DZ3263A1 - Antagonistes du recepteur de l'alpha v integrine - Google Patents

Antagonistes du recepteur de l'alpha v integrine

Info

Publication number
DZ3263A1
DZ3263A1 DZ003263A DZ003263A DZ3263A1 DZ 3263 A1 DZ3263 A1 DZ 3263A1 DZ 003263 A DZ003263 A DZ 003263A DZ 003263 A DZ003263 A DZ 003263A DZ 3263 A1 DZ3263 A1 DZ 3263A1
Authority
DZ
Algeria
Prior art keywords
receptor antagonists
integrin receptor
alpha
present
antagonists
Prior art date
Application number
DZ003263A
Other languages
English (en)
Inventor
Paul Coleman
Mark Duggan
Wasyl Halczenko
George Hartman
John Hutchinson
Robert Meissner
Michael Patane
James Perkins
Jiabing Wang
Michael Breslin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DZ3263A1 publication Critical patent/DZ3263A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DZ003263A 1999-06-02 2000-05-30 Antagonistes du recepteur de l'alpha v integrine DZ3263A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13710199P 1999-06-02 1999-06-02
US17921600P 2000-01-31 2000-01-31
PCT/US2000/014901 WO2000072801A2 (fr) 1999-06-02 2000-05-30 Antagonistes du recepteur de l'alpha v integrine

Publications (1)

Publication Number Publication Date
DZ3263A1 true DZ3263A1 (fr) 2000-12-07

Family

ID=26834930

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ003263A DZ3263A1 (fr) 1999-06-02 2000-05-30 Antagonistes du recepteur de l'alpha v integrine

Country Status (28)

Country Link
US (1) US6410526B1 (fr)
EP (1) EP1187592B1 (fr)
JP (3) JP3808707B2 (fr)
KR (1) KR20020021380A (fr)
CN (1) CN1589145A (fr)
AT (1) ATE368462T1 (fr)
AU (1) AU749351B2 (fr)
BG (1) BG106232A (fr)
BR (1) BR0011108A (fr)
CA (1) CA2373937A1 (fr)
CY (1) CY1107746T1 (fr)
CZ (1) CZ20014308A3 (fr)
DE (1) DE60035779T2 (fr)
DK (1) DK1187592T3 (fr)
DZ (1) DZ3263A1 (fr)
EA (1) EA200101272A1 (fr)
EE (1) EE200100642A (fr)
ES (1) ES2288861T3 (fr)
HR (1) HRP20010895A2 (fr)
HU (1) HUP0302468A2 (fr)
IL (1) IL146378A0 (fr)
IS (1) IS6157A (fr)
NO (1) NO323906B1 (fr)
PL (1) PL353364A1 (fr)
PT (1) PT1187592E (fr)
SK (1) SK17442001A3 (fr)
TR (1) TR200103431T2 (fr)
WO (1) WO2000072801A2 (fr)

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US6048861A (en) * 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
CA2397665A1 (fr) 2000-01-24 2001-07-26 Merck & Co., Inc. Antagonistes du recepteur de l'integrine alpha v
US7119098B2 (en) 2000-06-15 2006-10-10 Pharmacia Corporation Heteroarylakanoic acids as intergrin receptor antagonists
US7056909B2 (en) * 2000-07-26 2006-06-06 Merck & Co., Inc. Alpha v integrin receptor antagonists
WO2002022616A2 (fr) * 2000-09-14 2002-03-21 Merck & Co., Inc. Antagonistes du recepteur des integrines alpha v
CA2424117A1 (fr) * 2000-10-04 2002-04-11 Merck & Co., Inc. Sel d'acide phosphorique tire d'un antagoniste d'un recepteur de l'integrine
EP1349548A4 (fr) * 2001-01-03 2004-06-02 Merck & Co Inc Methodes et compositions de traitement d'une parodontopathie
EP1381384B1 (fr) 2001-04-24 2011-05-25 Merck Patent GmbH POLYTHERAPIE A BASE D'AGENTS ANTIANGIOGENIQUES ET DE FACTEUR DE NECROSE TUMORALE TNFalpha
EP1487489A4 (fr) * 2002-03-04 2008-10-01 Medimmune Inc PROCEDES PERMETTANT DE PREVENIR OU DE TRAITER DES TROUBLES PAR ADMINISTRATION D'UN ANTAGONISTE DE L'INTEGRINE avb3 ASSOCIE A UN INHIBITEUR DE LA REDUCTASE HMG-COA OU UN BISPHOSPHONATE
JP2005533001A (ja) * 2002-03-04 2005-11-04 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
CA2510084A1 (fr) 2002-12-20 2004-07-15 Pharmacia Corporation Composes de thiazole en tant que derives d'antagonistes des recepteurs de l'integrine
US7288655B2 (en) * 2003-03-07 2007-10-30 Merck & Co., Inc. α v integrin receptor antagonists
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
EP1973569B1 (fr) 2006-01-18 2013-05-22 Merck Patent GmbH Traitement specifique utilisant des ligands de integrine destine a traiter un cancer
JP2010516645A (ja) 2007-01-18 2010-05-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドを用いる特異的療法および薬剤
TW200904437A (en) * 2007-02-14 2009-02-01 Janssen Pharmaceutica Nv 2-aminopyrimidine modulators of the histamine H4 receptor
JP5637855B2 (ja) 2007-11-08 2014-12-10 ザ ジェネラル ホスピタル コーポレイション 蛋白尿症の治療のための方法及び組成物
US20120130146A1 (en) 2009-05-25 2012-05-24 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
US8901144B2 (en) 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
ES2651162T3 (es) 2013-02-07 2018-01-24 Scifluor Life Sciences, Inc Antagonistas fluorados de integrina
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
HUE057203T2 (hu) 2013-09-24 2022-04-28 Fujifilm Corp Új nitrogén-tartalmú vegyület vagy sója, vagy azok fémkomplexe
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
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GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
EP3925959A1 (fr) * 2015-02-19 2021-12-22 OcuTerra Therapeutics, Inc. Dérivés fluorés de l'acide 3-(2-oxo-3-(3-(5,6,7,8-tétrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoïque et leurs utilisations
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
US10118929B2 (en) 2016-04-27 2018-11-06 Scifluor Life Sciences, Inc. Nonanoic and decanoic acid derivatives and uses thereof
US11192889B2 (en) * 2016-07-05 2021-12-07 The Rockefeller University Tetrahydronaphthyridinepentanamide integrin antagonists
US10604520B2 (en) 2016-09-07 2020-03-31 Pliant Therapeutics, Inc. N-acyl amino acid compounds and methods of use
BR112019009245A2 (pt) * 2016-11-08 2019-07-16 Bristol-Myers Squibb Company azol amidas e aminas como inibidores de alfav integrina
CA3042710A1 (fr) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Composes mono et spirocycliques contenant du cyclobutane et de l'azetidine en tant qu'inhibiteurs de l'integrine .alpha.v
IL316954A (en) 2017-02-28 2025-01-01 Morphic Therapeutic Inc (Alpha-V)(beta-6)integrin inhibitors
EP3760202A1 (fr) 2017-02-28 2021-01-06 Morphic Therapeutic, Inc. Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
UY38352A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
WO2020047208A1 (fr) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibiteurs de l'intégrine (alpha-v)(bêta-6)
UY38353A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibición de integrina alfavbeta6
WO2025259747A2 (fr) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Compositions d'arni de protéine kinase myotonique de dystrophie (dmpk) et leurs procédés d'utilisation
WO2025259743A1 (fr) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Composés conjugués doubles pour administration extrahépatique

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DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
WO1997037655A1 (fr) 1996-04-10 1997-10-16 Merck & Co., Inc. ANTAGONISTES DU RECEPTEUR αvβ3
US5668159A (en) 1996-05-08 1997-09-16 The Dupont Merck Pharmaceutical Company 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
JP2002511052A (ja) 1996-08-29 2002-04-09 メルク エンド カンパニー インコーポレーテッド インテグリンアンタゴニスト
WO1998018461A1 (fr) 1996-10-30 1998-05-07 Merck & Co., Inc. Antagonistes de l'integrine
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CA2277273C (fr) 1997-01-17 2008-03-25 Merck & Co., Inc. Antagonistes d'integrine
EP1047425A4 (fr) 1997-12-17 2009-04-22 Merck & Co Inc Antagonistes du recepteur de l'integrine
WO1999030713A1 (fr) 1997-12-17 1999-06-24 Merck & Co., Inc. Antagonistes du recepteur de l'integrine
US6048861A (en) * 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
US6017926A (en) 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
BR9813769A (pt) * 1997-12-17 2000-10-10 Merck & Co Inc Composto, composição farmacêutica, e, processos para fabricar a mesma, para evocar um efeito antagonizante do receptor da integrina em um mamìfero em necessidade deste, para tratar ou prevenir uma condição mediada pelo antagonismo de um receptor da integrina em um mamìfero em necessidade deste, para inibir a reabsorção óssea em um mamìfero em necessidade deste, e para tratar o desenvolvimento tumoral em um mamìfero em necessidade deste.
HUP0100178A3 (en) 1997-12-17 2002-12-28 Merck & Co Inc Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
NO20015858L (no) 2002-02-04
JP3808707B2 (ja) 2006-08-16
CN1589145A (zh) 2005-03-02
JP2006232844A (ja) 2006-09-07
SK17442001A3 (sk) 2002-03-05
JP2004500326A (ja) 2004-01-08
EE200100642A (et) 2003-02-17
DE60035779D1 (de) 2007-09-13
DE60035779T2 (de) 2008-04-30
IL146378A0 (en) 2002-07-25
WO2000072801A3 (fr) 2007-10-11
AU5724600A (en) 2000-12-18
KR20020021380A (ko) 2002-03-20
EP1187592A4 (fr) 2002-11-06
US6410526B1 (en) 2002-06-25
HUP0302468A2 (hu) 2003-11-28
ATE368462T1 (de) 2007-08-15
BR0011108A (pt) 2002-03-19
HRP20010895A2 (en) 2003-08-31
CZ20014308A3 (cs) 2002-03-13
ES2288861T3 (es) 2008-02-01
EP1187592A2 (fr) 2002-03-20
EA200101272A1 (ru) 2002-06-27
PL353364A1 (en) 2003-11-17
PT1187592E (pt) 2007-10-19
NO323906B1 (no) 2007-07-16
CY1107746T1 (el) 2013-04-18
TR200103431T2 (tr) 2002-06-21
DK1187592T3 (da) 2007-11-05
AU749351B2 (en) 2002-06-27
EP1187592B1 (fr) 2007-08-01
NO20015858D0 (no) 2001-11-30
JP2006206604A (ja) 2006-08-10
BG106232A (en) 2002-06-28
IS6157A (is) 2001-11-13
WO2000072801A2 (fr) 2000-12-07
CA2373937A1 (fr) 2000-12-07

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