MA35407B1 - Modulateurs allostériques positifs des récepteurs nicotiniques d'acétylcholine - Google Patents

Modulateurs allostériques positifs des récepteurs nicotiniques d'acétylcholine

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Publication number
MA35407B1
MA35407B1 MA36644A MA36644A MA35407B1 MA 35407 B1 MA35407 B1 MA 35407B1 MA 36644 A MA36644 A MA 36644A MA 36644 A MA36644 A MA 36644A MA 35407 B1 MA35407 B1 MA 35407B1
Authority
MA
Morocco
Prior art keywords
nicotinic acetylcholine
positive allosteric
allosteric modulators
acetylcholine receptors
compounds
Prior art date
Application number
MA36644A
Other languages
English (en)
Inventor
Jørgen Eskildsen
Anette Graven Sams
Ask Püschl
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/063219 external-priority patent/WO2013007621A1/fr
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of MA35407B1 publication Critical patent/MA35407B1/fr

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (i) utiles pour des traitements, des compositions comprenant lesdits composés et des procédés de traitement de maladies comprenant l'administration desdits composés. Les composés évoqués sont des modulateurs allostériques positifs (pam) du récepteur nicotinique d'acétylcholine ±7.
MA36644A 2011-07-08 2014-01-03 Modulateurs allostériques positifs des récepteurs nicotiniques d'acétylcholine MA35407B1 (fr)

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US201161505847P 2011-07-08 2011-07-08
DKPA201100520 2011-07-08
PCT/EP2012/063219 WO2013007621A1 (fr) 2011-07-08 2012-07-06 Modulateurs allostériques positifs des récepteurs nicotiniques d'acétylcholine

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HRP20180913T1 (hr) 2011-07-08 2018-07-27 H. Lundbeck A/S Pozitivni alosterni modulatori receptora nikotinskog acetilkolina
US10275109B2 (en) * 2013-05-21 2019-04-30 Oracle International Corporation Traversing between nodes
CA2944017C (fr) * 2014-03-25 2022-08-09 Emicipi Llc Traitement du syndrome de rett
US9696967B2 (en) * 2015-11-09 2017-07-04 Microsoft Technology Licensing, Llc Generation of an application from data
UA120571C2 (uk) 2016-03-22 2019-12-26 Мерк Шарп Енд Дохме Корп. Алостеричні модулятори нікотинових ацетилхолінових рецепторів
US11382875B2 (en) 2017-04-07 2022-07-12 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Methods and compositions for modulating β-amyloid/α7-nAChR interactions
MA52482B1 (fr) 2018-05-01 2024-12-31 Merck Sharp & Dohme Llc Dérivés de spiropipéridine en tant que modulateurs allostériques des récepteurs nicotiniques de l'acétylcholine
US12534458B2 (en) 2019-11-05 2026-01-27 Merck Sharp & Dohme Llc Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors
US20240368109A1 (en) * 2021-09-21 2024-11-07 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors
US20250002448A1 (en) * 2021-09-21 2025-01-02 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors

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WO2004047738A2 (fr) * 2002-11-22 2004-06-10 Bristol-Myers Squibb Company Amides arylcyclopropylcarboxyliques utilises en tant qu'agents d'ouverture des canaux potassiques
MXPA06001738A (es) 2003-08-15 2006-05-12 Lundbeck & Co As H Derivados de ciclopropilo como antagonistas del receptor nk3.
EA200701745A1 (ru) 2005-03-17 2008-06-30 Пфайзер, Инк. Циклопропанкарбоксамидные производные
ES2460897T3 (es) * 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
CN105254557A (zh) 2009-05-29 2016-01-20 拉夸里亚创药株式会社 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物
US8497271B2 (en) 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
KR20140040235A (ko) 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
HRP20180913T1 (hr) 2011-07-08 2018-07-27 H. Lundbeck A/S Pozitivni alosterni modulatori receptora nikotinskog acetilkolina

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TN2013000462A1 (en) 2015-03-30
US8765790B2 (en) 2014-07-01
US8815914B2 (en) 2014-08-26
US9889122B2 (en) 2018-02-13
JP2015129161A (ja) 2015-07-16
US20140323523A1 (en) 2014-10-30
US20140010897A1 (en) 2014-01-09
HRP20180913T1 (hr) 2018-07-27
US9549919B2 (en) 2017-01-24
US9050327B2 (en) 2015-06-09
US9023870B2 (en) 2015-05-05
US20180250277A1 (en) 2018-09-06
DOP2013000304A (es) 2014-04-15
US8598213B2 (en) 2013-12-03
US20150231121A1 (en) 2015-08-20
JP5993472B2 (ja) 2016-09-14
US20140010898A1 (en) 2014-01-09
US20130012530A1 (en) 2013-01-10
PH12016500136A1 (en) 2017-02-20
US20170079967A1 (en) 2017-03-23
PH12016500136B1 (en) 2017-02-20

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