DOP2004000986A - BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITY - Google Patents
BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITYInfo
- Publication number
- DOP2004000986A DOP2004000986A DO2004000986A DO2004000986A DOP2004000986A DO P2004000986 A DOP2004000986 A DO P2004000986A DO 2004000986 A DO2004000986 A DO 2004000986A DO 2004000986 A DO2004000986 A DO 2004000986A DO P2004000986 A DOP2004000986 A DO P2004000986A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- disease
- compounds
- dyspepsia
- irritable bowel
- gastroesophageal reflux
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 2
- 201000006549 dyspepsia Diseases 0.000 abstract 5
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 2
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 206010030216 Oesophagitis Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000006881 esophagitis Diseases 0.000 abstract 1
- 230000030135 gastric motility Effects 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002859 sleep apnea Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invencion proporciona un compuesto de formula (I): o una sal farmaceuticamente aceptable del mismo, y composiciones que contienen dichos compuestos y el use de dichos compuestos para la preparacion de un medicamento para enfermedad por reflujo gastroesofagico, enfermedad gastrointestinal, trastorno de motilidad gastrica, dispepsia noulcerosa, dispepsia funcional, sindrome de intestino irritable (IBS), estrenimiento, dispepsia, esofagitis, enfermedad gastresofagica, nauseas, enfermedad del sistema nervioso central, enfermedad de Alzheimer, trastomo cognitivo, emesis, migranas, enfermedad neurologica, dolor, trastomos cardiovasculares, insuficiencia cardiaca, arritmia cardiaca, diabetes y sindrome de apnea. Estos compuestos tienen actividad agonista del receptor 5-HT4, y por lo tanto son utiles para el tratamiento de enfermedad por reflujo gastroesofagico, dispepsia no ulcerosa, dispepsia funcional, sindrome de intestino irritable o similares en mamiferos, especialmente en seres humanos.This invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing said compounds and the use of said compounds for the preparation of a medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder , noulcerous dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastresophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraines, neurological disease, pain, cardiovascular disorders , heart failure, cardiac arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonist activity, and are therefore useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammals, especially in humans.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2004000986A DOP2004000986A (en) | 2004-08-31 | 2004-08-31 | BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2004000986A DOP2004000986A (en) | 2004-08-31 | 2004-08-31 | BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2004000986A true DOP2004000986A (en) | 2005-03-15 |
Family
ID=44261402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2004000986A DOP2004000986A (en) | 2004-08-31 | 2004-08-31 | BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITY |
Country Status (1)
| Country | Link |
|---|---|
| DO (1) | DOP2004000986A (en) |
-
2004
- 2004-08-31 DO DO2004000986A patent/DOP2004000986A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP066407A (en) | BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5-HT4 RECEPTOR AGONIST ACTIVITY | |
| DOP2006000046A (en) | OXINDOL DERIVATIVES | |
| UY27992A1 (en) | N-SUBSTITUTED PIPERIDINYL-IMIDAZOPIRIDINE COMPOUNDS AS 5-HT RECEIVER MODULATORS | |
| ECSP067079A (en) | BENCIMIDAZOLONA CARBOXYL ACID DERIVATIVES | |
| NO20070213L (en) | Glucagon Receptor Antagonists, Preparation and Therapeutic Uses | |
| PY0225099A (en) | IMIDAZOPYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | |
| WO2007061763A3 (en) | Indole orexin receptor antagonists | |
| WO2008007211A8 (en) | Substituted n-bicyclicalkyl bicyclic carboxyamide compounds | |
| AR041302A1 (en) | IMIDAZOPIRIDINE COMPOUNDS AS RECEIVER AGONISTS 5- HT4 AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH COMPOUNDS | |
| ATE455776T1 (en) | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AGAINST CNS DISEASES | |
| WO2024192150A3 (en) | 3-alkylamine indole activators of serotonin receptors | |
| ATE449092T1 (en) | INDAZOLE CARBONIC ACID AMIDE DERIVATIVES AS AGONISTS OF THE 5HT4 RECEPTOR | |
| ATE473961T1 (en) | GLUCAGON RECEPTOR ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | |
| EA200800421A1 (en) | CONNECTIONS | |
| DOP2004000986A (en) | BENCIMIDAZOLONE COMPOUNDS THAT HAVE 5HT-4 RECEIVER ACTIVITY | |
| CU20070183A7 (en) | OXINDOL DERIVATIVES | |
| DOP2005000113A (en) | BENCIMIDAZOLONA CARBOXILIC ACID DRIVATES | |
| UY27504A1 (en) | IMIDAZOPIRIDIN COMPOUNDS AS 5-HT4 RECEIVER MODULATORS | |
| TH106943A (en) | Benzimidazolone compounds with anti-active 5-HT4 receptor | |
| TH76314A (en) | Simidazolone carboxylic acid derivatives |