DK77787A - Fremgangsmaade til fremstilling af en makromolekylaer baerer ladet med et biologisk aktivt stof - Google Patents

Fremgangsmaade til fremstilling af en makromolekylaer baerer ladet med et biologisk aktivt stof

Info

Publication number: DK77787A
Authority: DK; Denmark
Prior art keywords: ldl; active substance; biologically active; lyophilised; dissolved
Prior art date: 1985-06-17

Application number

DK077787A

Other languages

English (en)

Other versions

DK168785B1 (da

DK77787D0 (da

Inventor

Michele Masquelier

Curt Peterson

Mikael Ros

Mats Rudling

Sigurd Vitols

Original Assignee

Oncholab Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-17

Filing date

1987-02-16

Publication date

1987-02-16

1987-02-16 Application filed by Oncholab Ab filed Critical Oncholab Ab

1987-02-16 Publication of DK77787A publication Critical patent/DK77787A/da

1987-02-16 Publication of DK77787D0 publication Critical patent/DK77787D0/da

1994-06-13 Application granted granted Critical

1994-06-13 Publication of DK168785B1 publication Critical patent/DK168785B1/da

Links

229940088623 biologically active substance Drugs 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
102000007330 LDL Lipoproteins Human genes 0.000 abstract 11
108010007622 LDL Lipoproteins Proteins 0.000 abstract 11
239000003223 protective agent Substances 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
229930091371 Fructose Natural products 0.000 abstract 1
239000005715 Fructose Substances 0.000 abstract 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
229930006000 Sucrose Natural products 0.000 abstract 1
239000012062 aqueous buffer Substances 0.000 abstract 1
FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
150000002016 disaccharides Chemical class 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
150000002772 monosaccharides Chemical group 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
239000005720 sucrose Substances 0.000 abstract 1
150000005846 sugar alcohols Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Medicinal Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromonomer-Based Addition Polymer (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK077787A 1985-06-17 1987-02-16 Fremgangsmåde til fremstilling af en bærer ladet med lipofilt biologisk aktivt stof på basis af rekonstitueret LDL DK168785B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
SE8502998		1985-06-17
SE8502998A SE456136B (sv)	1985-06-17	1985-06-17	Forfarande for framstellning av en med ett lipofilt biologiskt aktivt emne bemengd berare pa basis av rekonstituerat ldl (lagdensitetslipoprotein)
SE8600291		1986-06-17
PCT/SE1986/000291 WO1986007540A1 (en)	1985-06-17	1986-06-17	Method for the preparation of a macromolecular carrier loaded with a biologically active substance, product thus obtained and use thereof

Publications (3)

Publication Number	Publication Date
DK77787A true DK77787A (da)	1987-02-16
DK77787D0 DK77787D0 (da)	1987-02-16
DK168785B1 DK168785B1 (da)	1994-06-13

Family

ID=20360603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK077787A DK168785B1 (da)	1985-06-17	1987-02-16	Fremgangsmåde til fremstilling af en bærer ladet med lipofilt biologisk aktivt stof på basis af rekonstitueret LDL

Country Status (11)

Country	Link
US (1)	US4868158A (da)
EP (1)	EP0229100B1 (da)
JP (1)	JPS62502549A (da)
AT (1)	ATE67412T1 (da)
AU (1)	AU583402B2 (da)
DE (1)	DE3681578D1 (da)
DK (1)	DK168785B1 (da)
FI (1)	FI86802C (da)
NO (1)	NO169048C (da)
SE (1)	SE456136B (da)
WO (1)	WO1986007540A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2609399A1 (fr) *	1987-01-13	1988-07-15	Ire Celltarg Sa	Procede d'incorporation d'un ou plusieurs principes actifs lipophiles dans des lipoproteines, lipoproteines obtenues et composition pharmaceutique les contenant
FR2664500B1 (fr) *	1990-07-13	1994-10-28	Lille Ii Universite Droit Sant	Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile, lipoproteine modifiee ainsi obtenue et composition pharmaceutique ou cosmetique la contenant.
EP0611306B1 (en) *	1991-11-08	1998-07-08	Somatogen, Inc.	Hemoglobins as drug delivery agents
WO1993020800A1 (en) *	1992-04-08	1993-10-28	Paavo Kai Johannes Kinnunen	Composition for therapeutic or diagnostic use, process for its preparation and its use
AU690592B2 (en) *	1993-11-08	1998-04-30	Peptide Delivery Systems Pty Ltd	Labelled diagnostic compositions and methods of their use
US5756067A (en) *	1993-11-08	1998-05-26	Peptide Delivery Systems Pty Ltd	Labelled diagnostic compositions and method of their use
US5652339A (en) *	1993-12-31	1997-07-29	Rotkreuzstiftung Zentrallaboratorium	Method of producing reconstituted lipoproteins
CA2259179C (en) *	1996-07-03	2008-09-23	University Of Pittsburgh	Emulsion formulations for hydrophilic active agents
AUPP032097A0 (en) *	1997-11-11	1997-12-04	Peptide Delivery Systems Pty Ltd	Improved labelled diagnostic compositions and methods of their use
US6514523B1 (en)	2000-02-14	2003-02-04	Ottawa Heart Institute Research Corporation	Carrier particles for drug delivery and process for preparation
US20090110739A1 (en) *	2007-05-15	2009-04-30	University Of North Texas Health Science Center At Forth Worth	Targeted cancer chemotherapy using synthetic nanoparticles
US8734853B2 (en)	2008-11-17	2014-05-27	University Of North Texas Health Science Center At Fort Worth	HDL particles for delivery of nucleic acids
US20160346219A1 (en)	2015-06-01	2016-12-01	Autotelic Llc	Phospholipid-coated therapeutic agent nanoparticles and related methods
US12194157B2 (en)	2020-04-09	2025-01-14	Finncure Oy	Carrier for targeted delivery to a host
FI20215508A1 (en)	2020-04-09	2021-10-10	Niemelae Erik Johan	Mimetic nanoparticles to prevent the spread of new coronaviruses and reduce the rate of infection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ180199A (en) *	1976-03-04	1978-11-13	New Zealand Dev Finance	Method of testing for the presence of elevated plasma liprotein concentration
US4186192A (en) *	1978-12-18	1980-01-29	Cutter Laboratories, Inc.	Stabilized immune serum globulin
US4440679A (en) *	1980-03-05	1984-04-03	Cutter Laboratories, Inc.	Pasteurized therapeutically active protein compositions
US4356117A (en) *	1980-10-23	1982-10-26	U.S. Govt., Dept. Of Health & Human Services	Chemical modifications of proteins which induce new receptor specificities and therefore elicit new effects in cells
JPS5967228A (ja) *	1982-10-07	1984-04-16	Green Cross Corp:The	寒冷不溶性グロブリンの凍結乾燥方法
US4478829A (en) *	1983-04-28	1984-10-23	Armour Pharmaceutical Company	Pharmaceutical preparation containing purified fibronectin
NZ208241A (en) *	1984-05-22	1987-09-30	John Stephen Ayers	Purification of blood plasma or serum: selective removal of (very) low density lipoproteins (ldl and vldl)
AU6408586A (en) *	1985-10-03	1987-04-24	Biotechnology Research Partners Limited	Novel lipoprotein-based drug-delivery systems

1985
- 1985-06-17 SE SE8502998A patent/SE456136B/sv not_active IP Right Cessation
1986
- 1986-06-17 JP JP61503451A patent/JPS62502549A/ja active Granted
- 1986-06-17 EP EP86903706A patent/EP0229100B1/en not_active Expired - Lifetime
- 1986-06-17 AT AT86903706T patent/ATE67412T1/de not_active IP Right Cessation
- 1986-06-17 AU AU59968/86A patent/AU583402B2/en not_active Ceased
- 1986-06-17 WO PCT/SE1986/000291 patent/WO1986007540A1/en not_active Ceased
- 1986-06-17 US US07/030,861 patent/US4868158A/en not_active Expired - Fee Related
- 1986-06-17 DE DE8686903706T patent/DE3681578D1/de not_active Expired - Fee Related
1987
- 1987-02-11 NO NO870545A patent/NO169048C/no unknown
- 1987-02-16 FI FI870644A patent/FI86802C/fi not_active IP Right Cessation
- 1987-02-16 DK DK077787A patent/DK168785B1/da active

Also Published As

Publication number	Publication date
SE8502998L (sv)	1986-12-18
NO870545D0 (no)	1987-02-11
FI870644A0 (fi)	1987-02-16
WO1986007540A1 (en)	1986-12-31
SE8502998D0 (sv)	1985-06-17
NO870545L (no)	1987-02-11
DE3681578D1 (de)	1991-10-24
FI86802C (fi)	1992-10-26
DK168785B1 (da)	1994-06-13
EP0229100B1 (en)	1991-09-18
ATE67412T1 (de)	1991-10-15
JPS62502549A (ja)	1987-10-01
FI86802B (fi)	1992-07-15
AU5996886A (en)	1987-01-13
AU583402B2 (en)	1989-04-27
US4868158A (en)	1989-09-19
NO169048C (no)	1992-05-06
EP0229100A1 (en)	1987-07-22
SE456136B (sv)	1988-09-12
FI870644A7 (fi)	1987-02-16
NO169048B (no)	1992-01-27
DK77787D0 (da)	1987-02-16
JPH0586935B2 (da)	1993-12-14

Publication	Publication Date	Title
DK77787A (da)	1987-02-16	Fremgangsmaade til fremstilling af en makromolekylaer baerer ladet med et biologisk aktivt stof
Coore et al.	1971	Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones
ES2131573T3 (es)	1999-08-01	Procedimiento para el replegamiento de igf-i a una conformacion activa.
CHAKRAVARTY et al.	1959	Mechanism of tho Release by Componnd 48/80 of Histamine and of a Lipid‐Soluble Smooth Muscle Stimulating Principle (“SRS”)
DE3686953D1 (de)	1992-11-12	Lyophilisierter schaum.
KR830002327A (ko)	1983-05-28	약학적 제제
DK0627490T3 (da)	1997-12-08	Fremgangsmåde til fremstilling af langkædet inuli n
ES2070827T3 (es)	1995-06-16	Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion.
DK0652754T3 (da)	2003-06-10	Lægemidler til topisk påføring af kønssteroider til behandling af tørt øje-syndrom samt fremgangsmåder til fremstilling og påføring deraf
GB2314508A (en)	1998-01-07	Diamide-dicarboxylic acid microspheres
OA08170A (fr)	1987-03-31	Procédé de solubilisation de principes actifs et compositions pharmaceutiques ainsi obtenues.
DE3785330D1 (de)	1993-05-13	Arzneimittel mit verzoegerter wirkstofffreisetzung.
HUT54885A (en)	1991-04-29	Process for producing liofilized pharmaceutical compositions containing active components
Narurkar et al.	1989	Prodrugs of 5-iodo-2′-deoxyuridine for enhanced ocular transport
ES522637A0 (es)	1984-12-01	Procedimiento para la preparacion de nuevas sustancias ws 6049.
ZENSER et al.	1974	Effects of prostaglandins on hepatic adenylate cyclase activity and cyclic adenosine 3', 5',-monophosphate content
Turner	1953	Synthesis of sucrose by a plant enzyme extract
Wigglesworth	1988	Histological staining of lipids for the light and electron microscope
Ackerman et al.	1974	Solubilization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from lyophilized rat liver microsomes: lack of evidence for cold lability in this soluble enzyme preparation
KR860002274A (ko)	1986-04-24	저장성 카모밀레 추출물의 제조방법
Kempen et al.	1977	Rat pancreatic adenylate cyclase: IV. Effect of hormones and other agents on cyclic AMP level and enzyme release
Anez et al.	1994	Sugars in the alimentary canal of Lutzomyia youngi (Diptera: Phlebotominae)
Bushway et al.	1988	Isolaton, partial purification and characterization of a potato peel glycoalkaloid glycosidase
Vandenberg et al.	1975	Adenyl cyclase in the haemocytes of the American cockroach
KR890701596A (ko)	1989-12-21	알카로이드 추출