DK586589A - Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid - Google Patents

Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid

Info

Publication number
DK586589A
DK586589A DK586589A DK586589A DK586589A DK 586589 A DK586589 A DK 586589A DK 586589 A DK586589 A DK 586589A DK 586589 A DK586589 A DK 586589A DK 586589 A DK586589 A DK 586589A
Authority
DK
Denmark
Prior art keywords
chlorphenyl
phenylmethyl
dihydrochloride
piperazinyl
ethoxy
Prior art date
Application number
DK586589A
Other languages
English (en)
Other versions
DK586589D0 (da
DK174289B1 (da
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of DK586589D0 publication Critical patent/DK586589D0/da
Publication of DK586589A publication Critical patent/DK586589A/da
Application granted granted Critical
Publication of DK174289B1 publication Critical patent/DK174289B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198905865A 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[(4-chlorphenyl)phenylmethyl]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid DK174289B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390 1988-11-23

Publications (3)

Publication Number Publication Date
DK586589D0 DK586589D0 (da) 1989-11-22
DK586589A true DK586589A (da) 1990-05-24
DK174289B1 DK174289B1 (da) 2002-11-18

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905865A DK174289B1 (da) 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[(4-chlorphenyl)phenylmethyl]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid

Country Status (17)

Country Link
KR (1) KR970009727B1 (da)
AT (1) AT398970B (da)
CA (1) CA1320732C (da)
CY (1) CY1696A (da)
DK (1) DK174289B1 (da)
ES (1) ES2018967A6 (da)
FI (1) FI91861C (da)
GB (2) GB8827390D0 (da)
GR (1) GR1000576B (da)
HK (1) HK45493A (da)
HU (1) HU208002B (da)
NO (1) NO172287C (da)
PH (1) PH26334A (da)
PL (1) PL161374B1 (da)
PT (1) PT92363B (da)
RU (1) RU1838306C (da)
SG (1) SG12793G (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2122042T3 (es) * 1992-09-24 1998-12-16 Sepracor Inc Tratamiento de rinitis alergica y asma que emplea (-)cetirizina.
ES2128556T3 (es) * 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2003104212A1 (en) * 2002-06-05 2003-12-18 Dr.Reddy's Laboratories Ltd. A novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetic acid dihydrochloride (cetirizine dihydrochloride)
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates
AU2003228011A1 (en) * 2003-05-21 2004-12-13 Wockhardt Limited 2-(2-(4-((4-chlorophenyl) phenylmethyl)-1-piperazinyl)ethoxy)acetic acid monohydrochloride as anti-allergenic compound and process for its production
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.

Also Published As

Publication number Publication date
RU1838306C (ru) 1993-08-30
NO172287B (no) 1993-03-22
PT92363A (pt) 1990-05-31
NO894650D0 (no) 1989-11-22
PH26334A (en) 1992-04-29
SG12793G (en) 1993-04-16
PL161374B1 (pl) 1993-06-30
AT398970B (de) 1995-02-27
NO172287C (no) 1993-06-30
KR970009727B1 (ko) 1997-06-17
CA1320732C (en) 1993-07-27
FI91861C (fi) 1994-08-25
DK586589D0 (da) 1989-11-22
PT92363B (pt) 1995-07-18
HUT53626A (en) 1990-11-28
HU208002B (en) 1993-07-28
FI895563A0 (fi) 1989-11-22
CY1696A (en) 1994-01-14
GR890100771A (en) 1990-12-31
HU896130D0 (en) 1990-02-28
GB2225320B (en) 1992-09-02
NO894650L (no) 1990-05-25
DK174289B1 (da) 2002-11-18
GB2225320A (en) 1990-05-30
KR900007824A (ko) 1990-06-02
FI91861B (fi) 1994-05-13
ATA266489A (de) 1994-07-15
ES2018967A6 (es) 1991-05-16
GR1000576B (el) 1992-08-26
HK45493A (en) 1993-05-21
GB8827390D0 (en) 1988-12-29
GB8926242D0 (en) 1990-01-10

Similar Documents

Publication Publication Date Title
DK586789A (da) Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid
DK586589A (da) Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid
PL294704A1 (en) Method of obtaining 4-(2-(2-hydroxy-2-phenylethylamine)ethoxy) phenyloacetic acid and its bioprecursor substances
ATE267185T1 (de) Therapeutisch wirksame linksdrehende und rechtsdrehende 1-((4-chlorphenyl)phenylmethyl) piperazine
DK8985D0 (da) 4-((bicyklisk heterocyclyl)-methyl og -hetero)-piperidin-derivater ogfremgangsmaade til fremstilling deraf
DK108891D0 (da) 4-(4-phenyl-1-piperazinyl)phenoler og fremgangsmaade til fremstilling deraf
DK285190A (da) 2-(5-fluornicotinoyl)eddikesyrederivat og fremgangsmaade til fremstilling deraf
CS717982A2 (en) Method of 2-susbstituted 2-(omega-quanidino-alkamido,omega-quandino-alkenamido and omega-quanidino-hydroxyalkamiso-n-(4-(3-aminopropyl)aminobutyl(erganamides and teir salts production
DK573282A (da) Fremgangsmaade til fremstilling af 2-(4-((4,4-dialkyl-2,6-piperidindion-1-yl)-butyl)-1-piperazinyl)pyridiner
DK39988A (da) 4-aryl-n-(2-(dialkylamino og heterocyclisk amino)alkyl)-1-piperazincarboxamider og anvendelsen heraf
IE812069L (en) Azaspirodecanediones
NO306860B1 (no) Fremgangsmåte for fremstilling av 2-[2-[4-[(4-klorfenyl)fenylmetyl]-1-piperazinyl]etoksy]eddiksyre og dens salter
PL287224A1 (en) Method of obtaining 2-(2-(4-(/4-chlorophenyl/phenylmethyl)-1-piperazinyl) ethoxy) acetic acid and its dihydrohloride
JPS57149282A (en) 2-(4-(diphenylmethyl)-1-piperazinyl)acetic acid and their derivatives as medicine
DK557184A (da) 2-(3-pyridyl)-2-phenylaminoeddikesyrederivater, fremgangsmaade tilfremstilling deraf og anvendelse af saadanne derivater som anti-fungusmidler
NO870891D0 (no) Fremgangsmaate for fremstilling av 4-(2-pyrimidinyl)-1-piperazinyl heterocykliske carbonyl-derivater.
DK590084A (da) 2-(1-imidazolyl)-ethanol-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse
AU579775B2 (en) Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4- imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof
NO168824C (no) Fremgangsmaate for fremstilling av 2-(substituert-3-guanidino)-4-(2-metyl-4-imidazolyl)-tiazol og n-(substituert amidino)tiourea derav

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK