DK691287A - 5-floururacilderivater - Google Patents
5-floururacilderivaterInfo
- Publication number
- DK691287A DK691287A DK691287A DK691287A DK691287A DK 691287 A DK691287 A DK 691287A DK 691287 A DK691287 A DK 691287A DK 691287 A DK691287 A DK 691287A DK 691287 A DK691287 A DK 691287A
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- floururacil
- image
- group
- alkyl group
- Prior art date
Links
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical class FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10128586 | 1986-04-30 | ||
| JP10128586 | 1986-04-30 | ||
| JP4575487 | 1987-02-27 | ||
| JP4575487 | 1987-02-27 | ||
| JP8700275 | 1987-04-30 | ||
| PCT/JP1987/000275 WO1987006582A1 (fr) | 1986-04-30 | 1987-04-30 | Derives de 5-fluorouracyle |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK691287D0 DK691287D0 (da) | 1987-12-29 |
| DK691287A true DK691287A (da) | 1988-02-19 |
| DK166088B DK166088B (da) | 1993-03-08 |
| DK166088C DK166088C (da) | 1993-08-23 |
Family
ID=26385819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK691287A DK166088C (da) | 1986-04-30 | 1987-12-29 | 2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5047521A (da) |
| EP (1) | EP0247381B1 (da) |
| JP (1) | JPH07103112B2 (da) |
| KR (1) | KR950002161B1 (da) |
| DE (1) | DE3786834T2 (da) |
| DK (1) | DK166088C (da) |
| ES (1) | ES2058073T3 (da) |
| GB (1) | GB2200352B (da) |
| WO (1) | WO1987006582A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| EP1594842A1 (en) * | 2003-02-22 | 2005-11-16 | MERCK PATENT GmbH | Cyanopyridone derivatives as liquid crystals |
| CA2526289A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex |
| JP2007077109A (ja) * | 2005-09-16 | 2007-03-29 | Tokyo Institute Of Technology | ヌクレオシド誘導体及びその製造方法 |
| US7561776B2 (en) * | 2005-11-29 | 2009-07-14 | Petrospec Engineering Ltd. | Method of preventing hydrogen darkening of optic fibre |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
| ES2619937T3 (es) | 2009-10-27 | 2017-06-27 | Delta-Fly Pharma, Inc. | Nuevo derivado de 5-fluorouracilo |
| KR20200118827A (ko) | 2018-02-02 | 2020-10-16 | 마베릭스 온콜로지, 잉크. | 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124765A (en) * | 1975-05-13 | 1978-11-07 | Ono Pharmaceutical Co., Ltd. | 5-Fluorouracil derivatives |
| JPS6011704B2 (ja) * | 1976-07-30 | 1985-03-27 | 大鵬薬品工業株式会社 | ５−フルオルウラシル誘導体の製造法 |
| DE2658672A1 (de) * | 1976-12-23 | 1978-06-29 | Robugen Gmbh | Neue nucleosid-verbindungen und verfahren zu ihrer herstellung |
| JPS5379879A (en) * | 1976-12-23 | 1978-07-14 | Mitsui Toatsu Chem Inc | 1,3-substituted-5-fluorouracils and process for their preparation |
| JPS5924999B2 (ja) * | 1978-06-10 | 1984-06-13 | 富山化学工業株式会社 | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法 |
| JPS5535057A (en) * | 1978-09-05 | 1980-03-11 | Funai Corp | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it |
| US4340728A (en) * | 1979-11-28 | 1982-07-20 | Fuji Kagaku Kogyo Kabushiki Kaisha | Nucleoside derivatives and process for preparing same |
| GB2072164B (en) * | 1980-02-15 | 1983-12-21 | Funai Pharmaceutical Ind Ltd | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives |
| JPS5929699A (ja) * | 1982-08-11 | 1984-02-16 | Funai Corp | ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤 |
| JPS58185522A (ja) * | 1983-02-28 | 1983-10-29 | Toyama Chem Co Ltd | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体 |
| JPS6061593A (ja) * | 1983-09-14 | 1985-04-09 | Taiho Yakuhin Kogyo Kk | ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤 |
| DE3469533D1 (en) * | 1983-05-23 | 1988-04-07 | Taiho Pharmaceutical Co Ltd | Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same |
| EP0151189B1 (en) * | 1983-07-20 | 1990-01-31 | Teijin Limited | Antineoplastic agent |
| US4515618A (en) * | 1983-12-07 | 1985-05-07 | Chevron Research Company | 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives |
| DE3585869D1 (de) * | 1984-10-30 | 1992-05-21 | Otsuka Pharma Co Ltd | Zusammensetzung zur steigerung der antikrebsaktivitaet einer antikrebsverbindung. |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| JPH02187484A (ja) * | 1989-01-13 | 1990-07-23 | Okitsumo Kk | 紙用瞬間接着剤 |
-
1987
- 1987-04-29 DE DE87106264T patent/DE3786834T2/de not_active Expired - Fee Related
- 1987-04-29 ES ES87106264T patent/ES2058073T3/es not_active Expired - Lifetime
- 1987-04-29 EP EP87106264A patent/EP0247381B1/en not_active Expired - Lifetime
- 1987-04-30 KR KR1019870701257A patent/KR950002161B1/ko not_active Expired - Fee Related
- 1987-04-30 WO PCT/JP1987/000275 patent/WO1987006582A1/ja not_active Ceased
- 1987-04-30 US US07/150,407 patent/US5047521A/en not_active Expired - Fee Related
- 1987-04-30 JP JP62-502695A patent/JPH07103112B2/ja not_active Expired - Lifetime
- 1987-04-30 GB GB8730031A patent/GB2200352B/en not_active Expired - Fee Related
- 1987-12-29 DK DK691287A patent/DK166088C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07103112B1 (da) | 1995-11-08 |
| DK166088B (da) | 1993-03-08 |
| ES2058073T3 (es) | 1994-11-01 |
| GB8730031D0 (en) | 1988-02-03 |
| WO1987006582A1 (fr) | 1987-11-05 |
| DK691287D0 (da) | 1987-12-29 |
| GB2200352A (en) | 1988-08-03 |
| US5047521A (en) | 1991-09-10 |
| EP0247381B1 (en) | 1993-08-04 |
| DE3786834T2 (de) | 1994-03-03 |
| KR880701232A (ko) | 1988-07-26 |
| EP0247381A3 (en) | 1988-11-23 |
| KR950002161B1 (ko) | 1995-03-14 |
| DE3786834D1 (de) | 1993-09-09 |
| EP0247381A2 (en) | 1987-12-02 |
| DK166088C (da) | 1993-08-23 |
| JPH07103112B2 (ja) | 1995-11-08 |
| GB2200352B (en) | 1990-07-25 |
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