EE200100642A - Alfa-v integriinretseptori antagonistid ja farmatseutiline kompositsioon - Google Patents

Alfa-v integriinretseptori antagonistid ja farmatseutiline kompositsioon

Info

Publication number
EE200100642A
EE200100642A EEP200100642A EEP200100642A EE200100642A EE 200100642 A EE200100642 A EE 200100642A EE P200100642 A EEP200100642 A EE P200100642A EE P200100642 A EEP200100642 A EE P200100642A EE 200100642 A EE200100642 A EE 200100642A
Authority
EE
Estonia
Prior art keywords
receptor antagonists
integrin receptor
alpha
pharmaceutical composition
present
Prior art date
Application number
EEP200100642A
Other languages
English (en)
Estonian (et)
Inventor
J. Coleman Paul
E. Duggan Mark
Halczenko Wasyl
D. Hartman George
H. Hutchinson John
S. Meissner Robert
A. Patane Michael
J. Perkins James
Wang Jiabing
J. Breslin Michael
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE200100642A publication Critical patent/EE200100642A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100642A 1999-06-02 2000-05-30 Alfa-v integriinretseptori antagonistid ja farmatseutiline kompositsioon EE200100642A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13710199P 1999-06-02 1999-06-02
US17921600P 2000-01-31 2000-01-31
PCT/US2000/014901 WO2000072801A2 (fr) 1999-06-02 2000-05-30 Antagonistes du recepteur de l'alpha v integrine

Publications (1)

Publication Number Publication Date
EE200100642A true EE200100642A (et) 2003-02-17

Family

ID=26834930

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100642A EE200100642A (et) 1999-06-02 2000-05-30 Alfa-v integriinretseptori antagonistid ja farmatseutiline kompositsioon

Country Status (28)

Country Link
US (1) US6410526B1 (fr)
EP (1) EP1187592B1 (fr)
JP (3) JP3808707B2 (fr)
KR (1) KR20020021380A (fr)
CN (1) CN1589145A (fr)
AT (1) ATE368462T1 (fr)
AU (1) AU749351B2 (fr)
BG (1) BG106232A (fr)
BR (1) BR0011108A (fr)
CA (1) CA2373937A1 (fr)
CY (1) CY1107746T1 (fr)
CZ (1) CZ20014308A3 (fr)
DE (1) DE60035779T2 (fr)
DK (1) DK1187592T3 (fr)
DZ (1) DZ3263A1 (fr)
EA (1) EA200101272A1 (fr)
EE (1) EE200100642A (fr)
ES (1) ES2288861T3 (fr)
HR (1) HRP20010895A2 (fr)
HU (1) HUP0302468A2 (fr)
IL (1) IL146378A0 (fr)
IS (1) IS6157A (fr)
NO (1) NO323906B1 (fr)
PL (1) PL353364A1 (fr)
PT (1) PT1187592E (fr)
SK (1) SK17442001A3 (fr)
TR (1) TR200103431T2 (fr)
WO (1) WO2000072801A2 (fr)

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DE60126496T2 (de) * 2000-07-26 2007-11-15 Merck & Co., Inc. Alpha v integrin-rezeptor-antagonisten
AU2001290772A1 (en) * 2000-09-14 2002-03-26 Merck And Co., Inc. Alpha v integrin receptor antagonists
JP2004510738A (ja) * 2000-10-04 2004-04-08 メルク　エンド　カムパニー　インコーポレーテッド インテグリン受容体アンタゴニストのリン酸塩
JP2004517853A (ja) * 2001-01-03 2004-06-17 メルク　エンド　カムパニー　インコーポレーテッド 歯周病の治療方法及び治療用組成物
WO2002085405A2 (fr) 2001-04-24 2002-10-31 Merck Patent Gmbh POLYTHERAPIE A BASE D'AGENTS ANTIANGIOGENIQUES ET DE FACTEUR DE NECROSE TUMORALE TNF$g(a)
CA2478317A1 (fr) * 2002-03-04 2003-09-18 Medimmune, Inc. Procedes permettant de prevenir ou de traiter des troubles par administration d'un antagoniste de l'integrine .alpha.v.beta.3 associe a un inhibiteur de la reductase hmg-coa ou unbisphosphonate
AU2003217930A1 (en) * 2002-03-04 2003-09-22 Medimmune, Llc The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
EP1572690A1 (fr) 2002-12-20 2005-09-14 Pharmacia Corporation Composés de thiazole en tant que dérives d'antagonistes des récepteurs de l'integrine
WO2004078109A2 (fr) * 2003-03-07 2004-09-16 Merck Sharp & Dohme Limited Procede de synthese de produits intermediaires destines a la preparation d'antagonistes des recepteurs d'$g(a)$g(n)$g(b)3
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
AU2007207465B2 (en) 2006-01-18 2012-12-06 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
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CL2008000467A1 (es) * 2007-02-14 2008-08-22 Janssen Pharmaceutica Nv Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma
ES2457822T3 (es) 2007-11-08 2014-04-29 The General Hospital Corporation Procedimientos y composiciones de tratamiento de enfermedades proteinúricas
NZ597339A (en) 2009-05-25 2013-10-25 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
US8901144B2 (en) 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
HRP20171873T1 (hr) 2013-02-07 2018-02-23 Scifluor Life Sciences, Inc Fluorinirani antagonisti integrina
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
PL3050878T3 (pl) 2013-09-24 2022-01-24 Fujifilm Corporation Zawierający atom azotu związek lub jego sól, lub ich kompleks z metalem
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
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KR102647026B1 (ko) 2015-02-19 2024-03-12 사이플루어 라이프 사이언시즈, 인크 플루오르화 테트라히드로나프티리디닐 노난산 유도체 및 이의 용도
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EP3481814B1 (fr) * 2016-07-05 2022-04-27 The Rockefeller University Antagonistes de l'intégrine tetrahydronaphthyridinepentanamide
CN109996541A (zh) 2016-09-07 2019-07-09 普利安特治疗公司 N-酰基氨基酸化合物及其使用方法
MX2019005234A (es) * 2016-11-08 2019-08-12 Squibb Bristol Myers Co Amidas y aminas de azol como inhibidores de integrina alfa v.
AU2017359025A1 (en) * 2016-11-08 2019-06-20 Bristol-Myers Squibb Company Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha V integrin inhibitors
MA47697A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
WO2020047208A1 (fr) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibiteurs de l'intégrine (alpha-v)(bêta-6)
FI3844162T3 (fi) 2018-08-29 2025-03-27 Morphic Therapeutic Inc Alfa v beeta6 -integriinin estäjiä
EP4086254B1 (fr) 2018-08-29 2024-12-18 Morphic Therapeutic, Inc. Inhibiteurs d'intégrine
WO2025259747A2 (fr) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Compositions d'arni de protéine kinase myotonique de dystrophie (dmpk) et leurs procédés d'utilisation
WO2025259743A1 (fr) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Composés conjugués doubles pour administration extrahépatique

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Also Published As

Publication number Publication date
CA2373937A1 (fr) 2000-12-07
TR200103431T2 (tr) 2002-06-21
BG106232A (en) 2002-06-28
ES2288861T3 (es) 2008-02-01
PT1187592E (pt) 2007-10-19
US6410526B1 (en) 2002-06-25
JP2004500326A (ja) 2004-01-08
NO20015858D0 (no) 2001-11-30
DE60035779T2 (de) 2008-04-30
HUP0302468A2 (hu) 2003-11-28
BR0011108A (pt) 2002-03-19
PL353364A1 (en) 2003-11-17
EP1187592B1 (fr) 2007-08-01
DK1187592T3 (da) 2007-11-05
EP1187592A2 (fr) 2002-03-20
JP3808707B2 (ja) 2006-08-16
NO20015858L (no) 2002-02-04
AU5724600A (en) 2000-12-18
WO2000072801A2 (fr) 2000-12-07
AU749351B2 (en) 2002-06-27
HRP20010895A2 (en) 2003-08-31
JP2006206604A (ja) 2006-08-10
EP1187592A4 (fr) 2002-11-06
CY1107746T1 (el) 2013-04-18
ATE368462T1 (de) 2007-08-15
DE60035779D1 (de) 2007-09-13
DZ3263A1 (fr) 2000-12-07
JP2006232844A (ja) 2006-09-07
NO323906B1 (no) 2007-07-16
EA200101272A1 (ru) 2002-06-27
CN1589145A (zh) 2005-03-02
CZ20014308A3 (cs) 2002-03-13
WO2000072801A3 (fr) 2007-10-11
KR20020021380A (ko) 2002-03-20
SK17442001A3 (sk) 2002-03-05
IS6157A (is) 2001-11-13
IL146378A0 (en) 2002-07-25

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