DK558185A - Benzoxazol- og benzothiazolaminderivater - Google Patents

Benzoxazol- og benzothiazolaminderivater Download PDF

Info

Publication number: DK558185A
Authority: DK; Denmark
Prior art keywords: chem; compounds; formula; benzoxazole; cycloalkyl
Prior art date: 1984-12-03

Application number

DK558185A

Other languages

English (en)

Other versions

DK558185D0 (da

DK165370B (da

DK165370C (da

Inventor

Raymond Antoine Stokbroekx

Marcel Gerebernus Maria Luyckx

Frans Eduard Janssens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-03

Filing date

1985-12-02

Publication date

1986-06-04

1985-12-02 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1985-12-02 Publication of DK558185D0 publication Critical patent/DK558185D0/da

1986-06-04 Publication of DK558185A publication Critical patent/DK558185A/da

1992-11-16 Publication of DK165370B publication Critical patent/DK165370B/da

1993-04-05 Application granted granted Critical

1993-04-05 Publication of DK165370C publication Critical patent/DK165370C/da

Links

BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
UHGULLIUJBCTEF-UHFFFAOYSA-N 2-aminobenzothiazole Chemical class C1=CC=C2SC(N)=NC2=C1 UHGULLIUJBCTEF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
SPLBDRVSAMREPT-UHFFFAOYSA-N 1,3-benzothiazol-2-amine;1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1.C1=CC=C2SC(N)=NC2=C1 SPLBDRVSAMREPT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000000496 anti-anoxic effect Effects 0.000 abstract 1
230000000141 anti-hypoxic effect Effects 0.000 abstract 1
-1 aryl C2-6 alkenyl Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Paints Or Removers (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

DK558185A 1984-12-03 1985-12-02 Benzoxazol-, benzothiazol- og thiazolopyridinaminderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse DK165370C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67741284A	1984-12-03	1984-12-03
US67741284		1984-12-03

Publications (4)

Publication Number	Publication Date
DK558185D0 DK558185D0 (da)	1985-12-02
DK558185A true DK558185A (da)	1986-06-04
DK165370B DK165370B (da)	1992-11-16
DK165370C DK165370C (da)	1993-04-05

Family

ID=24718604

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK558185A DK165370C (da)	1984-12-03	1985-12-02	Benzoxazol-, benzothiazol- og thiazolopyridinaminderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse

Country Status (27)

Country	Link
EP (1)	EP0184257B1 (da)
JP (1)	JPH0759578B2 (da)
KR (1)	KR870001512B1 (da)
CN (1)	CN1014790B (da)
AT (1)	ATE54916T1 (da)
AU (1)	AU582601B2 (da)
BG (1)	BG60431B2 (da)
CA (1)	CA1260474A (da)
CY (1)	CY1690A (da)
DE (1)	DE3578885D1 (da)
DK (1)	DK165370C (da)
DZ (1)	DZ863A1 (da)
ES (1)	ES8606306A1 (da)
FI (1)	FI82046C (da)
GR (1)	GR852830B (da)
HK (1)	HK49593A (da)
HU (1)	HU196068B (da)
IE (1)	IE58807B1 (da)
IL (1)	IL77197A (da)
MA (1)	MA20582A1 (da)
NO (1)	NO160076C (da)
NZ (1)	NZ214320A (da)
PH (1)	PH26458A (da)
PT (1)	PT81586B (da)
SU (1)	SU1428203A3 (da)
ZA (1)	ZA859224B (da)
ZW (1)	ZW21685A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8333514D0 (en) *	1983-12-16	1984-01-25	Erba Farmitalia	Tetrahydrothiazolo(5 4-c)pyridine derivatives
KR930005004B1 (ko) *	1985-04-15	1993-06-11	쟈안센 파아마슈우티카 엔. 부이.	치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
IE63474B1 (en) *	1987-12-24	1995-04-19	Wyeth John & Brother Ltd	Heterocyclic compounds
GB2225574B (en) *	1987-12-24	1991-04-24	Wyeth John & Brother Ltd	Heterocyclic compounds
JPH0393762A (ja) *	1989-09-04	1991-04-18	Wako Pure Chem Ind Ltd	４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法
MX9100517A (es) *	1990-08-06	1992-04-01	Smith Kline French Lab	Compuestos
ZW1992A1 (en) *	1991-02-25	1993-09-22	Janssen Pharmaceutica Nv	4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (da) *	1993-06-11	1996-08-01	Janssen Pharmaceutica Nv
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
FR2725989B1 (fr) *	1994-10-20	1997-01-10	Pf Medicament	Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
US5744484A (en) *	1994-11-24	1998-04-28	Janssen Pharmaceutica, N.V.	Lubeluzole intravenous solutions
FR2737207B1 (fr) *	1995-07-26	1997-10-17	Pf Medicament	Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique
AU7298296A (en) *	1995-10-25	1997-05-15	Janssen Pharmaceutica N.V.	Lubeluzole n-oxide
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5998439A (en) *	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
FR2753970B1 (fr) *	1996-10-01	1998-10-30	Synthelabo	Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
WO2006067532A1 (en)	2004-12-24	2006-06-29	Prosidion Ltd	G-protein coupled receptor agonists
BRPI0608245A2 (pt) *	2005-03-09	2009-12-01	Hoffmann La Roche	compostos; processo para a sua fabricação; composições farmacêuticas; método para o tratamento e/ou prevenção de doenças que estejam associadas à modulação de receptores de sst subtipo 5 e uso dos compostos
ES2359431T3 (es) *	2005-09-02	2011-05-23	F. Hoffmann-La Roche Ag	Derivados de benzooxazol, oxazolopiridina, benzotiazol y tiazolopiridina.
ES2453590T3 (es)	2007-04-27	2014-04-08	Daiichi Sankyo Company, Limited	Derivado de anillo aromático nitrogenado de 6 miembros y agente farmacéutico que comprende el mismo
FR3001151B1 (fr)	2013-01-21	2016-04-08	Pf Medicament	Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
CN107573301B (zh) *	2017-11-08	2020-08-11	江苏长青农化股份有限公司	一种三环唑中间体的制备方法
CN114349745B (zh) *	2022-01-14	2023-12-08	黑龙江中医药大学	一种用于治疗心肌缺血的药物及其制备方法
CN117229228B (zh) *	2023-09-15	2025-09-12	中国人民解放军军事科学院防化研究院	一种2-硫代苯并噻唑类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE831249C (de) *	1948-02-09	1952-02-11	Ciba A G	Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline
GB1234058A (da) *	1968-10-21	1971-06-03
DE2545645C2 (de) *	1975-10-11	1983-04-14	Bayer Ag, 5090 Leverkusen	Thiazolinylamino-piperidin-Derivate
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
DE3484096D1 (de) *	1983-11-30	1991-03-14	Janssen Pharmaceutica Nv	Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines

1985
- 1985-10-30 CA CA000494185A patent/CA1260474A/en not_active Expired
- 1985-11-01 KR KR1019850008142A patent/KR870001512B1/ko not_active Expired
- 1985-11-12 SU SU853982357A patent/SU1428203A3/ru active
- 1985-11-22 DE DE8585201937T patent/DE3578885D1/de not_active Expired - Fee Related
- 1985-11-22 EP EP85201937A patent/EP0184257B1/en not_active Expired - Lifetime
- 1985-11-22 AT AT85201937T patent/ATE54916T1/de not_active IP Right Cessation
- 1985-11-25 NZ NZ214320A patent/NZ214320A/en unknown
- 1985-11-25 GR GR852830A patent/GR852830B/el unknown
- 1985-12-01 DZ DZ850258A patent/DZ863A1/fr active
- 1985-12-02 PT PT81586A patent/PT81586B/pt not_active IP Right Cessation
- 1985-12-02 ZA ZA859224A patent/ZA859224B/xx unknown
- 1985-12-02 MA MA20807A patent/MA20582A1/fr unknown
- 1985-12-02 HU HU854596A patent/HU196068B/hu not_active IP Right Cessation
- 1985-12-02 NO NO854837A patent/NO160076C/no unknown
- 1985-12-02 DK DK558185A patent/DK165370C/da not_active IP Right Cessation
- 1985-12-02 AU AU50574/85A patent/AU582601B2/en not_active Ceased
- 1985-12-02 IE IE302385A patent/IE58807B1/en not_active IP Right Cessation
- 1985-12-02 IL IL77197A patent/IL77197A/xx not_active IP Right Cessation
- 1985-12-02 ZW ZW216/85A patent/ZW21685A1/xx unknown
- 1985-12-02 CN CN85108556A patent/CN1014790B/zh not_active Expired
- 1985-12-02 FI FI854768A patent/FI82046C/fi not_active IP Right Cessation
- 1985-12-03 ES ES549542A patent/ES8606306A1/es not_active Expired
- 1985-12-03 JP JP60270848A patent/JPH0759578B2/ja not_active Expired - Fee Related
- 1985-12-03 PH PH33124A patent/PH26458A/en unknown
1993
- 1993-05-20 HK HK495/93A patent/HK49593A/en not_active IP Right Cessation
- 1993-06-16 BG BG097875A patent/BG60431B2/bg unknown
1994
- 1994-01-14 CY CY169094A patent/CY1690A/xx unknown

Also Published As

Publication number	Publication date
HUT40668A (en)	1987-01-28
ES549542A0 (es)	1986-04-16
FI854768A7 (fi)	1986-06-04
FI82046B (fi)	1990-09-28
HK49593A (en)	1993-05-27
IE853023L (en)	1986-06-03
MA20582A1 (fr)	1986-07-01
ZW21685A1 (en)	1987-06-17
SU1428203A3 (ru)	1988-09-30
JPS61137884A (ja)	1986-06-25
FI854768A0 (fi)	1985-12-02
PT81586B (pt)	1988-01-22
IE58807B1 (en)	1993-11-17
ES8606306A1 (es)	1986-04-16
BG60431B2 (bg)	1995-03-31
CN1014790B (zh)	1991-11-20
PT81586A (en)	1986-01-01
NO160076B (no)	1988-11-28
KR870001512B1 (ko)	1987-08-20
AU582601B2 (en)	1989-04-06
DE3578885D1 (de)	1990-08-30
DZ863A1 (fr)	2004-09-13
AU5057485A (en)	1986-07-17
IL77197A (en)	1991-07-18
ZA859224B (en)	1987-07-29
GR852830B (da)	1986-03-27
DK558185D0 (da)	1985-12-02
EP0184257B1 (en)	1990-07-25
FI82046C (fi)	1991-01-10
NO854837L (no)	1986-06-04
NO160076C (no)	1989-03-08
DK165370B (da)	1992-11-16
EP0184257A1 (en)	1986-06-11
DK165370C (da)	1993-04-05
JPH0759578B2 (ja)	1995-06-28
PH26458A (en)	1992-07-27
KR860004894A (ko)	1986-07-14
CY1690A (en)	1994-01-14
ATE54916T1 (de)	1990-08-15
CN85108556A (zh)	1986-07-30
CA1260474A (en)	1989-09-26
HU196068B (en)	1988-09-28
NZ214320A (en)	1988-03-30

Legal Events

Date	Code	Title	Description
2005-08-22	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK558185A (da)	1986-06-04	Benzoxazol- og benzothiazolaminderivater
NO865235D0 (no)	1986-12-22	Nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl metyl)-1h-imidazoler-og-1h-1,2,4-triazoler.
NO884208L (no)	1989-03-28	Substituerte n-(1-alkyl-3-hydroksy-4-piperidinyl) benzamider.
DK169486D0 (da)	1986-04-14	Substituerede n-((4-piperidinyl)alkyl)-bicyklisk kondenseret oxazol- og thiazolaminer
ATE122348T1 (de)	1995-05-15	Antipsychotische 3-piperazinylbenzazolderivate.
DE3585990D1 (de)	1992-06-11	Derivate von hydroxy- oder amino-substituierten piperidinylalkylchinazolinen.
ATE124410T1 (de)	1995-07-15	Antihypertensive 3-piperidinylindazol-derivate.