ES2033774T3 - Derivados antiviricos fosfonometoxialquilenicos de purina y pirimidina. - Google Patents

Derivados antiviricos fosfonometoxialquilenicos de purina y pirimidina.

Info

Publication number
ES2033774T3
ES2033774T3 ES198787116996T ES87116996T ES2033774T3 ES 2033774 T3 ES2033774 T3 ES 2033774T3 ES 198787116996 T ES198787116996 T ES 198787116996T ES 87116996 T ES87116996 T ES 87116996T ES 2033774 T3 ES2033774 T3 ES 2033774T3
Authority
ES
Spain
Prior art keywords
phosphonometoxialkyllene
antiviric
pirimidine
purine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787116996T
Other languages
English (en)
Other versions
ES2033774T5 (es
Inventor
Robert R. Ii Webb
Joanne J. Bronson
John C. Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26812069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2033774(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ES2033774T3 publication Critical patent/ES2033774T3/es
Application granted granted Critical
Publication of ES2033774T5 publication Critical patent/ES2033774T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN UNA SERIE DE COMPUESTOS DE FORMULA (I) LOS CUALES SE USAN EN EL TRATAMIENTO DE INFECCIONES VIRICAS, SU COMPOSICION Y SU USO. EN LA FORMULA (I) B ES UNA BASE PURICA O PIRIMIDINICA; ALK 1, ALK 2 Y ALK 3 SON ENLACES QUIMICOS O GRUPOS ALQUILENOS; Q ES HIDROGENO O HIDROXILO; Y R1-R4 SON HIDROGENOS O ALQUILOS.
ES87116996T 1986-11-18 1987-11-17 Derivados antiviricos fosfonometoxialquilenicos de purina y pirimidina. Expired - Lifetime ES2033774T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93211286A 1986-11-18 1986-11-18
US11434087A 1987-11-04 1987-11-04

Publications (2)

Publication Number Publication Date
ES2033774T3 true ES2033774T3 (es) 1993-04-01
ES2033774T5 ES2033774T5 (es) 1997-03-16

Family

ID=26812069

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87116996T Expired - Lifetime ES2033774T5 (es) 1986-11-18 1987-11-17 Derivados antiviricos fosfonometoxialquilenicos de purina y pirimidina.

Country Status (12)

Country Link
EP (1) EP0269947B2 (es)
JP (1) JP2593895B2 (es)
KR (1) KR950009195B1 (es)
AU (1) AU613592B2 (es)
CA (1) CA1339780C (es)
DE (1) DE3780581T3 (es)
DK (1) DK170049B1 (es)
EG (1) EG19346A (es)
ES (1) ES2033774T5 (es)
GR (2) GR3005256T3 (es)
IL (1) IL84477A (es)
NZ (1) NZ222553A (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
US5266722A (en) * 1988-11-09 1993-11-30 W. R. Grace & Co.-Conn. Polyether bis-phosphonic acid compounds
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
EP0452935B1 (en) * 1990-04-20 1995-06-21 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ287745B6 (cs) * 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
EP0719274A1 (en) * 1993-09-17 1996-07-03 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
IT1270008B (it) * 1994-09-23 1997-04-16 Ist Superiore Sanita Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5717095A (en) * 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
CA2261619C (en) * 1996-07-26 2006-05-23 Gilead Sciences, Inc. Nucleotide analogs
AU740264C (en) * 1997-09-11 2002-06-06 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
WO2003002580A1 (en) 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
EA200400690A1 (ru) * 2001-11-14 2005-06-30 Байокрист Фармасьютикалз, Инк. Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
MXPA05007016A (es) 2003-01-14 2005-09-12 Gilead Sciences Inc Composiciones y metodos para terapia antiviral de combinacion.
US7371852B2 (en) 2003-01-22 2008-05-13 Serenex, Inc. Alkyl-linked nucleotide compositions
DE602004031115D1 (de) 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
AU2004260789B2 (en) 2003-07-30 2011-06-30 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
RU2606845C2 (ru) 2010-12-10 2017-01-10 СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
BR112017005111B1 (pt) * 2014-09-15 2023-02-14 The Regents Of The University Of California Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them

Also Published As

Publication number Publication date
GR3005256T3 (en) 1993-05-24
KR950009195B1 (ko) 1995-08-16
JP2593895B2 (ja) 1997-03-26
EP0269947B2 (en) 1996-10-16
DK604087A (da) 1988-05-19
DE3780581T3 (de) 1997-06-05
DE3780581T2 (de) 1992-12-17
KR880006256A (ko) 1988-07-22
DK604087D0 (da) 1987-11-17
EP0269947B1 (en) 1992-07-22
DE3780581D1 (de) 1992-08-27
EP0269947A1 (en) 1988-06-08
IL84477A (en) 1995-12-08
AU8125087A (en) 1988-05-19
NZ222553A (en) 1991-07-26
AU613592B2 (en) 1991-08-08
EG19346A (en) 1995-01-31
DK170049B1 (da) 1995-05-08
ES2033774T5 (es) 1997-03-16
CA1339780C (en) 1998-03-24
JPS63170388A (ja) 1988-07-14
GR3021389T3 (en) 1997-01-31

Similar Documents

Publication Publication Date Title
ES2033774T5 (es) Derivados antiviricos fosfonometoxialquilenicos de purina y pirimidina.
DE3750834D1 (de) Herstellung von Poly(Vinylaminen) mit hohem Molekulargewicht.
FI930753A0 (fi) Nya fosfolipidderivat av nukleosider, deras framstaellning och deras anvaendning saosom antivirala laekemedel
ES2131116T3 (es) Analogos de nucleotidos enantiomericos antirretrovirales.
IL99628A0 (en) Backbone cyclic peptides,processes for their preparation and pharmaceutical compositions containing them
DK51986D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
BG95575A (bg) 3'-(2')-амино-и тиолмодифицирани, свързани с флуоресциращо багрило нуклеозиди,нуклеотиди и олигонуклеотиди и метод за тяхното получаване и приложението им
ES2066808T3 (es) Derivados de quinoleina, su produccion y uso.
ATE100098T1 (de) Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen.
PL268927A1 (en) Method of obtaining novel derivatives of benzimidazole
ES8704904A1 (es) Procedimiento para incrementar la velocidad de asentamiento de un cemento hidraulico.
AR021695A1 (es) 4,5-pirazinoxindoles, composicion farmaceutica y uso
ES2037670T3 (es) Procedimiento para la preparacion de complejos de (2,2-bis(aminometil)-1,3-propanodiol-n,n') platino.
DE3776391D1 (de) Fluessige zubereitungen von 1,2-benzisothiazolin-3-on, ihre herstellung und verwendung.
ES2031892T3 (es) Agentes antialergicos y antiinflamatorios.
AU591772B2 (en) Substituted oxime-ethers and their use as bioregulators to lower the endogenous ethylene level in plants
ES8801622A1 (es) Un procedimiento para preparar derivados arilicos de dienamidas
GR1001067B (el) Νέες κτηνιατρικές και προστι?έμενες συν?έσεις προστασίας φυτών.
ES2054821T3 (es) Composiciones de prepolimero de poliisocianato y el uso de las mismas en la preparacion de poliuretanos.
DE3779187D1 (de) 2-trifluormethyl-benzimidazole.
ES2193248T3 (es) Antraquinonas mono- y disulfosustituidas y su uso para el tratamiento de desordenes de la matriz osea.
ES2059473T3 (es) Sales de acidos amino-(poli)percarboxilicos.
DK624989D0 (da) Hidtil ukendte forbindelser
BG92842A (bg) Метод за получаване на бета-карбонил-карбоксиамиди на 1,3-тиазолидини
ES2052526T3 (es) Derivados de pirimidina, su preparacion y medicamentos que contienen estos derivados.