DOP2014000093A - Compuestos con actividad nematicida - Google Patents

Compuestos con actividad nematicida

Info

Publication number
DOP2014000093A
DOP2014000093A DO2014000093A DO2014000093A DOP2014000093A DO P2014000093 A DOP2014000093 A DO P2014000093A DO 2014000093 A DO2014000093 A DO 2014000093A DO 2014000093 A DO2014000093 A DO 2014000093A DO P2014000093 A DOP2014000093 A DO P2014000093A
Authority
DO
Dominican Republic
Prior art keywords
compounds
nematiciated
activity
pyridylcarboxamide
derivatives
Prior art date
Application number
DO2014000093A
Other languages
English (en)
Inventor
Ulrich Gorgens
Olga Malsam
Arnd Voerste
Heiko Rieck
Matthias Riedrich
Peter Losel
Hans-Georg Schwarz
Kerstin Ilg
Pierre-Yves Coqueron
Philippe Meresse
Darren Mansfield
Martin Fusslein
Lars Rodefeld
Kristian Kather
Lionel Carles
Philippe Desbordes
Jorg Nico Greul
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48191397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2014000093(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP11187507.6A external-priority patent/EP2589292A1/en
Priority claimed from EP11194886.5A external-priority patent/EP2606728A1/en
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of DOP2014000093A publication Critical patent/DOP2014000093A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere al uso de derivados conocidos de piridilcarboxamida y derivados novedosos de piridilcarboxamida como nematicidas, composiciones que contienen tales compuestos y procedimientos para el control de nematodos.
DO2014000093A 2011-11-02 2014-04-30 Compuestos con actividad nematicida DOP2014000093A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11187507.6A EP2589292A1 (en) 2011-11-02 2011-11-02 Compounds with nematicidal activity
US201161555127P 2011-11-03 2011-11-03
EP11194886.5A EP2606728A1 (en) 2011-12-21 2011-12-21 Compounds with nematicidal activity

Publications (1)

Publication Number Publication Date
DOP2014000093A true DOP2014000093A (es) 2014-07-15

Family

ID=48191397

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000093A DOP2014000093A (es) 2011-11-02 2014-04-30 Compuestos con actividad nematicida

Country Status (21)

Country Link
US (1) US9301526B2 (es)
EP (1) EP2773203A1 (es)
JP (1) JP2015501326A (es)
KR (1) KR20140097243A (es)
CN (1) CN104023534A (es)
AR (1) AR088614A1 (es)
AU (2) AU2012331284B2 (es)
BR (1) BR112014010714A2 (es)
CA (1) CA2853876A1 (es)
CL (1) CL2014001145A1 (es)
CO (1) CO6950490A2 (es)
CR (1) CR20140197A (es)
DO (1) DOP2014000093A (es)
EC (1) ECSP14013339A (es)
IL (1) IL232153A0 (es)
MX (1) MX2014005201A (es)
NI (1) NI201400036A (es)
PE (1) PE20141996A1 (es)
PH (1) PH12014500977A1 (es)
RU (1) RU2608217C2 (es)
WO (1) WO2013064460A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140256728A1 (en) * 2011-11-02 2014-09-11 Bayer Intellectual Property Gmbh Compounds with nematicidal activity
EP2773617B1 (en) * 2011-11-04 2018-08-22 Syngenta Participations AG Pesticidal compounds
TW201427947A (zh) * 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
TWI598325B (zh) * 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
WO2014173921A1 (en) * 2013-04-26 2014-10-30 Syngenta Participations Ag Carboxamides as pesticidal compounds
PL3019476T3 (pl) 2013-07-08 2018-05-30 Syngenta Participations Ag Związki karboksyamidowe o 4-członowym pierścieniu jako nematocydy
WO2015004091A1 (en) 2013-07-12 2015-01-15 Syngenta Participations Ag Nicotinamide derivatives and their use against nematodes
MX2016001641A (es) 2013-08-13 2016-05-02 Syngenta Participations Ag Ciclobutilcarboxamidas como nematicidas.
AR097423A1 (es) * 2013-08-26 2016-03-16 Bayer Cropscience Ag Compuestos con actividad plaguicida
UY35772A (es) * 2013-10-14 2015-05-29 Bayer Cropscience Ag Nuevos compuestos plaguicidas
JPWO2015125824A1 (ja) 2014-02-18 2017-03-30 日産化学工業株式会社 アルキニルピリジン置換アミド化合物及び有害生物防除剤
UY36196A (es) * 2014-07-25 2016-02-29 Bayer Animal Health Gmbh Compuestos para usar en el tratamiento antihelmíntico
CN107108469A (zh) 2014-10-28 2017-08-29 拜耳动物保健有限责任公司 用于抗蠕虫治疗的化合物
BR112017011667B1 (pt) 2014-12-02 2021-07-06 Bayer Cropscience Aktiengesellschaft Compostos bicíclicos como agentes de controle de pragas
WO2017165304A2 (en) * 2016-03-21 2017-09-28 The Scripps Research Institute Pd(II)-CATALYZED ENANTIOSELECTIVE BETA-METHYLENE C(sp3)-H BOND ACTIVATION
EP3321264A1 (en) * 2016-11-14 2018-05-16 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways
WO2018114484A1 (en) * 2016-12-21 2018-06-28 Bayer Cropscience Aktiengesellschaft Process for the preparation of a 2-pyridylethylcarboxamide derivative
KR102635481B1 (ko) 2017-09-18 2024-02-07 신젠타 파티서페이션즈 아게 황 함유 치환기를 갖는 살충 활성 헤테로사이클릭 유도체
KR102831570B1 (ko) 2018-05-04 2025-07-10 레미디 플랜, 인크. 암 줄기 세포를 표적화하는 암 치료
AR117169A1 (es) 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
CN110698392A (zh) * 2019-09-09 2020-01-17 中国农业大学 一种双酰胺类化合物及其制备方法与应用
CN115915941B (zh) 2020-05-06 2025-07-15 拜耳公司 作为杀真菌化合物的吡啶（硫代）酰胺
EP4149929B1 (en) 2020-05-12 2026-01-28 Bayer Aktiengesellschaft Triazine and pyrimidine (thio)amides as fungicidal compounds
CN115803317B (zh) 2020-05-19 2025-07-15 拜耳作物科学股份公司 作为杀真菌化合物的氮杂双环(硫代)酰胺
WO2021239766A1 (en) 2020-05-27 2021-12-02 Bayer Aktiengesellschaft Active compound combinations
AR123053A1 (es) * 2020-07-29 2022-10-26 Fmc Corp Compuestos de triazolona para controlar plagas de invertebrados
EP4247811A1 (en) * 2020-11-19 2023-09-27 F. Hoffmann-La Roche AG Bicyclo[1.1.1]pentane compounds for the treatment and prophylaxis of hepatitis b virus infection
US20250064060A1 (en) 2021-11-03 2025-02-27 Bayer Aktiengesellschaft Bis(hetero)aryl thioether (thio)amides as fungicidal compounds
CN115215793A (zh) * 2022-08-11 2022-10-21 南开大学 氟吡菌酰胺的合成方法
CN116947749B (zh) * 2023-09-18 2023-12-01 帕潘纳(北京)科技有限公司 一类酰胺类化合物及其应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061642A (en) 1972-06-22 1977-12-06 Cassella Farbwerke Mainkur Ag 2,4,6-Trisubstituted-3-pyridine carboxamides
DE2230392A1 (de) * 1972-06-22 1974-01-31 Cassella Farbwerke Mainkur Ag Substituierte pyridinverbindungen und verfahren zu ihrer herstellung
US4260619A (en) * 1980-02-19 1981-04-07 Ciba-Geigy Corporation 2-Aminoalkyl-5-pyridinols
EP0139661A1 (en) 1983-02-19 1985-05-08 Beecham Group Plc Secondary amines
US6037357A (en) * 1999-04-21 2000-03-14 Unitech Pharmaceuticals, Inc. N-benzoyl-α-alkylated azatyrosines as anticancer agents
CN1209016C (zh) * 1999-08-18 2005-07-06 阿方蒂农科有限公司 杀真菌剂
US7683096B2 (en) * 2001-09-18 2010-03-23 Ishihara Sangyo Kaisha, Ltd. Acid amide derivatives, process for producing these, and pest control agent containing these
DE60303147T2 (de) 2002-08-12 2006-08-31 Bayer Cropscience S.A. Neues 2-pyridylethylbenzamid-derivat
EP1449841A1 (en) 2003-02-19 2004-08-25 Bayer CropScience SA New fungicidal compounds
EP1500651A1 (en) 2003-07-25 2005-01-26 Bayer CropScience S.A. N-[2-(2-Pyridinyl)ethyl]benzamide compounds and their use as fungicides
EP1548007A1 (en) 2003-12-19 2005-06-29 Bayer CropScience S.A. 2-Pyridinylethylcarboxamide derivatives and their use as fungicides
TWI368482B (en) 2003-12-19 2012-07-21 Bayer Sas New 2-pyridinylethylbenzamide derivatives
EP1574511A1 (en) 2004-03-03 2005-09-14 Bayer CropScience S.A. 2-Pyridinylethylcarboxamide derivatives and their use as fungicides
EP1591442A1 (en) * 2004-04-26 2005-11-02 Bayer CropScience S.A. 2-Pyridinycycloalkylbenzamide derivatives and their use as fungicides
MXPA06012159A (es) 2004-04-26 2007-01-31 Bayer Cropscience Sa Derivados de 2-piridinilcicloalquilcarboxamidas utiles como fungicidas.
US20080096932A1 (en) 2004-07-23 2008-04-24 Darren Mansfield 3-Pyridinylethylcarboxamide Derivatives as Fungicides
EP1771439A1 (en) 2004-07-23 2007-04-11 Bayer CropScience S.A. 4-pyridinylethylcarboxamide derivatives useful as fungicides
EP1773777A1 (en) 2004-07-23 2007-04-18 Bayer Cropscience Sa N-[2-(4-pyridinyl)ethyl]benzamide derivatives as fungicides
WO2006008191A1 (en) 2004-07-23 2006-01-26 Bayer Cropscience Sa 3-pyridinylethylbenzamide derivatives as fungicides
WO2006029828A1 (de) * 2004-09-16 2006-03-23 Basf Aktiengesellschaft Benzoylsubstituierte serin-amide
US7790901B2 (en) * 2004-12-21 2010-09-07 Bayer Cropscience S.A. Process for the preparation of a 2-pyridylethylcarboxamide derivative
PT1885712E (pt) 2005-05-18 2011-04-29 Bayer Cropscience Ag Novos derivados de 2-piridinilcicloalquilcrboxamida como fungicidas
WO2006122952A1 (en) * 2005-05-18 2006-11-23 Bayer Cropscience Sa 2-pyridinylcycloalkylbenzamide derivatives and their use as fungicides
EP1957476A1 (en) * 2005-11-23 2008-08-20 AstraZeneca AB L-alanine derivatives
WO2007093539A2 (de) 2006-02-16 2007-08-23 Basf Se Benzoylsubstituierte alanine
TWI435863B (zh) * 2006-03-20 2014-05-01 Nihon Nohyaku Co Ltd Ｎ-２-（雜）芳基乙基甲醯胺衍生物及含該衍生物之蟲害防治劑
DE102006032824A1 (de) 2006-07-14 2008-01-17 Bayer Healthcare Ag Substituierte Indazole
HUE029331T2 (en) * 2007-04-12 2017-02-28 Nihon Nohyaku Co Ltd Worm-control agent for use in the preparation and method
WO2010145788A1 (en) * 2009-06-18 2010-12-23 Bayer Cropscience Ag Propargyloxybenzamide derivatives
EP2289880A1 (en) 2009-07-08 2011-03-02 Bayer CropScience AG 2-Pyridinylcyclopropylbenzamide fungicides
PH12013501809A1 (en) 2011-03-02 2013-10-14 Nihon Nohyaku Co Ltd Endoparasite control agent
US8815772B2 (en) * 2012-06-29 2014-08-26 E I Du Pont De Nemours And Company Fungicidal heterocyclic carboxamides

Also Published As

Publication number Publication date
WO2013064460A1 (en) 2013-05-10
IL232153A0 (en) 2014-05-28
AR088614A1 (es) 2014-06-25
ECSP14013339A (es) 2015-05-29
PE20141996A1 (es) 2014-11-28
MX2014005201A (es) 2014-08-27
NI201400036A (es) 2015-12-10
CL2014001145A1 (es) 2014-09-05
AU2016238835A1 (en) 2016-10-27
US20140249149A1 (en) 2014-09-04
PH12014500977A1 (en) 2014-06-09
RU2608217C2 (ru) 2017-01-17
AU2012331284B2 (en) 2016-06-30
CO6950490A2 (es) 2014-05-20
CA2853876A1 (en) 2013-05-10
NZ623874A (en) 2016-04-29
RU2014122033A (ru) 2015-12-10
KR20140097243A (ko) 2014-08-06
EP2773203A1 (en) 2014-09-10
BR112014010714A2 (pt) 2017-05-02
AU2012331284A1 (en) 2014-05-08
JP2015501326A (ja) 2015-01-15
CN104023534A (zh) 2014-09-03
CR20140197A (es) 2014-05-27
US9301526B2 (en) 2016-04-05

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