DOP2016000176A - Insulina de acción prolongada y uso de la misma - Google Patents

Insulina de acción prolongada y uso de la misma

Info

Publication number
DOP2016000176A
DOP2016000176A DO2016000176A DO2016000176A DOP2016000176A DO P2016000176 A DOP2016000176 A DO P2016000176A DO 2016000176 A DO2016000176 A DO 2016000176A DO 2016000176 A DO2016000176 A DO 2016000176A DO P2016000176 A DOP2016000176 A DO P2016000176A
Authority
DO
Dominican Republic
Prior art keywords
insulin
same
prolonged action
prolonged
action
Prior art date
Application number
DO2016000176A
Other languages
English (en)
Inventor
Sung Youb Jung
Sang Youn Hwang
Euh Lim Oh
Sung Hee Park
Hyun Uk Kim
Chang Ki Lim
Se Chang Kwon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of DOP2016000176A publication Critical patent/DOP2016000176A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN ANÁLOGO DE INSULINA QUE PRESENTA UNA AFINIDAD REDUCIDA DE LA UNIÓN AL RECEPTOR DE INSULINA CON EL PROPÓSITO DE AUMENTAR LA VIDA MEDIA EN SANGRE DE LA INSULINA, Y A UNA INSULINA DE ACCIÓN PROLONGADA, A UN CONJUGADO, Y A UN MÉTODO DE PREPARACIÓN DE UNA INSULINA DE ACCIÓN PROLONGADA QUE LA UTILICE.
DO2016000176A 2014-01-20 2016-07-14 Insulina de acción prolongada y uso de la misma DOP2016000176A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20140006938 2014-01-20

Publications (1)

Publication Number Publication Date
DOP2016000176A true DOP2016000176A (es) 2017-02-15

Family

ID=53543214

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2016000176A DOP2016000176A (es) 2014-01-20 2016-07-14 Insulina de acción prolongada y uso de la misma

Country Status (22)

Country Link
US (1) US10253082B2 (es)
EP (1) EP3098235A4 (es)
JP (1) JP2017505141A (es)
KR (1) KR102406654B1 (es)
CN (2) CN116987172A (es)
AU (1) AU2015206890B2 (es)
BR (1) BR112016016578A2 (es)
CA (1) CA2937168A1 (es)
CL (1) CL2016001844A1 (es)
CR (1) CR20160376A (es)
DO (1) DOP2016000176A (es)
EA (1) EA201691374A1 (es)
EC (1) ECSP16068524A (es)
IL (1) IL246782B (es)
MA (3) MA43289B1 (es)
MX (1) MX369656B (es)
MY (1) MY186251A (es)
PE (1) PE20161153A1 (es)
PH (1) PH12016501414B1 (es)
SG (1) SG11201605680PA (es)
WO (1) WO2015108398A1 (es)
ZA (1) ZA201605626B (es)

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JP6387111B2 (ja) 2014-01-20 2018-09-05 クリーブ バイオサイエンシズ インコーポレイテッド ｐ９７複合体の阻害剤としての縮合ピリミジン
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JP7158378B2 (ja) * 2016-09-23 2022-10-21 ハンミ ファーマシューティカル カンパニー リミテッド インスリン受容体との結合力が減少された、インスリンアナログ及びその用途
CN110545849A (zh) * 2017-02-03 2019-12-06 韩美药品株式会社 具有增加的持续性的生理活性物质的缀合物及其应用
KR102629006B1 (ko) * 2017-03-23 2024-01-25 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
WO2019066603A1 (ko) * 2017-09-29 2019-04-04 한미약품 주식회사 효력이 향상된 지속성 단백질 결합체
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
KR102646845B1 (ko) * 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법
KR20210102347A (ko) 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
TWI844709B (zh) * 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
CN118271419A (zh) 2020-03-31 2024-07-02 韩美药品株式会社 新型免疫刺激il-2类似物
CN115894720B (zh) * 2023-01-16 2024-07-09 中国科学院上海药物研究所 一种长效胰岛素-Fc融合蛋白
WO2025101094A1 (en) * 2023-11-08 2025-05-15 Ооо «Geropharm» Fc fragment polypeptide for producing therapeutically active fusion polypeptides and conjugates

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Also Published As

Publication number Publication date
BR112016016578A2 (pt) 2017-10-03
CA2937168A1 (en) 2015-07-23
CR20160376A (es) 2016-10-07
IL246782A0 (en) 2016-08-31
MA43289B1 (fr) 2019-12-31
EP3098235A4 (en) 2017-10-18
MX369656B (es) 2019-11-15
ECSP16068524A (es) 2018-11-30
AU2015206890B2 (en) 2019-05-23
MY186251A (en) 2021-06-30
KR20150087130A (ko) 2015-07-29
SG11201605680PA (en) 2016-09-29
PE20161153A1 (es) 2016-10-27
MX2016009434A (es) 2017-01-18
IL246782B (en) 2020-01-30
PH12016501414A1 (en) 2016-09-14
EA201691374A1 (ru) 2016-12-30
AU2015206890A1 (en) 2016-08-04
MA46146A1 (fr) 2020-12-31
CN116987172A (zh) 2023-11-03
EP3098235A1 (en) 2016-11-30
CL2016001844A1 (es) 2017-01-06
WO2015108398A1 (ko) 2015-07-23
KR102406654B1 (ko) 2022-06-10
CN105916877A (zh) 2016-08-31
MA39301A1 (fr) 2018-01-31
US10253082B2 (en) 2019-04-09
ZA201605626B (en) 2017-11-29
US20170101455A1 (en) 2017-04-13
JP2017505141A (ja) 2017-02-16
PH12016501414B1 (en) 2020-10-30

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