NO894539L - Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater. - Google Patents

Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater.

Info

Publication number: NO894539L
Authority: NO; Norway
Prior art keywords: uriden; halomethylidene; guanosin; ethynylcytidine; ethenylidene
Prior art date: 1988-11-15

Application number

NO89894539A

Other languages

English (en)

Other versions

NO894539D0 (no

NO172240B (no

NO172240C (no

Inventor

James Ray Mccarthy

Michael Louis Edwards

Donald Paul Matthews

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-15

Filing date

1989-11-14

Publication date

1990-05-16

1989-11-14 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-11-14 Publication of NO894539D0 publication Critical patent/NO894539D0/no

1990-05-16 Publication of NO894539L publication Critical patent/NO894539L/no

1993-03-15 Publication of NO172240B publication Critical patent/NO172240B/no

1993-06-23 Publication of NO172240C publication Critical patent/NO172240C/no

Links

LMPQMWCSENOFHW-PNHWDRBUSA-N 4-amino-1-[(2r,3r,4r,5r)-3-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@](C#C)(O)[C@H](O)[C@@H](CO)O1 LMPQMWCSENOFHW-PNHWDRBUSA-N 0.000 title 1
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical class C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

NO894539A 1988-11-15 1989-11-14 Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater NO172240C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US27147988A	1988-11-15	1988-11-15

Publications (4)

Publication Number	Publication Date
NO894539D0 NO894539D0 (no)	1989-11-14
NO894539L true NO894539L (no)	1990-05-16
NO172240B NO172240B (no)	1993-03-15
NO172240C NO172240C (no)	1993-06-23

Family

ID=23035764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894539A NO172240C (no)	1988-11-15	1989-11-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive nye 2'-halometylidenderivater

Country Status (19)

Country	Link
EP (1)	EP0372268B1 (no)
JP (1)	JP2802947B2 (no)
KR (1)	KR0144865B1 (no)
CN (1)	CN1022248C (no)
AR (1)	AR247891A1 (no)
AT (1)	ATE105297T1 (no)
AU (1)	AU621160B2 (no)
CA (1)	CA2002648C (no)
DE (1)	DE68915128T2 (no)
DK (1)	DK171844B1 (no)
ES (1)	ES2056180T3 (no)
FI (1)	FI92588C (no)
HU (3)	HU205134B (no)
IE (1)	IE63563B1 (no)
IL (1)	IL92293A (no)
NO (1)	NO172240C (no)
NZ (1)	NZ231365A (no)
PT (1)	PT92309B (no)
ZA (1)	ZA898567B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
IE902574A1 (en) *	1989-07-17	1991-02-27	Univ Birmingham	Antiviral pyrimidine nucleosides
US5521163A (en) *	1990-07-13	1996-05-28	University Of Birmingham	Antiviral pyrimidine nucleosides and methods for using same
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993022327A1 (fr) *	1992-04-23	1993-11-11	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de 2'-methylidenenucleoside et utilisation pharmaceutique de ce compose
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
DK0640092T3 (da) *	1992-05-12	1996-12-30	Merrell Pharma Inc	Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer
ES2105599T3 (es) *	1992-12-03	1997-10-16	Merrell Pharma Inc	Composiciones que contienen compuestos analogos al aciclovir y analogos nucleosidicos sustituidos por vinilo en la posicion 2' utilizados en el tratamiento de infecciones virales.
WO1995018815A1 (en) *	1994-01-07	1995-07-13	Merrell Pharmaceuticals Inc.	Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
US5627053A (en) *	1994-03-29	1997-05-06	Ribozyme Pharmaceuticals, Inc.	2'deoxy-2'-alkylnucleotide containing nucleic acid
AU2768295A (en) *	1994-07-11	1996-02-09	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO1996001834A1 (en) *	1994-07-12	1996-01-25	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
WO2003026675A1 (en) *	2001-09-28	2003-04-03	Idenix (Cayman) Limited	Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
EP1480982A4 (en) *	2002-02-14	2007-08-01	Pharmasset Inc	MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
CN100389119C (zh) *	2004-10-27	2008-05-21	北京东华康明生物科技有限公司	（反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
KR102072041B1 (ko)	2011-12-22	2020-01-31	앨리오스 바이오파마 인크.	치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
JP2016501200A (ja) *	2012-11-19	2016-01-18	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	ウイルス性疾患を処置するための２−アルキニル置換ヌクレオシド誘導体
WO2018092107A1 (en) *	2016-11-21	2018-05-24	Munisekhar Medasani	Novel anti-viral and anti-cancer molecule

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof

1989
- 1989-11-09 CA CA002002648A patent/CA2002648C/en not_active Expired - Lifetime
- 1989-11-09 ZA ZA898567A patent/ZA898567B/xx unknown
- 1989-11-10 AU AU44611/89A patent/AU621160B2/en not_active Ceased
- 1989-11-10 AR AR89315416A patent/AR247891A1/es active
- 1989-11-13 IL IL9229389A patent/IL92293A/en not_active IP Right Cessation
- 1989-11-13 NZ NZ231365A patent/NZ231365A/en unknown
- 1989-11-14 PT PT92309A patent/PT92309B/pt not_active IP Right Cessation
- 1989-11-14 IE IE365189A patent/IE63563B1/en not_active IP Right Cessation
- 1989-11-14 DK DK570089A patent/DK171844B1/da not_active IP Right Cessation
- 1989-11-14 FI FI895417A patent/FI92588C/fi not_active IP Right Cessation
- 1989-11-14 NO NO894539A patent/NO172240C/no not_active IP Right Cessation
- 1989-11-14 KR KR1019890016636A patent/KR0144865B1/ko not_active Expired - Fee Related
- 1989-11-14 HU HU895900A patent/HU205134B/hu not_active IP Right Cessation
- 1989-11-15 JP JP1297225A patent/JP2802947B2/ja not_active Expired - Fee Related
- 1989-11-15 CN CN89108557A patent/CN1022248C/zh not_active Expired - Fee Related
- 1989-11-15 DE DE68915128T patent/DE68915128T2/de not_active Expired - Fee Related
- 1989-11-15 ES ES89121139T patent/ES2056180T3/es not_active Expired - Lifetime
- 1989-11-15 EP EP89121139A patent/EP0372268B1/en not_active Expired - Lifetime
- 1989-11-15 AT AT8989121139T patent/ATE105297T1/de not_active IP Right Cessation
1994
- 1994-11-14 HU HU94P/P00045P patent/HU00045A9/hu unknown
- 1994-11-14 HU HU94P/P00045P patent/HU210343A9/hu unknown

Also Published As

Publication number	Publication date
HU895900D0 (en)	1990-02-28
NO894539D0 (no)	1989-11-14
DK570089D0 (da)	1989-11-14
KR900007833A (ko)	1990-06-02
HU205134B (en)	1992-03-30
KR0144865B1 (ko)	1998-07-01
AU621160B2 (en)	1992-03-05
CA2002648A1 (en)	1990-05-15
NZ231365A (en)	1992-08-26
EP0372268B1 (en)	1994-05-04
FI895417A0 (fi)	1989-11-14
IE893651L (en)	1990-05-15
PT92309A (pt)	1990-05-31
IE63563B1 (en)	1995-05-17
AR247891A1 (es)	1995-04-28
IL92293A0 (en)	1990-07-26
CN1022248C (zh)	1993-09-29
NO172240B (no)	1993-03-15
HU210343A9 (en)	1995-03-28
DE68915128D1 (de)	1994-06-09
FI92588B (fi)	1994-08-31
JP2802947B2 (ja)	1998-09-24
ZA898567B (en)	1990-08-29
HUT51642A (en)	1990-05-28
HU00045A9 (en)	1995-01-30
PT92309B (pt)	1996-06-28
AU4461189A (en)	1990-05-24
NO172240C (no)	1993-06-23
FI92588C (fi)	1994-12-12
EP0372268A1 (en)	1990-06-13
IL92293A (en)	1995-01-24
DK570089A (da)	1990-05-16
ATE105297T1 (de)	1994-05-15
CN1042715A (zh)	1990-06-06
DE68915128T2 (de)	1994-08-25
CA2002648C (en)	2000-02-29
ES2056180T3 (es)	1994-10-01
JPH02178272A (ja)	1990-07-11
DK171844B1 (da)	1997-06-30

Legal Events

Date	Code	Title	Description
2009-11-23	MK1K	Patent expired

Publication	Publication Date	Title
NO892083L (no)	1989-11-27	Fremgangsmaate for fremstilling av arylmetylenyl-derivaterav tiazolidinoner, imidazolidinoner og oksazolidinoner.
NO894539D0 (no)	1989-11-14	Fremgangsmaate for fremstilling av nye 2'-halomethyliden-,2'-ethenyliden- og 2'-ethynylcytidin-, uriden og guanosinderivater.
NO891951D0 (no)	1989-05-16	Fremgangsmaate for fremstilling av nye hydroksamat-derivater.
NO892936L (no)	1990-01-19	Fremgangsmaate for fremstilling av furanderivater.
MX9203459A (es)	1992-08-01	Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
NO893826D0 (no)	1989-09-26	Fremgangsmaate for fremstilling av 2'-halomethyliden, 2'-ethenyliden og 2'-ethenyladenosinderivater.
NO901813D0 (no)	1990-04-24	Fremgangsmaate for fremstilling av nye tieno-triazolo-diazepin-derivater.
NO900643L (no)	1990-08-13	Fremgangsmaate for fremstilling og anvendelse av 2,3,23-trihydroksi-urs-12-ener og deres derivater.
NO891588L (no)	1989-10-20	Fremgangsmaate for fremstilling av fosfonoalkylpurinderivater.
NO903347D0 (no)	1990-07-27	Fremgangsmaate for fremstilling av 14,17alfa-ethano- og ethanooestratriener.
NO892977L (no)	1990-01-22	Fremgangsmaate for fremstilling av nye s-adenosylmethionin-derivater.
NO891985D0 (no)	1989-05-18	Fremgangsmaate for fremstilling av dibenzotiofen- og tioxanten-derivater.
NO921086L (no)	1992-10-06	Fremgangsmaate for fremstilling og anvendelse av substituerte 2',3'-didesoksy-5-trifluormetyluridiner
NO891025L (no)	1989-09-11	Fremgangsmaate for fremstilling av nye, terapeutisk aktivesialosylglycerider.
NO894516D0 (no)	1989-11-13	Fremgangsmaate for fremstilling av 1-aminoalkyl-3-oksosubstituert-4-aryl-1,3,4,5-tetrahydro-2h-1,3-benzodiazepin-2-on, og deres anvendelse som medikamenter.
NO904108L (no)	1990-09-20	Fremstilling av 2,6-dioksypiperidinderivater.
NO901732L (no)	1990-10-22	Fremgangsmaate for fremstilling av 4-alkoksyalkyl-4-aminofenylpiperidiner og derivater derav.
NO894037L (no)	1990-04-17	Fremgangsmaate for fremstilling av nye 2-metoksykarbonyl-substituerte n,n'-di(trimetoksybenzoyl) piperaziner.
NO894707L (no)	1990-05-28	Fremgangsmaate for fremstilling av benzoksazinderivater.
NO891987D0 (no)	1989-05-18	Fremgangsmaate for fremstilling av n-substituerte fenyltioaniliner, fenylsulfinylaniliner og fenylsulfonylaniliner.
NO893291D0 (no)	1989-08-16	Fremgangsmaate for fremstilling av nye benzasolderivater og farmasoeytiske preparater derav.
NO894476D0 (no)	1989-11-09	Derivater av 2,3-difluorhydrokinon.
NO912279L (no)	1991-06-13	Fremgangsmaate for fremstilling og anvendelse av eksplosjonssikre 1-dimetylamino-3-dimetylimino-2-arylprop-1-en-salter.
NO902293D0 (no)	1990-05-23	Fremgangsmaate for fremstilling av nye tiazepinderivater.
NO883525L (no)	1989-02-13	Framgangsmaate for framstilling av 1,5-benzotiazepinderivater.