DOP2002000384A - MODULATORS OF ESTROGEN RECEPTORS. - Google Patents
MODULATORS OF ESTROGEN RECEPTORS.Info
- Publication number
- DOP2002000384A DOP2002000384A DO2002000384A DO2002000384A DOP2002000384A DO P2002000384 A DOP2002000384 A DO P2002000384A DO 2002000384 A DO2002000384 A DO 2002000384A DO 2002000384 A DO2002000384 A DO 2002000384A DO P2002000384 A DOP2002000384 A DO P2002000384A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- estrogenic
- estrogen
- cancer
- modulators
- Prior art date
Links
- 102000015694 estrogen receptors Human genes 0.000 title 1
- 108010038795 estrogen receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001076 estrogenic effect Effects 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 208000033830 Hot Flashes Diseases 0.000 abstract 1
- 206010060800 Hot flush Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000031481 Pathologic Constriction Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000003920 cognitive function Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000002834 estrogen receptor modulator Substances 0.000 abstract 1
- 201000000079 gynecomastia Diseases 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 208000037804 stenosis Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El invento presente se relaciona a compuestos y derivados del mismo, su síntesis, y su uso como moduladores de receptores estrogénicos. Los compuestos del invento instante son ligandos para los receptores estrogénicos y como tales pueden ser útiles en el tratamiento o prevención de una variedad de condiciones relacionadas con el funcionamiento estrogénico incluyendo: pérdida de hueso, fracturas óseas, osteoporosis, degeneración de cartílago, endometriosis, miomatosis uterina, calores inducidos por menopausia o ausencia de estrógeno (bochornos), niveles aumentados de colesterol LDL, enfermedad cardiovascular, impedimento de la función cognoscitiva, enfermedades cerebrales degenerativas, re-estenosis, ginecomastia, proliferaciones de células de músculo liso vascular, incontinencia, y cáncer, en especial cáncer de mama, útero y próstata.The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogenic receptors and as such may be useful in the treatment or prevention of a variety of conditions related to estrogenic functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, myomatosis uterine, menopausal-induced heats or absence of estrogen (hot flashes), increased levels of LDL cholesterol, cardiovascular disease, impaired cognitive function, degenerative brain diseases, re-stenosis, gynecomastia, vascular smooth muscle cell proliferations, incontinence, and cancer, especially breast, uterus and prostate cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2002000384A DOP2002000384A (en) | 2002-04-19 | 2002-04-19 | MODULATORS OF ESTROGEN RECEPTORS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2002000384A DOP2002000384A (en) | 2002-04-19 | 2002-04-19 | MODULATORS OF ESTROGEN RECEPTORS. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2002000384A true DOP2002000384A (en) | 2003-09-30 |
Family
ID=44261073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2002000384A DOP2002000384A (en) | 2002-04-19 | 2002-04-19 | MODULATORS OF ESTROGEN RECEPTORS. |
Country Status (1)
| Country | Link |
|---|---|
| DO (1) | DOP2002000384A (en) |
-
2002
- 2002-04-19 DO DO2002000384A patent/DOP2002000384A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1501819T3 (en) | estrogen | |
| ATE524170T1 (en) | ESTROGEN RECEPTOR MODULATORS | |
| WO2002091993A3 (en) | Estrogen receptor modulators | |
| ATE329904T1 (en) | ESTROGEN RECEPTOR MODULATORS | |
| BRPI0518874A2 (en) | compound, pharmaceutical composition, and, uses of a compound, and a composition | |
| NO20072771L (en) | estrogen | |
| DK1272504T3 (en) | 8. Beta-hydrocarbyl-substituted estradiol for use as selective estrogens | |
| MY161549A (en) | Progesterone antagonists such as cdb-4124 in the treatment of breast cancer | |
| WO2002032377A3 (en) | Estrogen receptor modulators | |
| WO2004073612A3 (en) | Estrogen receptor modulators | |
| AR039282A1 (en) | STROGEN RECEIVERS MODULATORS | |
| WO2002032373A3 (en) | Estrogen receptor modulators | |
| DOP2002000384A (en) | MODULATORS OF ESTROGEN RECEPTORS. | |
| EA201100226A1 (en) | DERIVATIVES OF ESTRATRIEN CONTAINING HETEROCYCLIC BIOISOLAS FOR A-RING PHENOL | |
| WO2009059806A3 (en) | Preparation of 6-oxa-8alpha-steroid estrogen analogues - a new group of unnatural estrogens and their use in medicine | |
| WO2006081152A3 (en) | Estrogen receptor modulators | |
| ATE517871T1 (en) | ESTROGEN RECEPTOR MODULATORS | |
| WO2005097141A3 (en) | Estrogen receptor modulators | |
| IL156151A0 (en) | Phenanthrene derivatives and pharmaceutical compositions containing the same | |
| WO2002058639A3 (en) | Pyranoflavonoid compounds and their use as estrogen receptor modulators | |
| WO2004073610A3 (en) | Estrogen receptor modulators | |
| TN2010000007A1 (en) | 8-beta- substituted estratrienes as selectively active estrogens | |
| WO2004026887A3 (en) | Estrogen receptor modulators | |
| DOP2005000224A (en) | MODULATORS OF STROGEN RECEIVERS | |
| WO2008057309A3 (en) | Estrogen receptor modulators |