EA199600007A2 - Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза - Google Patents

Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза

Info

Publication number
EA199600007A2
EA199600007A2 EA199600007A EA199600007A EA199600007A2 EA 199600007 A2 EA199600007 A2 EA 199600007A2 EA 199600007 A EA199600007 A EA 199600007A EA 199600007 A EA199600007 A EA 199600007A EA 199600007 A2 EA199600007 A2 EA 199600007A2
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
preparation
thiocolchicine
analogues
optically active
Prior art date
Application number
EA199600007A
Other languages
English (en)
Other versions
EA000093B1 (ru
EA199600007A3 (ru
Inventor
Франсис Брион
Бернадет Шаппер
Кристиан Диолез
Кристиан Мари
Алан Мазюри
Мишель Миддендорп
Дидье Пронин
Эдмон Тороманофф
Original Assignee
Руссель Юклаф
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Руссель Юклаф filed Critical Руссель Юклаф
Publication of EA199600007A2 publication Critical patent/EA199600007A2/ru
Publication of EA199600007A3 publication Critical patent/EA199600007A3/ru
Publication of EA000093B1 publication Critical patent/EA000093B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/543—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к трициклическим производным общей формулы I где Rи R- алкил, R- водород или A-SO, при этом А - алкил или фенил с возможностью замещения, или Rи R- водород или алкил, a R- A-SO, или R, Rи R- водород или алкил, или R- A-SOили водород, a Rи Rобразуют защитную группу, или R- A-SO, a Rи Rобразуют защитную группу, или R- водород, a Rи R- алкил или образуют защитную группу, которые могут быть использованы для получения рацемических и оптически активных колхицина и тиоколхицина, их аналогов или производных. Изобретение относится также к способам получения трициклических производных формулы I, к способу получения колхицина и тиоколхицина с использованием соединений формулы I и к промежуточным соединениям синтеза.
EA199600007A 1995-03-03 1996-03-01 Трициклические соединения, способ их получения, способы получения оптически активных или рацемических производных колхицина и тиоколхицина с использованием трициклических соединений и промежуточные продукты синтеза EA000093B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502480A FR2731217B1 (fr) 1995-03-03 1995-03-03 Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

Publications (3)

Publication Number Publication Date
EA199600007A2 true EA199600007A2 (ru) 1996-10-01
EA199600007A3 EA199600007A3 (ru) 1996-12-30
EA000093B1 EA000093B1 (ru) 1998-06-25

Family

ID=9476700

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199600007A EA000093B1 (ru) 1995-03-03 1996-03-01 Трициклические соединения, способ их получения, способы получения оптически активных или рацемических производных колхицина и тиоколхицина с использованием трициклических соединений и промежуточные продукты синтеза

Country Status (18)

Country Link
US (3) US5705704A (ru)
EP (1) EP0729933B1 (ru)
JP (1) JP3831445B2 (ru)
KR (2) KR100415038B1 (ru)
CN (2) CN1067044C (ru)
AT (1) ATE189203T1 (ru)
AU (1) AU717153B2 (ru)
CA (1) CA2170806C (ru)
DE (1) DE69606337T2 (ru)
DK (1) DK0729933T3 (ru)
EA (1) EA000093B1 (ru)
ES (1) ES2141445T3 (ru)
FR (1) FR2731217B1 (ru)
GR (1) GR3033123T3 (ru)
HU (1) HUP9600517A3 (ru)
MX (1) MX9600816A (ru)
PT (1) PT729933E (ru)
ZA (1) ZA961694B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE69707843T2 (de) * 1996-03-20 2002-05-16 Aventis Pharma S.A., Antony TRIZYCLISCHE VERBINDUNGEN MIT WIRKUNG AUF INTEGRINE, BESONDERS AUF DAS ALPHAvBETA3-INTEGRIN, VERFAHREN ZUR IHRER HERSTELLUNG UND ZWISCHENPRODUKTE DES VERFAHRENS, IHRE VERWENDUNG ALS ARZNEIMITTEL UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
US6459001B1 (en) * 1997-03-20 2002-10-01 Aventis Pharma S.A. Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
FR2768734B1 (fr) * 1997-09-24 2000-01-28 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2768736B1 (fr) 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
CN1391553A (zh) * 1999-11-18 2003-01-15 味之素株式会社 高甜度甜味剂用的新型中间体以及它的制造方法
IT1318436B1 (it) * 2000-03-31 2003-08-25 Enichem Spa Ciclopentadieni sostituiti policiclici e metodo per la loropreparazione.
US7204754B2 (en) * 2001-09-28 2007-04-17 Igt Gaming device having a mechanical award indicator
DK2470499T3 (da) * 2009-08-26 2019-09-23 Alberta Health Services Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf
KR20250172901A (ko) 2018-06-29 2025-12-09 알버타 헬스 서비시즈 콜히친 유도체의 방법 및 용도
US12617745B2 (en) * 2020-09-29 2026-05-05 Purdue Research Foundation Curcusone diterpenoids and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method

Also Published As

Publication number Publication date
JP3831445B2 (ja) 2006-10-11
KR960034153A (ko) 1996-10-22
FR2731217A1 (fr) 1996-09-06
US5959146A (en) 1999-09-28
CN1143622A (zh) 1997-02-26
HU9600517D0 (en) 1996-04-29
DE69606337D1 (de) 2000-03-02
PT729933E (pt) 2000-05-31
MX9600816A (es) 1997-02-28
DE69606337T2 (de) 2000-08-10
AU717153B2 (en) 2000-03-16
GR3033123T3 (en) 2000-08-31
FR2731217B1 (fr) 1997-06-13
US5705704A (en) 1998-01-06
EA000093B1 (ru) 1998-06-25
CN1310171A (zh) 2001-08-29
EP0729933B1 (fr) 2000-01-26
US6268520B1 (en) 2001-07-31
CA2170806C (fr) 2009-12-01
EP0729933A1 (fr) 1996-09-04
ATE189203T1 (de) 2000-02-15
EA199600007A3 (ru) 1996-12-30
DK0729933T3 (da) 2000-07-17
CN1067044C (zh) 2001-06-13
ES2141445T3 (es) 2000-03-16
KR100415038B1 (ko) 2004-04-13
ZA961694B (en) 1997-03-03
HUP9600517A2 (en) 1997-01-28
HUP9600517A3 (en) 1998-07-28
CA2170806A1 (fr) 1996-09-04
JPH0967326A (ja) 1997-03-11
KR100414622B1 (ko) 2004-01-13
AU4585096A (en) 1996-09-12

Similar Documents

Publication Publication Date Title
LU91587I2 (fr) Agomélatine et ses dérivés pharmaceutiquement acceptables (VALDOXAN)
ES2186672T3 (es) Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.
MY115679A (en) Process for preparing intermediates to florfenicol
DE59108707D1 (de) Verfahren zur Herstellung von Oxetanonen
ATE185558T1 (de) Prostaglandin-synthase hemmer
ATE132848T1 (de) Verfahren zur herstellung von sertralin- zwischenprodukten
DK165003C (da) Chlorsulfat
NZ511739A (en) New esters derived from substituted phenyl-cyclohexyl compounds
DK160877C (da) Fremgangsmaade til fremstilling af 2-penemforbindelser
ES556288A0 (es) Procedimiento para la obtencion de derivados del acido (met)-acrilo de triciclodecanos.
EA199600007A3 (ru) Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза
ATE127779T1 (de) Verfahren zur herstellung von sertralin.
NO924028D0 (no) Forbedret fremgangsmaate for fremstilling av substituerte indolonderivater
ES2180638T3 (es) Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.
PT93126A (pt) Processo para a preparacao de eteres carboxialquilicos da 2-amino-7- -hidroxitetralina
PT95990A (pt) Processo para a preparacao de novos derivados do tiofeno
DE69616357D1 (de) Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung
NO873564L (no) Nye tyroninderivater.
EA200500032A1 (ru) Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов
PT1347960E (pt) Processo para a preparacao de (+)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperidina
ES2038159T3 (es) Procedimiento para preparar derivados sustituidos de 2-aminoacetamida.
EA200200352A1 (ru) Фенил- и пиридил-тетрагидропиридины, обладающие ингибирующей активностью в отношении фактора некроза опухоли (фно)
BR9509752A (pt) Composto e processo para preparar um composto
EA199700300A1 (ru) СПОСОБ ПОЛУЧЕНИЯ ПРАКТИЧЕСКИ ЧИСТЫХ ИЗОМЕРОВ α-БИСОКСИМОВ
DK0846111T3 (da) Syntese af optisk rene forbindelser, der er anvendelige som GARFT-inhibitorer, og deres mellemprodukter

Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU