BRPI0906444B8 - compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos - Google Patents

compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos

Info

Publication number
BRPI0906444B8
BRPI0906444B8 BRPI0906444A BRPI0906444A BRPI0906444B8 BR PI0906444 B8 BRPI0906444 B8 BR PI0906444B8 BR PI0906444 A BRPI0906444 A BR PI0906444A BR PI0906444 A BRPI0906444 A BR PI0906444A BR PI0906444 B8 BRPI0906444 B8 BR PI0906444B8
Authority
BR
Brazil
Prior art keywords
well
pharmaceutical composition
compounds
pyridinone compounds
pyridinone
Prior art date
Application number
BRPI0906444A
Other languages
English (en)
Inventor
M Borzilleri Robert
Cai Zhen-Wei
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BRPI0906444A2 publication Critical patent/BRPI0906444A2/pt
Publication of BRPI0906444A8 publication Critical patent/BRPI0906444A8/pt
Publication of BRPI0906444B1 publication Critical patent/BRPI0906444B1/pt
Publication of BRPI0906444B8 publication Critical patent/BRPI0906444B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos. a presente invenção refere-se a compostos de fórmula (i) e sais dos mesmos. também, refere-se a métodos para usar os compostos no tratamento de doenças proliferativas, tal como câncer, e composições farmacêuticas compreendendo ao menos um composto de fórmula (i) ou um sal farmaceuticamente aceitável.
BRPI0906444A 2008-01-23 2009-01-22 compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos BRPI0906444B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2284808P 2008-01-23 2008-01-23
US61/022,848 2008-01-23
PCT/US2009/031649 WO2009094417A1 (en) 2008-01-23 2009-01-22 4-pyridinone compounds and their use for cancer

Publications (4)

Publication Number Publication Date
BRPI0906444A2 BRPI0906444A2 (pt) 2015-07-14
BRPI0906444A8 BRPI0906444A8 (pt) 2020-02-27
BRPI0906444B1 BRPI0906444B1 (pt) 2021-03-16
BRPI0906444B8 true BRPI0906444B8 (pt) 2021-05-25

Family

ID=40637826

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906444A BRPI0906444B8 (pt) 2008-01-23 2009-01-22 compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos

Country Status (21)

Country Link
US (2) US8124768B2 (pt)
EP (1) EP2235002B1 (pt)
JP (1) JP5314050B2 (pt)
KR (1) KR101596527B1 (pt)
CN (1) CN101977906B (pt)
AU (1) AU2009206440B2 (pt)
BR (1) BRPI0906444B8 (pt)
CA (1) CA2713111C (pt)
CO (1) CO6230986A2 (pt)
CY (1) CY1114140T1 (pt)
DK (1) DK2235002T3 (pt)
EA (1) EA017736B1 (pt)
ES (1) ES2398335T3 (pt)
HR (1) HRP20130040T1 (pt)
IL (1) IL207212A (pt)
NZ (1) NZ586630A (pt)
PL (1) PL2235002T3 (pt)
PT (1) PT2235002E (pt)
SI (1) SI2235002T1 (pt)
WO (1) WO2009094417A1 (pt)
ZA (1) ZA201005248B (pt)

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EP2340244A4 (en) 2008-10-14 2012-07-25 Ning Xi COMPOUNDS AND APPLICATION PROCEDURES
ES2578990T3 (es) 2009-03-21 2016-08-03 Sunshine Lake Pharma Co., Ltd. Derivados de amino éster, sales de los mismos y métodos de uso
EP2563773A1 (en) * 2010-04-29 2013-03-06 Deciphera Pharmaceuticals, LLC Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
RU2477723C2 (ru) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
RS55728B1 (sr) 2012-01-31 2017-07-31 Daiichi Sankyo Co Ltd Derivat piridona
WO2014022117A1 (en) 2012-07-28 2014-02-06 Calitor Sciences, Llc Substituted pyrazolone compounds and methods of use
US8975282B2 (en) 2012-07-28 2015-03-10 Sunshine Lake Pharma Co., Ltd. Substituted pyrazolone compounds and methods of use
US9102624B2 (en) * 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) * 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
TWI690525B (zh) 2014-07-07 2020-04-11 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
CN105153026B (zh) * 2015-08-21 2018-02-02 江西科技师范大学 含联芳基酰胺结构的索拉非尼衍生物及其制备方法和应用
CR20210364A (es) * 2019-01-03 2021-08-18 Array Biopharma Inc Compuestos de quinolina como inhibidores de quinasas tam y met
US20240293386A1 (en) * 2021-06-22 2024-09-05 Lg Chem, Ltd. Novel compound as protein kinase inhibitor
TW202315628A (zh) * 2021-06-24 2023-04-16 南韓商Ｌｇ化學股份有限公司 作為ｒｏｎ抑制劑之新穎吡啶衍生物化合物
TW202428285A (zh) * 2022-09-28 2024-07-16 大陸商上海濟煜醫藥科技有限公司 含磷類化合物及其製備方法和醫藥應用

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EP0430885A3 (en) 1989-12-01 1991-11-06 Ciba-Geigy Ag Anthelmintical compounds
US6143764A (en) * 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
AU4692399A (en) * 1998-06-17 2000-01-05 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6521622B1 (en) * 1999-07-20 2003-02-18 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
US6355660B1 (en) * 1999-07-20 2002-03-12 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
US7709479B1 (en) 1999-09-21 2010-05-04 Astrazeneca Quinazoline derivatives and their use as pharmaceuticals
JP2003528106A (ja) * 2000-03-22 2003-09-24 メルク フロスト カナダ アンド カンパニー Ｐｔｐ−１ｂ阻害薬としての硫黄置換アリールジフルオロメチルホスホン酸類
FR2812633A1 (fr) * 2000-08-04 2002-02-08 Aventis Cropscience Sa Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides
SE0102384D0 (sv) * 2001-07-03 2001-07-03 Pharmacia Ab New compounds
JP2005510564A (ja) * 2001-11-28 2005-04-21 藤沢薬品工業株式会社 アポリポタンパク質ｂ阻害剤としての複素環式アミド化合物
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2005263787A (ja) * 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
EP1751136B1 (en) * 2004-05-07 2014-07-02 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
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US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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US7348325B2 (en) * 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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Also Published As

Publication number Publication date
KR101596527B1 (ko) 2016-02-22
SI2235002T1 (sl) 2013-06-28
EA201001196A1 (ru) 2011-02-28
AU2009206440A1 (en) 2009-07-30
NZ586630A (en) 2011-12-22
IL207212A (en) 2015-01-29
CO6230986A2 (es) 2010-12-20
AU2009206440B2 (en) 2013-08-15
KR20100103636A (ko) 2010-09-27
ZA201005248B (en) 2011-09-28
IL207212A0 (en) 2010-12-30
PT2235002E (pt) 2013-01-30
DK2235002T3 (da) 2013-03-11
EA017736B1 (ru) 2013-02-28
EP2235002A1 (en) 2010-10-06
CA2713111C (en) 2015-06-30
US8124768B2 (en) 2012-02-28
CA2713111A1 (en) 2009-07-30
CN101977906B (zh) 2014-11-05
CY1114140T1 (el) 2016-07-27
BRPI0906444B1 (pt) 2021-03-16
ES2398335T3 (es) 2013-03-15
US20120114643A1 (en) 2012-05-10
JP2011510087A (ja) 2011-03-31
US8258118B2 (en) 2012-09-04
HK1143157A1 (en) 2010-12-24
PL2235002T3 (pl) 2013-04-30
JP5314050B2 (ja) 2013-10-16
US20110034416A1 (en) 2011-02-10
WO2009094417A1 (en) 2009-07-30
BRPI0906444A2 (pt) 2015-07-14
BRPI0906444A8 (pt) 2020-02-27
CN101977906A (zh) 2011-02-16
EP2235002B1 (en) 2012-11-21
HRP20130040T1 (hr) 2013-02-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/01/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF