DOP2009000012A - (s)-n-((s)-1-ciclohexil-2-{(s)-2-[4-(4-fluoro-benzoil)-tiazol-2-il]-pirrolidin-1-il}-2-oxo-etil)-2-metilamino- propionamida, un pectidomimético de smac útil como un inhibidor de iap, activo en la inhibición de la proliferación de células cancerosas - Google Patents

(s)-n-((s)-1-ciclohexil-2-{(s)-2-[4-(4-fluoro-benzoil)-tiazol-2-il]-pirrolidin-1-il}-2-oxo-etil)-2-metilamino- propionamida, un pectidomimético de smac útil como un inhibidor de iap, activo en la inhibición de la proliferación de células cancerosas

Info

Publication number
DOP2009000012A
DOP2009000012A DO2009000012A DO2009000012A DOP2009000012A DO P2009000012 A DOP2009000012 A DO P2009000012A DO 2009000012 A DO2009000012 A DO 2009000012A DO 2009000012 A DO2009000012 A DO 2009000012A DO P2009000012 A DOP2009000012 A DO P2009000012A
Authority
DO
Dominican Republic
Prior art keywords
propionamide
oxo
fluoro
pectidomimetic
cancerose
Prior art date
Application number
DO2009000012A
Other languages
English (en)
Inventor
Huangshu Lei
Miao Dai
Mark G Charest
Christine Hiu-Tung Chen
Zhuoliang Chen
Feng He
Ly Luu Pham
Sushil Kumar Sharma
Christopher Sean Straub
Run-Ming David Wang
Fan Yang
Leigh Zawel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DOP2009000012A publication Critical patent/DOP2009000012A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere al compuesto de la fórmula (I); que es la (S)-N-((S)-1-ciclohexil-2-{(S)-2-[4-(4-fluoro-benzoil)-tiazol-2-il]-pirrolidin-1-il}-2-oxo-etil)-2-metilamino-propionamida o sales farmacéuticamente aceptables del mismo, y al uso de este compuestos para el tratamiento de enfermedades proliferativas, tales como cáncer, en mamíferos.
DO2009000012A 2008-08-02 2009-01-30 (s)-n-((s)-1-ciclohexil-2-{(s)-2-[4-(4-fluoro-benzoil)-tiazol-2-il]-pirrolidin-1-il}-2-oxo-etil)-2-metilamino- propionamida, un pectidomimético de smac útil como un inhibidor de iap, activo en la inhibición de la proliferación de células cancerosas DOP2009000012A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83500008P 2008-08-02 2008-08-02

Publications (1)

Publication Number Publication Date
DOP2009000012A true DOP2009000012A (es) 2016-12-30

Family

ID=57734035

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2009000012A DOP2009000012A (es) 2008-08-02 2009-01-30 (s)-n-((s)-1-ciclohexil-2-{(s)-2-[4-(4-fluoro-benzoil)-tiazol-2-il]-pirrolidin-1-il}-2-oxo-etil)-2-metilamino- propionamida, un pectidomimético de smac útil como un inhibidor de iap, activo en la inhibición de la proliferación de células cancerosas

Country Status (1)

Country Link
DO (1) DOP2009000012A (es)

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