DK592589D0 - Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse - Google Patents

Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse

Info

Publication number: DK592589D0
Authority: DK; Denmark
Prior art keywords: loweralkyl; hydrogen; preparation; tetrahydroacridine; condensed heterocyclic
Prior art date: 1988-11-25

Application number

DK592589A

Other languages

English (en)

Other versions

DK592589A (da

Inventor

Gregory M Shutske

Kevin J Kapples

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-25

Filing date

1989-11-24

Publication date

1989-11-24

1989-11-24 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1989-11-24 Publication of DK592589D0 publication Critical patent/DK592589D0/da

1990-05-26 Publication of DK592589A publication Critical patent/DK592589A/da

Links

RXBYRTSOWREATF-UHFFFAOYSA-N 1,2,3,4-tetrahydroacridine Chemical class C1=CC=C2C=C(CCCC3)C3=NC2=C1 RXBYRTSOWREATF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
101100097467 Arabidopsis thaliana SYD gene Chemical group 0.000 abstract 1
101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)

DK592589A 1988-11-25 1989-11-24 Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse DK592589A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/276,259 US4927820A (en)	1988-11-25	1988-11-25	Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine

Publications (2)

Publication Number	Publication Date
DK592589D0 true DK592589D0 (da)	1989-11-24
DK592589A DK592589A (da)	1990-05-26

Family

ID=23055896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK592589A DK592589A (da)	1988-11-25	1989-11-24	Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse

Country Status (18)

Country	Link
US (1)	US4927820A (da)
EP (1)	EP0370449B1 (da)
JP (1)	JPH085881B2 (da)
KR (1)	KR0143235B1 (da)
AT (1)	ATE104298T1 (da)
AU (1)	AU623452B2 (da)
CA (1)	CA2003837C (da)
DE (1)	DE68914600T2 (da)
DK (1)	DK592589A (da)
ES (1)	ES2051965T3 (da)
FI (1)	FI90871C (da)
HU (1)	HU203551B (da)
IE (1)	IE63120B1 (da)
IL (1)	IL92420A (da)
NO (1)	NO173783C (da)
NZ (1)	NZ231494A (da)
PT (1)	PT92389B (da)
ZA (1)	ZA898989B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4920117A (en) *	1989-06-09	1990-04-24	Hoechst-Roussel Pharmaceuticals Inc.	4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use
US5112829A (en) *	1989-11-28	1992-05-12	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) *	1989-11-28	1991-02-19	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US5861398A (en) *	1996-08-26	1999-01-19	Alanex Corporation	Benzoperimidine-carboxylic acids and derivatives thereof
ES2523169T3 (es)	2008-01-25	2014-11-21	High Point Pharmaceuticals, Llc	Compuestos tricíclicos como moduladores de la síntesis de TNF y como inhibidores de PDE4
CN113861189A (zh)	2020-06-29	2021-12-31	Vtv治疗有限责任公司	喹啉衍生物，其药学上可接受的盐及其使用方法
US12545676B2 (en)	2020-07-28	2026-02-10	Vtv Therapeutics Llc	Crystalline form of hydrochloride salt of quinoline derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0179383B1 (en) *	1984-10-25	1991-05-29	Hoechst-Roussel Pharmaceuticals Incorporated	9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
US4695573A (en) *	1984-10-25	1987-09-22	Hoechst-Roussel Pharmaceuticals Inc.	9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
MX13270A (es) *	1987-10-05	1993-06-01	Pfizer	Procedimiento para la preparacion de derivados de 4-aminopiridina
US4920117A (en) *	1989-06-09	1990-04-24	Hoechst-Roussel Pharmaceuticals Inc.	4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use

1988
- 1988-11-25 US US07/276,259 patent/US4927820A/en not_active Expired - Fee Related
1989
- 1989-11-21 EP EP89121488A patent/EP0370449B1/en not_active Expired - Lifetime
- 1989-11-21 DE DE68914600T patent/DE68914600T2/de not_active Expired - Fee Related
- 1989-11-21 AT AT89121488T patent/ATE104298T1/de not_active IP Right Cessation
- 1989-11-21 ES ES89121488T patent/ES2051965T3/es not_active Expired - Lifetime
- 1989-11-23 NZ NZ231494A patent/NZ231494A/en unknown
- 1989-11-23 KR KR1019890017024A patent/KR0143235B1/ko not_active Expired - Fee Related
- 1989-11-23 PT PT92389A patent/PT92389B/pt not_active IP Right Cessation
- 1989-11-23 FI FI895605A patent/FI90871C/fi not_active IP Right Cessation
- 1989-11-23 IL IL9242089A patent/IL92420A/en not_active IP Right Cessation
- 1989-11-24 DK DK592589A patent/DK592589A/da not_active Application Discontinuation
- 1989-11-24 AU AU45480/89A patent/AU623452B2/en not_active Ceased
- 1989-11-24 NO NO894698A patent/NO173783C/no not_active IP Right Cessation
- 1989-11-24 ZA ZA898989A patent/ZA898989B/xx unknown
- 1989-11-24 IE IE375889A patent/IE63120B1/en not_active IP Right Cessation
- 1989-11-24 CA CA002003837A patent/CA2003837C/en not_active Expired - Fee Related
- 1989-11-24 JP JP1303465A patent/JPH085881B2/ja not_active Expired - Fee Related
- 1989-11-24 HU HU896174A patent/HU203551B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2003837C (en)	2000-01-18
FI90871C (fi)	1994-04-11
ES2051965T3 (es)	1994-07-01
AU623452B2 (en)	1992-05-14
IE63120B1 (en)	1995-03-22
FI895605A0 (fi)	1989-11-23
DE68914600D1 (de)	1994-05-19
DK592589A (da)	1990-05-26
ZA898989B (en)	1990-08-29
IL92420A0 (en)	1990-07-26
CA2003837A1 (en)	1990-05-25
NO173783C (no)	1994-02-02
AU4548089A (en)	1990-05-31
HUT53107A (en)	1990-09-28
NO894698D0 (no)	1989-11-24
ATE104298T1 (de)	1994-04-15
JPH02193996A (ja)	1990-07-31
DE68914600T2 (de)	1994-09-15
HU896174D0 (en)	1990-02-28
HU203551B (en)	1991-08-28
IL92420A (en)	1994-02-27
IE893758L (en)	1990-05-25
PT92389A (pt)	1990-05-31
NZ231494A (en)	1992-04-28
US4927820A (en)	1990-05-22
KR900007848A (ko)	1990-06-02
EP0370449A1 (en)	1990-05-30
KR0143235B1 (ko)	1998-07-15
EP0370449B1 (en)	1994-04-13
NO173783B (no)	1993-10-25
NO894698L (no)	1990-05-28
PT92389B (pt)	1995-07-18
FI90871B (fi)	1993-12-31
JPH085881B2 (ja)	1996-01-24

Legal Events

Date	Code	Title	Description
2004-05-24	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK0420140T3 (da)	1998-03-16	N-Aminocarbamater beslægtede med physostigmin, en fremgangsmåde til deres fremstilling og deres anvedelse som lægemidler
NZ221543A (en)	1990-09-26	4-aminoquinoline derivatives and pharmaceutical compositions containing such
DK592589A (da)	1990-05-26	Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse
NO881835D0 (no)	1988-04-27	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
NO894445L (no)	1990-05-10	Fremgangsmaate for fremstilling av 1,2,3,4-tetrahydro-1,9-acridindiaminer, og deres anvendelse som medikamenter.
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
AU619985B2 (en)	1992-02-06	4,5,5a,6-tetrahydro-3h-isoxazolo(5,4,3-kl)acridines derivatives, a process for their preparation and their use as medicaments
MX9100638A (es)	1992-04-01	1-(piridinilalquil)-1h-indoles,indolinas y compuestos analogos afines
PT98646A (pt)	1992-06-30	Processo para a preparacao de carbamoil-1-(piridinalquil)-1h-indois indolinas e os seus analogos