DK76286A - Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling deraf - Google Patents

Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number
DK76286A
DK76286A DK76286A DK76286A DK76286A DK 76286 A DK76286 A DK 76286A DK 76286 A DK76286 A DK 76286A DK 76286 A DK76286 A DK 76286A DK 76286 A DK76286 A DK 76286A
Authority
DK
Denmark
Prior art keywords
antitrypsin
alfa1
humant
procedures
derivatives
Prior art date
Application number
DK76286A
Other languages
English (en)
Other versions
DK171064B1 (da
DK76286D0 (da
Inventor
Michael Courtney
Sophie Jallat
Luc-Henri Tessier
Jean-Pierre Lecocq
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8409592A external-priority patent/FR2565983B1/fr
Priority claimed from FR8507393A external-priority patent/FR2582001B2/fr
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of DK76286A publication Critical patent/DK76286A/da
Publication of DK76286D0 publication Critical patent/DK76286D0/da
Application granted granted Critical
Publication of DK171064B1 publication Critical patent/DK171064B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK076286A 1984-06-19 1986-02-18 Analoger af humant alfa1-antitrypsin, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende analogerne, biologisk reagens indeholdende analogerne, samt anvendelse af analogerne DK171064B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8409592A FR2565983B1 (fr) 1984-06-19 1984-06-19 Derives de l'a1-antitrypsine humaine et procede pour leur preparation
FR8409592 1984-06-19
FR8507393A FR2582001B2 (fr) 1985-05-15 1985-05-15 Nouveaux derives de l'a1-antitrypsine humaine, composition et reactif biologique les contenant
FR8507393 1985-05-15
PCT/FR1985/000158 WO1986000337A1 (fr) 1984-06-19 1985-06-18 DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION
FR8500158 1985-06-18

Publications (3)

Publication Number Publication Date
DK76286A true DK76286A (da) 1986-02-18
DK76286D0 DK76286D0 (da) 1986-02-18
DK171064B1 DK171064B1 (da) 1996-05-13

Family

ID=26224015

Family Applications (1)

Application Number Title Priority Date Filing Date
DK076286A DK171064B1 (da) 1984-06-19 1986-02-18 Analoger af humant alfa1-antitrypsin, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende analogerne, biologisk reagens indeholdende analogerne, samt anvendelse af analogerne

Country Status (7)

Country Link
US (1) US6072029A (da)
EP (1) EP0169114B1 (da)
JP (1) JP2599585B2 (da)
CA (1) CA1341216C (da)
DE (1) DE3581328D1 (da)
DK (1) DK171064B1 (da)
WO (1) WO1986000337A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0164719B1 (en) * 1984-06-14 1992-05-06 Chiron Corporation Active site modified protease alpha-1-antitrypsin inhibitors and their production
JP2599585B2 (ja) * 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
AU6469886A (en) * 1985-11-08 1987-05-14 Smithkline Beckman Corporation Mutant alpha-1-antitryosin and dna sequence therefor
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
FR2599752B1 (fr) * 1986-06-10 1989-11-03 Transgene Sa Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) * 1986-07-02 1990-01-19 Transgene Sa Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
FR2618159B2 (fr) * 1987-07-15 1990-02-02 Transgene Sa Procede de stabilisation d'un plasmide contenu dans une souche bacterienne et souche obtenue
JP2772793B2 (ja) * 1986-08-05 1998-07-09 トランスジ−ン ソシエテ アノニム 細菌中に含まれるプラスミドの安定化方法及びこれにより得られる菌株
EP0260350B1 (en) * 1986-09-05 1992-02-12 Cetus Oncology Corporation Oxidation-resistant interferon-beta muteins and their production; formulations containing such muteins
FR2637613B1 (fr) * 1987-06-19 1991-09-27 Transgene Sa Procede de preparation de lignees cellulaires stables pour la production de proteines determinees, a partir d'animaux transgeniques; lignees cellulaires tumorales et proteines obtenues
JPH01191687A (ja) * 1988-01-28 1989-08-01 Hoechst Japan Kk ヒトα↓２−プラスミンインヒビターまたはそれと類似の蛋白質から誘導される新規蛋白質
AU3479495A (en) * 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
GB9825374D0 (en) * 1998-11-19 1999-01-13 Ppl Therapeutics Scotland Ltd Method
DK2520654T3 (da) 2003-08-26 2017-05-01 Univ Colorado Regents Inhibitorer for serinproteaseaktivitet og disses anvendelse i fremgangsmåder og sammensætninger til behandling af bakterielle infektioner
CN102655876B (zh) 2009-11-03 2015-07-15 基立福疗法公司 α-1蛋白酶抑制剂组合物、方法和试剂盒
BR112012012460B1 (pt) 2009-11-24 2020-06-23 Grifols Therapeutics Inc. Método de liofilização de uma composição
EP3628327A1 (en) 2011-06-24 2020-04-01 The Regents of the University of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
BR112014007127A2 (pt) 2011-12-30 2017-04-04 Grifols Sa métodos para retardar o início ou diminuir a progressão de um ou mais sintomas, para retardar o início ou a progressão de um ou mais sintomas, para identificar um indivíduo em necessidade de terapia de manutenção de a1pi, e para identificar indivíduos com risco elevado para exacerbações pulmonares, uso de a1pi, aparelho e meio para a administração aerossolizada de a1pi para a inalação, e, kit
KR20140137347A (ko) 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
RU2573933C1 (ru) * 2014-08-21 2016-01-27 Дафот Энтерпрайсис Лимитед Пептид для лечения сахарного диабета 2-го типа и его осложнений
EP3397274A1 (en) 2015-12-31 2018-11-07 The Regents of the University of Colorado, a body corporate Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications
US12031144B2 (en) * 2017-03-29 2024-07-09 Cornell University Oxidation-resistant AAT gene therapy
ES2984415T3 (es) 2017-12-12 2024-10-29 Kamada Ltd Métodos para inducir tolerancia inmunitaria y reducir la respuesta de anticuerpos anti-fármaco
EP4430069A1 (en) 2021-11-09 2024-09-18 Danmarks Tekniske Universitet Variants of alpha-1-antitrypsin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
BE895961A (fr) * 1983-02-21 1983-06-16 Wallone Region Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0164719B1 (en) * 1984-06-14 1992-05-06 Chiron Corporation Active site modified protease alpha-1-antitrypsin inhibitors and their production
US4732973A (en) * 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
JP2599585B2 (ja) * 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins

Also Published As

Publication number Publication date
EP0169114B1 (fr) 1991-01-16
EP0169114A2 (fr) 1986-01-22
JPS62500420A (ja) 1987-02-26
JP2599585B2 (ja) 1997-04-09
US6072029A (en) 2000-06-06
DK171064B1 (da) 1996-05-13
DE3581328D1 (de) 1991-02-21
EP0169114A3 (en) 1986-11-20
CA1341216C (fr) 2001-04-24
DK76286D0 (da) 1986-02-18
WO1986000337A1 (fr) 1986-01-16

Similar Documents

Publication Publication Date Title
DK512686D0 (da) Thrombinpraeparater, deres fremstilling og anvendelse
DK186989A (da) Stabiliserede hoejumaettede fedtsyrer og derivater af saadanne syrer samt fremgangsmaade til fremstilling deraf
IT8048102A0 (it) Procedimento di preparazione di un idrolisato di proteine purificato
NO890921D0 (no) Fremgangsmaate for fremstilling av aminosyrederivater.
DK31088D0 (da) Blodkoaguleringsnedsaettende peptidderivater
NO831317L (no) Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner.
NO920671L (no) Fremgangsmaate for aktivering av rekombinante proteiner
NO892745D0 (no) Aminoalkylaminokarbonylaminodiolaminosyrederivater og fremgangsmaate for deres fremstilling.
FI883487A0 (fi) Ihmisen kudostekijäinhibiittorin DNA-klooni
DK430486D0 (da) Fremgangsmaade til udvinding af protein
DK98192D0 (da) Triphenylmethyl-derivater af sn-glycero-3-phosphocholin og sn-glycero-3-phosphoethanolamin og fremgangsmaade til fremstilling deraf
DK76286D0 (da) Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling deraf
NO885013D0 (no) FremgangsmŸte for fremstilling av bionedbrytbare mikrokapsler av vannopplelige peptider og proteiner, samt mikroka psler oppnŸdd ved fremgangsmŸten.
DK424188D0 (da) Thrombin-koagulerbare proteiner og fremgangsmaade til deres fremstilling
ATE140962T1 (de) Dns-klone von menschlichem thrombomodulin
DK250190D0 (da) Aminosyrer, homo- og heterooligomere samt konjugater deraf og fremgangsmaade til fremstilling af saadanne forbindelser
DK282985A (da) S-(carbamoyl-phenylselenyl)-derivater af glutathion og af aminomercaptocarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
NO890062D0 (no) 3,5-dihydrokarboksylsyrer og derivater derav samt fremgangsmaater for fremstilling av disse.
DK627687A (da) Hirudinvariant
DK429585A (da) Antibakterielt virksomme 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl)amino)-3-furancarboxylsyrer og derivater deraf
NO885231L (no) Peptidstrukturer, immunogener og anvendelse for fertilitetskontroll.
DK203087A (da) Fremgangsmaade til fremstilling af fusionsproteiner og anvendelse af det derved fremstillede fusionsprotein som vaccine
DK450187D0 (da) Fremgangsmaade til fremstilling af proteiner
NO892744D0 (no) N-terminale aminodiol-aminosyrederivater og fremgangsmaatefor deres fremstilling.
NO881502D0 (no) Rekombinante htlv-111 proteiner og anvendelse av disse.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK