DOP2007000131A - Sal de la 5-amino-3-(2,o-acetil-3´-desoxi-eta-d-ribofuranosil)-3h-tiazol[4,5-d)pirimidin-2-ona del acido p-toluensulfonico y metodos para su preparacion - Google Patents

Sal de la 5-amino-3-(2,o-acetil-3´-desoxi-eta-d-ribofuranosil)-3h-tiazol[4,5-d)pirimidin-2-ona del acido p-toluensulfonico y metodos para su preparacion

Info

Publication number: DOP2007000131A
Authority: DO; Dominican Republic
Prior art keywords: amino; salt; preparation; methods; ribofuranosil
Prior art date: 2006-10-17

Application number

DO2007000131A

Other languages

English (en)

Spanish (es)

Inventor

David Kucera

Gregory J Haley

Erik J Rueden

Tingman Wang

Fritz Blatter

Martin Viertelhaus

Original Assignee

Anadys Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-17

Filing date

2007-10-17

Publication date

2008-09-15

2007-10-17 Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc

2008-09-15 Publication of DOP2007000131A publication Critical patent/DOP2007000131A/es

Links

JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 title abstract 6
150000003839 salts Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
208000036142 Viral infection Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 furanose compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DO2007000131A 2006-10-17 2007-10-17 Sal de la 5-amino-3-(2,o-acetil-3´-desoxi-eta-d-ribofuranosil)-3h-tiazol[4,5-d)pirimidin-2-ona del acido p-toluensulfonico y metodos para su preparacion DOP2007000131A (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US85200206P	2006-10-17	2006-10-17
US89940507P	2007-02-05	2007-02-05
US95359707P	2007-08-02	2007-08-02

Publications (1)

Publication Number	Publication Date
DOP2007000131A true DOP2007000131A (es)	2008-09-15

Family

ID=39472747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DO2007000131A DOP2007000131A (es)	2006-10-17	2007-10-17	Sal de la 5-amino-3-(2,o-acetil-3´-desoxi-eta-d-ribofuranosil)-3h-tiazol[4,5-d)pirimidin-2-ona del acido p-toluensulfonico y metodos para su preparacion

Country Status (24)

Country	Link
US (2)	US7928085B2 (pt)
EP (1)	EP2076132B1 (pt)
JP (2)	JP5279715B2 (pt)
KR (2)	KR101515077B1 (pt)
AR (1)	AR063484A1 (pt)
AU (1)	AU2007353381B2 (pt)
BR (1)	BRPI0717741A2 (pt)
CA (2)	CA2898225A1 (pt)
CY (1)	CY1113368T1 (pt)
DK (1)	DK2076132T3 (pt)
DO (1)	DOP2007000131A (pt)
EA (1)	EA017005B1 (pt)
ES (1)	ES2390930T3 (pt)
IL (2)	IL198180A (pt)
MX (1)	MX2009004028A (pt)
MY (1)	MY150408A (pt)
NO (1)	NO20091598L (pt)
NZ (1)	NZ576408A (pt)
PE (1)	PE20081105A1 (pt)
PL (1)	PL2076132T3 (pt)
PT (1)	PT2076132E (pt)
TW (1)	TWI415854B (pt)
UY (1)	UY30650A1 (pt)
WO (1)	WO2008140549A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2655904C (en)	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
WO2009026292A1 (en)	2007-08-20	2009-02-26	Anadys Pharmaceuticals, Inc.	Dosing methods for treating disease
HUE053704T2 (hu)	2014-12-08	2021-07-28	Hoffmann La Roche	3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
US9676793B2 (en)	2014-12-23	2017-06-13	Hoffmann-Laroche Inc.	Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
CN107427514B (zh)	2015-03-16	2021-07-13	豪夫迈·罗氏有限公司	使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
EP3294745B1 (en)	2015-05-08	2020-01-01	H. Hoffnabb-La Roche Ag	Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
CN107592864B (zh)	2015-05-12	2021-04-16	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
CN107820498B (zh)	2015-06-30	2020-06-19	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的取代的氨基噻唑并嘧啶二酮
WO2018127525A1 (en) *	2017-01-06	2018-07-12	F. Hoffmann-La Roche Ag	PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS
CN110007010A (zh) *	2018-01-05	2019-07-12	大鹏药品工业株式会社	源自曲氟尿苷的类似物质的检测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07224081A (ja) *	1994-02-10	1995-08-22	Kobayashi Koryo Kk	デオキシリボフラノシルハライド誘導体の製造方法
US5532374A (en)	1995-06-06	1996-07-02	Hitachi Chemical Company, Ltd.	Method of preparation of bis-quinolines
JP4067226B2 (ja) *	1999-04-01	2008-03-26	三井化学株式会社	１―ハロゲノ−２−デオキシリボフラノース誘導体の製造方法
JP2000327693A (ja) *	1999-05-21	2000-11-28	Mitsui Chemicals Inc	２’−デオキシ−β−シチジン誘導体の製造方法
US6649761B2 (en) *	2001-05-30	2003-11-18	Merck & Co., Inc.	Process for preparing piperazinepentaneamide HIV protease inhibitors
WO2003045968A1 (en) *	2001-11-27	2003-06-05	Anadys Pharmaceuticals, Inc.	3-β-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
US20060229322A1 (en) *	2002-12-09	2006-10-12	Pau Cid	Anhydrous crystalline form of valacyclovir hydrochloride
EP1667694B1 (en) *	2003-09-05	2010-04-28	Anadys Pharmaceuticals, Inc.	Tlr7 ligands for the treatment of hepatitis c
AU2004320625B2 (en) *	2004-06-07	2009-08-27	Anadys Pharmaceuticals, Inc.	3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
ES2459368T3 (es)	2004-12-17	2014-05-09	Anadys Pharmaceuticals, Inc.	Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
US7501526B2 (en) *	2005-01-20	2009-03-10	Taigen Biotechnology	Synthesis of polyamine compounds
CA2655904C (en) *	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
CN101595117B (zh) *	2006-12-08	2014-01-22	株式会社Api	呋喃糖衍生物的制造方法

2007
- 2007-10-06 BR BRPI0717741-0A2A patent/BRPI0717741A2/pt not_active Application Discontinuation
- 2007-10-16 WO PCT/US2007/081526 patent/WO2008140549A1/en not_active Ceased
- 2007-10-16 CA CA2898225A patent/CA2898225A1/en not_active Abandoned
- 2007-10-16 AU AU2007353381A patent/AU2007353381B2/en not_active Ceased
- 2007-10-16 CA CA2666537A patent/CA2666537C/en not_active Expired - Fee Related
- 2007-10-16 DK DK07873546.1T patent/DK2076132T3/da active
- 2007-10-16 JP JP2009533481A patent/JP5279715B2/ja not_active Expired - Fee Related
- 2007-10-16 EA EA200970387A patent/EA017005B1/ru not_active IP Right Cessation
- 2007-10-16 TW TW096138583A patent/TWI415854B/zh not_active IP Right Cessation
- 2007-10-16 PE PE2007001399A patent/PE20081105A1/es not_active Application Discontinuation
- 2007-10-16 US US11/873,202 patent/US7928085B2/en not_active Expired - Fee Related
- 2007-10-16 KR KR1020147026217A patent/KR101515077B1/ko not_active Expired - Fee Related
- 2007-10-16 PL PL07873546T patent/PL2076132T3/pl unknown
- 2007-10-16 PT PT07873546T patent/PT2076132E/pt unknown
- 2007-10-16 MX MX2009004028A patent/MX2009004028A/es active IP Right Grant
- 2007-10-16 EP EP07873546A patent/EP2076132B1/en not_active Not-in-force
- 2007-10-16 ES ES07873546T patent/ES2390930T3/es active Active
- 2007-10-16 NZ NZ576408A patent/NZ576408A/en not_active IP Right Cessation
- 2007-10-16 MY MYPI20091559 patent/MY150408A/en unknown
- 2007-10-16 KR KR1020097010038A patent/KR101486444B1/ko not_active Expired - Fee Related
- 2007-10-17 AR ARP070104611A patent/AR063484A1/es unknown
- 2007-10-17 DO DO2007000131A patent/DOP2007000131A/es unknown
- 2007-10-17 UY UY30650A patent/UY30650A1/es not_active Application Discontinuation
2009
- 2009-04-16 IL IL198180A patent/IL198180A/en active IP Right Grant
- 2009-04-22 NO NO20091598A patent/NO20091598L/no not_active Application Discontinuation
2011
- 2011-03-23 US US13/069,426 patent/US8193342B2/en not_active Expired - Fee Related
2012
- 2012-09-28 CY CY20121100897T patent/CY1113368T1/el unknown
- 2012-11-19 IL IL223126A patent/IL223126A/en active IP Right Grant
2013
- 2013-05-21 JP JP2013107302A patent/JP5703334B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL223126A (en)	2016-08-31
TW200833699A (en)	2008-08-16
EP2076132B1 (en)	2012-07-11
ES2390930T3 (es)	2012-11-19
US20110172447A1 (en)	2011-07-14
TWI415854B (zh)	2013-11-21
JP2010506947A (ja)	2010-03-04
UY30650A1 (es)	2008-05-31
PT2076132E (pt)	2012-10-03
EP2076132A1 (en)	2009-07-08
CA2666537A1 (en)	2008-11-20
NO20091598L (no)	2009-07-10
AR063484A1 (es)	2009-01-28
EP2076132A4 (en)	2011-05-04
KR20090074237A (ko)	2009-07-06
AU2007353381A1 (en)	2008-11-20
US7928085B2 (en)	2011-04-19
CA2898225A1 (en)	2008-11-20
CA2666537C (en)	2015-12-08
KR20140119203A (ko)	2014-10-08
NZ576408A (en)	2012-04-27
EA017005B1 (ru)	2012-09-28
KR101486444B1 (ko)	2015-01-26
JP2013166782A (ja)	2013-08-29
JP5703334B2 (ja)	2015-04-15
DK2076132T3 (da)	2012-09-10
EA200970387A1 (ru)	2009-10-30
CY1113368T1 (el)	2016-06-22
PE20081105A1 (es)	2008-08-15
IL198180A (en)	2015-06-30
WO2008140549A1 (en)	2008-11-20
PL2076132T3 (pl)	2013-01-31
IL223126A0 (en)	2012-12-31
MX2009004028A (es)	2009-05-11
JP5279715B2 (ja)	2013-09-04
AU2007353381B2 (en)	2013-07-04
MY150408A (en)	2014-01-15
US8193342B2 (en)	2012-06-05
HK1132429A1 (en)	2010-02-26
KR101515077B1 (ko)	2015-04-24
IL198180A0 (en)	2009-12-24
US20090197826A1 (en)	2009-08-06
BRPI0717741A2 (pt)	2014-04-08

Similar Documents

Publication	Publication Date	Title
UY30650A1 (es)	2008-05-31	Sal de acido p-toluensulfonico de 5-amino-3-(2??-o-acetil-3??-desoxi-b-d-ribofuranosil)-3h-tiazol[4,5-d]pirimidin-2-ona y métodos de preparacion
MX374401B (es)	2025-03-06	Compuestos de imidazo [4,5-c] quinolin-2-ona y su uso para tratar cancer.
CL2007001710A1 (es)	2008-01-04	Compuestos derivados de amino-pirazolopiridina sustituidos; metodo de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como tumores, artritis reumatoide, enfermedades de crecimiento vascular desregulado, entre otras.
CL2013003227A1 (es)	2014-06-27	“compuestos derivados de indazol sustituidos, moduladores de la actividad de proteínas quinasas; proceso de obtención de ellos; método in vitro para inhibir proteínas quinasas; composición y combinación farmacéutica que los comprende; y su uso en el tratamiento del cáncer" pct
ECSP109935A (es)	2010-03-31	Derivados de morfolino pirimidina utilizados en enfermedades relacionadas con mtor quinasa y/o pi3k
CR10874A (es)	2009-07-23	Polimorfos de sal de succinato 2-[6-(3-amino-piperidin-1-ilo)-3 metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil]-4-fluoro benzonitrilo y metodos para el uso de los mismos
EA201070929A1 (ru)	2011-04-29	ФУРО- И ТИЕНО[3,2-c]ПИРИДИНЫ
GT201300121A (es)	2014-12-22	Derivados de 2,3-dihidroimidazo(1,2-c)quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogénesis
CL2008002966A1 (es)	2010-06-25	Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros.
CL2007001165A1 (es)	2008-01-25	2-(1h-indazol-4-il)-6-(4-metanosulfonil-piperazin-1-ilmetil)-4-morfolin-4-il-tieno[3,2-d]pirimidina; procedimiento de preparacion; composicion farmaceutica; proceso de preparacion de dicha composicion; kit farmaceutico; y uso para tratar enfermedades tales como cancer, desordenes inmunes y enfermedades cardiovasculares.
CA2925624C (en)	2021-06-15	Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
UY32882A (es)	2011-04-29	(heteroarilmetil) tiohidantoínas sustituidas
EA200901138A1 (ru)	2010-04-30	Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
DOP2018000065A (es)	2018-03-30	Derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cáncer
CA2918938C (en)	2021-05-18	Substituted aminopyrimidine compounds and methods of use
CO6620050A2 (es)	2013-02-15	Derivados de aminopirimidina como moduladores de la lrrk2
CL2011003346A1 (es)	2012-05-25	Compuestos derivados de 2,3-dihidro-5h-[1,3]tiazolo[3,2-a]pirimidin-5-ona, moduladores de pi3k; composicion farmaceutica; y uso para tratar una enfermedad de base inmunologica, cancer o enfermedad pulmonar en un paciente.
EA202090258A3 (ru)	2020-07-31	Производные пирроло[3,2-d]пиримидина для лечения вирусных инфекций и других заболеваний
BR112015007698A2 (pt)	2017-08-22	Composto, composição farmacêutica, e, uso de um composto
CY1114911T1 (el)	2016-12-14	Ενωσεις [1,2,4]τριαζολο[1,5-α]πυριδινης και [1,2,4]τριαζολο[1,5-c]πυριμιδινης και χρηση αυτων
CL2008000670A1 (es)	2008-11-03	Compuestos derivados de tiazolidindionas y oxazolidindionas sustituidas; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis reumatoide, epoc, cancer, entre otras.
EA201791727A1 (ru)	2018-01-31	7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-а]пиридо[3,4-е]пиримидин-5(1н)-он, его аналоги и соли и способы их применения в терапии
BR112012033117A2 (pt)	2016-11-22	pirazolo[1,5-a]pirimidinas como agentes antivirais
SV2011003939A (es)	2011-07-28	Piridiloxi-indoles inhibidores del vegf-r2 y uso de los mismos para el tratamiento de enfermedades
EA201201343A1 (ru)	2013-03-29	Производные 4-аминопиримидина и их действующее вещество как антагонисты аденозинового рецептора а