DK617288A - Renin-inhibitorer, deres fremstilling og anvendelse - Google Patents

Renin-inhibitorer, deres fremstilling og anvendelse

Info

Publication number
DK617288A
DK617288A DK617288A DK617288A DK617288A DK 617288 A DK617288 A DK 617288A DK 617288 A DK617288 A DK 617288A DK 617288 A DK617288 A DK 617288A DK 617288 A DK617288 A DK 617288A
Authority
DK
Denmark
Prior art keywords
inhibitors
cleaning
preparation
cleaning inhibitors
Prior art date
Application number
DK617288A
Other languages
Danish (da)
English (en)
Other versions
DK617288D0 (da
Inventor
Heinz-Werner Kleemann
Hansjoerg Urbach
Dieter Ruppert
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK617288D0 publication Critical patent/DK617288D0/da
Publication of DK617288A publication Critical patent/DK617288A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK617288A 1987-11-05 1988-11-04 Renin-inhibitorer, deres fremstilling og anvendelse DK617288A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3737498 1987-11-05
DE3818436 1988-05-31

Publications (2)

Publication Number Publication Date
DK617288D0 DK617288D0 (da) 1988-11-04
DK617288A true DK617288A (da) 1989-05-06

Family

ID=25861468

Family Applications (1)

Application Number Title Priority Date Filing Date
DK617288A DK617288A (da) 1987-11-05 1988-11-04 Renin-inhibitorer, deres fremstilling og anvendelse

Country Status (11)

Country Link
US (1) US5169841A (fr)
EP (1) EP0315574A3 (fr)
JP (1) JPH01163185A (fr)
KR (1) KR890008170A (fr)
AU (1) AU608379B2 (fr)
DK (1) DK617288A (fr)
FI (1) FI885068L (fr)
IL (1) IL88273A0 (fr)
NO (1) NO884925L (fr)
NZ (1) NZ226826A (fr)
PT (1) PT88949B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242904A (en) * 1987-06-05 1993-09-07 The Dupont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE3827340A1 (de) * 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
JPH07505875A (ja) * 1992-04-16 1995-06-29 ゼネカ・リミテッド α−アミノボロン酸ペプチドおよびエラスターゼ阻害物質としてのそれらの用途
JPH07505877A (ja) * 1992-04-16 1995-06-29 ゼネカ・リミテッド α−アミノボロン酸ペプチド及びエラスターゼ阻害剤としてのそれらの使用
US5442100A (en) * 1992-08-14 1995-08-15 The Procter & Gamble Company β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IL111175A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
US6060462A (en) * 1993-10-20 2000-05-09 Dupont Pharmaceuticals Company Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5693617A (en) * 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
FR2718451B1 (fr) * 1994-04-12 1996-05-10 Synthelabo Dérivés de peptides boroniques, leur préparation et leur application en thérapeutique.
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5639739A (en) * 1995-03-24 1997-06-17 The Dupont Merck Pharmaceutical Company Imidazole containing aminoboronic acids
FR2739858B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de n-sulfonyl- et n-sulfamoylpeptidylprolinamide, leur preparation et leur application en therapeutique
WO2002054931A2 (fr) * 2001-01-10 2002-07-18 Bristol Myers Squibb Company P Acides alpha-aminoboroniques prepares par de nouvelles methodes de synthese
PT3078667T (pt) * 2001-01-25 2018-12-28 The United States Of America Represented By The Sec Dep Of Health And Human Services Formulação de compostos de ácido borónico
CA2446282A1 (fr) 2001-05-30 2002-12-05 Novartis Ag Derives d'acide 2-{[n-(2-amino-3-(heteroaryl ou aryl)propionyl)-aminoacyl]-amino}-alkylboronique
US20050282757A1 (en) * 2002-09-09 2005-12-22 Trigen Limited Peptide boronic acid compounds useful in anticoagulation
AU2003263343A1 (en) 2002-09-09 2004-03-29 Trigen Limited Boronic acid salts ant their use in the treatment of thromobis
US7112572B2 (en) * 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
US20050119226A1 (en) * 2003-09-09 2005-06-02 Trigen Limited Methods for synthesizing organoboronic compounds and products thereof
US20050176651A1 (en) * 2002-09-09 2005-08-11 Trigen Limited Peptide boronic acids useful in making salts thereof
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
US7223745B2 (en) * 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
RS53259B (sr) * 2004-03-30 2014-08-29 Millennium Pharmaceuticals Inc. Sinteza bortezomiba
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US20070059382A1 (en) * 2005-09-09 2007-03-15 Board Of Regents, Univ. And Comm. College System Of Nevada... Medical treatment of breast cancer with boric acid materials
EP2178888B1 (fr) 2007-08-06 2012-07-04 Millennium Pharmaceuticals, Inc. Inhibiteurs de protéasomes
US7838673B2 (en) * 2007-10-16 2010-11-23 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
JP5746612B2 (ja) 2008-03-19 2015-07-08 オーリムメッド・ファルマ・インコーポレーテッド 中枢神経系疾患および障害の治療に有効な新規化合物
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
US20210130285A1 (en) 2008-03-19 2021-05-06 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
US9212155B2 (en) 2008-03-19 2015-12-15 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
HRP20150592T4 (hr) 2008-06-17 2025-02-14 Millennium Pharmaceuticals, Inc Organoborni esterski spojevi i njihove farmaceutske kompozicije
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
EP2344165A4 (fr) * 2008-10-01 2012-12-05 Reddys Lab Ltd Dr Compositions pharmaceutiques comprenant des composés d acide boronique
EP2270019A1 (fr) 2009-06-19 2011-01-05 LEK Pharmaceuticals d.d. Nouvelle voie de synthèse pour la préparation d'esters boronique alpha-aminé
EP2280016A1 (fr) 2009-07-27 2011-02-02 LEK Pharmaceuticals d.d. Nouvelle voie de synthèse pour la préparation d'esters boroniques aminés via des Alk-1-ynes substitués
AU2010261710A1 (en) 2009-06-19 2012-01-19 Lek Pharmaceuticals D.D. Process for hydrogenation of halogenoalkenes without dehalogenation
WO2011022502A1 (fr) 2009-08-18 2011-02-24 Georgetown University Compositions d'acide boronique et procédés se rapportant au cancer
WO2011087822A1 (fr) 2009-12-22 2011-07-21 Cephalon, Inc. Inhibiteurs du protéasome et leurs procédés de préparation, d'épuration et d'utilisation
JP5933523B2 (ja) 2010-03-31 2016-06-08 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． １−アミノ−２−シクロプロピルエチルボロン酸の誘導体
AU2011312264B2 (en) 2010-10-05 2015-07-02 Fresenius Kabi Usa, Llc Bortezomib formulations stabilised with boric acid
EP2819673B1 (fr) 2012-03-02 2016-09-07 Dr. Reddy's Laboratories Ltd. Compositions pharmaceutiques comprenant des composés acide boronique
WO2014072985A1 (fr) 2012-11-06 2014-05-15 Natco Pharma Limited Nouveaux dérivés d'acide boronique an tant qu'agents anticancéreux
WO2014170628A1 (fr) 2013-04-16 2014-10-23 Cipla Limited Procédé pour la préparation d'ester de mannitol du bortézomib
US10478445B2 (en) 2013-07-03 2019-11-19 Georgetown University Boronic acid derivatives of resveratrol for activating deacetylase enzymes
WO2015117136A1 (fr) 2014-02-03 2015-08-06 Ohio State Innovation Foundation Esters d'acide boronique et leurs formulations pharmaceutiques
SG10202003693RA (en) 2014-05-20 2020-05-28 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
EP3270891A1 (fr) 2015-03-17 2018-01-24 Leon-Nanodrugs GmbH Nanoparticules comprenant un composé d'acide boronique stabilisé
WO2016205790A2 (fr) 2015-06-19 2016-12-22 Hanlin Scientific, Inc. Composés spécifiques chiraux à base de bore et leur utilisation dans le traitement du cancer ou de l'amyloïdose
WO2017222914A1 (fr) 2016-06-21 2017-12-28 Inception 4, Inc. Dérivés de prolinamide carbocycliques
EP4257191A3 (fr) 2016-06-21 2023-11-22 Orion Ophthalmology LLC Dérivés hétérocycliques de prolinamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) * 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE3827340A1 (de) * 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen

Also Published As

Publication number Publication date
EP0315574A2 (fr) 1989-05-10
FI885068A0 (fi) 1988-11-03
FI885068A7 (fi) 1989-05-06
JPH01163185A (ja) 1989-06-27
AU608379B2 (en) 1991-03-28
KR890008170A (ko) 1989-07-10
AU2469388A (en) 1989-05-11
NZ226826A (en) 1991-06-25
PT88949A (pt) 1988-12-01
IL88273A0 (en) 1989-06-30
NO884925D0 (no) 1988-11-04
PT88949B (pt) 1993-02-26
EP0315574A3 (fr) 1990-08-22
NO884925L (no) 1989-05-08
FI885068L (fi) 1989-05-06
US5169841A (en) 1992-12-08
DK617288D0 (da) 1988-11-04

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Legal Events

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