DK571989A - Hydroxy-1,2,3,4-tetrahydroaminoacridiner, deres fremstilling og anvendelse - Google Patents

Hydroxy-1,2,3,4-tetrahydroaminoacridiner, deres fremstilling og anvendelse

Info

Publication number: DK571989A
Authority: DK; Denmark
Prior art keywords: loweralkyl; hydrogen; hydroxy; preparation; arylloweralkyl
Prior art date: 1988-11-16

Application number

DK571989A

Other languages

English (en)

Other versions

DK571989D0 (da

DK168290B1 (da

Inventor

Gregory Michael Shutske

Iv John Dick Tomer

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-16

Filing date

1989-11-15

Publication date

1990-05-17

1989-11-15 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1989-11-15 Publication of DK571989D0 publication Critical patent/DK571989D0/da

1990-05-17 Publication of DK571989A publication Critical patent/DK571989A/da

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK168290B1 publication Critical patent/DK168290B1/da

Links

150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)

DK571989A 1988-11-16 1989-11-15 4-Amino-2,3-alkylen-quinolinderivater, en fremgangsmåde til deres fremstilling og anvendelse til fremstilling af et lægemiddel med aktivitet til lettelse af hukommelses-dysfunktion samt farmaceutisk præparat indeholdende et af de nævnte derivater DK168290B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27178888A	1988-11-16	1988-11-16
US27178888		1988-11-16

Publications (3)

Publication Number	Publication Date
DK571989D0 DK571989D0 (da)	1989-11-15
DK571989A true DK571989A (da)	1990-05-17
DK168290B1 DK168290B1 (da)	1994-03-07

Family

ID=23037088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK571989A DK168290B1 (da)	1988-11-16	1989-11-15	4-Amino-2,3-alkylen-quinolinderivater, en fremgangsmåde til deres fremstilling og anvendelse til fremstilling af et lægemiddel med aktivitet til lettelse af hukommelses-dysfunktion samt farmaceutisk præparat indeholdende et af de nævnte derivater

Country Status (15)

Country	Link
EP (1)	EP0369388B1 (da)
KR (1)	KR0156241B1 (da)
AT (1)	ATE89553T1 (da)
CA (1)	CA2003023C (da)
DE (1)	DE68906647T2 (da)
DK (1)	DK168290B1 (da)
ES (1)	ES2054987T3 (da)
FI (1)	FI90417C (da)
HU (2)	HU208674B (da)
IE (1)	IE63038B1 (da)
IL (1)	IL92307A0 (da)
NO (1)	NO894547L (da)
NZ (1)	NZ231376A (da)
PT (1)	PT92319B (da)
ZA (1)	ZA898720B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200462B (da) *	1990-09-27	1993-02-21	Hoechst Roussel Pharma
GB2264707A (en) *	1991-06-18	1993-09-08	Roger Michael Marchbanks	Acridine derivatives for treating alzheimer's disease
US5466696A (en) *	1992-09-10	1995-11-14	Warner Lambert Company	Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) *	1992-09-10	1995-06-06	Warner-Lambert Company	Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
WO2019207604A1 (en) *	2018-04-25	2019-10-31	Rajiv Gandhi Centre For Biotechnology	Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3582995D1 (de) *	1984-10-25	1991-07-04	Hoechst Roussel Pharma	9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
FI91401C (fi) *	1987-03-17	1994-06-27	Hoechst Roussel Pharma	Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi

1989
- 1989-11-14 IL IL92307A patent/IL92307A0/xx unknown
- 1989-11-14 ES ES89121037T patent/ES2054987T3/es not_active Expired - Lifetime
- 1989-11-14 EP EP89121037A patent/EP0369388B1/en not_active Expired - Lifetime
- 1989-11-14 DE DE89121037T patent/DE68906647T2/de not_active Expired - Fee Related
- 1989-11-14 NZ NZ231376A patent/NZ231376A/en unknown
- 1989-11-14 KR KR1019890016456A patent/KR0156241B1/ko not_active Expired - Fee Related
- 1989-11-14 FI FI895416A patent/FI90417C/fi not_active IP Right Cessation
- 1989-11-14 AT AT89121037T patent/ATE89553T1/de not_active IP Right Cessation
- 1989-11-15 ZA ZA898720A patent/ZA898720B/xx unknown
- 1989-11-15 DK DK571989A patent/DK168290B1/da not_active IP Right Cessation
- 1989-11-15 PT PT92319A patent/PT92319B/pt active IP Right Grant
- 1989-11-15 CA CA002003023A patent/CA2003023C/en not_active Expired - Fee Related
- 1989-11-15 NO NO89894547A patent/NO894547L/no unknown
- 1989-11-15 IE IE365989A patent/IE63038B1/en not_active IP Right Cessation
- 1989-11-16 HU HU593189A patent/HU208674B/hu unknown
1995
- 1995-06-22 HU HU95P/P00336P patent/HU211701A9/hu unknown

Also Published As

Publication number	Publication date
HU208674B (en)	1993-12-28
IL92307A0 (en)	1990-07-26
KR0156241B1 (ko)	1998-11-16
DK571989D0 (da)	1989-11-15
IE893659L (en)	1990-05-16
NO894547D0 (no)	1989-11-15
ZA898720B (en)	1990-08-29
DE68906647T2 (de)	1993-10-07
HUT53087A (en)	1990-09-28
HU895931D0 (en)	1990-02-28
CA2003023A1 (en)	1990-05-16
KR900007809A (ko)	1990-06-02
FI895416A0 (fi)	1989-11-14
NZ231376A (en)	1992-05-26
EP0369388B1 (en)	1993-05-19
FI90417C (fi)	1994-02-10
PT92319A (pt)	1990-05-31
HU211701A9 (en)	1995-12-28
ATE89553T1 (de)	1993-06-15
ES2054987T3 (es)	1994-08-16
NO894547L (no)	1990-05-18
DE68906647D1 (de)	1993-06-24
DK168290B1 (da)	1994-03-07
FI90417B (fi)	1993-10-29
IE63038B1 (en)	1995-03-22
EP0369388A1 (en)	1990-05-23
CA2003023C (en)	2001-05-29
PT92319B (pt)	1995-08-09

Legal Events

Date	Code	Title	Description
2004-07-12	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
PH25571A (en)	1991-08-08	Alpha'-alkyl-4-amino-3-quinolinemethanols, 1-(4-aralkylamino-3-quinolinyl) alaknones, their use as medicaments
DE3764724D1 (de)	1990-10-11	2-phenylbenzoxepin-derivat.
DK571989D0 (da)	1989-11-15	Hydroxy-1,2,3,4-tetrahydroaminoacridiner, deres fremstilling og anvendelse
PT92234A (pt)	1990-05-31	Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
AU4720389A (en)	1990-07-05	N-pyridinyl-9h-carbazol-9-amines, a process their preparation and their use as medicaments
DK0628039T3 (da)	1997-12-08	2,3,4,5-tetrahydro-1H-benzazepiner og farmaceutisk acceptable syreadditionssalte deraf.
AU619985B2 (en)	1992-02-06	4,5,5a,6-tetrahydro-3h-isoxazolo(5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments
GR3005011T3 (da)	1993-05-24