JOP20200024A1 - مركبات ثنائي هيدروكساديازينون - Google Patents
مركبات ثنائي هيدروكساديازينونInfo
- Publication number
- JOP20200024A1 JOP20200024A1 JOP/2020/0024A JOP20200024A JOP20200024A1 JO P20200024 A1 JOP20200024 A1 JO P20200024A1 JO P20200024 A JOP20200024 A JO P20200024A JO P20200024 A1 JOP20200024 A1 JO P20200024A1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- aforementioned
- dihydrooxadiazinones
- diseases
- dihydroxydiazinone
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- CWADBNYOBWCBMX-UHFFFAOYSA-N OC(OP(=S)(OC(C)O)OC1=NC(=NC(=C1)C)C(C)C)C Chemical class OC(OP(=S)(OC(C)O)OC1=NC(=NC(=C1)C)C(C)C)C CWADBNYOBWCBMX-UHFFFAOYSA-N 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
مركبات ثنائي هيدروكساديازينون الملخص يزود الاختراع الحالي مركبات ثنائي هيدروكسي ديازينون بالصيغة العامة (I): " معادلة" (I)، حيث R1، R2، R3، و R4 كما هي معرفة هنا، طرق لتحضير المركبات المذكورة، مركبات وسيطة مفيدة لتحضير المركبات المذكورة، تراكيب صيدلانية وتوليفات تتضمن المركبات المذكورة واستخدام المركبات المذكورة لتصنيع تراكيب صيدلانية لعلاج أو الوقاية من الأمراض، وتحديداً أمراض فرط التكاثر، في صورة عامل وحيد أو
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541627P | 2017-08-04 | 2017-08-04 | |
| PCT/EP2018/071039 WO2019025562A1 (en) | 2017-08-04 | 2018-08-02 | DIHYDROOXADIAZINONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20200024A1 true JOP20200024A1 (ar) | 2020-02-02 |
Family
ID=63207725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2020/0024A JOP20200024A1 (ar) | 2017-08-04 | 2018-08-01 | مركبات ثنائي هيدروكساديازينون |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US11427553B2 (ar) |
| EP (1) | EP3661517B1 (ar) |
| JP (2) | JP7676141B2 (ar) |
| KR (1) | KR20200036914A (ar) |
| CN (1) | CN111212647B (ar) |
| AR (1) | AR112402A1 (ar) |
| AU (1) | AU2018309356B2 (ar) |
| BR (1) | BR112020002351A2 (ar) |
| CA (1) | CA3071800A1 (ar) |
| CL (1) | CL2020000303A1 (ar) |
| CO (1) | CO2020001242A2 (ar) |
| CR (1) | CR20200057A (ar) |
| CU (1) | CU24608B1 (ar) |
| EA (1) | EA202090448A1 (ar) |
| EC (1) | ECSP20008441A (ar) |
| IL (1) | IL272098B2 (ar) |
| JO (1) | JOP20200024A1 (ar) |
| MA (1) | MA49750A (ar) |
| MX (1) | MX2020001404A (ar) |
| PE (1) | PE20200936A1 (ar) |
| PH (1) | PH12020500134A1 (ar) |
| SG (1) | SG11201913775UA (ar) |
| TW (1) | TWI791581B (ar) |
| UA (1) | UA125731C2 (ar) |
| UY (1) | UY37832A (ar) |
| WO (1) | WO2019025562A1 (ar) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3071795A1 (en) | 2017-08-04 | 2019-02-07 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer |
| JOP20200024A1 (ar) | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| US12325880B2 (en) | 2018-11-01 | 2025-06-10 | The Broad Institute, Inc. | Identification of PDE3 modulator responsive cancers |
| WO2020157194A1 (en) | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2h)-one compounds for the treatment of hyperproliferative diseases |
| WO2020157188A1 (en) * | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | Dihydrooxadiazinones for the treatment of hyperproliferative diseases |
| CA3212314A1 (en) * | 2021-03-03 | 2022-09-09 | Bayer Aktiengesellschaft | Substituted 3,6-dihydro-2h-1,3,4-oxadiazin-2-ones for the treatment of sarcoma |
| EP4289828A1 (en) | 2022-06-10 | 2023-12-13 | Bayer Aktiengesellschaft | Method for the preparation of a 3,6-dihydro-2h-1,3,4-oxadiazin-2-one |
| EP4289829A1 (en) | 2022-06-10 | 2023-12-13 | Bayer Aktiengesellschaft | Crystalline forms of (6s)-5-[4'-fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro- 2h-1,3,4-oxadiazin-2-one |
| CN120187704A (zh) * | 2022-11-24 | 2025-06-20 | 盛睿泽华医药科技（苏州）有限公司 | 吡啶酮化合物及其制备方法和用途 |
| CN117903077B (zh) * | 2023-01-13 | 2024-09-03 | 上海超阳药业有限公司 | 二氢噁二嗪酮化合物及其应用 |
| CN118420559B (zh) * | 2023-04-27 | 2025-02-14 | 上海超阳药业有限公司 | 氘代噁二嗪酮化合物及其用途 |
| CN118047833B (zh) * | 2024-01-31 | 2025-03-14 | 海南大学 | 含二茂铁的取代氨基乙酰胺类化合物及其制备方法和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097671A (en) * | 1975-08-28 | 1978-06-27 | General Electric Company | Dihydrooxadiazinones and method for making |
| US4052395A (en) | 1975-09-11 | 1977-10-04 | Sankyo Company Limited | Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones |
| US4258094A (en) * | 1979-04-26 | 1981-03-24 | Brunswick Corporation | Melt bonded fabrics and a method for their production |
| US4334030A (en) | 1979-11-23 | 1982-06-08 | General Electric Company | Thermoplastic foamable blends |
| DE3172252D1 (en) | 1980-11-14 | 1985-10-17 | Ici Plc | Heterocyclic compounds |
| DE3263497D1 (en) | 1981-03-04 | 1985-06-20 | Ciba Geigy Ag | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use |
| ZA827641B (en) | 1981-11-12 | 1983-09-28 | Ici Plc | Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity |
| US4495185A (en) | 1981-11-12 | 1985-01-22 | Imperial Chemical Industries, Plc | 1,2,4-Triazin-3(2H) ones |
| US4581356A (en) | 1983-03-22 | 1986-04-08 | Fujisawa Pharmaceutical Co., Ltd. | Triazine derivatives, and pharmaceutical compositions comprising the same |
| GB8310435D0 (en) | 1983-04-18 | 1983-05-25 | Fujisawa Pharmaceutical Co | Triazine derivatives |
| JPS59196874A (ja) | 1983-04-22 | 1984-11-08 | Fujisawa Pharmaceut Co Ltd | トリアジン誘導体 |
| JPS6153270A (ja) | 1984-08-17 | 1986-03-17 | チバ・ガイギー・アクチエンゲゼルシヤフト | 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤 |
| US4816454A (en) | 1984-09-21 | 1989-03-28 | Cassella Aktiengesellschaft | 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use |
| GB8426804D0 (en) | 1984-10-23 | 1984-11-28 | Ciba Geigy Ag | Pyridazinones preparations |
| EP0220044B1 (en) | 1985-10-17 | 1991-01-30 | Smith Kline & French Laboratories Limited | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives |
| EP0303418A3 (en) | 1987-08-11 | 1990-11-07 | Smithkline Beecham Laboratoires Pharmaceutiques | Substituted indolones, useful in the treatment of heart or asthmatic diseases |
| ES2131506T3 (es) | 1990-09-21 | 1999-08-01 | Rohm & Haas | Dihidropiridacinonas y piridacinonas como fungicidas. |
| JPH0676325B2 (ja) * | 1992-05-08 | 1994-09-28 | 三井東圧化学株式会社 | オキサジアジン誘導体を有効成分として含有する抗血栓剤 |
| DK0650480T3 (da) | 1992-07-01 | 2002-05-13 | Ortho Pharma Corp | 1-Arylsulfonyl-3-phenyl-1,4,5,6-tetrahydropyridaziner |
| JPH07291968A (ja) | 1994-04-26 | 1995-11-07 | Mitsubishi Chem Corp | トリアジノン誘導体またはその塩類 |
| DE19929787A1 (de) | 1999-06-29 | 2001-01-04 | Bayer Ag | Neue 4-(2-Oxodihydrooxadiazinylphenyl)amide und ihre Verwendung |
| US20050070529A1 (en) | 2001-02-12 | 2005-03-31 | Merk Pantent Gmbh | Use of type 4 phosphodiesterase inhibitors in myocardial diseases |
| WO2008108602A1 (en) | 2007-03-07 | 2008-09-12 | Dong-A Pharm. Co., Ltd. | Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same |
| US9212146B2 (en) | 2008-03-18 | 2015-12-15 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted pyridazinones for the treatment of tumors |
| CN101538245B (zh) | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
| JP5711724B2 (ja) | 2009-04-15 | 2015-05-07 | リサーチ・トライアングル・インスティチュート | モノアミン再取り込み阻害剤 |
| FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2566864B1 (en) | 2010-05-07 | 2014-09-03 | Boehringer Ingelheim International GmbH | Pyridazinones as gpr119 agonists |
| WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| TWI532742B (zh) | 2011-02-28 | 2016-05-11 | 艾伯維有限公司 | 激酶之三環抑制劑 |
| JP6511430B2 (ja) | 2013-03-11 | 2019-05-15 | ザ・ブロード・インスティテュート・インコーポレイテッド | がんの治療のための化合物および組成物 |
| TWI700283B (zh) | 2014-08-04 | 2020-08-01 | 德商拜耳製藥公司 | ２-(嗎啉-４-基)-１,７-萘啶 |
| CA2995375C (en) | 2015-08-13 | 2024-06-18 | The Broad Institute, Inc. | Compositions and methods for cancer expressing pde3a or slfn12 |
| JP6873145B2 (ja) | 2016-01-14 | 2021-05-19 | バイエル・ファルマ・アクティエンゲゼルシャフト | ５−置換２−（モルホリン−４−イル）−１，７−ナフチリジン |
| CA3013402C (en) | 2016-02-05 | 2024-05-28 | Bayer Pharma Aktiengesellschaft | Compounds, compositions and methods for cancer patient stratification and cancer treatment |
| KR101831772B1 (ko) * | 2016-03-24 | 2018-03-06 | 아이디에스(주) | 복합 광원 모듈을 가지는 카메라 접사용 기구 및 이를 이용한 지문 시편 촬영 방법 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| JOP20200024A1 (ar) | 2017-08-04 | 2020-02-02 | Bayer Ag | مركبات ثنائي هيدروكساديازينون |
| CA3071795A1 (en) | 2017-08-04 | 2019-02-07 | Bayer Aktiengesellschaft | 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer |
| US12325880B2 (en) | 2018-11-01 | 2025-06-10 | The Broad Institute, Inc. | Identification of PDE3 modulator responsive cancers |
| WO2020157194A1 (en) | 2019-02-01 | 2020-08-06 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2h)-one compounds for the treatment of hyperproliferative diseases |
-
2018
- 2018-08-01 JO JOP/2020/0024A patent/JOP20200024A1/ar unknown
- 2018-08-02 CR CR20200057A patent/CR20200057A/es unknown
- 2018-08-02 SG SG11201913775UA patent/SG11201913775UA/en unknown
- 2018-08-02 PE PE2020000184A patent/PE20200936A1/es unknown
- 2018-08-02 UA UAA202001558A patent/UA125731C2/uk unknown
- 2018-08-02 BR BR112020002351-5A patent/BR112020002351A2/pt not_active IP Right Cessation
- 2018-08-02 CA CA3071800A patent/CA3071800A1/en active Pending
- 2018-08-02 WO PCT/EP2018/071039 patent/WO2019025562A1/en not_active Ceased
- 2018-08-02 JP JP2020505898A patent/JP7676141B2/ja active Active
- 2018-08-02 MA MA049750A patent/MA49750A/fr unknown
- 2018-08-02 US US16/635,504 patent/US11427553B2/en active Active
- 2018-08-02 EP EP18755153.6A patent/EP3661517B1/en active Active
- 2018-08-02 MX MX2020001404A patent/MX2020001404A/es unknown
- 2018-08-02 CU CU2020000008A patent/CU24608B1/es unknown
- 2018-08-02 CN CN201880050751.0A patent/CN111212647B/zh active Active
- 2018-08-02 KR KR1020207005998A patent/KR20200036914A/ko not_active Withdrawn
- 2018-08-02 EA EA202090448A patent/EA202090448A1/ru unknown
- 2018-08-02 AU AU2018309356A patent/AU2018309356B2/en not_active Ceased
- 2018-08-03 AR ARP180102218 patent/AR112402A1/es not_active Application Discontinuation
- 2018-08-03 UY UY0001037832A patent/UY37832A/es not_active Application Discontinuation
- 2018-08-03 TW TW107127172A patent/TWI791581B/zh not_active IP Right Cessation
-
2020
- 2020-01-16 IL IL272098A patent/IL272098B2/en unknown
- 2020-01-17 PH PH12020500134A patent/PH12020500134A1/en unknown
- 2020-02-04 EC ECSENADI20208441A patent/ECSP20008441A/es unknown
- 2020-02-04 CL CL2020000303A patent/CL2020000303A1/es unknown
- 2020-02-04 CO CONC2020/0001242A patent/CO2020001242A2/es unknown
-
2022
- 2022-07-11 US US17/862,255 patent/US12258323B2/en active Active
- 2022-07-14 US US17/865,236 patent/US11773070B2/en active Active
-
2023
- 2023-06-13 JP JP2023097166A patent/JP2023115065A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20200024A1 (ar) | مركبات ثنائي هيدروكساديازينون | |
| ECSP19030002A (es) | 1,2,4-triazolonas 2,4,5-trisustituidas | |
| JOP20170135A1 (ar) | مركبات ديازاسبيروألكيل مثيل-إندول | |
| GEP20207105B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors | |
| UA109220C2 (uk) | Похідні (4-фенілімідазол-2-іл)етиламіну як модулятори натрієвих каналів | |
| TR201904455T4 (tr) | Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları. | |
| JOP20170126A1 (ar) | مركبات 3-أكسو-2، 6-ثنائي فنيل-2، 3-ثنائي هيدروبيريدازين-4-كربوكساميد | |
| TN2017000467A1 (en) | Amido-substituted cyclohexane derivatives | |
| EA201591890A1 (ru) | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| NZ768368A (en) | Modulators of cystic fibrosis transmembrane conductance regulator | |
| MX2015011984A (es) | Inhibidores de bromodominio de dihidro-pirrolopiridinona. | |
| MX359882B (es) | Amidas como moduladores de canales de sodio. | |
| JOP20190193A1 (ar) | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان | |
| DOP2015000245A (es) | Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos | |
| AU2018253590A1 (en) | Imidazopyridazine compounds | |
| MX2019012847A (es) | Compuestos de c5-anilinoquinazolina y su uso en el tratamiento del cancer. | |
| EA201891063A1 (ru) | Производные дигидроимидазопиразинона, применимые в лечении рака | |
| UY37973A (es) | Derivados de indol macrocíclicos | |
| EA201591541A1 (ru) | Ингибиторы бета-секретазы 1 (bace 1) | |
| UY37250A (es) | Derivados macrocíclicos de indol | |
| JOP20200100A1 (ar) | مشتقات بيرازولو-بيرولو-بيريميدين-ديون جديدة كمثبِّطات لـ p2x3 | |
| EA201692481A1 (ru) | Комбинация, содержащая глюкокортикоид и edo-s101 | |
| EA201492097A1 (ru) | 5-амино[1,4]тиазины в качестве ингибиторов бета-секретазы 1 | |
| MX2018010177A (es) | Compuestos de 6,7-dihidro-5h-pirazolo[5,1-b][1,3]oxazina-2-carboxa mida. | |
| JOP20240127A1 (ar) | مركبات ثنائي آزا سبيرو بها استبدال بكربونيل واستخدامها |