DOP2002000422A - ANTIBACTERIAL AGENTS. - Google Patents

ANTIBACTERIAL AGENTS.

Info

Publication number
DOP2002000422A
DOP2002000422A DO2002000422A DO2002000422A DOP2002000422A DO P2002000422 A DOP2002000422 A DO P2002000422A DO 2002000422 A DO2002000422 A DO 2002000422A DO 2002000422 A DO2002000422 A DO 2002000422A DO P2002000422 A DOP2002000422 A DO P2002000422A
Authority
DO
Dominican Republic
Prior art keywords
formula
antibacterial agents
compounds
useful
preparing compounds
Prior art date
Application number
DO2002000422A
Other languages
Spanish (es)
Inventor
Joseph Francis Krzyzaniak
Sharon Anne Powell
Joseph Peter Sanchez
James Alan Kerschen
Michael Andrew Stier
Tuan Phong Tran
Edmund Lee Elisworth
Howard Daniel Holls Showalter
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DOP2002000422A publication Critical patent/DOP2002000422A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención proporciona compuestos de fórmula (l): en la que Ri-R6 y J y K tienen cualquierade los valores definidos en la memoria descriptiva, y sales farmacéuticamente aceptables de los mismos, que son útiles como agentes antibacterianos. También se describen composiciones farmacéuticas que comprenden uno o más compuestos de fórmula l, pro dimientos para preparar compuestos de fórmuia l e intermedios útiles para preparar compuestos de Fórmula l.The present invention provides compounds of formula (1): wherein Ri-R6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as antibacterial agents. Also described are pharmaceutical compositions comprising one or more compounds of formula 1, procedures for preparing compounds of formula 1 and intermediates useful for preparing compounds of Formula 1.

DO2002000422A 2001-06-19 2002-06-19 ANTIBACTERIAL AGENTS. DOP2002000422A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29924901P 2001-06-19 2001-06-19

Publications (1)

Publication Number Publication Date
DOP2002000422A true DOP2002000422A (en) 2002-12-30

Family

ID=23153973

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2002000422A DOP2002000422A (en) 2001-06-19 2002-06-19 ANTIBACTERIAL AGENTS.

Country Status (13)

Country Link
EP (1) EP1401830A2 (en)
JP (1) JP2005501021A (en)
AU (1) AU2002302894A1 (en)
BR (1) BR0210028A (en)
CA (1) CA2446963A1 (en)
DO (1) DOP2002000422A (en)
GT (1) GT200200104A (en)
HN (1) HN2002000150A (en)
MX (1) MXPA03009894A (en)
PA (1) PA8548401A1 (en)
PE (1) PE20030272A1 (en)
SV (1) SV2003001089A (en)
WO (1) WO2002102793A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0414319A (en) * 2003-09-12 2006-11-07 Warner Lambert Co quinolone antibacterial agents
JP2007511597A (en) * 2003-11-18 2007-05-10 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Antibacterial aminoquinazolidinone derivatives
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
EP2686305B1 (en) 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones and their use
TWI527800B (en) 2011-04-01 2016-04-01 南京英派藥業有限公司 1-(arylmethyl)quinazoline-2,4(1h,3h)-diones as parp inhibitors and the use thereof
LT3495367T (en) 2012-06-13 2021-02-25 Incyte Holdings Corporation MODIFIED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
LT2986610T (en) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
SG11201706287PA (en) 2015-02-20 2017-09-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
CL2015003780A1 (en) 2015-12-30 2016-09-16 Univ Chile Pyrimido-isoquinolin-quinone derivative compounds, their salts, isomers, acceptable pharmaceutical tautomers; farm compositions; preparation procedure; and its use in the treatment of multiresistant bacterial and bacterial diseases.
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
MX2020008537A (en) 2018-02-16 2021-01-08 Sunovion Pharmaceuticals Inc SALTS, CRYSTALLINE FORMS AND METHODS OF PRODUCTION THEREOF.
MX2020011718A (en) 2018-05-04 2021-02-15 Incyte Corp SOLID FORMS OF A FIBROBLAST GROWTH FACTOR RECEPTOR (FGFR) INHIBITOR AND PROCESSES FOR PREPARING THEM.
ES3061844T3 (en) 2018-05-04 2026-04-07 Incyte Corp Salts of an fgfr inhibitor
CN111620866A (en) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 Cis-7, 7-difluoro-hexahydro-1H pyrrolo [3,4-c ] pyridine derivative and preparation method thereof
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TWI891666B (en) 2019-10-14 2025-08-01 美商英塞特公司 Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
TW202304459A (en) 2021-04-12 2023-02-01 美商英塞特公司 Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
JP2024522189A (en) 2021-06-09 2024-06-11 インサイト・コーポレイション Tricyclic Heterocycles as FGFR Inhibitors
EP4352060A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
JP2024540935A (en) 2021-10-20 2024-11-06 インシリコ メディシン アイピー リミテッド Methionine adenosyltransferase 2A (MAT2A) inhibitors and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1311573A (en) * 1970-04-27 1973-03-28 Hisamitsu Pharmaceutical Co Quinazolinedione derivatives
DE2334266A1 (en) * 1972-07-07 1974-01-31 Hisamitsu Pharmaceutical Co PYRIDO SQUARE BRACKET ON 2.3-D SQUARE BRACKET FOR PYRIMIDINE-2,4 (1H, 3H) -DIONE
JPS5758347B2 (en) * 1974-04-03 1982-12-09 Hisamitsu Pharmaceutical Co
JPS5761743B2 (en) * 1974-04-25 1982-12-25 Hisamitsu Pharmaceutical Co
DE2446543A1 (en) * 1974-09-28 1976-04-15 Hoechst Ag Monoazomethine pigments - from 3-hydroxy 4-formylnaphthalic acid or derivs.
DE2614148A1 (en) * 1976-04-02 1977-10-20 Henkel & Cie Gmbh OXIDIZING AGENTS, BLEACHING AGENTS AND DETERGENTS WITH A BLEACH ACTIVATOR CONTENT
IT1228293B (en) * 1989-02-06 1991-06-07 Angeli Inst Spa BENZODERIVATES OF HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN.
WO1994014809A1 (en) * 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
JPH09208543A (en) * 1995-11-29 1997-08-12 Ono Pharmaceut Co Ltd Method for producing isocyanate derivative and related compounds
EP0896961A4 (en) * 1995-12-28 1999-04-07 Fuji Chem Ind Co Ltd Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
US5780628A (en) * 1996-02-01 1998-07-14 Sumitomo Chemical Company, Limited Process for producing dioxoquinazolines
JPH09295977A (en) * 1996-04-30 1997-11-18 Terumo Corp Pyridopyrimidine derivative and medicinal composition containing the same
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
PT1028950E (en) * 1997-10-28 2003-09-30 Warner Lambert Co QUINAZOLIN-2,4-DIONAS 7-SUBSTITUTES UTEIS AS ANTIBACTERIAL AGENTS
YU55902A (en) * 2000-01-24 2006-01-16 Warner-Lambert Company 3-aminoquinazolin-2,4-dione antibacterial agents
WO2001079206A1 (en) * 2000-04-18 2001-10-25 Sumitomo Pharmaceuticals Company, Limited Tricyclic quinazolinediones
JP2002284699A (en) * 2001-03-28 2002-10-03 Sumitomo Pharmaceut Co Ltd Remedies for photoreceptor degenerative diseases

Also Published As

Publication number Publication date
AU2002302894A1 (en) 2003-01-02
WO2002102793A3 (en) 2003-04-10
HN2002000150A (en) 2002-09-13
SV2003001089A (en) 2003-03-18
BR0210028A (en) 2004-06-22
CA2446963A1 (en) 2002-12-27
WO2002102793A2 (en) 2002-12-27
PE20030272A1 (en) 2003-03-21
PA8548401A1 (en) 2003-05-14
MXPA03009894A (en) 2004-02-17
GT200200104A (en) 2003-02-11
EP1401830A2 (en) 2004-03-31
JP2005501021A (en) 2005-01-13

Similar Documents

Publication Publication Date Title
PA8548401A1 (en) ANTIBACTERIAL AGENTS
UY27424A1 (en) ANTIDIABETIC AGENTS
ATE433447T1 (en) PYRIMIIDINE COMPOUNDS
CR7332A (en) INHIBITORS OF THE FACTOR Xa AND OTHER SERINE PROTEASES INVOLVED IN THE CASCADA DE LA COAGULACION
UA88012C2 (en) QUINAZOLINDIONE DERIVATIVES AS PARP INHIBITORS$ QUINAZOLINDIONE DERIVATIVES AS PARP INHIBITORS
UY27226A1 (en) PIRAZOLOPIRIMIDINAS AS THERAPEUTIC AGENTS
ECSP034773A (en) PIRAZOLOPIRIMMIDINAS AS THERAPEUTIC AGENTS
UY27350A1 (en) AZAINDOLS
ATE296826T1 (en) PYRAZOLO(1,5)PYRIDINE DERIVATIVES
SE0302811D0 (en) Novel compounds
UY28671A1 (en) PIRIDO (2.3-D) PIRIMIDINA-2,4-DIAMINAS AS PDE 2 INHIBITORS
SE0301446D0 (en) New Compounds
ATE300541T1 (en) PYRAZOLOPYRIDINE DERIVATIVES
SE0302192D0 (en) Novel compounds
LTPA2016016I1 (en) AZETINIDES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
SE0403171D0 (en) New compounds
PA8568101A1 (en) INDOLIL-UREA DERIVED FROM USEFUL TIENOPIRIDINS AS ANTIANGIOGEN AGENTS, AND PROCEDURES FOR USE
CR7956A (en) INTERMEDIATE ANTIBACTERIAL INDOLONA OXAZOLIDINONES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
GT200600161A (en) NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS
ATE373000T1 (en) PYRAZOLOPYRIDINE DERIVATIVES AS ANTHERPESICS
ATE274515T1 (en) PYRAZOLOPYRIDINE DERIVATIVES
UY27514A1 (en) BASIC LINEAR COMPOUNDS THAT HAVE NK-2 ANTAGONIST ACTIVITY AND ITS FORMULATIONS.
DOP2002000386A (en) ANTIBACTERIAL AGENTS
UY29999A1 (en) "N-PIRAZINIL-PHENYLSULPHONAMIDS, PROCEDURES AND COMPOUNDS AVERAGE USED IN ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS"
SE0403118D0 (en) New compounds 2