DK625889A - Serinprotease-inhibitor-proteiner, laegemidler indeholdende disse, dna-sekvenser, som koder for disse proteiner, og fremgangsmaader til fremstilling af disse proteiner, laegemidler og dna-sekvenser - Google Patents

Serinprotease-inhibitor-proteiner, laegemidler indeholdende disse, dna-sekvenser, som koder for disse proteiner, og fremgangsmaader til fremstilling af disse proteiner, laegemidler og dna-sekvenser Download PDF

Info

Publication number: DK625889A
Authority: DK; Denmark
Prior art keywords: proteins; synthesis; dna sequences; dna; image
Prior art date: 1988-12-13

Application number

DK625889A

Other languages

Danish (da)

English (en)

Other versions

DK625889D0 (da

Inventor

Regina Heinzel-Wieland

Joachim Ammann

Gerd Josef Steffens

Leopold Flohe

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-13

Filing date

1989-12-12

Publication date

1990-06-14

1989-12-12 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

1989-12-12 Publication of DK625889D0 publication Critical patent/DK625889D0/da

1990-06-14 Publication of DK625889A publication Critical patent/DK625889A/da

Links

108091028043 Nucleic acid sequence Proteins 0.000 title abstract 9
108090000623 proteins and genes Proteins 0.000 title abstract 8
102000004169 proteins and genes Human genes 0.000 title abstract 8
239000003814 drug Substances 0.000 title abstract 5
101710102218 Serine protease inhibitor Proteins 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 6
235000018102 proteins Nutrition 0.000 abstract 6
238000003786 synthesis reaction Methods 0.000 abstract 6
101150080498 ALP gene Proteins 0.000 abstract 4
108091034117 Oligonucleotide Proteins 0.000 abstract 4
108020004414 DNA Proteins 0.000 abstract 3
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 3
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 2
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 2
239000004475 Arginine Chemical group 0.000 abstract 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Chemical group OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
102100033174 Neutrophil elastase Human genes 0.000 abstract 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
239000004220 glutamic acid Chemical group 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
108091006086 inhibitor proteins Proteins 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
229960000310 isoleucine Drugs 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cardiology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

DK625889A 1988-12-13 1989-12-12 Serinprotease-inhibitor-proteiner, laegemidler indeholdende disse, dna-sekvenser, som koder for disse proteiner, og fremgangsmaader til fremstilling af disse proteiner, laegemidler og dna-sekvenser DK625889A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3841873A DE3841873A1 (de)	1988-12-13	1988-12-13	Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen

Publications (2)

Publication Number	Publication Date
DK625889D0 DK625889D0 (da)	1989-12-12
DK625889A true DK625889A (da)	1990-06-14

Family

ID=6369020

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK625889A DK625889A (da)	1988-12-13	1989-12-12	Serinprotease-inhibitor-proteiner, laegemidler indeholdende disse, dna-sekvenser, som koder for disse proteiner, og fremgangsmaader til fremstilling af disse proteiner, laegemidler og dna-sekvenser

Country Status (13)

Country	Link
EP (1)	EP0373335B1 (fr)
JP (1)	JP2915032B2 (fr)
AT (1)	ATE161019T1 (fr)
AU (1)	AU618430B2 (fr)
CA (1)	CA2002047A1 (fr)
DE (2)	DE3841873A1 (fr)
DK (1)	DK625889A (fr)
ES (1)	ES2112826T3 (fr)
HK (1)	HK1005337A1 (fr)
HU (1)	HUT54208A (fr)
IL (1)	IL92170A0 (fr)
PT (1)	PT92552B (fr)
ZA (1)	ZA898395B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI963753L (fi) *	1994-03-23	1996-09-20	Tokyo Tanabe Co	Uusi lääke hengitysteiden virustaudin hoitamiseksi
DE19800363A1 (de) *	1998-01-08	1999-07-15	Forssmann Wolf Georg Prof Dr	Serin-Proteinase-Inhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4760130A (en) *	1984-12-06	1988-07-26	Synergen Biologicals, Inc.	Serine protease inhibitors and methods for isolation of same
AU591474B2 (en) *	1984-12-06	1989-12-07	Amgen, Inc.	Serine protease inhibitors and methods for isolation of same
DE3600571A1 (de) *	1986-01-10	1987-08-06	Gruenenthal Gmbh	Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
CA1340877C (fr) *	1987-12-28	2000-01-18	Takashi Sugiyama	Polypeptide inhibant l'elastage et procede de production par la technologie de l'adn recombinant

1988
- 1988-12-13 DE DE3841873A patent/DE3841873A1/de not_active Withdrawn
1989
- 1989-10-31 AT AT89120173T patent/ATE161019T1/de not_active IP Right Cessation
- 1989-10-31 ES ES89120173T patent/ES2112826T3/es not_active Expired - Lifetime
- 1989-10-31 EP EP89120173A patent/EP0373335B1/fr not_active Expired - Lifetime
- 1989-10-31 DE DE58909824T patent/DE58909824D1/de not_active Expired - Fee Related
- 1989-10-31 IL IL92170A patent/IL92170A0/xx unknown
- 1989-11-02 CA CA002002047A patent/CA2002047A1/fr not_active Abandoned
- 1989-11-03 ZA ZA898395A patent/ZA898395B/xx unknown
- 1989-11-22 HU HU896124A patent/HUT54208A/hu unknown
- 1989-12-07 AU AU46026/89A patent/AU618430B2/en not_active Ceased
- 1989-12-12 PT PT92552A patent/PT92552B/pt not_active IP Right Cessation
- 1989-12-12 DK DK625889A patent/DK625889A/da not_active Application Discontinuation
- 1989-12-13 JP JP1323682A patent/JP2915032B2/ja not_active Expired - Lifetime
1998
- 1998-05-15 HK HK98104214A patent/HK1005337A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT92552B (pt)	1999-02-26
AU4602689A (en)	1990-06-21
JP2915032B2 (ja)	1999-07-05
EP0373335B1 (fr)	1997-12-10
DK625889D0 (da)	1989-12-12
CA2002047A1 (fr)	1990-06-13
JPH03123490A (ja)	1991-05-27
EP0373335A3 (fr)	1990-08-22
IL92170A0 (en)	1990-07-12
ATE161019T1 (de)	1997-12-15
PT92552A (pt)	1990-06-29
HU896124D0 (en)	1990-02-28
HUT54208A (en)	1991-01-28
HK1005337A1 (en)	1998-12-31
DE58909824D1 (de)	1998-01-22
DE3841873A1 (de)	1990-06-21
ZA898395B (en)	1990-10-31
AU618430B2 (en)	1991-12-19
ES2112826T3 (es)	1998-04-16
EP0373335A2 (fr)	1990-06-20

Legal Events

Date	Code	Title	Description
1997-08-25	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
ATE78040T1 (de)	1992-07-15	Oligopeptide sowie zwischenprodukte und verfahren zu ihrer herstellung.
ATE196650T1 (de)	2000-10-15	Stabile bakterizide proteine, welche die permeabilität erhöhen und pharmazeutische zusammensetzungen, diese enthaltend
DE60320362D1 (de)	2008-05-29	Verfahren zur Herstellung von Dipeptiden
NO20073914L (no)	2004-03-10	Biologisk aktive peptider
CA2334941A1 (fr)	2000-02-24	Peptides derives du tnf utilises dans le traitement des oedemes
MY147920A (en)	2013-02-15	Antibacterial and antiviral peptides from actinomadura namibiensis
DK625889A (da)	1990-06-14	Serinprotease-inhibitor-proteiner, laegemidler indeholdende disse, dna-sekvenser, som koder for disse proteiner, og fremgangsmaader til fremstilling af disse proteiner, laegemidler og dna-sekvenser
DK0640098T3 (da)	2002-10-28	S-gen fra hundecoronavirus og anvendelser deraf
ATE452903T1 (de)	2010-01-15	Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten
RU95109909A (ru)	1997-03-27	Способ ингибирования ретровирусной инфекции, ингибитор протеазы, кодирующая его нуклеиновая кислота и способ рекомбинантного продуцирования серинового ингибитора
ATE235509T1 (de)	2003-04-15	Peptide zur inhibition von hpv e7 proteinen
ATE394364T1 (de)	2008-05-15	Reinigungsverfahren von n-(1(s)-ethoxycarbonyl-3- phenylpropyl)-l-alanin