DOP2014000007A - Proteinas de union a antigeno de tnf-alfa con union a fcrn incrementada - Google Patents

Proteinas de union a antigeno de tnf-alfa con union a fcrn incrementada

Info

Publication number
DOP2014000007A
DOP2014000007A DO2014000007A DO2014000007A DOP2014000007A DO P2014000007 A DOP2014000007 A DO P2014000007A DO 2014000007 A DO2014000007 A DO 2014000007A DO 2014000007 A DO2014000007 A DO 2014000007A DO P2014000007 A DOP2014000007 A DO P2014000007A
Authority
DO
Dominican Republic
Prior art keywords
union
tnf
antigen
fcrn
incredible
Prior art date
Application number
DO2014000007A
Other languages
English (en)
Inventor
Tejash Shah
Jonathan Henry Ellis
Michael J Molloy
Ian M Tomlinson
Ahmed Yasin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44586854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2014000007(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DOP2014000007A publication Critical patent/DOP2014000007A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención provee proteínas de unión a antígeno que se unen específicamente a TNF-alfa. Por ejemplo variantes novedosas de anticuerpos anti-TNF, tal como adalimumab las cuales muestran unión incrementada al receptor FcRn o tiempo de vida media incrementado en comparación con adalimumab. También se proveen composiciones que comprenden las proteínas de unión a antígeno y los usos de dichas composiciones en el tratamiento de trastornos y enfermedad.
DO2014000007A 2011-07-19 2014-01-17 Proteinas de union a antigeno de tnf-alfa con union a fcrn incrementada DOP2014000007A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1112429.4A GB201112429D0 (en) 2011-07-19 2011-07-19 Antigen-binding proteins with increased FcRn binding

Publications (1)

Publication Number Publication Date
DOP2014000007A true DOP2014000007A (es) 2014-04-30

Family

ID=44586854

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000007A DOP2014000007A (es) 2011-07-19 2014-01-17 Proteinas de union a antigeno de tnf-alfa con union a fcrn incrementada

Country Status (22)

Country Link
US (1) US20130243764A1 (es)
EP (2) EP3009450A1 (es)
JP (1) JP2014524748A (es)
KR (1) KR20140054085A (es)
CN (1) CN103748110A (es)
AU (1) AU2012285786B2 (es)
BR (1) BR112014000341A2 (es)
CA (1) CA2841105A1 (es)
CL (1) CL2014000134A1 (es)
CO (1) CO6862106A2 (es)
CR (1) CR20140029A (es)
DO (1) DOP2014000007A (es)
EA (1) EA201391789A1 (es)
ES (1) ES2600854T3 (es)
GB (1) GB201112429D0 (es)
MA (1) MA35345B1 (es)
MX (1) MX2014000739A (es)
PE (1) PE20141660A1 (es)
PH (1) PH12014500167A1 (es)
SG (1) SG10201601154QA (es)
WO (1) WO2013011076A2 (es)
ZA (1) ZA201400062B (es)

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Also Published As

Publication number Publication date
EP3009450A1 (en) 2016-04-20
AU2012285786A1 (en) 2014-02-06
PH12014500167A1 (en) 2019-03-22
WO2013011076A2 (en) 2013-01-24
JP2014524748A (ja) 2014-09-25
CO6862106A2 (es) 2014-02-10
CR20140029A (es) 2014-03-05
PE20141660A1 (es) 2014-11-21
NZ618897A (en) 2016-02-26
ES2600854T3 (es) 2017-02-13
MX2014000739A (es) 2014-02-19
CL2014000134A1 (es) 2014-07-25
BR112014000341A2 (pt) 2017-02-14
SG10201601154QA (en) 2016-03-30
ZA201400062B (en) 2017-08-30
CN103748110A (zh) 2014-04-23
GB201112429D0 (en) 2011-08-31
EP2734548A2 (en) 2014-05-28
US20130243764A1 (en) 2013-09-19
AU2012285786B2 (en) 2016-05-12
KR20140054085A (ko) 2014-05-08
CA2841105A1 (en) 2013-01-24
EP2734548B1 (en) 2016-08-17
MA35345B1 (fr) 2014-08-01
WO2013011076A3 (en) 2013-04-04
EA201391789A1 (ru) 2014-06-30

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