DK661088A - N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre, fremgangsmaade til deres fremstilling og farmaceutiske midelr indeholdende dem - Google Patents

N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre, fremgangsmaade til deres fremstilling og farmaceutiske midelr indeholdende dem

Info

Publication number
DK661088A
DK661088A DK661088A DK661088A DK661088A DK 661088 A DK661088 A DK 661088A DK 661088 A DK661088 A DK 661088A DK 661088 A DK661088 A DK 661088A DK 661088 A DK661088 A DK 661088A
Authority
DK
Denmark
Prior art keywords
radical
carbon atoms
vinblastinoyl
derivatives
linear
Prior art date
Application number
DK661088A
Other languages
English (en)
Other versions
DK168386B1 (da
DK661088D0 (da
Inventor
Gilbert Lavielle
Patrick Hautefaye
Claude Cudennec
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of DK661088D0 publication Critical patent/DK661088D0/da
Publication of DK661088A publication Critical patent/DK661088A/da
Application granted granted Critical
Publication of DK168386B1 publication Critical patent/DK168386B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK661088A 1987-11-25 1988-11-25 N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre og en fremgangsmåde til deres fremstilling DK168386B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8716327 1987-11-25
FR8716327A FR2623504B1 (fr) 1987-11-25 1987-11-25 Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
DK661088D0 DK661088D0 (da) 1988-11-25
DK661088A true DK661088A (da) 1989-05-26
DK168386B1 DK168386B1 (da) 1994-03-21

Family

ID=9357148

Family Applications (1)

Application Number Title Priority Date Filing Date
DK661088A DK168386B1 (da) 1987-11-25 1988-11-25 N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre og en fremgangsmåde til deres fremstilling

Country Status (16)

Country Link
US (1) US4946833A (da)
EP (1) EP0318392B1 (da)
JP (1) JPH02189A (da)
AT (1) ATE74924T1 (da)
AU (1) AU607554B2 (da)
CA (1) CA1315278C (da)
DE (1) DE3870167D1 (da)
DK (1) DK168386B1 (da)
ES (1) ES2032217T3 (da)
FR (1) FR2623504B1 (da)
GR (1) GR3005101T3 (da)
IE (1) IE61031B1 (da)
NZ (1) NZ227082A (da)
OA (1) OA08972A (da)
PT (1) PT89082B (da)
ZA (1) ZA888853B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632643B1 (fr) * 1988-06-10 1990-09-07 Adir Nouveau procede de preparation de derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique
FR2651348B1 (da) * 1989-08-04 1993-01-22 Adir
FR2672287B1 (fr) * 1991-01-31 1994-07-22 Adir Nouveau procede industriel de preparation du n-(desacetyl-o-4 vinblastinoyl-23) amino-1 methyl-2 propylphosphonate de diethyle (1s) et de ses sels.
US5321153A (en) * 1992-06-15 1994-06-14 Monsanto Company Process for making chiral alpha-amino phosphonates selected novel chiral alpha-amino phosphonates
US5473092A (en) * 1992-11-20 1995-12-05 Monsanto Company Synthesis of optically-active phosphono analogs of succinates
US5776129A (en) * 1996-06-12 1998-07-07 Ethicon Endo-Surgery, Inc. Endometrial ablation apparatus and method
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
LT3615544T (lt) 2017-04-27 2023-05-10 Pharma Mar S.A. Priešnavikiniai junginiai
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
BE659112A (fr) * 1965-02-01 1965-08-02 Lilly Co Eli Désacétylindoles polynucléaires et procédés de préparation
US3749784A (en) * 1972-05-03 1973-07-31 Lilly Co Eli Psoriasis treatment
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
AT377988B (de) * 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4208414A (en) * 1978-06-05 1980-06-17 Eli Lilly And Company Vinblastine in rheumatoid arthritis
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
DE3128018A1 (de) * 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
EP0233101A1 (fr) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Dérivés de vinblastine et composition pharmaceutique les contenant
JP2773246B2 (ja) * 1989-05-30 1998-07-09 スズキ株式会社 船外機のパワーステアリング装置

Also Published As

Publication number Publication date
NZ227082A (en) 1990-08-28
US4946833A (en) 1990-08-07
EP0318392B1 (fr) 1992-04-15
IE61031B1 (en) 1994-09-07
FR2623504B1 (fr) 1990-03-09
DK168386B1 (da) 1994-03-21
OA08972A (fr) 1990-11-30
FR2623504A1 (fr) 1989-05-26
AU2585188A (en) 1989-05-25
AU607554B2 (en) 1991-03-07
JPH02189A (ja) 1990-01-05
ZA888853B (en) 1989-08-30
DK661088D0 (da) 1988-11-25
IE883515L (en) 1989-05-25
ATE74924T1 (de) 1992-05-15
DE3870167D1 (de) 1992-05-21
CA1315278C (fr) 1993-03-30
PT89082B (pt) 1993-03-31
ES2032217T3 (es) 1993-01-16
GR3005101T3 (da) 1993-05-24
PT89082A (pt) 1988-12-01
EP0318392A1 (fr) 1989-05-31
JPH0551597B2 (da) 1993-08-03

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Legal Events

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PUP Patent expired