DOP2002000548A - Peptidos para el tratamiento del cancer asociado al virus papiloma humano (vph) y de otros tumores epiteliales - Google Patents

Peptidos para el tratamiento del cancer asociado al virus papiloma humano (vph) y de otros tumores epiteliales

Info

Publication number
DOP2002000548A
DOP2002000548A DO2002000548A DO2002000548A DOP2002000548A DO P2002000548 A DOP2002000548 A DO P2002000548A DO 2002000548 A DO2002000548 A DO 2002000548A DO 2002000548 A DO2002000548 A DO 2002000548A DO P2002000548 A DOP2002000548 A DO P2002000548A
Authority
DO
Dominican Republic
Prior art keywords
peptides
hpv
tumors
treatment
ckii
Prior art date
Application number
DO2002000548A
Other languages
English (en)
Inventor
Rodriguez Silvio Ernesto Perea
Acosta Osvaldo Reyes
Vispo Nelson Francisco Santiago
Izaguirre Yaquelin Puchades
Rodriguez Ricardo Silva
Soria Alejandro Moro
Savio Alicia Santos
Lopez Luis Javier Gonzalez
Barrios Belkis Gonzalez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Publication of DOP2002000548A publication Critical patent/DOP2002000548A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Péptidos útiles para el tratamiento de tumores de origen epitelial y especialmente los asociados a tipos oncogénicos de Virus Papiloma (VPH). Identificación de péptidos cuya estructura permita el bloqueo del dominio de fosforilación por Caseína Kinasa II (CKII) mediante la interacción directa con dicho sitio. En la presente invención se muestran once péptidos de estructura cíclica y secuencia aminoacídica diferente, los cuales inhiben el sitio de fosforilación por CKII in vitro, producen citotoxicidad en células de carcinoma de cuello uterino humano transformadas por VPH-16 (CaSki) y además incrementan la sensibilidad de dichas células al efecto citostático del Interferón (IFN). La invención se relaciona además con el uso de estos péptidos conjugados o fusionados a otros péptidos y compuestos químicos de penetración intracelular así como con el uso de moléculas miméticas tanto de origen peptídico como de origen químico.
DO2002000548A 2001-12-20 2002-12-17 Peptidos para el tratamiento del cancer asociado al virus papiloma humano (vph) y de otros tumores epiteliales DOP2002000548A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20010309A CU23225A1 (es) 2001-12-20 2001-12-20 PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES

Publications (1)

Publication Number Publication Date
DOP2002000548A true DOP2002000548A (es) 2003-06-30

Family

ID=40091679

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2002000548A DOP2002000548A (es) 2001-12-20 2002-12-17 Peptidos para el tratamiento del cancer asociado al virus papiloma humano (vph) y de otros tumores epiteliales

Country Status (33)

Country Link
US (2) US7374767B2 (es)
EP (2) EP2383282A1 (es)
JP (1) JP4056476B2 (es)
KR (1) KR100642437B1 (es)
CN (1) CN100368431C (es)
AR (1) AR037825A1 (es)
AT (1) ATE520704T1 (es)
AU (1) AU2002361922B2 (es)
BR (1) BRPI0215213C1 (es)
CA (1) CA2471110C (es)
CR (1) CR7361A (es)
CU (1) CU23225A1 (es)
DK (1) DK1491553T3 (es)
DO (1) DOP2002000548A (es)
ES (1) ES2371239T3 (es)
HN (1) HN2002000377A (es)
HR (1) HRP20040663B1 (es)
IL (2) IL162633A0 (es)
IS (1) IS2906B (es)
MA (1) MA27868A1 (es)
MX (1) MXPA04005832A (es)
MY (1) MY133530A (es)
NO (1) NO333259B1 (es)
NZ (1) NZ534170A (es)
PE (1) PE20030861A1 (es)
PT (1) PT1491553E (es)
RU (1) RU2290410C2 (es)
SI (1) SI1491553T1 (es)
TN (1) TNSN04114A1 (es)
UA (1) UA81403C2 (es)
UY (1) UY27602A1 (es)
WO (1) WO2003054002A1 (es)
ZA (1) ZA200405514B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23225A1 (es) * 2001-12-20 2007-08-30 Ct Ingenieria Genetica Biotech PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES
CU23431B6 (es) 2005-05-12 2009-10-16 Ct Ingenieria Genetica Biotech Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer
GB2433740A (en) * 2005-12-23 2007-07-04 Rapid Biosensor Systems Ltd Detection of tuberculosis infection
CU23511B6 (es) 2006-02-28 2010-04-13 Biorec B V Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas
GB2441131A (en) * 2006-08-24 2008-02-27 Univ Dundee Modulation of binding of CK2a to NDPK
CN100522992C (zh) * 2007-02-12 2009-08-05 中国科学院昆明动物研究所 一种环状小肽ba
JP4670107B2 (ja) 2007-03-27 2011-04-13 大幸薬品株式会社 感染性皮膚および粘膜疾患治療薬
WO2010096751A1 (en) 2009-02-23 2010-08-26 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta
JP2012520085A (ja) * 2009-03-13 2012-09-06 エーゲン、インコーポレイテッド 生物活性ｒｎａの送達のための組成物及び方法
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
CU20200103A7 (es) * 2020-12-18 2022-07-08 Ct Ingenieria Genetica Biotecnologia Péptido sintético para la inducción de inmunidad antitumoral y antiviral
CU24766B1 (es) 2021-07-09 2025-08-13 Ct Ingenieria Genetica Biotecnologia Péptidos lineales que inhiben la fosforilación mediada por ck2
CN118370805B (zh) * 2024-04-29 2025-02-14 广州中科佰氏健康产业有限公司 一种抑菌妇科凝胶及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902820A1 (en) * 1989-08-07 1991-02-27 Merck & Co Inc Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins
JPH05310784A (ja) 1991-09-04 1993-11-22 Merck & Co Inc ヒト乳頭腫ウイルスタンパク質と網膜芽細胞腫遺伝子タンパク質との結合のペプチド阻害剤
GB9313556D0 (en) * 1993-07-01 1993-08-18 British Tech Group Synthetic peptides of human papillomavirus
US5625031A (en) * 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
ATE235509T1 (de) * 1998-06-30 2003-04-15 Deutsches Krebsforsch Peptide zur inhibition von hpv e7 proteinen
WO2001064835A2 (en) * 2000-02-28 2001-09-07 Hyseq, Inc. Novel nucleic acids and polypeptides
US6641994B2 (en) * 1999-08-25 2003-11-04 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
CU23225A1 (es) * 2001-12-20 2007-08-30 Ct Ingenieria Genetica Biotech PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES

Also Published As

Publication number Publication date
IL162633A (en) 2011-02-28
PE20030861A1 (es) 2003-12-02
UY27602A1 (es) 2003-04-30
WO2003054002A1 (es) 2003-07-03
BRPI0215213C1 (pt) 2021-05-25
UA81403C2 (en) 2008-01-10
EP1491553B1 (en) 2011-08-17
BRPI0215213B1 (pt) 2018-09-11
JP4056476B2 (ja) 2008-03-05
AU2002361922A1 (en) 2003-07-09
MA27868A1 (fr) 2006-05-02
IS2906B (is) 2014-11-15
SI1491553T1 (sl) 2011-12-30
NO20043112L (no) 2004-07-20
CA2471110A1 (en) 2003-07-03
DK1491553T3 (da) 2011-12-05
HRP20040663B1 (hr) 2013-05-31
KR100642437B1 (ko) 2006-11-06
RU2290410C2 (ru) 2006-12-27
RU2004122084A (ru) 2005-03-27
CA2471110C (en) 2017-01-31
AR037825A1 (es) 2004-12-09
CN1620464A (zh) 2005-05-25
IL162633A0 (es) 2005-11-20
CN100368431C (zh) 2008-02-13
US20090005294A1 (en) 2009-01-01
KR20050002811A (ko) 2005-01-10
ZA200405514B (en) 2005-03-30
US20060233742A1 (en) 2006-10-19
IS7320A (is) 2004-06-16
HK1068901A1 (en) 2005-05-06
PT1491553E (pt) 2011-11-25
NZ534170A (en) 2006-08-31
US7374767B2 (en) 2008-05-20
ATE520704T1 (de) 2011-09-15
EP2383282A1 (en) 2011-11-02
ES2371239T3 (es) 2011-12-28
NO333259B1 (no) 2013-04-22
CR7361A (es) 2005-02-18
TNSN04114A1 (en) 2006-06-01
HN2002000377A (es) 2003-04-10
US7947287B2 (en) 2011-05-24
AU2002361922B2 (en) 2007-04-05
EP1491553A1 (en) 2004-12-29
HRP20040663A2 (en) 2005-08-31
CU23225A1 (es) 2007-08-30
MXPA04005832A (es) 2004-09-13
MY133530A (en) 2007-11-30
JP2005525090A (ja) 2005-08-25
BR0215213A (pt) 2004-12-07

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