DK0628039T3 - 2,3,4,5-tetrahydro-1H-benzazepiner og farmaceutisk acceptable syreadditionssalte deraf. - Google Patents

2,3,4,5-tetrahydro-1H-benzazepiner og farmaceutisk acceptable syreadditionssalte deraf.

Info

Publication number: DK0628039T3
Authority: DK; Denmark
Prior art keywords: benzazepines; tetrahydro; pharmaceutically acceptable; acid addition; addition salts
Prior art date: 1992-02-24

Application number

DK93905215.5T

Other languages

English (en)

Inventor

Christian Foged

Rolf Hohlweg

Erik Bardrum Nielsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-24

Filing date

1993-02-05

Publication date

1997-12-08

1993-02-05 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-12-08 Application granted granted Critical

1997-12-08 Publication of DK0628039T3 publication Critical patent/DK0628039T3/da

Links

MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical class N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK93905215.5T 1992-02-24 1993-02-05 2,3,4,5-tetrahydro-1H-benzazepiner og farmaceutisk acceptable syreadditionssalte deraf. DK0628039T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK92233A DK23392D0 (da)	1992-02-24	1992-02-24	Heterocykliske forbindelser, deres anvendelse og fremstilling

Publications (1)

Publication Number	Publication Date
DK0628039T3 true DK0628039T3 (da)	1997-12-08

Family

ID=8091236

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK92233A DK23392D0 (da)	1992-02-24	1992-02-24	Heterocykliske forbindelser, deres anvendelse og fremstilling
DK93905215.5T DK0628039T3 (da)	1992-02-24	1993-02-05	2,3,4,5-tetrahydro-1H-benzazepiner og farmaceutisk acceptable syreadditionssalte deraf.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK92233A DK23392D0 (da)	1992-02-24	1992-02-24	Heterocykliske forbindelser, deres anvendelse og fremstilling

Country Status (23)

Country	Link
EP (1)	EP0628039B1 (da)
JP (1)	JPH07504172A (da)
KR (1)	KR100255739B1 (da)
AT (1)	ATE152450T1 (da)
AU (1)	AU667878B2 (da)
BG (1)	BG62208B1 (da)
CA (1)	CA2130678C (da)
CZ (1)	CZ288626B6 (da)
DE (1)	DE69310353T2 (da)
DK (2)	DK23392D0 (da)
ES (1)	ES2102019T3 (da)
FI (1)	FI113770B (da)
GR (1)	GR3023896T3 (da)
HU (1)	HU221314B1 (da)
IL (1)	IL104657A (da)
NO (1)	NO310193B1 (da)
NZ (1)	NZ249465A (da)
RO (1)	RO116088B1 (da)
RU (1)	RU2114839C1 (da)
SK (1)	SK281390B6 (da)
UA (1)	UA34451C2 (da)
WO (1)	WO1993017012A1 (da)
ZA (1)	ZA931099B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH09510222A (ja) *	1994-03-16	1997-10-14	ノボノルディスクアクティーゼルスカブ	２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピン化合物の酸付加塩
AU700596B2 (en) *	1995-09-15	1999-01-07	Cenes Limited	Acid addition salts of 2,3,4,5-tetrahydro-1H-3-benzazepine compounds
GB0130576D0 (en) *	2001-12-20	2002-02-06	Cenes Ltd	Dopamine D1 receptor agonist pro-drug compounds & derivatives
PT1572215E (pt) *	2002-12-20	2009-12-09	Glaxo Group Ltd	Derivados de benzo[d]azepina para o tratamento de perturbações neurológicas
WO2014066659A1 (en)	2012-10-25	2014-05-01	Tetra Discovery Partners, Llc.	Heteroaryl inhibitors of pde4
WO2015048407A1 (en) *	2013-09-26	2015-04-02	Tetra Discovery Partners, LLC	Heteroaryl inhibitors of pde4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK180485D0 (da) *	1985-04-22	1985-04-23	Novo Industri As	Nitrogenholdige forbindelser
DK325188D0 (da) *	1988-06-15	1988-06-15	Novo Industri As	Hidtil ukendte benzazepinderivater
DK67489D0 (da) *	1989-02-14	1989-02-14	Novo Industri As	Nye benzazepinderivater

1992
- 1992-02-24 DK DK92233A patent/DK23392D0/da not_active Application Discontinuation
1993
- 1993-02-05 JP JP5514460A patent/JPH07504172A/ja active Pending
- 1993-02-05 HU HU9402434A patent/HU221314B1/hu not_active IP Right Cessation
- 1993-02-05 NZ NZ249465A patent/NZ249465A/en unknown
- 1993-02-05 AT AT93905215T patent/ATE152450T1/de not_active IP Right Cessation
- 1993-02-05 EP EP93905215A patent/EP0628039B1/en not_active Expired - Lifetime
- 1993-02-05 KR KR1019940702944A patent/KR100255739B1/ko not_active Expired - Fee Related
- 1993-02-05 AU AU36265/93A patent/AU667878B2/en not_active Ceased
- 1993-02-05 DK DK93905215.5T patent/DK0628039T3/da active
- 1993-02-05 WO PCT/DK1993/000041 patent/WO1993017012A1/en not_active Ceased
- 1993-02-05 RU RU94040719A patent/RU2114839C1/ru not_active IP Right Cessation
- 1993-02-05 CA CA002130678A patent/CA2130678C/en not_active Expired - Fee Related
- 1993-02-05 CZ CZ19941988A patent/CZ288626B6/cs not_active IP Right Cessation
- 1993-02-05 ES ES93905215T patent/ES2102019T3/es not_active Expired - Lifetime
- 1993-02-05 SK SK1000-94A patent/SK281390B6/sk unknown
- 1993-02-05 UA UA94085741A patent/UA34451C2/uk unknown
- 1993-02-05 DE DE69310353T patent/DE69310353T2/de not_active Expired - Fee Related
- 1993-02-05 RO RO94-01400A patent/RO116088B1/ro unknown
- 1993-02-09 IL IL10465793A patent/IL104657A/en not_active IP Right Cessation
- 1993-02-17 ZA ZA931099A patent/ZA931099B/xx unknown
1994
- 1994-08-22 BG BG98993A patent/BG62208B1/bg unknown
- 1994-08-23 FI FI943875A patent/FI113770B/fi not_active IP Right Cessation
- 1994-08-24 NO NO19943123A patent/NO310193B1/no not_active IP Right Cessation
1997
- 1997-06-26 GR GR970401543T patent/GR3023896T3/el unknown

Also Published As

Publication number	Publication date
IL104657A (en)	1999-11-30
AU3626593A (en)	1993-09-13
JPH07504172A (ja)	1995-05-11
IL104657A0 (en)	1993-06-10
NZ249465A (en)	1996-02-27
CZ198894A3 (en)	1995-10-18
EP0628039A1 (en)	1994-12-14
NO310193B1 (no)	2001-06-05
EP0628039B1 (en)	1997-05-02
WO1993017012A1 (en)	1993-09-02
GR3023896T3 (en)	1997-09-30
RO116088B1 (ro)	2000-10-30
ES2102019T3 (es)	1997-07-16
RU2114839C1 (ru)	1998-07-10
AU667878B2 (en)	1996-04-18
FI113770B (fi)	2004-06-15
RU94040719A (ru)	1996-07-10
HU9402434D0 (en)	1994-10-28
KR950700286A (ko)	1995-01-16
SK100094A3 (en)	1995-04-12
CA2130678A1 (en)	1993-08-25
BG62208B1 (bg)	1999-05-31
SK281390B6 (sk)	2001-03-12
NO943123L (no)	1994-08-24
BG98993A (bg)	1995-05-31
HUT71127A (en)	1995-11-28
CA2130678C (en)	2004-04-20
DE69310353T2 (de)	1997-10-02
ZA931099B (en)	1994-08-17
KR100255739B1 (ko)	2000-05-01
HU221314B1 (en)	2002-09-28
UA34451C2 (uk)	2001-03-15
CZ288626B6 (cs)	2001-08-15
FI943875A0 (fi)	1994-08-23
DE69310353D1 (de)	1997-06-05
FI943875L (fi)	1994-08-23
NO943123D0 (no)	1994-08-24
ATE152450T1 (de)	1997-05-15
DK23392D0 (da)	1992-02-24

Publication	Publication Date	Title
DK0585328T3 (da)	2002-02-11	Substituerede 3-aminoquinuclidiner
NO941052L (no)	1994-09-26	Benzimidazolforbindelser, deres anvendelse og fremstilling
DK441187D0 (da)	1987-08-24	Alfa-alkyl-4-amino-3-quinolinmethanoler og 1-(4-aralkylamino-3-quinolinyl)alkanoner, deres fremstilling og anvendelse
DK0850215T3 (da)	2000-11-20	N-(aroyl)glycinhydroxamsyrederivater og beslægtede forbindelser
MY110110A (en)	1998-01-27	Pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and cns disorders
DE69523155D1 (de)	2001-11-15	Benzimidazolonderivate mit zentraler dopaminerger aktivität
ATE242220T1 (de)	2003-06-15	Benzimidazolderivate mit dopaminerger wirkung
NO943123D0 (no)	1994-08-24	2,3,4,5-tetrahydro-1H-3-benzazepiner og farmasöytisk akseptable syreaddisjonssalter derav
DE69030665D1 (de)	1997-06-12	(1,2n) und (3,2n)-karbozyklische-2-amino-tetralinderivate
FI865220A0 (fi)	1986-12-19	Foerfarande foer framstaellning av sulfinyl- och sulfonylsubstituerade 3-benzazepiner.
DK571989A (da)	1990-05-17	Hydroxy-1,2,3,4-tetrahydroaminoacridiner, deres fremstilling og anvendelse