0 (da)	1992-04-28	1992-04-28	1-piperazino-1,2-dihydroindenderivater
DK93909807T DK0638073T3 (da)	1992-04-28	1993-04-23	1-Piperazino-1,2-dihydroindenderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK93909807T DK0638073T3 (da)	1992-04-28	1993-04-23	1-Piperazino-1,2-dihydroindenderivater

Country Status (23)

Country	Link
US (1)	US5807855A (es)
EP (1)	EP0638073B1 (es)
JP (1)	JP3255416B2 (es)
KR (1)	KR100267635B1 (es)
AT (1)	ATE194003T1 (es)
AU (1)	AU669709B2 (es)
CA (1)	CA2134566C (es)
CL (1)	CL2003002050A1 (es)
CZ (1)	CZ281676B6 (es)
DE (1)	DE69328901T2 (es)
DK (2)	DK55192D0 (es)
ES (1)	ES2148227T3 (es)
FI (1)	FI113862B (es)
GR (1)	GR3034396T3 (es)
HU (2)	HUT71419A (es)
IL (1)	IL105464A (es)
NO (1)	NO306946B1 (es)
NZ (1)	NZ252098A (es)
PT (1)	PT638073E (es)
RU (1)	RU2114106C1 (es)
SK (1)	SK281613B6 (es)
WO (1)	WO1993022293A1 (es)
ZA (1)	ZA932840B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
DE10041478A1 (de)	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung
WO2002068409A1 (en) *	2001-02-23	2002-09-06	Merck & Co., Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
AU2002351747B2 (en)	2001-12-21	2008-06-05	H. Lundbeck A/S	Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors
IS7282A (is) *	2001-12-21	2004-05-21	H. Lundbeck A/S	Amínóindan afleiður sem serótónín og noradrenalínupptökuhindrar
PL199016B1 (pl) †	2002-06-20	2008-08-29	Adamed Sp Z Oo	Sposób wytwarzania olanzapiny
DE10334188B4 (de) *	2003-07-26	2007-07-05	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung von Depressionen
DE10334187A1 (de) *	2003-07-26	2005-03-03	Schwarz Pharma Ag	Substituierte 2-Aminotetraline zur Behandlung von Depressionen
PT1658277E (pt) *	2003-08-18	2012-05-25	Lundbeck & Co As H	Sal succinato e malonato de trans-4-((1r,3s)-6-cloro-3- fenilindan-1-il)-1,2,2-trimetilpiperazina e a sua utilização como medicamento
PL1658277T3 (pl) *	2003-08-18	2012-10-31	H Lundbeck As	Sól bursztynianowa i malonianowa trans-4-((1R,3S)-6-chloro-3-fenyloindan-1-ylo)-1,2,2-tri-metylopiperazyny i zastosowanie jako lek
DE10361258A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) *	2004-02-20	2005-09-08	Schwarz Pharma Ag	Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) *	2004-03-24	2006-07-06	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI453198B (zh)	2005-02-16	2014-09-21	Lundbeck & Co As H	製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
JP2008530039A (ja) *	2005-02-16	2008-08-07	ハー・ルンドベック・アクチエゼルスカベット	トランス−１−（（１ｒ，３ｓ）−６−クロロ−３−フェニルインダン−１−イル）−３，３−ジメチルピペラジンの酒石酸塩およびリンゴ酸塩
TWI376373B (en) *	2005-02-16	2012-11-11	Lundbeck & Co As H	Crystalline base of a pharmaceutical compound
TW200819426A (en)	2006-08-31	2008-05-01	Lundbeck & Co As H	Novel indane compounds
WO2009135495A1 (en) *	2008-05-07	2009-11-12	H. Lundbeck A/S	Method for treating cognitive deficits
BRPI0919165A2 (pt) *	2008-10-03	2015-12-08	Lundbeck & Co As H	composição farmacêutica,e, uso de um composto
TW201102370A (en)	2009-07-07	2011-01-16	Lundbeck & Co As H	Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine
JP5941410B2 (ja)	2010-11-09	2016-06-29	株式会社カネカ	ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
CA2823103A1 (en) *	2011-01-07	2012-07-12	H. Lundbeck A/S	Method for resolution of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl-piperazine
PL3135656T3 (pl)	2011-06-20	2019-07-31	H. Lundbeck A/S	Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
TWI552751B (zh)	2011-06-20	2016-10-11	Ｈ朗德貝克公司	投予４－（（１ｒ，３ｓ）－６－氯－３－苯基－二氫茚－１－基）－１，２，２－三甲基－哌及其鹽用於治療精神分裂症的方法
CN111868041A (zh) *	2018-04-06	2020-10-30	H.隆德贝克有限公司	用于制备2,2-二甲基哌嗪的方法
US20210395208A1 (en)	2018-10-29	2021-12-23	H. Lundeck A/S	Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts
EP3891134A1 (en)	2018-12-03	2021-10-13	H. Lundbeck A/S	Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

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US4038395A (en) *	1973-06-25	1977-07-26	Kefalas A/S	Compositions of and method of treating with the alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof and acid addition salts of these compounds
GB1469108A (en) *	1973-06-25	1977-03-30	Kefalas As	Thiaxanthene derivative
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IE55972B1 (en) *	1982-10-07	1991-03-13	Kefalas As	Phenylindene derivatives,acid addition salts thereof,and methods of preparation
HU198036B (en) *	1983-08-22	1989-07-28	Hoechst Roussel Pharma	Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
GB8427125D0 (en) *	1984-10-26	1984-12-05	Lundbeck & Co As H	Organic compounds
EP0202322B1 (en) *	1984-12-03	1991-05-08	Hughes Aircraft Company	Variable lens and birefringence compensator for continuous operation
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DE3521761A1 (de) *	1985-06-19	1987-01-02	Bayer Ag	Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8628644D0 (en) *	1986-12-01	1987-01-07	Lunbeck A S H	Intermediates
GB8704572D0 (en) *	1987-02-26	1987-04-01	Lundbeck & Co As H	Organic compounds
MX173362B (es) *	1987-03-02	1994-02-23	Pfizer	Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
EP0302423A3 (en) *	1987-08-07	1991-01-09	Hoechst-Roussel Pharmaceuticals Incorporated	1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
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GB8830312D0 (en) *	1988-12-28	1989-02-22	Lundbeck & Co As H	Heterocyclic compounds
AU658134B2 (en) *	1989-12-28	1995-04-06	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater
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US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives

1992
- 1992-04-28 DK DK92551A patent/DK55192D0/da not_active Application Discontinuation
1993
- 1993-04-20 IL IL105464A patent/IL105464A/en not_active IP Right Cessation
- 1993-04-22 ZA ZA932840A patent/ZA932840B/xx unknown
- 1993-04-23 WO PCT/DK1993/000136 patent/WO1993022293A1/en not_active Ceased
- 1993-04-23 AU AU40599/93A patent/AU669709B2/en not_active Expired
- 1993-04-23 KR KR1019940703815A patent/KR100267635B1/ko not_active Expired - Lifetime
- 1993-04-23 DK DK93909807T patent/DK0638073T3/da active
- 1993-04-23 JP JP51884593A patent/JP3255416B2/ja not_active Expired - Lifetime
- 1993-04-23 HU HU9403098A patent/HUT71419A/hu unknown
- 1993-04-23 PT PT93909807T patent/PT638073E/pt unknown
- 1993-04-23 CZ CZ942619A patent/CZ281676B6/cs not_active IP Right Cessation
- 1993-04-23 EP EP93909807A patent/EP0638073B1/en not_active Expired - Lifetime
- 1993-04-23 AT AT93909807T patent/ATE194003T1/de active
- 1993-04-23 SK SK1293-94A patent/SK281613B6/sk not_active IP Right Cessation
- 1993-04-23 NZ NZ252098A patent/NZ252098A/en not_active IP Right Cessation
- 1993-04-23 DE DE69328901T patent/DE69328901T2/de not_active Expired - Lifetime
- 1993-04-23 CA CA002134566A patent/CA2134566C/en not_active Expired - Lifetime
- 1993-04-23 ES ES93909807T patent/ES2148227T3/es not_active Expired - Lifetime
- 1993-04-23 RU RU94045948A patent/RU2114106C1/ru active
1994
- 1994-10-26 FI FI945042A patent/FI113862B/fi not_active IP Right Cessation
- 1994-10-27 NO NO944090A patent/NO306946B1/no not_active IP Right Cessation
- 1994-10-28 US US08/331,213 patent/US5807855A/en not_active Expired - Lifetime
1995
- 1995-06-29 HU HU95P/P00587P patent/HU211909A9/hu unknown
2000
- 2000-09-13 GR GR20000402086T patent/GR3034396T3/el unknown
2003
- 2003-10-10 CL CL200302050A patent/CL2003002050A1/es unknown

Also Published As

Publication number	Publication date
JPH07505895A (ja)	1995-06-29
HK1013816A1 (en)	1999-09-10
RU94045948A (ru)	1996-09-10
DE69328901D1 (de)	2000-07-27
WO1993022293A1 (en)	1993-11-11
FI945042A0 (fi)	1994-10-26
IL105464A (en)	1998-01-04
DE69328901T2 (de)	2001-01-11
EP0638073B1 (en)	2000-06-21
CZ281676B6 (cs)	1996-12-11
SK129394A3 (en)	1995-05-10
PT638073E (pt)	2000-11-30
IL105464A0 (en)	1993-08-18
CA2134566C (en)	2004-08-10
GR3034396T3 (en)	2000-12-29
FI945042A7 (fi)	1994-10-26
SK281613B6 (sk)	2001-05-10
CL2003002050A1 (es)	2005-01-07
KR950701323A (ko)	1995-03-23
RU2114106C1 (ru)	1998-06-27
AU669709B2 (en)	1996-06-20
AU4059993A (en)	1993-11-29
KR100267635B1 (ko)	2000-11-01
FI113862B (fi)	2004-06-30
CA2134566A1 (en)	1993-11-11
NO944090D0 (no)	1994-10-27
JP3255416B2 (ja)	2002-02-12
NO306946B1 (no)	2000-01-17
ATE194003T1 (de)	2000-07-15
NO944090L (no)	1994-12-20
EP0638073A1 (en)	1995-02-15
US5807855A (en)	1998-09-15
CZ261994A3 (en)	1995-05-17
NZ252098A (en)	1996-05-28
DK0638073T3 (da)	2000-11-06
HU9403098D0 (en)	1994-12-28
HU211909A9 (en)	1996-01-29
HUT71419A (en)	1995-11-28
ES2148227T3 (es)	2000-10-16
ZA932840B (en)	1993-11-23

Legal Events

Date	Code	Title	Description
1993-03-08	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DE69328901D1 (de)	2000-07-27	1-piperazino-1,2-dihydroindenderivate
BR9206500A (pt)	1995-10-03	Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P
AR016129A1 (es)	2001-06-20	Compuestos derivados de 5h-tiazolo[3,2-a]pirimidina; su uso, un procedimiento para prepararlos, medicamentos que los contienen y compuestos utiles comointermediarios
PT98168A (pt)	1992-05-29	Processo para a preparacao de novos derivados do indole e de composicoes farmaceuticas que os contem
NZ331874A (en)	2000-03-27	Arylamino fused pyridines and pyrimidines and their use in treating psychiatric and neurological diseases
AR004516A1 (es)	1998-12-16	Derivados de pirimidina, su uso, procedimientos para prepararlos y medicamentos que los contienen
PT99673A (pt)	1992-10-30	Processo para a preparacao de derivados de 1-piperazino-indano e de composicoes farmaceuticas que os contem
NO953543D0 (no)	1995-09-08	Heterosykliske forbindelser, deres anvendelse og fremstilling
ATE102626T1 (de)	1994-03-15	Heterocyclische verbindungen, ihre darstellung und verwendung.
ES2111326T3 (es)	1998-03-01	Derivados de imidazolona y oxazolona como antagonistas de dopamina.
DE69925160D1 (de)	2005-06-09	Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
BRPI0410613A (pt)	2006-06-20	preparação de quinoxalinas substituìdas a partir da dianlina com 2,3-diidróxi-1,4-dioxano
MX9703671A (es)	1997-12-31	Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina.
BR9506763A (pt)	1997-10-07	Derivados de carbamoil metil uréia
ES2188155T3 (es)	2003-06-16	N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.

DK55192D0 - 1-piperazino-1,2-dihydroindenderivater - Google Patents

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