DK557782A - Fremgangsmaade til fremstilling af 8-fluor-5-(p-fluorphenyl)-2-(4-(p-fluorphenyl)-4-hydroxybutyl)-2,3,4,5-tetrahydro-1h-pyrido(4,3-b)indol samt forbindelser, der er nyttige som mellemprodukter herved - Google Patents

Fremgangsmaade til fremstilling af 8-fluor-5-(p-fluorphenyl)-2-(4-(p-fluorphenyl)-4-hydroxybutyl)-2,3,4,5-tetrahydro-1h-pyrido(4,3-b)indol samt forbindelser, der er nyttige som mellemprodukter herved Download PDF

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Publication number
DK557782A
DK557782A DK557782A DK557782A DK557782A DK 557782 A DK557782 A DK 557782A DK 557782 A DK557782 A DK 557782A DK 557782 A DK557782 A DK 557782A DK 557782 A DK557782 A DK 557782A
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Prior art keywords
fluorphenyl
pyrido
indol
hydroxybutyl
tetrahydro
Prior art date
Application number
DK557782A
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English (en)
Inventor
Stephen Sargent Massett
Jr Harry Austin Watson
Jr Willard Mckowan Welch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/331,494 external-priority patent/US4510308A/en
Priority claimed from US06/425,152 external-priority patent/US4467090A/en
Priority claimed from US06/425,151 external-priority patent/US4477669A/en
Application filed by Pfizer filed Critical Pfizer
Publication of DK557782A publication Critical patent/DK557782A/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483Monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK557782A 1981-12-17 1982-12-16 Fremgangsmaade til fremstilling af 8-fluor-5-(p-fluorphenyl)-2-(4-(p-fluorphenyl)-4-hydroxybutyl)-2,3,4,5-tetrahydro-1h-pyrido(4,3-b)indol samt forbindelser, der er nyttige som mellemprodukter herved DK557782A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/331,494 US4510308A (en) 1981-12-17 1981-12-17 Process for preparing carboline derivatives
US33419581A 1981-12-24 1981-12-24
US06/425,152 US4467090A (en) 1982-09-30 1982-09-30 Compound, 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyryl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
US06/425,151 US4477669A (en) 1982-09-30 1982-09-30 Processes and intermediates useful in the preparation of flutroline

Publications (1)

Publication Number Publication Date
DK557782A true DK557782A (da) 1983-06-18

Family

ID=27502448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK557782A DK557782A (da) 1981-12-17 1982-12-16 Fremgangsmaade til fremstilling af 8-fluor-5-(p-fluorphenyl)-2-(4-(p-fluorphenyl)-4-hydroxybutyl)-2,3,4,5-tetrahydro-1h-pyrido(4,3-b)indol samt forbindelser, der er nyttige som mellemprodukter herved

Country Status (9)

Country Link
EP (1) EP0082658A3 (da)
AU (1) AU537294B2 (da)
DD (1) DD209630A5 (da)
DK (1) DK557782A (da)
ES (3) ES518277A0 (da)
FI (1) FI824331L (da)
IL (1) IL67485A0 (da)
NO (1) NO824230L (da)
PT (1) PT75991B (da)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
US4014890A (en) * 1976-03-23 1977-03-29 Pfizer Inc. Process for preparing indole derivatives
US4044137A (en) * 1976-07-07 1977-08-23 Pfizer Inc. 2-(Phenylthiopropyl)-5-aryl-1,2,3,4-tetrahydro-γ-carbolines
US4267331A (en) * 1979-01-23 1981-05-12 Pfizer Inc. Process for the production of 2-substituted pyrido[4,3-b]-indoles

Also Published As

Publication number Publication date
AU537294B2 (en) 1984-06-14
FI824331A7 (fi) 1983-06-18
EP0082658A3 (en) 1984-06-06
PT75991A (en) 1983-01-01
ES524776A0 (es) 1984-12-16
FI824331A0 (fi) 1982-12-16
FI824331L (fi) 1983-06-18
ES8402296A1 (es) 1984-01-16
DD209630A5 (de) 1984-05-16
ES8604732A1 (es) 1984-12-16
AU9159582A (en) 1983-08-04
ES524777A0 (es) 1984-12-16
ES8604733A1 (es) 1984-12-16
IL67485A0 (en) 1983-05-15
EP0082658A2 (en) 1983-06-29
ES518277A0 (es) 1984-01-16
NO824230L (no) 1983-06-20
PT75991B (en) 1985-12-20

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