DK608686A - 4-thienyl-dihydropyridiner, fremgangsmaade til deres fremstilling og deres anvendelse i laegemidler - Google Patents

4-thienyl-dihydropyridiner, fremgangsmaade til deres fremstilling og deres anvendelse i laegemidler

Info

Publication number: DK608686A
Authority: DK; Denmark
Prior art keywords: amino; chain; alkylamino; branched; halogen
Prior art date: 1985-12-18

Application number

DK608686A

Other languages

English (en)

Other versions

DK158737B (da

DK158737C (da

DK608686D0 (da

Inventor

Siegfried Goldmann

Hilmar Bischoff

Walter Puls

Joachim Bender

Dieter Petzinna

Klaus Schlossmann

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-18

Filing date

1986-12-17

Publication date

1987-06-19

1986-12-17 Application filed by Bayer Ag filed Critical Bayer Ag

1986-12-17 Publication of DK608686D0 publication Critical patent/DK608686D0/da

1987-06-19 Publication of DK608686A publication Critical patent/DK608686A/da

1990-07-09 Publication of DK158737B publication Critical patent/DK158737B/da

1990-11-26 Application granted granted Critical

1990-11-26 Publication of DK158737C publication Critical patent/DK158737C/da

Links

-1 4-THIENYL Chemical class 0.000 title abstract 8
229940126601 medicinal product Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
ORUKLNVPNVKNJV-UHFFFAOYSA-N 4-thiophen-2-yl-1,2-dihydropyridine Chemical class C1NC=CC(C=2SC=CC=2)=C1 ORUKLNVPNVKNJV-UHFFFAOYSA-N 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
125000005505 thiomorpholino group Chemical group 0.000 abstract 1
229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)

DK608686A 1985-12-18 1986-12-17 4-thienyl-dihydropyridiner og deres anvendelse i laegemidler DK158737C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3544693		1985-12-18
DE19853544693 DE3544693A1 (de)	1985-12-18	1985-12-18	4-thienyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln

Publications (4)

Publication Number	Publication Date
DK608686D0 DK608686D0 (da)	1986-12-17
DK608686A true DK608686A (da)	1987-06-19
DK158737B DK158737B (da)	1990-07-09
DK158737C DK158737C (da)	1990-11-26

Family

ID=6288697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK608686A DK158737C (da)	1985-12-18	1986-12-17	4-thienyl-dihydropyridiner og deres anvendelse i laegemidler

Country Status (10)

Country	Link
US (2)	US4801715A (da)
EP (1)	EP0229963B1 (da)
JP (1)	JPH0764848B2 (da)
KR (1)	KR870006055A (da)
AT (1)	ATE67204T1 (da)
DE (2)	DE3544693A1 (da)
DK (1)	DK158737C (da)
ES (1)	ES2037657T3 (da)
FI (1)	FI865122A7 (da)
IL (1)	IL80976A0 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3544693A1 (de) *	1985-12-18	1987-06-19	Bayer Ag	4-thienyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
AU2004272078A1 (en) *	2003-09-10	2005-03-24	Synta Pharmaceuticals Corp.	Dihydropyridine compounds for treating or preventing metabolic disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1552911A (en) *	1975-07-02	1979-09-19	Fujisawa Pharmaceutical Co	1,4 dihydropyridine derivatives and the preparation thereof
NZ201395A (en) *	1981-07-30	1987-02-20	Bayer Ag	Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
EP0111453A1 (de) *	1982-12-10	1984-06-20	Ciba-Geigy Ag	Amid-Verbindungen
ZA839187B (en) *	1982-12-10	1984-07-25	Ciba Geigy Ag	Amide compounds
EP0111455A3 (de) *	1982-12-10	1984-07-25	Ciba-Geigy Ag	Ungesättigte Lactone
GB2133851A (en) *	1983-01-19	1984-08-01	Icore Int Ltd	Conduit coupling
DE3343658A1 (de) *	1983-12-02	1985-06-13	Bayer Ag, 5090 Leverkusen	Hydroxy-tetrahydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3370277D1 (en) *	1983-12-03	1987-04-23	Nat Starch Chem Corp	Starch thickener characterized by improved low temperature stability
DE3544693A1 (de) *	1985-12-18	1987-06-19	Bayer Ag	4-thienyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln

1985
- 1985-12-18 DE DE19853544693 patent/DE3544693A1/de not_active Withdrawn
1986
- 1986-12-04 US US06/937,870 patent/US4801715A/en not_active Expired - Fee Related
- 1986-12-06 AT AT86116982T patent/ATE67204T1/de not_active IP Right Cessation
- 1986-12-06 ES ES86116982T patent/ES2037657T3/es not_active Expired - Lifetime
- 1986-12-06 DE DE8686116982T patent/DE3681432D1/de not_active Expired - Lifetime
- 1986-12-06 EP EP86116982A patent/EP0229963B1/de not_active Expired - Lifetime
- 1986-12-15 IL IL80976A patent/IL80976A0/xx unknown
- 1986-12-16 FI FI865122A patent/FI865122A7/fi not_active Application Discontinuation
- 1986-12-17 DK DK608686A patent/DK158737C/da not_active IP Right Cessation
- 1986-12-17 KR KR860010834A patent/KR870006055A/ko not_active Withdrawn
- 1986-12-18 JP JP61300173A patent/JPH0764848B2/ja not_active Expired - Lifetime
1988
- 1988-06-22 US US07/210,061 patent/US4894378A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4894378A (en)	1990-01-16
JPH0764848B2 (ja)	1995-07-12
DK158737B (da)	1990-07-09
JPS62155280A (ja)	1987-07-10
EP0229963A3 (en)	1987-11-25
EP0229963A2 (de)	1987-07-29
KR870006055A (ko)	1987-07-09
EP0229963B1 (de)	1991-09-11
DK158737C (da)	1990-11-26
DE3681432D1 (de)	1991-10-17
ATE67204T1 (de)	1991-09-15
US4801715A (en)	1989-01-31
ES2037657T3 (es)	1996-07-16
DE3544693A1 (de)	1987-06-19
FI865122A0 (fi)	1986-12-16
IL80976A0 (en)	1987-03-31
DK608686D0 (da)	1986-12-17
FI865122A7 (fi)	1987-06-19

Legal Events

Date	Code	Title	Description
1992-08-24	PBP	Patent lapsed

Publication	Publication Date	Title
AU588045B2 (en)	1989-09-07	Bactericidal formulations for use in the area of veterinary medicine
NO875299L (no)	1987-12-17	Insulinpreparat for ikke-paranteral administrasjon.
NO171365C (no)	1993-03-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO883994D0 (no)	1988-09-08	Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidinylaminer.
DK0598770T3 (da)	1997-12-15	Pyrazinderivater samt fremstilling og anvendelse deraf
ATE82120T1 (de)	1992-11-15	Kalziumzusaetze.
AU5552886A (en)	1986-10-09	Amino propanol derivatives
ES2106096T3 (es)	1997-11-01	Procedimiento para asegurar glutation intracelular adecuado en el tejido.
DK608686D0 (da)	1986-12-17	4-thienyl-dihydropyridiner, fremgangsmaade til deres fremstilling og deres anvendelse i laegemidler
DK423289A (da)	1990-03-01	Sulfonamider med tetrazolylrest, fremgangsmaade til deres fremstilling samt laegemiddel
NO861923L (no)	1986-11-18	Nye isoksazolderivater, fremgangsmaate til deres fremstilling, og farmasoeytiske preparater inneholdende dem.
IL75742A0 (en)	1985-11-29	Phenylethylaminopropiophenone derivatives,their preparation and pharmaceutical compositions containing them
ES2001104A6 (es)	1988-04-16	Un procedimiento para la preparacion de nuevos derivados sustituidos del acido 1,4-dihidro-3,5-piridindicarboxilico.