DK604087A - Phosphonomethoxyalkylenpurin og pyrimidinderivater deraf - Google Patents

Phosphonomethoxyalkylenpurin og pyrimidinderivater deraf

Info

Publication number
DK604087A
DK604087A DK604087A DK604087A DK604087A DK 604087 A DK604087 A DK 604087A DK 604087 A DK604087 A DK 604087A DK 604087 A DK604087 A DK 604087A DK 604087 A DK604087 A DK 604087A
Authority
DK
Denmark
Prior art keywords
phosphonomethoxyalkylenpurin
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
DK604087A
Other languages
English (en)
Other versions
DK170049B1 (da
DK604087D0 (da
Inventor
Ii Robert R Webb
Joanne J Bronson
John C Martin
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26812069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK604087(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK604087D0 publication Critical patent/DK604087D0/da
Publication of DK604087A publication Critical patent/DK604087A/da
Application granted granted Critical
Publication of DK170049B1 publication Critical patent/DK170049B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK604087A 1986-11-18 1987-11-17 Phosphonomethoxyalkylenpurin- og pyrimidinderivater samt farmaceutiske præparater indeholdende sådanne derivater DK170049B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93211286A 1986-11-18 1986-11-18
US93211286 1986-11-18
US11434087A 1987-11-04 1987-11-04
US11434087 1987-11-04

Publications (3)

Publication Number Publication Date
DK604087D0 DK604087D0 (da) 1987-11-17
DK604087A true DK604087A (da) 1988-05-19
DK170049B1 DK170049B1 (da) 1995-05-08

Family

ID=26812069

Family Applications (1)

Application Number Title Priority Date Filing Date
DK604087A DK170049B1 (da) 1986-11-18 1987-11-17 Phosphonomethoxyalkylenpurin- og pyrimidinderivater samt farmaceutiske præparater indeholdende sådanne derivater

Country Status (12)

Country Link
EP (1) EP0269947B2 (da)
JP (1) JP2593895B2 (da)
KR (1) KR950009195B1 (da)
AU (1) AU613592B2 (da)
CA (1) CA1339780C (da)
DE (1) DE3780581T3 (da)
DK (1) DK170049B1 (da)
EG (1) EG19346A (da)
ES (1) ES2033774T5 (da)
GR (2) GR3005256T3 (da)
IL (1) IL84477A (da)
NZ (1) NZ222553A (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
US5266722A (en) * 1988-11-09 1993-11-30 W. R. Grace & Co.-Conn. Polyether bis-phosphonic acid compounds
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
FI911875L (fi) * 1990-04-20 1991-10-21 Bristol Myers Squibb Co Kirala 2-(fosfonometoxi) propylguaniner som antivirala aemnen.
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
DK0481214T3 (da) * 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
EP0630381B1 (en) * 1991-10-11 1997-04-09 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
IT1270008B (it) * 1994-09-23 1997-04-16 Ist Superiore Sanita Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5717095A (en) * 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
WO1998004569A1 (en) * 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
AU740264C (en) * 1997-09-11 2002-06-06 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
BRPI0210746B8 (pt) 2001-06-29 2021-05-25 Inst Of Organic Chemistry And Biochemistry Ascr derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação
EA200400690A1 (ru) * 2001-11-14 2005-06-30 Байокрист Фармасьютикалз, Инк. Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
US7371852B2 (en) 2003-01-22 2008-05-13 Serenex, Inc. Alkyl-linked nucleotide compositions
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060252729A1 (en) 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
WO2012079035A1 (en) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
CA2857490C (en) 2011-12-22 2020-03-31 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
MX377983B (es) * 2014-09-15 2025-03-04 Univ California Análogos de nucleótidos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them

Also Published As

Publication number Publication date
EP0269947A1 (en) 1988-06-08
AU8125087A (en) 1988-05-19
AU613592B2 (en) 1991-08-08
KR950009195B1 (ko) 1995-08-16
NZ222553A (en) 1991-07-26
KR880006256A (ko) 1988-07-22
DE3780581T3 (de) 1997-06-05
ES2033774T3 (es) 1993-04-01
ES2033774T5 (es) 1997-03-16
DE3780581D1 (de) 1992-08-27
DK170049B1 (da) 1995-05-08
GR3021389T3 (en) 1997-01-31
EP0269947B2 (en) 1996-10-16
JPS63170388A (ja) 1988-07-14
CA1339780C (en) 1998-03-24
JP2593895B2 (ja) 1997-03-26
DK604087D0 (da) 1987-11-17
GR3005256T3 (en) 1993-05-24
EG19346A (en) 1995-01-31
IL84477A (en) 1995-12-08
EP0269947B1 (en) 1992-07-22
DE3780581T2 (de) 1992-12-17

Similar Documents

Publication Publication Date Title
DK604087D0 (da) Phosphonomethoxyalkylenpurin og pyrimidinderivater deraf
IT1205010B (it) Tetraidronaftalin-derivati e indan-derivati
DK366887D0 (da) Pyrimidinderivater
DK297089D0 (da) Pyrimidinderivater og fremgangsmaade til fremstilling deraf
DK375787D0 (da) Pyrimidinderivater
DK254488D0 (da) Azaindol- og indolizinderivater
DK45188D0 (da) Substituerede aminderivater og deres anvendelse
DK617487A (da) Pyrrolderivater og deoxyanaloge deraf
DK274987D0 (da) Pyrimidin-derivater, deres fremstilling og anvendelse
DK363987D0 (da) Pyrimidinderivater
DK413187A (da) Semicarbazoner og thiosemicarbazoner
DK346787D0 (da) Pyrimidinderivater
DK235787A (da) Tripeptidderivater, deres fremstilling og anvendelse
BG82461A (bg) Пиримидинови производни
DK93487A (da) Addukter mellem menadion og pyridinderivater samt anvendelse heraf
DK9886A (da) Naphthalenderivater og fremstilling deraf
DK289887A (da) Anvendelse af avaron- og avarolderivater
DK289987A (da) Anvendelse af avaron- og avarolderivater
DK619589D0 (da) Sphingenin og derivater heraf
DK117587A (da) 5-acyloxy-13beta-alkyl-milbemycin-derivater samt deres fremstilling og anvendelse
DK324187A (da) Herbicidt praeparat indeholdende ureaderivater og en modgift
DK684187A (da) Flecainidderivat og anvendelse deraf
BR8601118A (pt) Imantador e desimantador
DK90087D0 (da) Stillads og stilladsbuk dertil
MX9203746A (es) Derivados de il-1alfa y farmacos de los mismos

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired