DK570089A - 2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-cytidin-, -uridin- og -guanosin-derivater, deres fremstilling og anvendelse - Google Patents

2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-cytidin-, -uridin- og -guanosin-derivater, deres fremstilling og anvendelse

Info

Publication number: DK570089A
Authority: DK; Denmark
Prior art keywords: halogenmethylidene; ethenylidene; cytidine; uridine; ethynyl
Prior art date: 1988-11-15

Application number

DK570089A

Other languages

English (en)

Other versions

DK171844B1 (da

DK570089D0 (da

Inventor

James Ray Mccarthy

Michael Louis Edwards

Donald Paul Matthews

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-15

Filing date

1989-11-14

Publication date

1990-05-16

1989-11-14 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-11-14 Publication of DK570089D0 publication Critical patent/DK570089D0/da

1990-05-16 Publication of DK570089A publication Critical patent/DK570089A/da

1997-06-30 Application granted granted Critical

1997-06-30 Publication of DK171844B1 publication Critical patent/DK171844B1/da

Links

KPLKOOBPQQYUTM-PNHWDRBUSA-N 1-[(2r,3r,4r,5r)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Chemical compound C#C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 KPLKOOBPQQYUTM-PNHWDRBUSA-N 0.000 title 1
LMPQMWCSENOFHW-PNHWDRBUSA-N 4-amino-1-[(2r,3r,4r,5r)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@](C#C)(O)[C@H](O)[C@@H](CO)O1 LMPQMWCSENOFHW-PNHWDRBUSA-N 0.000 title 1
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical class C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

DK570089A 1988-11-15 1989-11-14 2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid DK171844B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27147988A	1988-11-15	1988-11-15
US27147988		1988-11-15

Publications (3)

Publication Number	Publication Date
DK570089D0 DK570089D0 (da)	1989-11-14
DK570089A true DK570089A (da)	1990-05-16
DK171844B1 DK171844B1 (da)	1997-06-30

Family

ID=23035764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK570089A DK171844B1 (da)	1988-11-15	1989-11-14	2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid

Country Status (19)

Country	Link
EP (1)	EP0372268B1 (da)
JP (1)	JP2802947B2 (da)
KR (1)	KR0144865B1 (da)
CN (1)	CN1022248C (da)
AR (1)	AR247891A1 (da)
AT (1)	ATE105297T1 (da)
AU (1)	AU621160B2 (da)
CA (1)	CA2002648C (da)
DE (1)	DE68915128T2 (da)
DK (1)	DK171844B1 (da)
ES (1)	ES2056180T3 (da)
FI (1)	FI92588C (da)
HU (3)	HU205134B (da)
IE (1)	IE63563B1 (da)
IL (1)	IL92293A (da)
NO (1)	NO172240C (da)
NZ (1)	NZ231365A (da)
PT (1)	PT92309B (da)
ZA (1)	ZA898567B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
IE902574A1 (en) *	1989-07-17	1991-02-27	Univ Birmingham	Antiviral pyrimidine nucleosides
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (fr) *	1992-04-23	1993-11-11	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de 2'-methylidenenucleoside et utilisation pharmaceutique de ce compose
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
EP0640092B1 (en) *	1992-05-12	1996-12-11	Merrell Pharmaceuticals Inc.	A process for the preparation of ribonucleotide reductase inhibitors
CA2150671C (en) *	1992-12-03	2000-12-26	Sai P. Sunkara	Compositions containing acyclovir-like compounds and 2'-vinyl substituted nucleoside analogs for the treatment of viral infections
ATE186732T1 (de) *	1994-01-07	1999-12-15	Merrell Pharma Inc	(e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
US5627053A (en) *	1994-03-29	1997-05-06	Ribozyme Pharmaceuticals, Inc.	2'deoxy-2'-alkylnucleotide containing nucleic acid
WO1996001638A1 (en) *	1994-07-11	1996-01-25	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
EP0770621A4 (en) *	1994-07-12	1998-01-28	Yamasa Corp	2'-DEOXY-2 '(SUBSTITUTED OR Unsubstituted METHYLIDENE) -4-THIONUCLEOSIDE
EP1438054A4 (en) *	2001-09-28	2006-07-26	Idenix Cayman Ltd	METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
WO2003068162A2 (en) *	2002-02-14	2003-08-21	Pharmasset Ltd.	Modified fluorinated nucleoside analogues
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) *	2004-10-27	2008-05-21	北京东华康明生物科技有限公司	（反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
WO2014078463A1 (en) *	2012-11-19	2014-05-22	Merck Sharp & Dohme Corp.	2 -alkynyl substituted nucleoside derivatives for treating viral diseases
WO2018092107A1 (en) *	2016-11-21	2018-05-24	Munisekhar Medasani	Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof

1989
- 1989-11-09 CA CA002002648A patent/CA2002648C/en not_active Expired - Lifetime
- 1989-11-09 ZA ZA898567A patent/ZA898567B/xx unknown
- 1989-11-10 AU AU44611/89A patent/AU621160B2/en not_active Ceased
- 1989-11-10 AR AR89315416A patent/AR247891A1/es active
- 1989-11-13 NZ NZ231365A patent/NZ231365A/en unknown
- 1989-11-13 IL IL9229389A patent/IL92293A/en not_active IP Right Cessation
- 1989-11-14 FI FI895417A patent/FI92588C/fi not_active IP Right Cessation
- 1989-11-14 KR KR1019890016636A patent/KR0144865B1/ko not_active Expired - Fee Related
- 1989-11-14 HU HU895900A patent/HU205134B/hu not_active IP Right Cessation
- 1989-11-14 IE IE365189A patent/IE63563B1/en not_active IP Right Cessation
- 1989-11-14 NO NO894539A patent/NO172240C/no not_active IP Right Cessation
- 1989-11-14 DK DK570089A patent/DK171844B1/da not_active IP Right Cessation
- 1989-11-14 PT PT92309A patent/PT92309B/pt not_active IP Right Cessation
- 1989-11-15 EP EP89121139A patent/EP0372268B1/en not_active Expired - Lifetime
- 1989-11-15 CN CN89108557A patent/CN1022248C/zh not_active Expired - Fee Related
- 1989-11-15 JP JP1297225A patent/JP2802947B2/ja not_active Expired - Fee Related
- 1989-11-15 AT AT8989121139T patent/ATE105297T1/de not_active IP Right Cessation
- 1989-11-15 ES ES89121139T patent/ES2056180T3/es not_active Expired - Lifetime
- 1989-11-15 DE DE68915128T patent/DE68915128T2/de not_active Expired - Fee Related
1994
- 1994-11-14 HU HU94P/P00045P patent/HU210343A9/hu unknown
- 1994-11-14 HU HU94P/P00045P patent/HU00045A9/hu unknown

Also Published As

Publication number	Publication date
AU4461189A (en)	1990-05-24
JPH02178272A (ja)	1990-07-11
IL92293A0 (en)	1990-07-26
NO172240C (no)	1993-06-23
HU00045A9 (en)	1995-01-30
KR0144865B1 (ko)	1998-07-01
KR900007833A (ko)	1990-06-02
HUT51642A (en)	1990-05-28
DK171844B1 (da)	1997-06-30
CN1022248C (zh)	1993-09-29
HU210343A9 (en)	1995-03-28
PT92309A (pt)	1990-05-31
IL92293A (en)	1995-01-24
DE68915128D1 (de)	1994-06-09
NO172240B (no)	1993-03-15
NO894539D0 (no)	1989-11-14
AR247891A1 (es)	1995-04-28
NZ231365A (en)	1992-08-26
DK570089D0 (da)	1989-11-14
HU895900D0 (en)	1990-02-28
CA2002648A1 (en)	1990-05-15
IE893651L (en)	1990-05-15
FI895417A0 (fi)	1989-11-14
NO894539L (no)	1990-05-16
CN1042715A (zh)	1990-06-06
EP0372268B1 (en)	1994-05-04
ZA898567B (en)	1990-08-29
JP2802947B2 (ja)	1998-09-24
AU621160B2 (en)	1992-03-05
FI92588C (fi)	1994-12-12
EP0372268A1 (en)	1990-06-13
DE68915128T2 (de)	1994-08-25
PT92309B (pt)	1996-06-28
ATE105297T1 (de)	1994-05-15
IE63563B1 (en)	1995-05-17
FI92588B (fi)	1994-08-31
ES2056180T3 (es)	1994-10-01
HU205134B (en)	1992-03-30
CA2002648C (en)	2000-02-29

Legal Events

Date	Code	Title	Description
1997-06-30	B1	Patent granted (law 1993)
2009-07-06	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK11992A (da)	1992-01-31	Epipodophyllotoxinglycosid-4'-phosphatderivater, deres fremstilling og anvendelse
DK374389A (da)	1990-01-30	Arylbenzenoxazolidinoner, deres fremstilling og anvendelse
DK609489A (da)	1990-06-06	Imidazolderivater, deres fremstilling og anvendelse
DK570089D0 (da)	1989-11-14	2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-cytidin-, -uridin- og -guanosin-derivater, deres fremstilling og anvendelse
DK595388A (da)	1989-04-28	Benzopyranderivater, deres fremstilling og anvendelse
DK388989D0 (da)	1989-08-08	Acylcyanoguanidiner, deres fremstilling og anvendelse
DK473289D0 (da)	1989-09-26	2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-adenosin-derivater, deres fremstilling og anvendelse
DK435289A (da)	1990-03-04	Piperazindioner, deres fremstilling og anvendelse
DK193088D0 (da)	1988-04-08	2-acylpyrrolidin-derivater, deres fremstilling og anvendelse
DK191988A (da)	1988-10-12	Pyrrolidin-2-(1,3-dicarbonyl)-derivater, deres fresmtilling og anvendelse
DK278188D0 (da)	1988-05-20	Thiazolidin-4-on-derivater, deres fremstilling og anvendelse
DK225089D0 (da)	1989-05-08	2-adamantyl-4-isothiazolin-3-oner, deres fremstilling og anvendelse
DK8589A (da)	1989-07-12	Pyrazol- og indazolpyridinaminer, deres fremstilling og anvendelse
DK469389A (da)	1990-03-24	Piperidinyl-imidazol-derivater, deres fremstilling og anvendelse
DK189488D0 (da)	1988-04-07	Imidazothiadiazinderivater, deres fremstilling og anvendelse
DK223288A (da)	1988-10-25	Benzensulfornamid-derivater, deres fremstilling og anvendelse
DK592389D0 (da)	1989-11-24	Penemderivater, deres fremstilling og anvendelse
DK412188A (da)	1989-01-24	Benzothiazinon-derivater, deres fremstilling og anvendelse
DK231988A (da)	1988-11-03	2-aminoalkyl-4-benzyl-1-(2h)-phthalazinon-derivater, deres fremstilling og anvendelse
DK79589D0 (da)	1989-02-21	5-amino-8-phenyl-3h,6h-1,4,5a,8a-tetraazaacenaphthylen-3-oner, deres fremstilling og anvendelse
DK361388A (da)	1989-01-02	Cephemderivater, deres fremstilling og anvendelse
DK613888A (da)	1989-05-05	Acyllabdan-derivater, deres fremstilling og anvendelse
DK455189D0 (da)	1989-09-15	2,3,4,5-tetrahydro-1-benzoxepiner, deres fremstilling og anvendelse
DK668888A (da)	1989-06-02	Labdan-derivater, deres fremstilling og anvendelse
DK668788A (da)	1989-06-02	Labdanderivater, deres fremstilling og anvendelse