DOP2013000304A - Moduladores alostéricos positivos del receptor de acetilcolina nicotínico - Google Patents

Moduladores alostéricos positivos del receptor de acetilcolina nicotínico

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Publication number
DOP2013000304A
DOP2013000304A DO2013000304A DO2013000304A DOP2013000304A DO P2013000304 A DOP2013000304 A DO P2013000304A DO 2013000304 A DO2013000304 A DO 2013000304A DO 2013000304 A DO2013000304 A DO 2013000304A DO P2013000304 A DOP2013000304 A DO P2013000304A
Authority
DO
Dominican Republic
Prior art keywords
nicotinic
acetilcoline
receiver
compounds
positive
Prior art date
Application number
DO2013000304A
Other languages
English (en)
Inventor
Ask Puschl
Jorge Eskildsen
Anette Graven Sams
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of DOP2013000304A publication Critical patent/DOP2013000304A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

La presente invención se refiere a compuestos de fórmula (I) útiles en terapia, a composiciones que comprenden dichos compuestos, y a métodos para tratar enfermedades que comprenden la administración de dichos compuestos. Los compuestos a los que se hace referencia son moduladores alostéricos positivos (PAMs) del receptor nicotínico de acetilcolina a7.
DO2013000304A 2011-07-08 2013-12-13 Moduladores alostéricos positivos del receptor de acetilcolina nicotínico DOP2013000304A (es)

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HRP20180913T1 (hr) 2011-07-08 2018-07-27 H. Lundbeck A/S Pozitivni alosterni modulatori receptora nikotinskog acetilkolina
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AR107928A1 (es) 2016-03-22 2018-06-28 Merck Sharp & Dohme Moduladores alostéricos de receptores de acetilcolina nicotínicos
US11382875B2 (en) 2017-04-07 2022-07-12 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Methods and compositions for modulating β-amyloid/α7-nAChR interactions
RS66290B1 (sr) 2018-05-01 2025-01-31 Merck Sharp & Dohme Llc Spiropiperidin alosterični modulatori nikotinskih acetiholinskih receptora
EP4054569A4 (en) 2019-11-05 2023-10-25 Merck Sharp & Dohme LLC ALLOSTERIC SPIROPIPERIDINE MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
US20240368109A1 (en) * 2021-09-21 2024-11-07 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors
US20250002448A1 (en) * 2021-09-21 2025-01-02 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors

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US20180250277A1 (en) 2018-09-06
US9023870B2 (en) 2015-05-05
US20140323523A1 (en) 2014-10-30
US20140010898A1 (en) 2014-01-09
US20170079967A1 (en) 2017-03-23
JP5993472B2 (ja) 2016-09-14
US20150231121A1 (en) 2015-08-20
US9889122B2 (en) 2018-02-13
US9549919B2 (en) 2017-01-24
PH12016500136B1 (en) 2017-02-20
US20130012530A1 (en) 2013-01-10
US8598213B2 (en) 2013-12-03
PH12016500136A1 (en) 2017-02-20
US9050327B2 (en) 2015-06-09
US20140044806A1 (en) 2014-02-13
US8765790B2 (en) 2014-07-01
MA35407B1 (fr) 2014-09-01
TN2013000462A1 (en) 2015-03-30
US20140010897A1 (en) 2014-01-09
JP2015129161A (ja) 2015-07-16
HRP20180913T1 (hr) 2018-07-27

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