DK633088A - Kollagenaseinhibitorer - Google Patents

Kollagenaseinhibitorer

Info

Publication number: DK633088A
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; chem; optionally substituted; collagenase
Prior art date: 1987-11-14

Application number

DK633088A

Other languages

English (en)

Other versions

DK633088D0 (da

Inventor

David James Hunter

Roger Edward Markwell

Robert William Ward

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-14

Filing date

1988-11-11

Publication date

1989-05-15

1988-11-11 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1988-11-11 Publication of DK633088D0 publication Critical patent/DK633088D0/da

1989-05-15 Publication of DK633088A publication Critical patent/DK633088A/da

Links

102000029816 Collagenase Human genes 0.000 title 1
108060005980 Collagenase Proteins 0.000 title 1
229960002424 collagenase Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
239000002442 collagenase inhibitor Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK633088A 1987-11-14 1988-11-11 Kollagenaseinhibitorer DK633088A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878726714A GB8726714D0 (en)	1987-11-14	1987-11-14	Compounds

Publications (2)

Publication Number	Publication Date
DK633088D0 DK633088D0 (da)	1988-11-11
DK633088A true DK633088A (da)	1989-05-15

Family

ID=10626975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK633088A DK633088A (da)	1987-11-14	1988-11-11	Kollagenaseinhibitorer

Country Status (15)

Country	Link
US (1)	US4935404A (da)
EP (1)	EP0320118B1 (da)
JP (1)	JPH01160992A (da)
KR (1)	KR890008155A (da)
AT (1)	ATE90107T1 (da)
AU (1)	AU609900B2 (da)
CA (1)	CA1322076C (da)
DE (1)	DE3881489T2 (da)
DK (1)	DK633088A (da)
ES (1)	ES2054826T3 (da)
GB (1)	GB8726714D0 (da)
IE (1)	IE883391L (da)
NZ (1)	NZ226930A (da)
PT (1)	PT88992B (da)
ZA (1)	ZA888448B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5212163A (en) *	1989-04-13	1993-05-18	Beecham Group P.L.C.	Compounds
EP0401963A1 (en) *	1989-04-13	1990-12-12	Beecham Group p.l.c.	Phosphonopeptides with collagenase inhibiting activity
GB8921326D0 (en) *	1989-09-21	1989-11-08	Beecham Group Plc	Novel treatment
FR2654430B1 (fr) *	1989-11-15	1995-01-06	Commissariat Energie Atomique	Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
GB9008078D0 (en) *	1990-04-10	1990-06-06	Beecham Group Plc	Novel compounds
GB9008065D0 (en) *	1990-04-10	1990-06-06	Beecham Group Plc	Novel compounds
US5155100A (en) *	1991-05-01	1992-10-13	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) *	1991-05-01	1994-03-15	Ciba-Geigy Corporation	Phosphono/biaryl substituted dipetide derivatives
EP0520573A1 (en) *	1991-06-27	1992-12-30	Glaxo Inc.	Cyclic imide derivatives
US5250522A (en) *	1992-10-09	1993-10-05	Ciba-Geigy Corporation	Phosphono/biaryl substituted amino acid derivatives
GB9122859D0 (en) *	1991-10-28	1991-12-11	Smithkline Beecham Plc	Novel compounds
JPH05148277A (ja) *	1991-11-05	1993-06-15	Banyu Pharmaceut Co Ltd	アミノホスホン酸誘導体
US5504070A (en) *	1991-12-05	1996-04-02	Berlex Laboratories, Inc.	Inhibitors of the conversion of big endothelin to endothelin
US5270365A (en) *	1991-12-17	1993-12-14	Merck & Co., Inc.	Prevention and treatment of periodontal disease with alendronate
AU3475393A (en) *	1992-01-15	1993-08-03	Merck & Co., Inc.	Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
EP0639982A1 (en) *	1992-05-01	1995-03-01	British Biotech Pharmaceuticals Limited	Use of mmp inhibitors
US5326760A (en) *	1992-06-29	1994-07-05	Glaxo, Inc.	Aminobutanoic acid compounds having metalloprotease inhibiting properties
WO1994007481A1 (en) *	1992-10-02	1994-04-14	Merck & Co., Inc.	N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents
US6090785A (en) *	1992-10-15	2000-07-18	Merck & Co., Inc.	Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
US5672583A (en) *	1992-11-25	1997-09-30	Merck & Co., Inc.	Carboxy-peptidyl derivatives as antidegenerative active agents
US5608078A (en) *	1993-03-30	1997-03-04	Merrell Pharmaceuticals Inc.	Phosphonomethyldipeptides and process for preparation thereof
EP0618224A1 (en) *	1993-03-30	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Phosphonomethyldipeptides
CA2160139A1 (en) *	1993-04-07	1994-10-13	Richard Edward Galardy	Synthetic matrix metalloprotease inhibitors and uses thereof
US5831004A (en) *	1994-10-27	1998-11-03	Affymax Technologies N.V.	Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) *	1994-10-27	1998-11-24	Affymax Technologies N.V.	Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6953788B1 (en)	1996-09-19	2005-10-11	Aventis Pharmaceuticals Inc.	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6117841A (en) *	1997-05-30	2000-09-12	Warner-Lambert Company	Substituted peptidylamine calcium channel blockers
EP0922702A1 (de) *	1997-12-13	1999-06-16	Roche Diagnostics GmbH	Neue Azulenderivate und diese enthaltende Arzneimittel
PE20010659A1 (es)	1999-10-01	2001-06-20	Hoffmann La Roche	Derivados de las pirimidin-2,4,6-trionas como inhibidores de metaloproteasas
US6716845B2 (en)	2001-03-30	2004-04-06	Hoffmann-La Roche Inc.	Barbituric acid derivatives
US7420000B2 (en) *	2003-09-10	2008-09-02	University Of Southern California	Amino phosphonate and amino bis-phosphonate derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950402A (en) *	1972-05-31	1976-04-13	Monsanto Company	Process for producing N-phosphonomethyl glycine
IL48835A (en) *	1975-01-27	1979-05-31	Sparamedica Ag	Amino acyl and peptidyl derivatives of phophonic acids, their preparation and pharmaceutical compositions containingthem
EP0002039A1 (en) *	1977-11-19	1979-05-30	Ciba-Geigy Ag	Phosphonous acid derivatives, processes for their preparation and their use in combating microorganisms
US4331591A (en) *	1978-10-05	1982-05-25	Ciba-Geigy Corporation	Chemical process for the production of α-aminophosphonic acids and peptide derivatives
US4389349A (en) *	1982-01-25	1983-06-21	Cho Hung H	Process for preparing of N-phosphenomethyl glycine
US4661298A (en) *	1983-08-31	1987-04-28	Stauffer Chemical Company	Process for the formation of phosphonoalkylated amino acids
US4804500A (en) *	1985-04-22	1989-02-14	Monsanto Company	Amine dealkylation process

1987
- 1987-11-14 GB GB878726714A patent/GB8726714D0/en active Pending
1988
- 1988-11-08 AT AT88310492T patent/ATE90107T1/de not_active IP Right Cessation
- 1988-11-08 ES ES88310492T patent/ES2054826T3/es not_active Expired - Lifetime
- 1988-11-08 EP EP88310492A patent/EP0320118B1/en not_active Expired - Lifetime
- 1988-11-08 DE DE8888310492T patent/DE3881489T2/de not_active Expired - Fee Related
- 1988-11-10 CA CA000582852A patent/CA1322076C/en not_active Expired - Fee Related
- 1988-11-11 NZ NZ226930A patent/NZ226930A/en unknown
- 1988-11-11 PT PT88992A patent/PT88992B/pt active IP Right Grant
- 1988-11-11 IE IE883391A patent/IE883391L/xx unknown
- 1988-11-11 ZA ZA888448A patent/ZA888448B/xx unknown
- 1988-11-11 DK DK633088A patent/DK633088A/da not_active Application Discontinuation
- 1988-11-11 AU AU25070/88A patent/AU609900B2/en not_active Ceased
- 1988-11-12 KR KR1019880014928A patent/KR890008155A/ko not_active Ceased
- 1988-11-14 JP JP63285958A patent/JPH01160992A/ja active Pending
- 1988-11-14 US US07/270,085 patent/US4935404A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT88992A (pt)	1988-12-01
JPH01160992A (ja)	1989-06-23
KR890008155A (ko)	1989-07-10
ZA888448B (en)	1989-10-25
EP0320118B1 (en)	1993-06-02
DK633088D0 (da)	1988-11-11
DE3881489D1 (de)	1993-07-08
ES2054826T3 (es)	1994-08-16
CA1322076C (en)	1993-09-07
US4935404A (en)	1990-06-19
DE3881489T2 (de)	1993-09-16
NZ226930A (en)	1991-07-26
AU2507088A (en)	1989-05-25
EP0320118A3 (en)	1990-07-04
PT88992B (pt)	1993-02-26
AU609900B2 (en)	1991-05-09
ATE90107T1 (de)	1993-06-15
IE883391L (en)	1989-05-14
GB8726714D0 (en)	1987-12-16
EP0320118A2 (en)	1989-06-14

Legal Events

Date	Code	Title	Description
1995-07-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK633088D0 (da)	1988-11-11	Hidtil ukendte forbindelser
DK114783A (da)	1983-09-11	Hidtil ukendte forbindelser, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DE3069408D1 (en)	1984-11-15	5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
TW368501B (en)	1999-09-01	7-(2-aminoethyl)-benzothiazolones
DK0479546T3 (da)	1996-11-25	Piperazinderivater
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
PT90912A (pt)	1989-12-29	Processo para a preparacao de derivados de tiofenol
GB8729804D0 (en)	1988-02-03	Novel compounds
PL243132A1 (en)	1985-03-12	Process for manufacturing novel muramyl peptides
ES2016017A6 (es)	1990-10-01	Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
ATE23147T1 (de)	1986-11-15	Ungesaettigte verbindungen, ihre herstellung und anwendung.
ATE67194T1 (de)	1991-09-15	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
ATE39688T1 (de)	1989-01-15	Verfahren zur herstellung von aminotriazinonderivaten.
FI863897L (fi)	1988-03-27	Kemiskt foerfarande.
DE69022660D1 (de)	1995-11-02	Verfahren zur Herstellung von Carbamatderivaten des Lankacidines.
MY104164A (en)	1994-02-28	Heterocyclic compounds.