DK60993A - Laegemiddel indeholdende en aprotininhomolog samt anvendelse af aprotininhomologe til fremstilling af et laegemiddel - Google Patents

Laegemiddel indeholdende en aprotininhomolog samt anvendelse af aprotininhomologe til fremstilling af et laegemiddel

Info

Publication number
DK60993A
DK60993A DK060993A DK60993A DK60993A DK 60993 A DK60993 A DK 60993A DK 060993 A DK060993 A DK 060993A DK 60993 A DK60993 A DK 60993A DK 60993 A DK60993 A DK 60993A
Authority
DK
Denmark
Prior art keywords
inhomologist
aprotin
medicine
prepare
product containing
Prior art date
Application number
DK060993A
Other languages
English (en)
Other versions
DK171441B1 (da
DK60993D0 (da
Inventor
Harald Tschesche
Herbert Wenzel
Rainer Schmuck
Eugen Schnabel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833339693 external-priority patent/DE3339693A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK60993A publication Critical patent/DK60993A/da
Publication of DK60993D0 publication Critical patent/DK60993D0/da
Application granted granted Critical
Publication of DK171441B1 publication Critical patent/DK171441B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK060993A 1983-07-28 1993-05-27 Lægemiddel indeholdende mindst en aprotininhomolog DK171441B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3327277 1983-07-28
DE3327277 1983-07-28
DE3339693 1983-11-03
DE19833339693 DE3339693A1 (de) 1983-11-03 1983-11-03 Homologe des aprotinin mit anderen aminosaeuren in position 15 anstelle von lysin, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
DK60993A true DK60993A (da) 1993-05-27
DK60993D0 DK60993D0 (da) 1993-05-27
DK171441B1 DK171441B1 (da) 1996-10-28

Family

ID=25812701

Family Applications (2)

Application Number Title Priority Date Filing Date
DK369284A DK171895B1 (da) 1983-07-28 1984-07-27 Aprotininhomologe med andre aminosyrer i stilling 15 i stedet for lysin, fremgangsmåde til deres fremstilling samt mellemprodukter ved fremstillingen
DK060993A DK171441B1 (da) 1983-07-28 1993-05-27 Lægemiddel indeholdende mindst en aprotininhomolog

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK369284A DK171895B1 (da) 1983-07-28 1984-07-27 Aprotininhomologe med andre aminosyrer i stilling 15 i stedet for lysin, fremgangsmåde til deres fremstilling samt mellemprodukter ved fremstillingen

Country Status (14)

Country Link
US (1) US4595674A (da)
EP (1) EP0132732B1 (da)
JP (1) JPH0686479B2 (da)
KR (1) KR890004784B1 (da)
AU (1) AU560584B2 (da)
CA (1) CA1238000A (da)
DE (1) DE3471940D1 (da)
DK (2) DK171895B1 (da)
ES (1) ES8601858A1 (da)
GR (1) GR82265B (da)
HU (1) HU199880B (da)
IE (1) IE57628B1 (da)
IL (1) IL72494A (da)
NZ (1) NZ209001A (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
DE3587526T3 (de) * 1984-12-06 2002-08-08 Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks Serinproteaseinhibitoren und isolierungsverfahren dazu.
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
FI854634A0 (fi) * 1985-11-22 1985-11-22 Labsystems Oy Foerfarande foer bestaemning av proteolytisk aktivitet.
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
US5187153A (en) * 1986-11-17 1993-02-16 Scios Nova Inc. Methods of treatment using Alzheimer's amyloid polypeptide derivatives
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
US5220013A (en) * 1986-11-17 1993-06-15 Scios Nova Inc. DNA sequence useful for the detection of Alzheimer's disease
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
US5032573A (en) * 1987-03-23 1991-07-16 Bayer Aktiengesellschaft Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
JP2656944B2 (ja) * 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
CA2047702C (en) * 1989-03-06 2000-10-24 Joseph F. Sambrook Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
ATE114332T1 (de) * 1989-05-13 1994-12-15 Bayer Ag Proteinaseninhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel.
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
CA2105304C (en) * 1991-03-01 2005-10-04 Arthur C. Ley Inhibitors of human neutrophil elastase and human cathepsin g
EP0575485A1 (en) * 1991-03-01 1993-12-29 Dyax Corp. Process for the development of binding mini-proteins
CA2139945A1 (en) * 1992-07-13 1994-01-20 Ignace Lasters Bovine pancreatic trypsin inhibitor derived inhibitors of factor xa
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
TW492975B (en) * 1993-07-26 2002-07-01 Novartis Ag Tryptase inhibitor
ES2229236T3 (es) 1994-01-11 2005-04-16 Dyax Corporation Inhibidores de la plasmina humana derivados de los dominios de kunitz.
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz
DE19629982A1 (de) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
KR20040004562A (ko) * 2001-03-27 2004-01-13 어웨어, 인크. 수신기 투과성 ｑ-모드
EP1406652A2 (en) * 2001-07-10 2004-04-14 Omnio AB Novel drug targets for arthritis
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
WO2003103475A2 (en) 2002-06-07 2003-12-18 Dyax Corp. Prevention and reduction of blood loss
JP2005537006A (ja) 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
DK1587907T3 (da) * 2003-01-07 2011-04-04 Dyax Corp Kunitz-domænebibliotek
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7432238B2 (en) * 2004-04-16 2008-10-07 Stc.Unm Human Kunitz-type inhibitor with enhanced antifibrinolytic activity
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20090223893A1 (en) * 2005-12-01 2009-09-10 Gjerde Douglas T Method and Device for Desalting an Analyte
US20060118491A1 (en) * 2004-12-03 2006-06-08 Gjerde Douglas T Method and device for desalting an analyte
ES2431526T3 (es) 2005-12-29 2013-11-26 The Regents Of The University Of California Office Of Technology Transfer Procedimientos y composiciones relacionadas con el dominio Kunitz I mutante de TFPI-2
WO2008110301A1 (de) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Aprotinin-varianten mit verbesserten eigenschaften
CA2744235A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (en) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
CA2823776A1 (en) 2011-01-06 2012-07-12 Dyax Corp. Plasma kallikrein binding proteins
IL295414B2 (en) 2014-03-27 2026-02-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema due to diabetes
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US12528880B2 (en) 2020-01-13 2026-01-20 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Also Published As

Publication number Publication date
CA1238000A (en) 1988-06-14
DK369284A (da) 1985-01-29
ES534659A0 (es) 1985-11-16
JPH0686479B2 (ja) 1994-11-02
DK369284D0 (da) 1984-07-27
IL72494A0 (en) 1984-11-30
JPS6056999A (ja) 1985-04-02
ES8601858A1 (es) 1985-11-16
DE3471940D1 (en) 1988-07-14
EP0132732A3 (en) 1986-02-05
AU560584B2 (en) 1987-04-09
GR82265B (da) 1984-12-13
HUT34515A (en) 1985-03-28
KR850001288A (ko) 1985-03-18
HU199880B (en) 1990-03-28
EP0132732A2 (de) 1985-02-13
NZ209001A (en) 1989-02-24
IL72494A (en) 1988-02-29
KR890004784B1 (ko) 1989-11-27
DK171441B1 (da) 1996-10-28
US4595674A (en) 1986-06-17
IE841954L (en) 1985-01-28
AU3000184A (en) 1985-01-31
DK60993D0 (da) 1993-05-27
EP0132732B1 (de) 1988-06-08
DK171895B1 (da) 1997-08-04
IE57628B1 (en) 1993-02-10

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Legal Events

Date Code Title Description
A0 Application filed
B1 Patent granted (law 1993)
PBP Patent lapsed